Detailed information for compound 1819527

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.63 | Formula: C25H45NO2
  • H donors: 3 H acceptors: 2 LogP: 5.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](O)[C@@H]([C@H]2[C@]1(C)CC[C@H](C2)O)CC)C
  • InChi: 1S/C25H45NO2/c1-5-17-21-14-16(27)8-11-25(21,4)20-9-12-24(3)18(15(2)10-13-26)6-7-19(24)22(20)23(17)28/h15-23,27-28H,5-14,26H2,1-4H3/t15-,16-,17-,18-,19+,20+,21+,22+,23-,24-,25-/m1/s1
  • InChiKey: UHTWCKDYARKJBV-APIYUPOTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens G protein-coupled bile acid receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0094 0.0247
Brugia malayi nuclear receptor RXR 0.0012 0.0006 0.0031
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0094 0.029
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.011 0.011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0424
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0174 0.4525
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0155 0.1358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0665 0.0769
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0013
Echinococcus multilocularis beta galactosidase 0.0035 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0424
Loa Loa (eye worm) ctsf protein 0.0017 0.0072 0.0221
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0665 0.208
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0665 0.208
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0137 0.0158
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0137 0.0137
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.006 0.0069
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0424
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0137 0.0158
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0072 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0431 0.0498
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0665 0.0769
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0174 0.1701
Loa Loa (eye worm) hypothetical protein 0.0018 0.008 0.0247
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0013
Echinococcus granulosus cathepsin l1 0.0011 0.0001 0.0002
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0137 0.0137
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.008 0.0367
Loa Loa (eye worm) hypothetical protein 0.0268 0.3193 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0221
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.008 0.0215
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0671 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0006 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0632 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0137 0.1002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0137 0.0424
Echinococcus granulosus GPCR family 2 0.0016 0.006 0.0069
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0094 0.2821
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0424
Onchocerca volvulus 0.0017 0.0072 0.4586
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0174 0.4525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0137 0.0424
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0137 0.0158
Loa Loa (eye worm) hypothetical protein 0.0018 0.008 0.0247
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0329 0.0329
Echinococcus multilocularis microtubule associated protein 2 0.0707 0.8648 0.8648
Echinococcus granulosus RUN 0.002 0.011 0.0127
Onchocerca volvulus 0.002 0.011 0.7049
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0072 0.2152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0094 0.2821
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0522
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0072 0.0083
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0137 0.0158
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0137 0.0158
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0174 0.182
Loa Loa (eye worm) hypothetical protein 0.0024 0.0155 0.0482
Onchocerca volvulus 0.002 0.011 0.7049
Brugia malayi hypothetical protein 0.0016 0.0062 0.045
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0137 0.0137
Brugia malayi TAR-binding protein 0.0065 0.0665 0.4918
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0137 0.0158
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0137 0.0158
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.006 0.0182
Loa Loa (eye worm) hypothetical protein 0.0018 0.008 0.0247
Brugia malayi hypothetical protein 0.0012 0.0006 0.0031
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0137 0.0424
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0665 0.0769
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0424
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0522
Schistosoma mansoni hypothetical protein 0.002 0.011 0.0127
Brugia malayi RNA binding protein 0.0065 0.0665 0.4918
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0329 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0671 1
Schistosoma mansoni coup transcription factor 0.0022 0.0137 0.0158
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0155 0.4692
Onchocerca volvulus 0.0017 0.0072 0.4586
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0665 0.4918
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.006 0.006
Brugia malayi MH2 domain containing protein 0.012 0.1352 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0121 0.1361 0.1361
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0137 0.1002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0094 0.0973
Onchocerca volvulus 0.0022 0.0137 0.8801
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0329 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0094 0.5
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0094 0.0094
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0671 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0137 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0671 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0137 0.1002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0431 0.0431
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0329 0.4291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Toxoplasma gondii exonuclease III APE 0.0019 0.0094 0.0392
Mycobacterium ulcerans hypothetical protein 0.0024 0.0155 0.1358
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0329 0.038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0329 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0137 0.1002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0137 0.0137
Schistosoma mansoni rab6-interacting 0.002 0.011 0.0127
Schistosoma mansoni polycystin 1-related 0.002 0.011 0.0127
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0155 0.1358
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0137 0.0424
