Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0024 | 0.3971 | 0.3889 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0015 | 0.1676 | 0.224 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0008 | 0.0081 | 0.0108 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0039 | 0.7486 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0028 | 0.4773 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0017 | 0.2258 | 0.2981 |
Onchocerca volvulus | 0.004 | 0.7722 | 0.6887 | |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0018 | 0.2576 | 0.3708 |
Mycobacterium ulcerans | polyketide synthase | 0.0028 | 0.4773 | 0.6357 |
Onchocerca volvulus | 0.0045 | 0.9028 | 0.9285 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0021 | 0.324 | 0.4329 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0026 | 0.4383 | 0.4383 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0028 | 0.4773 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0026 | 0.4383 | 0.5856 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0039 | 0.7486 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0019 | 0.2616 | 0.3495 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0008 | 0.0039 | 0.0052 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.4383 | 0.5856 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.4383 | 0.5834 |
Leishmania major | hypothetical protein, conserved | 0.0008 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0025 | 0.4191 | 0.5599 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0028 | 0.4773 | 0.6376 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1625 | 0.0823 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0028 | 0.4773 | 0.6376 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0026 | 0.4383 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0017 | 0.2258 | 0.2941 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0039 | 0.7486 | 1 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0017 | 0.218 | 0.2574 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0026 | 0.4383 | 0.5856 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0008 | 0.0081 | 0.0056 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0011 | 0.0647 | 0.0864 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0026 | 0.4383 | 0.5834 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.4383 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0026 | 0.4383 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0025 | 0.4191 | 0.5599 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0022 | 0.3337 | 0.4398 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0028 | 0.4773 | 0.6376 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0039 | 0.7486 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0022 | 0.3337 | 0.4459 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0028 | 0.4773 | 0.6337 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0024 | 0.3971 | 0.5305 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0021 | 0.3157 | 0.4188 |
Mycobacterium ulcerans | thioesterase | 0.0022 | 0.3337 | 0.443 |
Giardia lamblia | Methyltransferase like 2 | 0.0008 | 0 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0028 | 0.4773 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.8648 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0009 | 0.0267 | 0.0356 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.4383 | 0.5834 |
Schistosoma mansoni | methyltransferase-related | 0.0008 | 0 | 0.5 |
Mycobacterium ulcerans | thioesterase TesA | 0.0022 | 0.3337 | 0.443 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0039 | 0.0039 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0047 | 0.9418 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0028 | 0.4773 | 0.6357 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.3971 | 0.3971 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0028 | 0.4773 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0021 | 0.3157 | 0.4188 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0021 | 0.3157 | 0.4155 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0017 | 0.2258 | 0.2981 |
Loa Loa (eye worm) | fatty acid synthase | 0.0026 | 0.43 | 0.4318 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC99 (functional) | = 3.75 uM | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution method | ChEMBL. | 24333580 |
MIC99 (functional) | > 120.02 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 3 weeks by microbroth dilution method | ChEMBL. | 24333580 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.