Detailed information for compound 1818106

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.455 | Formula: C23H25FN2O2
  • H donors: 1 H acceptors: 1 LogP: 4.57 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(c[nH]2)C(=O)CN1CCC(CC1)Cc1ccc(cc1)F
  • InChi: 1S/C23H25FN2O2/c1-28-19-6-7-22-20(13-19)21(14-25-22)23(27)15-26-10-8-17(9-11-26)12-16-2-4-18(24)5-3-16/h2-7,13-14,17,25H,8-12,15H2,1H3
  • InChiKey: ULJCLXJSYUBCDV-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) fibroinase 0.0164 0.1328 0.1999
Echinococcus granulosus cathepsin b 0.0301 0.2648 0.2648
Brugia malayi cathepsin Z-like cysteine proteinase 0.0041 0.0142 0.0214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0164 0.1328 1
Onchocerca volvulus 0.0087 0.0589 0.2664
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.014 0.021
Echinococcus multilocularis cysteine protease 0.0164 0.1328 0.1328
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0159
Onchocerca volvulus 0.0041 0.014 0.0632
Schistosoma mansoni hypothetical protein 0.0041 0.014 0.0376
Brugia malayi Histone deacetylase 1 0.0043 0.0168 0.0253
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Leishmania major cathepsin L-like protease 0.0164 0.1328 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0041 0.014 0.0376
Trypanosoma cruzi major cysteine proteinase, putative 0.0041 0.0142 0.0538
Brugia malayi Cathepsin L-like precursor 0.0037 0.0105 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0499 0.0751
Trypanosoma brucei histone deacetylase, putative 0.0056 0.0291 0.2192
Brugia malayi sulfakinin receptor protein 0.0041 0.014 0.021
Echinococcus granulosus apoptotic protease activating factor 1 0.0031 0.0051 0.0051
Echinococcus granulosus lysine specific histone demethylase 1A 0.0071 0.043 0.043
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0041 0.0142 0.1073
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0301 0.2648 0.7129
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0105 0.0159
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0043 0.0168 0.0253
Brugia malayi Papain family cysteine protease containing protein 0.0164 0.1328 0.1999
Onchocerca volvulus 0.0164 0.1328 0.6007
Schistosoma mansoni hypothetical protein 0.0087 0.0589 0.1586
Echinococcus multilocularis g protein coupled receptor 0.0041 0.014 0.014
Trypanosoma brucei prolyl endopeptidase 0.0128 0.0982 0.7394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0078 0.0499 0.1342
Plasmodium vivax vivapain-2 0.0164 0.1328 1
Brugia malayi Cathepsin L-like precursor 0.0127 0.0972 0.1463
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0164 0.1328 0.1999
Onchocerca volvulus 0.0041 0.014 0.0632
Loa Loa (eye worm) matrixin family protein 0.0166 0.1346 0.2026
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0087 0.0589 0.4435
Echinococcus multilocularis neuropeptide receptor A26 0.0041 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Schistosoma mansoni hypothetical protein 0.0255 0.2211 0.5953
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0462 0.0462
Echinococcus multilocularis chromobox protein 2 0.0378 0.3399 0.3399
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0214
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0041 0.014 0.014
Onchocerca volvulus 0.0041 0.014 0.0632
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0164 0.1328 0.1328
Onchocerca volvulus Cell death protein 3 homolog 0.0031 0.0051 0.023
Loa Loa (eye worm) hypothetical protein 0.0158 0.1274 0.1917
Brugia malayi cathepsin Z-like cysteine proteinase 0.0041 0.0142 0.0214
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Onchocerca volvulus 0.0127 0.0972 0.4396
Plasmodium falciparum serine repeat antigen 5 0.0041 0.0142 0.1073
Echinococcus granulosus tachykinin peptides receptor 99D 0.0041 0.014 0.014
Echinococcus multilocularis G protein coupled receptor 139 0.0041 0.014 0.014
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0078 0.0499 0.1342
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.014 0.014
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0041 0.0142 0.1073
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0078 0.0499 0.1342
Echinococcus multilocularis gamma secretase subunit aph 1 0.0257 0.223 0.223
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Schistosoma mansoni biogenic amine receptor 0.0041 0.014 0.0376
Toxoplasma gondii cathepsin CPL 0.0164 0.1328 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.014 0.0376
Echinococcus multilocularis cathepsin b 0.0301 0.2648 0.2648
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.014 0.014
Schistosoma mansoni amine GPCR 0.0041 0.014 0.0376
Loa Loa (eye worm) hypothetical protein 0.0048 0.0212 0.0319
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0078 0.0499 0.1883
Brugia malayi Matrixin family protein 0.0068 0.041 0.0617
Leishmania major cathepsin L-like protease 0.0164 0.1328 1
Entamoeba histolytica cysteine protease, putative 0.0164 0.1328 1
Entamoeba histolytica aminopeptidase, putative 0.0074 0.0462 0.2698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0164 0.1328 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0164 0.1328 1
Schistosoma mansoni adenoreceptor 0.0041 0.014 0.0376
Brugia malayi prolyl oligopeptidase family protein 0.0128 0.0982 0.1478
Brugia malayi neuropeptide F receptor 0.0041 0.014 0.021
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0041 0.0142 0.1073
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.014 0.0376
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0041 0.014 0.014
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0164 0.1328 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.014 0.014
Onchocerca volvulus Matrilysin homolog 0.0068 0.041 0.1853
Echinococcus multilocularis cathepsin b 0.0301 0.2648 0.2648
