Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Fatty acid desaturase family protein | 0.0044 | 0.0197 | 0.1283 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.021 | 0.2012 | 1 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0044 | 0.0197 | 0.1283 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0166 | 0.1532 | 0.7358 |
Brugia malayi | Fatty acid desaturase family protein | 0.0044 | 0.0197 | 0.1283 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0044 | 0.0197 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0746 | 0.7889 | 0.7889 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0166 | 0.1532 | 0.5 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0044 | 0.0197 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.021 | 0.2012 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0044 | 0.0197 | 0.5 |
Loa Loa (eye worm) | FAT-3 protein | 0.0044 | 0.0197 | 0.1283 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0166 | 0.1532 | 0.7358 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0044 | 0.0197 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0044 | 0.0197 | 0.1283 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0044 | 0.0197 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0044 | 0.0197 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0939 | 1 | 0.5 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0044 | 0.0197 | 0.0197 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0044 | 0.0197 | 0.0197 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0939 | 1 | 1 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0044 | 0.0197 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0044 | 0.0197 | 0.0197 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0197 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0044 | 0.0197 | 0.1283 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0197 | 0.5 |
Onchocerca volvulus | 0.0044 | 0.0197 | 0.0977 | |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0044 | 0.0197 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0939 | 1 | 0.5 |
Schistosoma mansoni | fatty acid desaturase | 0.0044 | 0.0197 | 0.0197 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0044 | 0.0197 | 0.0197 |
Leishmania major | stearic acid desaturase, putative | 0.021 | 0.2012 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0166 | 0.1532 | 0.5 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0044 | 0.0197 | 0.0197 |
Onchocerca volvulus | 0.021 | 0.2012 | 1 | |
Brugia malayi | acyl-CoA desaturase | 0.0166 | 0.1532 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.021 | 0.2012 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0166 | 0.1532 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0044 | 0.0197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0197 | 0.1283 |
Onchocerca volvulus | 0.021 | 0.2012 | 1 | |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0939 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0939 | 0.9996 | 0.9996 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0939 | 0.9996 | 0.9996 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.