Detailed information for compound 1816700

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 3506.92 | Formula: C155H249N47O46
  • H donors: 53 H acceptors: 47 LogP: -19.25 Rotable bonds: 135
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)NCCCC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)O)CCCCN)CC(=O)N)CC(C)C)[C@H](CC)C)CO)CC(=O)N)CC(C)C)Cc1ccc(cc1)O)CCCCN)CCCCN)C(C)C)C)NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1[nH]cnc1)N)CO)CC(=O)O)C)Cc1ccccc1)CC(=O)O)CC(=O)N)Cc1ccc(cc1)O)CCCNC(=N)N
  • InChi: 1S/C155H249N47O46/c1-15-79(10)122(150(244)193-101(60-76(4)5)139(233)189-105(65-113(162)210)128(222)173-71-117(214)177-99(153(247)248)37-22-27-55-159)200-147(241)111(73-204)197-142(236)107(67-115(164)212)190-138(232)100(59-75(2)3)186-140(234)102(62-85-40-44-88(207)45-41-85)187-134(228)93(34-20-25-53-157)180-131(225)94(35-21-26-54-158)184-148(242)120(77(6)7)198-125(219)80(11)175-129(223)91-36-23-28-56-170-116(213)51-49-98(136(230)181-95(38-29-57-171-154(165)166)132(226)179-92(33-19-24-52-156)130(224)182-97(135(229)178-91)48-50-112(161)209)183-133(227)96(39-30-58-172-155(167)168)185-151(245)123(82(13)205)201-144(238)103(63-86-42-46-89(208)47-43-86)188-141(235)106(66-114(163)211)191-143(237)109(69-119(217)218)195-152(246)124(83(14)206)202-145(239)104(61-84-31-17-16-18-32-84)194-149(243)121(78(8)9)199-126(220)81(12)176-137(231)108(68-118(215)216)192-146(240)110(72-203)196-127(221)90(160)64-87-70-169-74-174-87/h16-18,31-32,40-47,70,74-83,90-111,120-124,203-208H,15,19-30,33-39,48-69,71-73,156-160H2,1-14H3,(H2,161,209)(H2,162,210)(H2,163,211)(H2,164,212)(H,169,174)(H,170,213)(H,173,222)(H,175,223)(H,176,231)(H,177,214)(H,178,229)(H,179,226)(H,180,225)(H,181,230)(H,182,224)(H,183,227)(H,184,242)(H,185,245)(H,186,234)(H,187,228)(H,188,235)(H,189,233)(H,190,232)(H,191,237)(H,192,240)(H,193,244)(H,194,243)(H,195,246)(H,196,221)(H,197,236)(H,198,219)(H,199,220)(H,200,241)(H,201,238)(H,202,239)(H,215,216)(H,217,218)(H,247,248)(H4,165,166,171)(H4,167,168,172)/t79-,80-,81-,82+,83+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-/m0/s1
  • InChiKey: RFFRERQAKOWDMH-HBXFPQPYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens vasoactive intestinal peptide receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c vasoactive intestinal peptide receptor 2 438 aa 411 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0123 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0123 0.0123
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.1687 0.478
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0796 0.211
Onchocerca volvulus 0.0029 0.0306 0.0526
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0123 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.3599 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0247 0.0385
Entamoeba histolytica hypothetical protein 0.0241 0.3599 0.5
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0035 0.0035
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0241 0.3599 0.3599
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Schistosoma mansoni protein kinase 0.0241 0.3599 0.3577
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0241 0.3599 0.3599
Schistosoma mansoni adenoreceptor 0.0017 0.0123 0.0088
Loa Loa (eye worm) RGC/RGC protein kinase 0.0241 0.3599 1
Brugia malayi glutathione reductase 0.0046 0.0583 0.1509
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.3599 1
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0123 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Toxoplasma gondii protein kinase 0.0241 0.3599 1
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Brugia malayi Tyrosine-protein kinase PR2 0.0241 0.3599 1
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0247 0.0385
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0583 0.1348
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0701 0.1689
Loa Loa (eye worm) TK/ABL protein kinase 0.0241 0.3599 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0241 0.3599 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0241 0.3599 1
Schistosoma mansoni opsin-like receptor 0.0017 0.0123 0.0088
Entamoeba histolytica hypothetical protein 0.0241 0.3599 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0241 0.3599 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0418 0.0927
Entamoeba histolytica serine/threonine kinase, putative 0.0241 0.3599 0.5
Mycobacterium ulcerans beta-lactamase 0.0036 0.0418 1
Brugia malayi hypothetical protein 0.0017 0.0123 0.0216
Echinococcus granulosus tyrosine protein kinase pr2 0.0241 0.3599 0.3599
Onchocerca volvulus 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.013 0.0362
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0418 0.0927
Onchocerca volvulus 0.0241 0.3599 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5
Plasmodium falciparum protein kinase, putative 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0796 0.2211
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Schistosoma mansoni protein kinase 0.0241 0.3599 0.3577
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0241 0.3599 1
Onchocerca volvulus Tyrosine kinase homolog 0.0241 0.3599 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0241 0.3599 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0241 0.3599 0.3599
Echinococcus granulosus tyrosine protein kinase csk 0.0241 0.3599 0.3599
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0123 0.0216
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0241 0.3599 0.3599
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0123 0.0088
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.3599 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0241 0.3599 0.3599
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0123 0.0342
Loa Loa (eye worm) TK protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0123 0.0342
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0123 0.0088