Echinococcus granulosus tissue type plasminogen activator 0.0087 0.0589 0.0589
Entamoeba histolytica cysteine proteinase 1, putative 0.0078 0.0499 0.3003
Onchocerca volvulus 0.0031 0.0051 0.023
Onchocerca volvulus 0.0041 0.014 0.0632
Giardia lamblia Cathepsin B precursor 0.0121 0.0917 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0041 0.014 0.0376
Echinococcus granulosus histone deacetylase 6 0.0056 0.0291 0.0291
Onchocerca volvulus 0.0164 0.1328 0.6007
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0164 0.1328 1
Onchocerca volvulus Cathepsin L homolog 0.0041 0.0142 0.0644
Onchocerca volvulus 0.0041 0.014 0.0632
Plasmodium falciparum serine repeat antigen 8 0.0041 0.0142 0.1073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.014 0.0376
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0041 0.014 0.0376
Leishmania major hypothetical protein, conserved 0.0087 0.0589 0.4435
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0164 0.1328 0.1999
Leishmania major histone deacetylase, putative 0.0056 0.0291 0.2192
Entamoeba histolytica cysteine proteinase, putative 0.0164 0.1328 1
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0499 0.0751
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0247 0.0372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0499 0.3754
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0164 0.1328 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0041 0.014 0.021
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0462 0.0462
Trypanosoma cruzi cysteine peptidase, putative 0.0164 0.1328 0.5016
Schistosoma mansoni cathepsin C 0.0041 0.0142 0.0384
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.024 0.1803
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0083 0.0554 0.0833
Brugia malayi hypothetical protein 0.0031 0.0051 0.0077
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0214
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0255 0.2211 0.3329
Schistosoma mansoni cathepsin F (C01 family) 0.0127 0.0972 0.2617
Loa Loa (eye worm) hypothetical protein 0.0068 0.041 0.0617
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Echinococcus granulosus cathepsin L 0.0041 0.0142 0.0142
Plasmodium vivax vivapain-3 0.0078 0.0499 0.3754
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0041 0.0142 0.1073
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0249 0.215 0.215
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0041 0.014 0.021
Brugia malayi Cathepsin L-like precursor 0.0164 0.1328 0.1999
Brugia malayi Hemopexin family protein 0.0097 0.0686 0.1032
Schistosoma mansoni cathepsin F (C01 family) 0.0164 0.1328 0.3576
Echinococcus granulosus 7TM GPCR rhodopsin 0.0041 0.014 0.014
Loa Loa (eye worm) TK/ROR protein kinase 0.0087 0.0589 0.0887
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0462 0.0462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0041 0.0142 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0142 0.1073
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.014 0.0376
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.024 0.1803
Schistosoma mansoni histone deacetylase 4 5 0.0056 0.0291 0.0784
Echinococcus multilocularis neuropeptide receptor 0.0041 0.014 0.014
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0127 0.0972 0.3671
Schistosoma mansoni histamine h1 receptor 0.0041 0.014 0.0376
Echinococcus multilocularis somatostatin receptor 0.0041 0.014 0.014
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0041 0.014 0.021
Trypanosoma brucei Aph-1 protein, putative 0.01 0.0716 0.5389
Schistosoma mansoni histone deacetylase 0.0043 0.0168 0.0452
Echinococcus granulosus biogenic amine 5HT receptor 0.0167 0.1355 0.1355
Leishmania major cathepsin L-like protease 0.0164 0.1328 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.014 0.0376
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0041 0.014 0.014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0121 0.0917 0.247
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.014 0.014
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0462 0.0462
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0041 0.014 0.014
Schistosoma mansoni alpha-1 adrenergic receptor 0.0041 0.014 0.0376
Onchocerca volvulus 0.0164 0.1328 0.6007
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0041 0.0142 0.1073
Echinococcus multilocularis cathepsin L cysteine protease 0.0164 0.1328 0.1328
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.014 0.014
Brugia malayi cathepsin F-like cysteine proteinase 0.0041 0.0142 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0142 0.0214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0164 0.1328 1
Brugia malayi hypothetical protein 0.0041 0.014 0.021
Plasmodium vivax histone deacetylase 1, putative 0.0043 0.0168 0.1264
Brugia malayi hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Echinococcus granulosus neuropeptide FF receptor 2 0.0041 0.014 0.014
Brugia malayi cathepsin L-like precursor 0.0127 0.0972 0.1463
Leishmania major cysteine peptidase A (CPA) 0.0164 0.1328 1
Echinococcus granulosus neuropeptide s receptor 0.0041 0.014 0.014
Brugia malayi Peptidase family M1 containing protein 0.0163 0.1317 0.1983
Onchocerca volvulus 0.0074 0.0462 0.2091
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.014 0.0376
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0462 0.0462
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.014 0.021
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0168 0.1264
Echinococcus granulosus prolyl endopeptidase 0.0128 0.0982 0.0982
Onchocerca volvulus 0.0041 0.014 0.0632
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.014 0.014
Echinococcus multilocularis muscleblind protein 0.0158 0.1274 0.1274