Schistosoma mansoni hypothetical protein 0.0035 0.0293 0.0338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0431 0.0498
Brugia malayi hypothetical protein 0.0012 0.0006 0.0031
Onchocerca volvulus 0.0017 0.0072 0.4586
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0174 0.4525
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0137 0.1002
Onchocerca volvulus 0.0017 0.0072 0.4586
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0671 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0137 0.0158
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0601 0.8824
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0329 0.4291
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0155 0.1389
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0006 0.0013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0431 0.1345
Brugia malayi hypothetical protein 0.002 0.011 0.0803
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0632 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0137 0.0158
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0137 0.8801
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0137 0.1002
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0297 1
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1352 0.423
Loa Loa (eye worm) hypothetical protein 0.0025 0.0174 0.054
Entamoeba histolytica cysteine protease, putative 0.0017 0.0072 0.2152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Brugia malayi ecdysteroid receptor 0.0022 0.0137 0.1002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Onchocerca volvulus 0.0017 0.0072 0.4586
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0137 0.0158
Echinococcus granulosus microtubule associated protein 2 0.0707 0.8648 1
Brugia malayi Inositol-1 0.0038 0.0329 0.2427
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0329 0.4591
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0155 0.1358
Schistosoma mansoni lipoxygenase 0.0085 0.0909 0.1051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0671 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0018 0.008 0.0247
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0329 0.4291
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0006 0.0006
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0671 1
Brugia malayi steroid hormone receptor 0.0022 0.0137 0.1002
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0006 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0072 0.2152
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0497 0.7098
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0072 0.0072
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0094 0.0685
Loa Loa (eye worm) hypothetical protein 0.0024 0.0155 0.0482
Schistosoma mansoni inositol monophosphatase 0.0038 0.0329 0.038
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0137 0.1002
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0121 0.1361 0.1574
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0094 0.0457
Onchocerca volvulus 0.0024 0.0155 1
Leishmania major cathepsin L-like protease 0.0065 0.0671 1
Leishmania major hypothetical protein, conserved 0.0025 0.0174 0.1701
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0431 0.3179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0137 0.1002
Loa Loa (eye worm) fibroinase 0.0017 0.0072 0.0221
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0072 0.2152
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0072 0.0072
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0155 0.4692
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0137 0.0158
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0072 0.2152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0671 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0494 0.3645
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.028 0.3754
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0137 0.0137
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0094 0.0366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0137 0.0424
Schistosoma mansoni beta-galactosidase 0.0035 0.0297 0.0344
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0329 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0072 0.2152
Loa Loa (eye worm) hypothetical protein 0.0051 0.0494 0.1542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0522
Echinococcus granulosus tar DNA binding protein 0.0065 0.0665 0.0769
Loa Loa (eye worm) hypothetical protein 0.0024 0.0155 0.0482
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0016 0.006 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0072 0.2152
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0072 0.0221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0671 1
Brugia malayi nuclear hormone receptor 0.0022 0.0137 0.1002
Brugia malayi nuclear receptor NHR-88 0.0022 0.0137 0.1002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0671 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0137 0.0137
Schistosoma mansoni microtubule-associated protein tau 0.0707 0.8648 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0155 0.1358
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0137 0.0158
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0001 0.0002
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0632 1
Schistosoma mansoni hypothetical protein 0.0016 0.006 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0072 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.002 0.011 0.034
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0155 0.1389
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0013
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0137 0.0158
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.011 0.0127
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0424
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0072 0.2152
Echinococcus multilocularis cysteine protease 0.0017 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0072 0.2152
Brugia malayi hypothetical protein 0.002 0.011 0.0803
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.011 0.168
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0632 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.006 0.0431
Onchocerca volvulus 0.0017 0.0072 0.4586
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0137 0.1002
Loa Loa (eye worm) inositol-1 0.0038 0.0329 0.1027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0424
Brugia malayi Latrophilin receptor protein 2 0.0016 0.006 0.0431
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0137 0.8801
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0431 0.0498
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0297 0.0927
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0632 0.0731
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0094 0.2821
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0072 0.2152