Echinococcus granulosus tyrosine protein kinase Srms 0.0241 0.3599 0.3599
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0123 0.0216
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5
Entamoeba histolytica hypothetical protein 0.0241 0.3599 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0241 0.3599 0.3599
Trichomonas vaginalis TK family protein kinase 0.0241 0.3599 1
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0241 0.3599 0.3599
Schistosoma mansoni protein kinase 0.0241 0.3599 0.3577
Echinococcus granulosus tyrosine protein kinase Lyn 0.0241 0.3599 0.3599
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0241 0.3599 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.3599 1
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0241 0.3599 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0241 0.3599 0.3599
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0241 0.3599 0.3577
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Brugia malayi CXXC zinc finger family protein 0.0029 0.0306 0.073
Loa Loa (eye worm) serine/threonine protein kinase 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Schistosoma mansoni opsin-like receptor 0.0017 0.0123 0.0088
Trichomonas vaginalis protein tyrosine kinase, putative 0.0241 0.3599 1
Echinococcus granulosus hypothetical protein 0.0017 0.0123 0.0123
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0123 0.0123
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0123 0.0123
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Echinococcus granulosus activated cdc42 kinase 1 0.0241 0.3599 0.3599
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Echinococcus granulosus retinal guanylyl cyclase 2 0.0241 0.3599 0.3599
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0123 0.0123
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0418 0.0876
Schistosoma mansoni hypothetical protein 0.0017 0.0123 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus granulosus serotonin receptor 0.0017 0.0123 0.0123
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis protein tyrosine kinase 0.0241 0.3599 0.3599
Mycobacterium leprae Probable lipase LipE 0.0036 0.0418 0.1531
Loa Loa (eye worm) TK/ROR protein kinase 0.0241 0.3599 1
Schistosoma mansoni amine GPCR 0.0017 0.0123 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0241 0.3599 0.3599
Schistosoma mansoni hypothetical protein 0.0019 0.0158 0.0124
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Echinococcus multilocularis tyrosine protein kinase csk 0.0241 0.3599 0.3599
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0418 0.0418
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.3599 0.3577
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Plasmodium vivax tyrosine kinase-like protein, putative 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0241 0.3599 0.3599
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.3407 1
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Brugia malayi G protein-coupled receptor 0.0017 0.0123 0.0216
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0123 0.0216
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0123 0.0123
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0418 0.0927
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0038 0.0456 0.0957
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0418 0.0927
Brugia malayi neuropeptide F receptor 0.0017 0.0123 0.0216
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0418 0.0384
Brugia malayi hypothetical protein 0.0241 0.3599 1
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0123 0.0342
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0123 0.0123
Plasmodium vivax protein kinase, putative 0.0241 0.3599 1
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0158 0.0158
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0123 0.0123
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0241 0.3599 0.3599
Entamoeba histolytica hypothetical protein 0.0241 0.3599 0.5
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Trypanosoma brucei trypanothione reductase 0.0046 0.0583 0.1348
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0123 0.0088
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0123 0.0123
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0123 0.0123
Brugia malayi SH2 domain containing protein 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Brugia malayi Serotonin receptor 0.0017 0.0123 0.0216
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Echinococcus granulosus somatostatin receptor 0.0017 0.0123 0.0123
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0241 0.3599 1
Echinococcus granulosus tyrosine protein kinase csk 0.0241 0.3599 0.3599
Entamoeba histolytica hypothetical protein 0.0241 0.3599 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Toxoplasma gondii STE kinase 0.0241 0.3599 1
Onchocerca volvulus 0.0036 0.0418 0.0848
Echinococcus multilocularis tyrosine kinase 0.0241 0.3599 0.3599
Schistosoma mansoni protein kinase 0.0241 0.3599 0.3577
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0123 0.0123
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0241 0.3599 0.3599
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0241 0.3599 0.3599
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus granulosus activin receptor type 0.0241 0.3599 0.3599
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Loa Loa (eye worm) matrixin family protein 0.0042 0.0509 0.1414
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Echinococcus granulosus g protein coupled receptor 0.0017 0.0123 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0123 0.0088
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) TK protein kinase 0.0241 0.3599 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0241 0.3599 0.3599
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0241 0.3599 1