Loa Loa (eye worm) hypothetical protein 0.0112 0.0832 0.1252
Plasmodium falciparum serine repeat antigen 9 0.0041 0.0142 0.1073
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Echinococcus multilocularis dro:myosuppressin receptor 0.0041 0.014 0.014
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0369 0.2777
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0589 0.2224
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0164 0.1328 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Onchocerca volvulus 0.0041 0.014 0.0632
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0041 0.0142 0.0384
Plasmodium vivax serine-repeat antigen (SERA) 0.0041 0.0142 0.1073
Brugia malayi histone deacetylase 3 (HD3) 0.0043 0.0168 0.0253
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0159
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) cathepsin B 0.0121 0.0917 0.1381
Brugia malayi hypothetical protein 0.0074 0.0462 0.0696
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0105 0.0398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.1328 1
Echinococcus granulosus cathepsin b 0.0301 0.2648 0.2648
Trypanosoma cruzi histone deacetylase, putative 0.0056 0.0291 0.1099
Brugia malayi cathepsin F-like cysteine proteinase 0.0037 0.0105 0.0159
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0159
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0164 0.1328 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0164 0.1328 1
Onchocerca volvulus 0.0041 0.014 0.0632
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.014 0.014
Onchocerca volvulus 0.0041 0.014 0.0632
Toxoplasma gondii histone deacetylase HDAC3 0.0043 0.0168 0.1264
Schistosoma mansoni neuropeptide receptor 0.0041 0.014 0.0376
Echinococcus granulosus orexin receptor type 2 0.0041 0.014 0.014
Brugia malayi Cathepsin L-like cysteine proteinase 0.0127 0.0972 0.1463
Trypanosoma cruzi oligopeptidase b 0.0051 0.024 0.0905
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0168 0.1264
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0071 0.043 0.043
Echinococcus multilocularis histone deacetylase 3 0.0043 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0158 0.1274 0.1917
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0273 0.0411
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0499 0.3003
Echinococcus multilocularis neuropeptide receptor 0.0041 0.014 0.014
Leishmania major histone deacetylase, putative 0.0043 0.0168 0.1264
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0048 0.0212 0.0799
Brugia malayi gamma-secretase subunit aph-1 0.0257 0.223 0.3356
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.014 0.014
Schistosoma mansoni myosin xvIII 0.0041 0.014 0.0376
Onchocerca volvulus 0.0164 0.1328 0.6007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Echinococcus granulosus g protein coupled receptor 0.0041 0.014 0.014
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0041 0.0142 0.1073
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0041 0.014 0.014
Brugia malayi Protein kinase domain containing protein 0.0087 0.0589 0.0887
Brugia malayi hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) histone deacetylase 1 0.0043 0.0168 0.0253
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.014 0.014
Schistosoma mansoni neuropeptide receptor 0.0041 0.014 0.0376
Echinococcus multilocularis muscleblind protein 1 0.0158 0.1274 0.1274
Echinococcus multilocularis histone deacetylase 1 0.0043 0.0168 0.0168
Echinococcus multilocularis g protein coupled receptor 0.0041 0.014 0.014
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0369 0.2777
Plasmodium vivax vivapain-1 0.0078 0.0499 0.3754
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.014 0.014
Echinococcus granulosus peptide allatostatin:somatostatin 0.0041 0.014 0.014
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0043 0.0168 0.1264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0041 0.014 0.014
Echinococcus granulosus integrin beta 2 0.0523 0.4797 0.4797
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0107 0.0161
Trypanosoma brucei oligopeptidase b 0.0051 0.024 0.1803
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0037 0.0105 0.0159
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0214
Trypanosoma brucei histone deacetylase 3 0.0056 0.0291 0.2192
Brugia malayi follicle stimulating hormone receptor 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0068 0.041 0.0617
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0041 0.0142 0.1073
Trypanosoma cruzi Aminopeptidase M1, putative 0.0074 0.0462 0.1746
Loa Loa (eye worm) TYRA-2 protein 0.0041 0.014 0.021
Trypanosoma cruzi Aph-1 protein, putative 0.01 0.0716 0.2703
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.014 0.014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Trypanosoma cruzi Aph-1 protein, putative 0.01 0.0716 0.2703
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0068 0.041 0.1103
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0043 0.0168 0.1264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.1328 1
Schistosoma mansoni histone deacetylase 4 5 0.0056 0.0291 0.0784
Loa Loa (eye worm) hypothetical protein 0.0167 0.1355 0.204
Echinococcus granulosus G protein coupled receptor 139 0.0041 0.014 0.014
Brugia malayi Cathepsin L-like precursor 0.0164 0.1328 0.1999
Echinococcus multilocularis g-protein coupled receptor 0.0041 0.014 0.014
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.014 0.014
Brugia malayi Kelch motif family protein 0.0112 0.0832 0.1252
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0142 0.0214
Loa Loa (eye worm) hypothetical protein 0.0255 0.2211 0.3329
Trypanosoma cruzi histone deacetylase 1, putative 0.0043 0.0168 0.0634
Giardia lamblia Histone deacetylase 0.0043 0.0168 0.0327