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0035 0.0297 1
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0665 0.0665
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0155 0.1139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0072 0.2152
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0072 0.4586
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.028 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0137 0.1002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0155 0.1139
Loa Loa (eye worm) hypothetical protein 0.0035 0.0293 0.0913
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0072 0.2152
Schistosoma mansoni ap endonuclease 0.0019 0.0094 0.0108
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0137 0.0158
Echinococcus multilocularis cysteine protease 0.0017 0.0072 0.0072
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0137 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0137 0.0424
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0072 0.0083
Brugia malayi Doublecortin family protein 0.002 0.011 0.0803
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0671 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0137 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0013
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0632 0.0731
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0137 0.1002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0137 0.1002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0094 0.0973
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0522
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0155 0.1389
Loa Loa (eye worm) RNA binding protein 0.0065 0.0665 0.208
Schistosoma mansoni lipoxygenase 0.0121 0.1361 0.1574
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0632 0.0731
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.011 0.0127
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1352 0.423
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0137 0.1002
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0665 0.0769
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.008 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0174 0.1701
Brugia malayi hypothetical protein 0.0025 0.0174 0.1277
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.011 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0329 0.4075
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0155 0.1139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0072 0.2152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0431 0.0498
Echinococcus granulosus cathepsin l1 0.0017 0.0072 0.0083
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0155 0.4692
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0665 0.0769
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.008 0.0367
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0137 0.0158
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0137 0.8801
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0072 0.0522
Schistosoma mansoni hypothetical protein 0.0016 0.006 0.0069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0494 0.1542
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0329 1
Echinococcus multilocularis RUN 0.002 0.011 0.011
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0155 0.1544
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0174 0.1386
Schistosoma mansoni rab6-interacting 0.002 0.011 0.0127
Schistosoma mansoni loxhd1 0.002 0.011 0.0127
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.006 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0155 0.1358
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0137 0.0137
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0094 0.0366
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0137 0.0158
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0632 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0632 0.9347
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0137 0.1002
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0522
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0494 0.3645
Schistosoma mansoni inositol monophosphatase 0.0038 0.0329 0.038
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0137 0.0158
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0094 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0293 0.2157
Echinococcus granulosus beta galactosidase 0.0035 0.0297 0.0344
Loa Loa (eye worm) hypothetical protein 0.0018 0.008 0.0247
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0137 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0137 0.1002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0072 0.2152
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0137 0.0158
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0072 0.4586
Loa Loa (eye worm) doublecortin family protein 0.002 0.011 0.034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0431 0.0431
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0671 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0072 0.2152
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0424
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0072 0.0221
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0072 0.4586
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.006 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0137 0.0424
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0072 0.0083
Leishmania major cathepsin L-like protease 0.0065 0.0671 1
Schistosoma mansoni ap endonuclease 0.0019 0.0094 0.0108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0155 0.1544
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0329 0.451
Onchocerca volvulus 0.0017 0.0072 0.4586
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0137 0.0424
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0137 0.0158
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0155 0.1358
Plasmodium falciparum LCCL domain-containing protein 0.002 0.011 0.168
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0094 0.0366
Loa Loa (eye worm) hypothetical protein 0.002 0.011 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0671 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0094 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0137 0.1002
Schistosoma mansoni hypothetical protein 0.0016 0.006 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0431 0.0498
Leishmania major cathepsin L-like protease 0.0065 0.0671 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0155 0.1358
Loa Loa (eye worm) cysteine protease 0.0017 0.0072 0.0221

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 1.32 uM Agonist activity at wild type TGR5 (unknown origin) ChEMBL. 24900622

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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