Onchocerca volvulus 0.0241 0.3599 1
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.3599 1
Schistosoma mansoni ephrin receptor 0.0241 0.3599 0.3577
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0241 0.3599 0.3599
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Echinococcus granulosus g protein coupled receptor 0.0017 0.0123 0.0123
Loa Loa (eye worm) glutathione reductase 0.0046 0.0583 0.1619
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Schistosoma mansoni histamine h1 receptor 0.0017 0.0123 0.0088
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.013 0.0362
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0241 0.3599 0.3577
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0021 0.0188 0.04
Onchocerca volvulus 0.0241 0.3599 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.1687 0.478
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Trichomonas vaginalis esterase, putative 0.0036 0.0418 0.0876
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0241 0.3599 0.3599
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Echinococcus multilocularis epidermal growth factor receptor 0.0241 0.3599 0.3599
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0123 0.0216
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0123 0.0342
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0123 0.0123
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1504 0.4224
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Brugia malayi SH2 domain containing protein 0.0241 0.3599 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0241 0.3599 0.3599
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Schistosoma mansoni hypothetical protein 0.0019 0.0158 0.0124
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Echinococcus multilocularis raf serine:threonine protein kinase 0.0241 0.3599 0.3599
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0123 0.0088
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Loa Loa (eye worm) TK protein kinase 0.0241 0.3599 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0247 0.0385
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0241 0.3599 0.3599
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Echinococcus granulosus protein kinase 0.0241 0.3599 0.3599
Brugia malayi hypothetical protein 0.0017 0.0123 0.0216
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0241 0.3599 0.3599
Mycobacterium tuberculosis Conserved protein 0.0036 0.0418 0.0927
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0112 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Schistosoma mansoni protein kinase 0.0241 0.3599 0.3577
Brugia malayi Matrixin family protein 0.0017 0.013 0.0236
Schistosoma mansoni tyrosine protein kinase 0.0241 0.3599 0.3577
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Onchocerca volvulus 0.0241 0.3599 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0241 0.3599 0.3599
Brugia malayi G-protein coupled receptor 0.0017 0.0123 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.3599 0.3577
Echinococcus granulosus tyrosine protein kinase Fyn 0.0241 0.3599 0.3599
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0247 0.0385
Giardia lamblia Protein 21.1 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Schistosoma mansoni amine GPCR 0.0017 0.0123 0.0088
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0241 0.3599 0.3599
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0418 0.0876
Loa Loa (eye worm) TK/ACK protein kinase 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Schistosoma mansoni protein tyrosine kinase 0.0241 0.3599 0.3577
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Echinococcus multilocularis GPCR, family 2 0.0019 0.0158 0.0158
Echinococcus multilocularis integrin linked protein kinase 0.0241 0.3599 0.3599
Loa Loa (eye worm) TK protein kinase 0.0241 0.3599 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0123 0.0216
Brugia malayi Furin-like cysteine rich region family protein 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.3599 0.3577
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0041 0.0501 0.0467
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0123 0.0123
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1504 0.4224
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0241 0.3599 0.3577
Echinococcus multilocularis activated cdc42 kinase 1 0.0241 0.3599 0.3599
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0123 0.0088
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0241 0.3599 0.3577
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0418 0.0927
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0112 0.0112
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0123 0.0123
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0158 0.044
Entamoeba histolytica hypothetical protein 0.0241 0.3599 0.5
Schistosoma mansoni hypothetical protein 0.0017 0.0123 0.0088
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0247 0.0385
Echinococcus multilocularis transfer RNA-Thr 0.0241 0.3599 0.3599
Brugia malayi ephrin receptor 1 precursor 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0123 0.0123
Echinococcus granulosus integrin linked protein kinase 0.0241 0.3599 0.3599
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0123 0.0088
Loa Loa (eye worm) TK/CSK protein kinase 0.0241 0.3599 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0241 0.3599 0.5
Schistosoma mansoni neuropeptide receptor 0.0017 0.0123 0.0088
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0123 0.0123
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0241 0.3599 0.3599
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis serotonin receptor 0.0017 0.0123 0.0123
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Schistosoma mansoni protein kinase 0.0241 0.3599 0.3577
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0241 0.3599 0.3599