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0041 0.0142 0.1073
Echinococcus granulosus cysteine protease 0.0078 0.0499 0.0499
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0214
Loa Loa (eye worm) hypothetical protein 0.0089 0.0604 0.0909
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.014 0.014
Echinococcus multilocularis inhibitor of apoptosis protein 0.0255 0.2211 0.2211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.1328 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0043 0.0168 0.1264
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0142 0.0384
Schistosoma mansoni hypothetical protein 0.0097 0.0686 0.1846
Brugia malayi Cathepsin L-like precursor 0.0164 0.1328 0.1999
Loa Loa (eye worm) hypothetical protein 0.0128 0.0982 0.1478
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0499 0.1883
Echinococcus multilocularis histone deacetylase 0.0056 0.0291 0.0291
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0168 0.1264
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.014 0.014
Leishmania major oligopeptidase b 0.0051 0.024 0.1803
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.014 0.014
Brugia malayi Dopamine receptor protein 1 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Trypanosoma cruzi major cysteine proteinase, putative 0.0041 0.0142 0.0538
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0142 0.1073
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.014 0.014
Brugia malayi G protein-coupled receptor F59B2.13 0.0041 0.014 0.021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.1328 1
Mycobacterium ulcerans hydrolase 0.0083 0.0554 1
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0114 0.0853 1
Onchocerca volvulus Cathepsin L homolog 0.0164 0.1328 0.6007
Loa Loa (eye worm) hypothetical protein 0.0071 0.043 0.0648
Plasmodium vivax vivapain-2 0.0164 0.1328 1
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.014 0.021
Echinococcus granulosus histone deacetylase 1 0.0043 0.0168 0.0168
Brugia malayi hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) ctsf protein 0.0164 0.1328 0.1999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0142 0.1073
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0255 0.2211 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Echinococcus granulosus sex peptide receptor 0.0041 0.014 0.014
Schistosoma mansoni gamma-secretase subunit aph-1 0.0257 0.223 0.6003
Brugia malayi Kringle domain containing protein 0.0087 0.0589 0.0887
Onchocerca volvulus 0.0041 0.014 0.0632
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0041 0.014 0.021
Brugia malayi cathepsin B-like cysteine proteinase 0.0301 0.2648 0.3986
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.1328 1
Toxoplasma gondii kringle domain-containing protein 0.0087 0.0589 0.4435
Echinococcus granulosus inhibitor of apoptosis protein 0.0255 0.2211 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0142 0.1073
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0462 0.3482
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0121 0.0917 0.6907
Onchocerca volvulus Cathepsin F homolog 0.0164 0.1328 0.6007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0301 0.2648 0.7129
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0369 0.6664
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Plasmodium falciparum cysteine proteinase falcipain 3 0.0164 0.1328 1
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0142 0.1073
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0041 0.0142 0.0384
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0369 0.0369
Echinococcus multilocularis integrin beta 2 0.0523 0.4797 0.4797
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0041 0.014 0.0376
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.014 0.0376
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0142 0.1073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0164 0.1328 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0369 0.0369
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0142 0.0384
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0369 0.6664
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.014 0.014
Giardia lamblia Cathepsin B precursor 0.0121 0.0917 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0164 0.1328 0.1328
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.014 0.014
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.0982 0.2644
Onchocerca volvulus Neuropeptide F receptor homolog 0.0041 0.014 0.0632
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0041 0.0142 0.1073
Loa Loa (eye worm) hypothetical protein 0.0127 0.0972 0.1463
Trypanosoma cruzi aminopeptidase, putative 0.0074 0.0462 0.1746
Schistosoma mansoni hypothetical protein 0.0041 0.014 0.0376
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0255 0.2211 0.3329
Brugia malayi Matrixin family protein 0.0068 0.041 0.0617
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Schistosoma mansoni cathepsin s 0.0037 0.0105 0.0284
Brugia malayi Melatonin receptor type 1A 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0164 0.1328 1
Echinococcus multilocularis cathepsin L 0.0078 0.0499 0.0499
Onchocerca volvulus Prolyl endopeptidase homolog 0.0128 0.0982 0.4441
Echinococcus granulosus gamma secretase subunit aph 1 0.0257 0.223 0.223
Brugia malayi Serotonin receptor 0.0041 0.014 0.021
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.014 0.014
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0074 0.0462 0.3482
Loa Loa (eye worm) hypothetical protein 0.0127 0.0972 0.1463
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0499 0.3003
Plasmodium vivax unspecified product 0.0037 0.0105 0.0793
