Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0033 | 0.0039 | 0.0007 | |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.0048 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.4365 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.0048 | 0.5 |
Schistosoma mansoni | lamin | 0.003 | 0.0032 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0031 | 0.0031 |
Schistosoma mansoni | lamin | 0.003 | 0.0032 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.005 | 0.005 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0048 | 0.026 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.009 | 0.009 |
Toxoplasma gondii | prostaglandin-E synthase | 0.4365 | 1 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.0039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4365 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0761 | 0.1714 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0036 | 0.0192 |
Echinococcus granulosus | lamin | 0.003 | 0.0032 | 0.0166 |
Onchocerca volvulus | 0.4365 | 1 | 1 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0003 | 0.0003 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0261 | 0.0563 | 0.3273 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0761 | 0.1714 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0039 | 0.0209 |
Brugia malayi | hypothetical protein | 0.0261 | 0.0563 | 0.0563 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.005 | 0.0271 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0039 | 0.0209 |
Brugia malayi | follicle stimulating hormone receptor | 0.0235 | 0.0504 | 0.0504 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.4365 | 1 | 1 |
Onchocerca volvulus | 0.0053 | 0.0086 | 0.0054 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0039 | 0.0209 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0048 | 0.0048 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0039 | 0.0039 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0039 | 0.0209 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0003 | 0.0003 |
Brugia malayi | Pre-SET motif family protein | 0.023 | 0.0491 | 0.0491 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0003 | 0.0003 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0048 | 0.026 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0039 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0761 | 0.1714 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0086 | 0.0481 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0235 | 0.0504 | 0.0504 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0032 | 0.0032 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0032 | 0.0032 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.009 | 0.009 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0039 | 0.0209 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0261 | 0.0563 | 0.3273 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.023 | 0.0491 | 0.0491 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0039 | 0.0209 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0032 | 0.0166 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0048 | 0.026 |
Trypanosoma brucei | Prostaglandin E synthase | 0.4365 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0032 | 0.0166 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0039 | 0.0209 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0048 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.009 | 0.009 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.0086 | 0.0481 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.009 | 0.009 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0039 | 0.0039 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.4365 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.0563 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0032 | 0.0032 |
Echinococcus multilocularis | musashi | 0.003 | 0.0032 | 0.0166 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0032 | 0.0166 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0048 | 0.0009 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0032 | 0.0032 |
Echinococcus multilocularis | lamin | 0.003 | 0.0032 | 0.0166 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0048 | 0.0048 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.0086 | 0.0086 |
Onchocerca volvulus | 0.0261 | 0.0564 | 0.0534 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0261 | 0.0564 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.0048 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0032 | 0.0166 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.005 | 0.005 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.0039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0003 | 0.0003 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0032 | 0.0032 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 50 % | Inhibition of rat kidney NADPH-dependent aldose reductase assessed as DL-glyceraldehyde conversion to glycerol at 1 uM preincubated for 20 mins followed by NADPH addition measured after 5 mins by UV-Visible spectrophotometric analysis relative to control | ChEMBL. | 24275248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.