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0241 0.3599 0.3577
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0063 0.0834 0.0834
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0123 0.0123
Entamoeba histolytica tyrosin kinase, putative 0.0241 0.3599 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0158 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.3599 1
Trichomonas vaginalis AGC family protein kinase 0.0241 0.3599 1
Echinococcus granulosus g protein coupled receptor 0.0017 0.0123 0.0123
Schistosoma mansoni cpg binding protein 0.0029 0.0306 0.0271
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Schistosoma mansoni hypothetical protein 0.0241 0.3599 0.3577
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0123 0.0088
Brugia malayi Guanylyl cyclase protein 23 0.0241 0.3599 1
Echinococcus granulosus epidermal growth factor receptor 0.0241 0.3599 0.3599
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5
Echinococcus multilocularis insulin receptor 0.0241 0.3599 0.3599
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0796 0.2211
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0123 0.0088
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0418 0.1161
Brugia malayi bone morphogenetic protein type 1 receptor 0.0241 0.3599 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0123 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Brugia malayi AKH receptor 0.0017 0.0123 0.0216
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0241 0.3599 0.3599
Schistosoma mansoni myosin xvIII 0.0017 0.0123 0.0088
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Echinococcus multilocularis natriuretic peptide receptor 1 0.0241 0.3599 0.3599
Brugia malayi Receptor family ligand binding region containing protein 0.0241 0.3599 1
Schistosoma mansoni hypothetical protein 0.0019 0.0158 0.0124
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Schistosoma mansoni hypothetical protein 0.0017 0.0123 0.0088
Giardia lamblia Kinase, NEK 0.0241 0.3599 1
Echinococcus granulosus tyrosine protein kinase 0.0241 0.3599 0.3599
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0241 0.3599 1
Onchocerca volvulus 0.0024 0.0242 0.0342
Entamoeba histolytica hypothetical protein, conserved 0.0241 0.3599 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0241 0.3599 0.3599
Echinococcus granulosus tyrosine kinase 0.0241 0.3599 0.3599
Entamoeba histolytica ankyrin repeat protein 0.0241 0.3599 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0241 0.3599 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Echinococcus multilocularis tyrosine protein kinase csk 0.0241 0.3599 0.3599
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0241 0.3599 0.3599
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0123 0.0123
Echinococcus granulosus fmrfamide receptor 0.0017 0.0123 0.0123
Brugia malayi Dopamine receptor protein 2 0.0017 0.0123 0.0216
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.1687 0.478
Entamoeba histolytica serine/threonine kinase, putative 0.0241 0.3599 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0583 0.0583
Onchocerca volvulus 0.0241 0.3599 1
Schistosoma mansoni protein kinase 0.0241 0.3599 0.3577
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Trypanosoma brucei Flagellum attachment zone protein 20 0.0241 0.3599 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0241 0.3599 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0418 0.1161
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Loa Loa (eye worm) hypothetical protein 0.0036 0.0418 0.1161
Brugia malayi hypothetical protein 0.0017 0.0123 0.0216
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0123 0.0123
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0418 0.0876
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0241 0.3599 0.3599
Echinococcus multilocularis heat shock protein 70 0.0241 0.3599 0.3599
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Brugia malayi hypothetical protein 0.0017 0.0123 0.0216
Brugia malayi hypothetical protein 0.0017 0.0123 0.0216
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0123 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0418 0.1531
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0123 0.0123
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Brugia malayi hypothetical protein 0.0241 0.3599 1
Brugia malayi hypothetical protein 0.0017 0.0123 0.0216
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0123 0.0088
Brugia malayi putative neuropeptide receptor 0.0017 0.0123 0.0216
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Brugia malayi Matrixin family protein 0.0017 0.013 0.0236
Schistosoma mansoni opsin-like receptor 0.0017 0.0123 0.0088
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Treponema pallidum NADH oxidase 0.0016 0.0112 0.5
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Brugia malayi RE15519p 0.0017 0.0123 0.0216
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0247 0.0385
Echinococcus multilocularis tyrosine protein kinase shark 0.0241 0.3599 0.3599
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0241 0.3599 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0241 0.3599 0.3599
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0123 0.0342
Schistosoma mansoni amine GPCR 0.0017 0.0123 0.0088
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Echinococcus granulosus raf serine:threonine protein kinase 0.0241 0.3599 0.3599
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.013 0.0362
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0241 0.3599 0.3599
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Brugia malayi hypothetical protein 0.0017 0.0123 0.0216
Echinococcus granulosus c src tyrosine kinase 0.0241 0.3599 0.3599
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0123 0.0088
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0123 0.0123