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.1328 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0074 0.0462 0.0462
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0048 0.0212 0.0212
Plasmodium falciparum cysteine repeat modular protein 1 0.0087 0.0589 0.4435
Onchocerca volvulus 0.0041 0.014 0.0632
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Trypanosoma brucei Aminopeptidase M1, putative 0.0074 0.0462 0.3482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0499 0.3754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0972 0.7319
Loa Loa (eye worm) hypothetical protein 0.0044 0.0172 0.0258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.1328 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0041 0.0142 0.1073
Loa Loa (eye worm) matrixin family protein 0.0152 0.1214 0.1827
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0041 0.014 0.014
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0041 0.014 0.021
Schistosoma mansoni cathepsin B (C01 family) 0.0041 0.0142 0.0384
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Leishmania major cathepsin L-like protease 0.0164 0.1328 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0074 0.0462 0.1746
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Loa Loa (eye worm) histone deacetylase 7A 0.0056 0.0291 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0499 0.3754
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0142 0.0384
Echinococcus multilocularis caspase 2 0.0031 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0255 0.2211 0.2211
Echinococcus granulosus serotonin receptor 0.0041 0.014 0.014
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0041 0.014 0.014
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0074 0.0462 0.1245
Leishmania major cathepsin L-like protease 0.0164 0.1328 1
Schistosoma mansoni chromobox protein 0.0378 0.3399 0.9151
Plasmodium vivax unspecified product 0.0078 0.0499 0.3754
Brugia malayi RE15519p 0.0041 0.014 0.021
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0071 0.043 0.1159
Onchocerca volvulus 0.0164 0.1328 0.6007
Echinococcus granulosus histone deacetylase 7 0.0056 0.0291 0.0291
Brugia malayi hypothetical protein 0.0041 0.014 0.021
Onchocerca volvulus 0.0163 0.1317 0.5957
Brugia malayi Cathepsin L-like precursor 0.0164 0.1328 0.1999
Leishmania major histone deacetylase, putative 0.0043 0.0168 0.1264
Echinococcus granulosus hypothetical protein 0.0041 0.014 0.014
Schistosoma mansoni histone deacetylase hda2 0.0056 0.0291 0.0784
Brugia malayi Tachykinin-like peptides receptor 99D 0.0041 0.014 0.021
Trypanosoma cruzi cysteine proteinase, putative 0.0078 0.0499 0.1883
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0972 0.7319
Schistosoma mansoni opsin-like receptor 0.0041 0.014 0.0376
Trypanosoma cruzi cysteine protease, putative 0.0078 0.0499 0.1883
Trypanosoma cruzi histone deacetylase, putative 0.0056 0.0291 0.1099
Toxoplasma gondii cathepsin B 0.0121 0.0917 0.6907
Loa Loa (eye worm) hypothetical protein 0.0127 0.0972 0.1463
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0041 0.014 0.014
Echinococcus granulosus neuropeptide receptor A26 0.0041 0.014 0.014
Brugia malayi G-protein coupled receptor 0.0041 0.014 0.021
Echinococcus granulosus chromobox protein 2 0.0378 0.3399 0.3399
Schistosoma mansoni growth hormone secretagogue receptor 0.0041 0.014 0.0376
Echinococcus granulosus histone deacetylase 3 0.0043 0.0168 0.0168
Schistosoma mansoni hypothetical protein 0.0037 0.0107 0.0289
Plasmodium falciparum serine repeat antigen 3 0.0041 0.0142 0.1073
Echinococcus multilocularis prolyl endopeptidase 0.0128 0.0982 0.0982
Loa Loa (eye worm) hypothetical protein 0.0068 0.041 0.0617
Echinococcus multilocularis histone deacetylase 6 0.0056 0.0291 0.0291
Trypanosoma brucei histone deacetylase 1 0.0043 0.0168 0.1264
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Echinococcus granulosus g-protein coupled receptor 0.0041 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0142 0.1073
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Plasmodium falciparum histone deacetylase 1 0.0043 0.0168 0.1264
Schistosoma mansoni cathepsin S (C01 family) 0.0041 0.0142 0.0384
Echinococcus multilocularis cysteine protease 0.0164 0.1328 0.1328
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0048 0.0212 0.057
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0499 0.3003
Echinococcus granulosus cathepsin L 0.0078 0.0499 0.0499
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0041 0.014 0.014
Onchocerca volvulus 0.0164 0.1328 0.6007
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0142 0.0214
Plasmodium falciparum serine repeat antigen 1 0.0041 0.0142 0.1073
Brugia malayi Cytochrome P450 family protein 0.0052 0.0247 0.0372
Schistosoma mansoni integrin beta subunit 0.0411 0.3715 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0074 0.0462 0.3482
Entamoeba histolytica histone deacetylase, putative 0.0043 0.0168 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0369 0.0993
Brugia malayi cathepsin L-like cysteine proteinase 0.0041 0.0142 0.0214
Brugia malayi hypothetical protein 0.0041 0.014 0.021
Echinococcus granulosus muscleblind protein 0.0158 0.1274 0.1274
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0041 0.0142 0.0214
Schistosoma mansoni inhibitor of apoptosis protein 0.0255 0.2211 0.5953
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.014 0.014
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0041 0.0142 0.1073
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Brugia malayi hypothetical protein 0.0041 0.014 0.021
Schistosoma mansoni neuropeptide receptor 0.0041 0.014 0.0376
Trypanosoma brucei histone deacetylase 4 0.0056 0.0291 0.2192
Onchocerca volvulus 0.0041 0.014 0.0632