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0123 0.0123
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0112 0.5
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0123 0.0123
Onchocerca volvulus 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0123 0.0342
Echinococcus multilocularis somatostatin receptor 0.0017 0.0123 0.0123
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.3599 0.3577
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Onchocerca volvulus 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0241 0.3599 0.3599
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0123 0.0123
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0418 0.0876
Leishmania major hypothetical protein, conserved 0.0036 0.0418 0.0876
Entamoeba histolytica tyrosin kinase, putative 0.0241 0.3599 0.5
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0418 0.0927
Schistosoma mansoni cpg binding protein 0.003 0.0331 0.0297
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0418 0.0876
Entamoeba histolytica cysteine surface protein, putative 0.0241 0.3599 0.5
Entamoeba histolytica receptor protein kinase, putative 0.0241 0.3599 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Leishmania major protein kinase, putative 0.0241 0.3599 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0063 0.0834 0.0834
Mycobacterium tuberculosis Conserved protein 0.0036 0.0418 0.0927
Plasmodium vivax glutathione reductase, putative 0.0046 0.0583 0.1348
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Echinococcus granulosus tyrosine kinase 0.0241 0.3599 0.3599
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5
Loa Loa (eye worm) TK protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0418 0.0876
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0123 0.0123
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0241 0.3599 0.3599
Echinococcus granulosus cpg binding protein 0.003 0.0331 0.0331
Loa Loa (eye worm) TK/RYK protein kinase 0.0241 0.3599 1
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Trypanosoma cruzi protein kinase, putative 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Brugia malayi Hemopexin family protein 0.0024 0.0242 0.0551
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0036 0.0418 0.1161
Loa Loa (eye worm) TK protein kinase 0.0241 0.3599 1
Echinococcus multilocularis tyrosine protein kinase 0.0241 0.3599 0.3599
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Onchocerca volvulus 0.0017 0.013 0.0021
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0241 0.3599 0.3599
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0241 0.3599 0.3599
Loa Loa (eye worm) TK protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Brugia malayi Dopamine receptor protein 1 0.0017 0.0123 0.0216
Brugia malayi hypothetical protein 0.0025 0.0247 0.0564
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0418 1
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Plasmodium falciparum protein kinase, putative 0.0241 0.3599 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0123 0.0088
Loa Loa (eye worm) hypothetical protein 0.0036 0.0418 0.1161
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0241 0.3599 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1504 0.4224
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Schistosoma mansoni ephrin receptor 0.0241 0.3599 0.3577
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0123 0.0123
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0241 0.3599 0.3599
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0241 0.3599 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0241 0.3599 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0035 0.0035
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0583 0.1348
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0123 0.0123
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0017 0.013 0.0095
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Brugia malayi hypothetical protein 0.0017 0.0123 0.0216
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0123 0.0123
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Schistosoma mansoni protein kinase 0.0241 0.3599 0.3577
Echinococcus multilocularis FL cytokine receptor 0.0241 0.3599 0.3599
Brugia malayi Dopamine receptor 0.0017 0.0123 0.0216
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0123 0.0088
Entamoeba histolytica serine/threonine kinase, putative 0.0241 0.3599 0.5
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.1687 1
Brugia malayi GnHR receptor homolog 0.0017 0.0123 0.0216
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Trichomonas vaginalis protein kinase atn1, putative 0.0241 0.3599 1
Entamoeba histolytica hypothetical protein 0.0241 0.3599 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0241 0.3599 0.3599
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0123 0.0088
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0123 0.0088
Schistosoma mansoni protein kinase 0.0241 0.3599 0.3577
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0241 0.3599 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0241 0.3599 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0241 0.3599 0.3599
Onchocerca volvulus 0.0241 0.3599 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0123 0.0216
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Entamoeba histolytica hypothetical protein 0.0241 0.3599 0.5
Schistosoma mansoni serine/threonine RGC 0.0241 0.3599 0.3577
Brugia malayi hypothetical protein 0.0017 0.0123 0.0216
Entamoeba histolytica hypothetical protein 0.0241 0.3599 0.5
Brugia malayi Matrixin family protein 0.0042 0.0509 0.1302
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0247 0.0385
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0123 0.0123
Mycobacterium ulcerans lipase LipD 0.0036 0.0418 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.044