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Trypanosoma cruzi cruzipain precursor, putative 0.0164 0.1328 0.5016
Brugia malayi histone deacetylase 1 (HD1) 0.0043 0.0168 0.0253
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0041 0.014 0.0376
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0041 0.0142 0.1073
Schistosoma mansoni caspase-7 (C14 family) 0.0031 0.0051 0.0137
Toxoplasma gondii cathepsin CPC2 0.0041 0.0142 0.1073
Echinococcus multilocularis tissue type plasminogen activator 0.0087 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0077 0.0488 0.0735
Loa Loa (eye worm) hypothetical protein 0.0054 0.0273 0.0411
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0462 0.0462
Plasmodium vivax histone deacetylase 2, putative 0.0056 0.0291 0.2192
Loa Loa (eye worm) hypothetical protein 0.0071 0.043 0.0648
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0041 0.014 0.021
Loa Loa (eye worm) cysteine protease 0.0164 0.1328 0.1999
Trypanosoma brucei cysteine peptidase C (CPC) 0.0121 0.0917 0.6907
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0249 0.215 0.215
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.014 0.0376
Brugia malayi Cathepsin L-like precursor 0.0164 0.1328 0.1999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.014 0.0376
Brugia malayi AKH receptor 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0164 0.1328 1
Entamoeba histolytica cysteine proteinase, putative 0.0164 0.1328 1
Echinococcus multilocularis serotonin receptor 0.0167 0.1355 0.1355
Loa Loa (eye worm) hypothetical protein 0.0164 0.1328 0.1999
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.0982 0.2644
Trypanosoma cruzi cysteine proteinase, putative 0.0078 0.0499 0.1883
Mycobacterium leprae PROBABLE HYDROLASE 0.0083 0.0554 1
Echinococcus granulosus somatostatin receptor 0.0041 0.014 0.014
Mycobacterium ulcerans aminopeptidase N PepN 0.0074 0.0462 0.8354
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0041 0.014 0.0376
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0212 0.0319
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0142 0.1073
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0041 0.014 0.014
Echinococcus multilocularis neuropeptide FF receptor 2 0.0041 0.014 0.014
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0086 0.058 0.156
Brugia malayi Cathepsin L-like precursor 0.0164 0.1328 0.1999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.1328 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0142 0.1073
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0301 0.2648 0.3986
Onchocerca volvulus 0.0255 0.2211 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.1328 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.014 0.021
Plasmodium falciparum serine repeat antigen 7 0.0041 0.0142 0.1073
Loa Loa (eye worm) hypothetical protein 0.0083 0.0554 0.0833
Plasmodium falciparum serine repeat antigen 6 0.0041 0.0142 0.1073
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1063 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) integrin beta-2 0.0715 0.6644 1
Echinococcus granulosus histone deacetylase 6 0.0056 0.0291 0.0291
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0462 0.0462
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0041 0.014 0.021
Plasmodium falciparum cysteine proteinase falcipain 1 0.0078 0.0499 0.3754
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.014 0.014
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0041 0.0142 0.1073
Brugia malayi Cathepsin L-like precursor 0.0127 0.0972 0.1463
Echinococcus granulosus neuropeptide receptor 0.0041 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0142 0.1073
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.014 0.014
Loa Loa (eye worm) histone deacetylase 3 0.0043 0.0168 0.0253
Echinococcus multilocularis allatostatin A receptor 0.0041 0.014 0.014
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Brugia malayi Muscleblind-like protein 0.0158 0.1274 0.1917
Plasmodium vivax histone deacetylase, putative 0.0056 0.0291 0.2192
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0041 0.014 0.0376
Onchocerca volvulus Cathepsin L homolog 0.0164 0.1328 0.6007
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Echinococcus multilocularis aminopeptidase N 0.0163 0.1317 0.1317
Schistosoma mansoni neuropeptide f receptor 76f 0.0041 0.014 0.0376
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0301 0.2648 0.7129
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Brugia malayi G-protein coupled receptor 0.0041 0.014 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0142 0.1073
Echinococcus granulosus allatostatin A receptor 0.0041 0.014 0.014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.1328 1
Echinococcus multilocularis neuropeptide s receptor 0.0041 0.014 0.014
Onchocerca volvulus Deterin homolog 0.0255 0.2211 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Echinococcus granulosus histone deacetylase 0.0056 0.0291 0.0291
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0083 0.0554 0.5121
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0041 0.014 0.014
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.014 0.014
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0168 0.1264
Loa Loa (eye worm) hypothetical protein 0.0044 0.0172 0.0258
Brugia malayi putative neuropeptide receptor NPR1 0.0041 0.014 0.021
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0121 0.0917 0.3464
Onchocerca volvulus 0.0041 0.0142 0.0644
Brugia malayi hypothetical protein 0.0112 0.0832 0.1252
Brugia malayi SWIRM domain containing protein 0.0077 0.0488 0.0735
Onchocerca volvulus Matrilysin homolog 0.0152 0.1214 0.549
Echinococcus granulosus cathepsin l1 0.0127 0.0972 0.0972
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0369 0.211