Echinococcus granulosus tyrosine protein kinase Blk 0.0241 0.3599 0.3599
Echinococcus granulosus fibroblast growth factor receptor 4 0.0241 0.3599 0.3599
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Brugia malayi hypothetical protein 0.0016 0.0111 0.0181
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0123 0.0123
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0241 0.3599 1
Echinococcus granulosus orexin receptor type 2 0.0017 0.0123 0.0123
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0112 0.0112
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0112 0.0186
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0241 0.3599 0.3599
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Brugia malayi Melatonin receptor type 1A 0.0017 0.0123 0.0216
Echinococcus multilocularis protein kinase 0.0241 0.3599 0.3599
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0418 1
Schistosoma mansoni neuropeptide receptor 0.0654 1 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0241 0.3599 0.3599
Echinococcus multilocularis G protein coupled receptor 139 0.0654 1 1
Loa Loa (eye worm) TK protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0418 0.1161
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0306 0.0849
Echinococcus multilocularis protein KINase family member (kin 25) 0.0241 0.3599 0.3599
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1504 0.8778
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5
Brugia malayi Matrixin family protein 0.0017 0.013 0.0236
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0241 0.3599 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0158 0.0315
Echinococcus multilocularis serotonin receptor 0.0017 0.0123 0.0123
Brugia malayi neuropeptide F receptor 0.0017 0.0123 0.0216
Schistosoma mansoni hypothetical protein 0.0024 0.0242 0.0207
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0241 0.3599 0.3577
Schistosoma mansoni protein kinase 0.0241 0.3599 0.3577
Onchocerca volvulus 0.0241 0.3599 1
Brugia malayi Matrixin family protein 0.0017 0.013 0.0236
Entamoeba histolytica tyrosin kinase, putative 0.0241 0.3599 0.5
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Entamoeba histolytica serine/threonine kinase, putative 0.0241 0.3599 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0123 0.0216
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0241 0.3599 0.3599
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0123 0.0088
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Entamoeba histolytica hypothetical protein 0.0241 0.3599 0.5
Echinococcus multilocularis c src tyrosine kinase 0.0241 0.3599 0.3599
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0158 0.0315
Echinococcus multilocularis tyrosine protein kinase csk 0.0241 0.3599 0.3599
Echinococcus multilocularis activin receptor type 0.0241 0.3599 0.3599
Plasmodium falciparum thioredoxin reductase 0.0046 0.0583 0.1348
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0241 0.3599 0.3599
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Echinococcus multilocularis sex peptide receptor 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0158 0.0158
Echinococcus granulosus retinal guanylyl cyclase 2 0.0241 0.3599 0.3599
Echinococcus granulosus activated cdc42 kinase 1 0.0241 0.3599 0.3599
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Brugia malayi SRC-1 0.0241 0.3599 1
Giardia lamblia Kinase, NEK 0.0241 0.3599 1
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Brugia malayi C-terminal src kinase protein 1 0.0241 0.3599 1
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Echinococcus granulosus tyrosine kinase 0.0241 0.3599 0.3599
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Loa Loa (eye worm) hypothetical protein 0.0036 0.0418 0.1161
Brugia malayi Immunoglobulin I-set domain containing protein 0.0241 0.3599 1
Brugia malayi Serotonin receptor 0.0017 0.0123 0.0216
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0123 0.0088
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0241 0.3599 0.3599
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0123 0.0123
Toxoplasma gondii thioredoxin reductase 0.0046 0.0583 0.1348
Schistosoma mansoni amine GPCR 0.0017 0.0123 0.0088
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1504 0.4224
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0241 0.3599 0.3599
Loa Loa (eye worm) TK/FAK protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.168 0.4667
Echinococcus multilocularis epidermal growth factor receptor 0.0241 0.3599 0.3599
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus granulosus insulin receptor 0.0241 0.3599 0.3599
Brugia malayi larval opioid receptor 0.0017 0.0123 0.0216
Echinococcus multilocularis kinase suppressor of Ras 1 0.0241 0.3599 0.3599
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0241 0.3599 0.3599
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0123 0.0123
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0123 0.0123
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0241 0.3599 0.3599
Brugia malayi G-protein coupled receptor 0.0017 0.0123 0.0216
Entamoeba histolytica serine/threonine kinase, putative 0.0241 0.3599 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0418 0.0876
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Echinococcus multilocularis tyrosine protein kinase HCK 0.0241 0.3599 0.3599
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0112 0.5
Giardia lamblia Kinase 0.0241 0.3599 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0247 0.0685
Schistosoma mansoni neuropeptide receptor 0.0017 0.0123 0.0088
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0241 0.3599 0.3577
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Schistosoma mansoni cpg binding protein 0.003 0.0331 0.0297
Loa Loa (eye worm) matrix metalloproteinase 0.0017 0.013 0.0362
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0123 0.0123