Trypanosoma cruzi prolyl endopeptidase 0.0128 0.0982 0.3709
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0142 0.0384
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.014 0.014
Toxoplasma gondii preprocathepsin c precursor, putative 0.0041 0.0142 0.1073
Leishmania major cathepsin L-like protease 0.0164 0.1328 1
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Leishmania major cathepsin L-like protease 0.0164 0.1328 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.014 0.014
Schistosoma mansoni amine GPCR 0.0041 0.014 0.0376
Echinococcus multilocularis fmrfamide receptor 0.0041 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0214
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0369 0.0993
Echinococcus multilocularis histone deacetylase 6 0.0056 0.0291 0.0291
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0257 0.223 0.3356
Brugia malayi Histone deacetylase family protein 0.0056 0.0291 0.0438
Loa Loa (eye worm) hypothetical protein 0.0087 0.0589 0.0887
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0041 0.014 0.0632
Schistosoma mansoni cathepsin F (C01 family) 0.0164 0.1328 0.3576
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0301 0.2648 1
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Trypanosoma cruzi cysteine peptidase, putative 0.0164 0.1328 0.5016
Loa Loa (eye worm) aminopeptidase N 0.0074 0.0462 0.0696
Brugia malayi G protein-coupled receptor 0.0041 0.014 0.021
Echinococcus granulosus fmrfamide receptor 0.0041 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0167 0.1355 0.204
Schistosoma mansoni amine GPCR 0.0041 0.014 0.0376
Trypanosoma cruzi cysteine peptidase, putative 0.0164 0.1328 0.5016
Onchocerca volvulus 0.0041 0.014 0.0632
Schistosoma mansoni biogenic amine receptor 0.0041 0.014 0.0376
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0041 0.0142 0.1073
Trypanosoma cruzi oligopeptidase b 0.0051 0.024 0.0905
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.024 0.0905
Echinococcus multilocularis histone deacetylase 6 0.0056 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.014 0.0376
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0164 0.1328 0.1328
Toxoplasma gondii histone deacetylase HDAC2 0.0043 0.0168 0.1264
Schistosoma mansoni opsin-like receptor 0.0041 0.014 0.0376
Leishmania major cathepsin L-like protease 0.0164 0.1328 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0043 0.0168 0.0634
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.014 0.0376
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0142 0.0384
Echinococcus granulosus neuropeptide receptor 0.0041 0.014 0.014
Echinococcus multilocularis orexin receptor type 2 0.0041 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Brugia malayi hypothetical protein 0.0041 0.014 0.021
Brugia malayi Dopamine receptor 0.0041 0.014 0.021
Onchocerca volvulus 0.0041 0.014 0.0632
Loa Loa (eye worm) hypothetical protein 0.0255 0.2211 0.3329
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0137 0.1067 0.1605
Echinococcus multilocularis histone deacetylase 7 0.0056 0.0291 0.0291
Trypanosoma cruzi histone deacetylase, putative 0.0056 0.0291 0.1099
Schistosoma mansoni biogenic amine receptor 0.0041 0.014 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.014 0.0376
Plasmodium falciparum serine repeat antigen 2 0.0041 0.0142 0.1073
Brugia malayi Histone deacetylase family protein 0.0056 0.0291 0.0438
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Entamoeba histolytica cysteine proteinase 2 0.0078 0.0499 0.3003
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0462 0.0462
Brugia malayi Matrixin family protein 0.0166 0.1346 0.2026
Echinococcus granulosus caspase 2 0.0031 0.0051 0.0051
Echinococcus granulosus alpha 1A adrenergic receptor 0.0041 0.014 0.014
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0462 0.3482
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0168 0.1264
Echinococcus multilocularis fmrfamide receptor 0.0041 0.014 0.014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0164 0.1328 1
Brugia malayi larval opioid receptor 0.0041 0.014 0.021
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0041 0.0142 0.0214
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0041 0.014 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.014 0.0376
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0142 0.0214
Onchocerca volvulus 0.0097 0.0686 0.3101
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.014 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.014 0.0376
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.024 0.4327
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0499 0.3003
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Echinococcus granulosus 7tm_1 domain containing protein 0.0041 0.014 0.014
Echinococcus granulosus cathepsin L cysteine protease 0.0078 0.0499 0.0499
Onchocerca volvulus 0.0077 0.0488 0.2207
Brugia malayi Matrixin family protein 0.0068 0.041 0.0617
Loa Loa (eye worm) histone deacetylase 0.0056 0.0291 0.0438
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0041 0.0142 0.1073
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Leishmania major histone deacetylase, putative 0.0056 0.0291 0.2192
Schistosoma mansoni hypothetical protein 0.0041 0.014 0.0376
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0462 0.0462
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0168 0.1264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.014 0.0376
Schistosoma mansoni amine GPCR 0.0041 0.014 0.0376
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.024 0.1803
Brugia malayi neuropeptide F receptor 0.0041 0.014 0.021
Onchocerca volvulus 0.0068 0.041 0.1853
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0041 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0214