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0123 0.0342
Schistosoma mansoni hypothetical protein 0.0017 0.0123 0.0088
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0796 0.211
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0123 0.0123
Schistosoma mansoni biogenic amine receptor 0.0017 0.0123 0.0088
Leishmania major hypothetical protein, conserved 0.0241 0.3599 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0123 0.0088
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0241 0.3599 0.3599
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0158 0.0158
Brugia malayi ORL1-like opioid receptor 0.0017 0.0123 0.0216
Loa Loa (eye worm) TK protein kinase 0.0241 0.3599 1
Brugia malayi Raf kinase 0.0241 0.3599 1
Onchocerca volvulus 0.0241 0.3599 1
Schistosoma mansoni hypothetical protein 0.0019 0.0158 0.0124
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0241 0.3599 0.3599
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0123 0.0123
Echinococcus multilocularis tyrosine protein kinase Blk 0.0241 0.3599 0.3599
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0123 0.0123
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Plasmodium falciparum tyrosine kinase-like protein 0.0241 0.3599 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0241 0.3599 0.3599
Brugia malayi beta-lactamase 0.0036 0.0418 0.1046
Onchocerca volvulus 0.0036 0.0418 0.0848
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Brugia malayi hypothetical protein 0.0241 0.3599 1
Schistosoma mansoni neuropeptide receptor 0.0017 0.0123 0.0088
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0418 0.1161
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0123 0.0123
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0583 0.0583
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0241 0.3599 1
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0123 0.0088
Brugia malayi beta-lactamase family protein 0.0036 0.0418 0.1046
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0123 0.0123
Schistosoma mansoni biogenic amine receptor 0.0017 0.0123 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Loa Loa (eye worm) SRC-1 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Entamoeba histolytica receptor protein kinase, putative 0.0241 0.3599 0.5
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Onchocerca volvulus 0.0241 0.3599 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0241 0.3599 0.3599
Echinococcus multilocularis tyrosine kinase 0.0241 0.3599 0.3599
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0418 0.0876
Entamoeba histolytica tyrosin kinase, putative 0.0241 0.3599 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Leishmania major trypanothione reductase 0.0046 0.0583 0.1348
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0123 0.0342
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0241 0.3599 0.5
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Mycobacterium tuberculosis Probable reductase 0.0106 0.1504 0.4224
Loa Loa (eye worm) TK/Met protein kinase 0.0241 0.3599 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0501 0.1279
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0123 0.0123
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0123 0.0123
Plasmodium falciparum glutathione reductase 0.0046 0.0583 0.1348
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5
Trypanosoma cruzi protein kinase, putative 0.0241 0.3599 1
Trypanosoma brucei Pseudokinase, putative 0.0241 0.3599 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0123 0.0123
Echinococcus granulosus tyrosine protein kinase Src64B 0.0241 0.3599 0.3599
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Echinococcus granulosus tyrosine protein kinase shark 0.0241 0.3599 0.3599
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Brugia malayi integrin-linked kinase 0.0241 0.3599 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0241 0.3599 0.3599
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0241 0.3599 0.3599
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0241 0.3599 0.5
Trichomonas vaginalis STE family protein kinase 0.0241 0.3599 1
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0123 0.0123
Onchocerca volvulus Matrilysin homolog 0.0017 0.013 0.0021
Echinococcus granulosus natriuretic peptide receptor 1 0.0241 0.3599 0.3599
Echinococcus granulosus tyrosine protein kinase Fyn 0.0241 0.3599 0.3599
Echinococcus multilocularis tyrosine protein kinase csk 0.0241 0.3599 0.3599
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0123 0.0123
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Toxoplasma gondii protein kinase domain-containing protein 0.0241 0.3599 1
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0241 0.3599 0.3599
Loa Loa (eye worm) hypothetical protein 0.0021 0.0188 0.0524
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0241 0.3599 0.3599
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Onchocerca volvulus 0.0241 0.3599 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0241 0.3599 0.3599
Echinococcus granulosus ephrin type A receptor 4 A 0.0241 0.3599 0.3599
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0241 0.3599 0.3599
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Echinococcus multilocularis tyrosine protein kinase pr2 0.0241 0.3599 0.3599
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0123 0.0088
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0241 0.3599 1
Schistosoma mansoni biogenic amine receptor 0.0017 0.0123 0.0088
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0123 0.0123
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0418 0.0927
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0418 0.0927
Loa Loa (eye worm) TK/EGFR protein kinase 0.0241 0.3599 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0123 0.0088
Entamoeba histolytica ankyrin repeat protein 0.0241 0.3599 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0123 0.0123