Echinococcus multilocularis g protein coupled receptor 0.0041 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0031 0.0051 0.0137
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Brugia malayi Matrixin family protein 0.0068 0.041 0.0617
Plasmodium falciparum histone deacetylase, putative 0.0056 0.0291 0.2192
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0107 0.0161
Echinococcus multilocularis cathepsin L 0.0041 0.0142 0.0142
Schistosoma mansoni neuropeptide receptor 0.0041 0.014 0.0376
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.024 0.0905
Echinococcus granulosus cathepsin L cysteine proteinase 0.0164 0.1328 0.1328
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0041 0.0142 0.0384
Brugia malayi putative neuropeptide receptor 0.0041 0.014 0.021
Toxoplasma gondii prolyl endopeptidase 0.0128 0.0982 0.7394
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0121 0.0917 0.6907
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0112 0.0832 0.1252
Brugia malayi hypothetical protein 0.0041 0.014 0.021
Brugia malayi ORL1-like opioid receptor 0.0041 0.014 0.021
Echinococcus granulosus g protein coupled receptor 0.0041 0.014 0.014
Plasmodium falciparum serine repeat antigen 4 0.0041 0.0142 0.1073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0369 0.6664
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0301 0.2648 0.7129
Toxoplasma gondii cathepsin CPC1 0.0041 0.0142 0.1073
Entamoeba histolytica cysteine proteinase, putative 0.0127 0.0972 0.6997
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0142 0.1073
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Echinococcus granulosus g protein coupled receptor 0.0041 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0142 0.1073
Plasmodium vivax serine-repeat antigen (SERA) 0.0041 0.0142 0.1073
Echinococcus granulosus histone deacetylase 6 0.0056 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Plasmodium vivax unspecified product 0.0041 0.0142 0.1073
Plasmodium falciparum histone deacetylase 2 0.0056 0.0291 0.2192
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.0077
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0041 0.0142 0.0384
Entamoeba histolytica cysteine protease, putative 0.0078 0.0499 0.3003
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0142 0.0214
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.014 0.0376
Brugia malayi GnHR receptor homolog 0.0041 0.014 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0499 0.3754
Brugia malayi Peptidase family M1 containing protein 0.0074 0.0462 0.0696
Loa Loa (eye worm) peptidase family M1 containing protein 0.0115 0.0855 0.1287
Echinococcus granulosus aminopeptidase N 0.0163 0.1317 0.1317
Brugia malayi Serotonin receptor 0.0041 0.014 0.021
Brugia malayi cathepsin L precursor 0.0041 0.0142 0.0214
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0273 0.0411
Brugia malayi Dopamine receptor protein 2 0.0041 0.014 0.021
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.014 0.014
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0255 0.2211 0.5953
Echinococcus multilocularis serotonin receptor 0.0167 0.1355 0.1355
Echinococcus granulosus cathepsin l cysteine peptidase 0.0164 0.1328 0.1328
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0041 0.014 0.0376
Loa Loa (eye worm) matrix metalloproteinase 0.0068 0.041 0.0617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.1328 1
Schistosoma mansoni histone deacetylase 0.0043 0.0168 0.0452
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0041 0.0142 0.1073
Onchocerca volvulus 0.0041 0.014 0.0632
Brugia malayi Integrin beta pat-3 precursor 0.0715 0.6644 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.014 0.014
Onchocerca volvulus 0.0041 0.014 0.0632
Brugia malayi Cell death protein 3 precursor 0.0031 0.0051 0.0077
Onchocerca volvulus Matrix metalloproteinase homolog 0.0152 0.1214 0.549
Trypanosoma cruzi cysteine peptidase, putative 0.0164 0.1328 0.5016
Echinococcus granulosus dro:myosuppressin receptor 0.0041 0.014 0.014
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0462 0.3482
Echinococcus granulosus cathepsin l1 0.0164 0.1328 0.1328
Toxoplasma gondii histone deacetylase HDAC1 0.0056 0.0291 0.2192
Echinococcus multilocularis G-protein coupled receptor, putative 0.0041 0.014 0.014
Schistosoma mansoni opsin-like receptor 0.0041 0.014 0.0376
Echinococcus multilocularis sex peptide receptor 0.0041 0.014 0.014
Schistosoma mansoni biogenic amine (5HT) receptor 0.0167 0.1355 0.3649
Echinococcus multilocularis apoptotic protease activating factor 1 0.0031 0.0051 0.0051
Giardia lamblia Cathepsin B precursor 0.0121 0.0917 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0041 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.0077
Schistosoma mansoni amine GPCR 0.0041 0.014 0.0376
Brugia malayi hypothetical protein 0.0041 0.014 0.021
Brugia malayi fibroinase precursor 0.0041 0.0142 0.0214
Trypanosoma cruzi cruzipain precursor, putative 0.0037 0.0105 0.0398
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0273 0.0411
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0128 0.0982 0.7394
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0142 0.1073
Onchocerca volvulus 0.0164 0.1328 0.6007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0142 0.1073
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0462 0.3482
Onchocerca volvulus 0.0041 0.014 0.0632
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.014 0.014

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 73 % Displacement of [3H]Ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex at 10 uM ChEMBL. 24411196

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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