Plasmodium vivax tyrosine kinase-like protein, putative 0.0241 0.3599 1
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Echinococcus granulosus GPCR family 2 0.0019 0.0158 0.0158
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0241 0.3599 1
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Echinococcus granulosus protein tyrosine kinase 0.0241 0.3599 0.3599
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0123 0.0342
Loa Loa (eye worm) protein kinase domain-containing protein 0.0241 0.3599 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0418 0.0876
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0241 0.3599 0.3599
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0418 0.0384
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.168 0.4667
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Loa Loa (eye worm) TK protein kinase 0.0241 0.3599 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0241 0.3599 1
Toxoplasma gondii ABC1 family protein 0.0036 0.0418 0.0876
Schistosoma mansoni amine GPCR 0.0017 0.0123 0.0088
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0021 0.0188 0.0231
Entamoeba histolytica tyrosine kinase, putative 0.0241 0.3599 0.5
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Entamoeba histolytica protein kinase, putative 0.0241 0.3599 0.5
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0583 0.1427
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Entamoeba histolytica protein kinase domain containing protein 0.0241 0.3599 0.5
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Leishmania major hypothetical protein, conserved 0.0025 0.0247 0.0385
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0123 0.0123
Echinococcus granulosus neuropeptide receptor 0.0017 0.0123 0.0123
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Echinococcus granulosus sex peptide receptor 0.0017 0.0123 0.0123
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0123 0.0123
Echinococcus multilocularis neuropeptide receptor 0.0654 1 1
Schistosoma mansoni tyrosine kinase 0.0241 0.3599 0.3577
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0123 0.0123
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0123 0.0123
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0123 0.0123
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0123 0.0088
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0802 0.0769
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5
Onchocerca volvulus 0.0036 0.0418 0.0848
Echinococcus multilocularis tyrosine protein kinase Srms 0.0241 0.3599 0.3599
Echinococcus multilocularis cpg binding protein 0.003 0.0331 0.0331
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0418 0.1046
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0241 0.3599 0.3599
Echinococcus granulosus allatostatin A receptor 0.0017 0.0123 0.0123
Mycobacterium ulcerans hydrolase 0.0021 0.0188 0.2489
Brugia malayi beta-lactamase family protein 0.0036 0.0418 0.1046
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Entamoeba histolytica hypothetical protein 0.0241 0.3599 0.5
Brugia malayi MH2 domain containing protein 0.0117 0.168 0.4597
Entamoeba histolytica serine/threonine kinase, putative 0.0241 0.3599 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Onchocerca volvulus 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0123 0.0342
Brugia malayi sulfakinin receptor protein 0.0017 0.0123 0.0216
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1504 0.4224
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Brugia malayi hypothetical protein 0.0017 0.0123 0.0216
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0123 0.0088
Loa Loa (eye worm) RGC/RGC protein kinase 0.0241 0.3599 1
Echinococcus multilocularis protein kinase 0.0241 0.3599 0.3599
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0041 0.0497 0.0464
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0112 0.0078
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Trypanosoma brucei protein kinase, putative 0.0241 0.3599 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0241 0.3599 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0123 0.0088
Onchocerca volvulus Matrilysin homolog 0.0038 0.0456 0.0957
Onchocerca volvulus 0.0241 0.3599 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0583 0.1619
Loa Loa (eye worm) TK/FER protein kinase 0.0241 0.3599 1
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0501 0.1391
Leishmania major protein kinase, putative 0.0241 0.3599 1
Loa Loa (eye worm) matrixin family protein 0.0038 0.0456 0.1266
Loa Loa (eye worm) TK/INSR protein kinase 0.0241 0.3599 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0418 1
Trichomonas vaginalis TKL family protein kinase 0.0241 0.3599 1
Plasmodium falciparum protein kinase, putative 0.0241 0.3599 1
Brugia malayi protein-tyrosine kinase 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0342
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0123 0.0088
Echinococcus granulosus tyrosine protein kinase HCK 0.0241 0.3599 0.3599
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0123 0.0342
Schistosoma mansoni protein kinase 0.0241 0.3599 0.3577
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0241 0.3599 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0418 0.0418
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0123 0.0088
Brugia malayi Protein kinase domain containing protein 0.0241 0.3599 1
Brugia malayi Thioredoxin reductase 0.0046 0.0583 0.1509
Loa Loa (eye worm) hypothetical protein 0.0241 0.3599 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0241 0.3599 0.5

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 1.16 nM Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay ChEMBL. 24900623

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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