Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0676 | 0.2258 | 0.2981 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0676 | 0.2258 | 0.2981 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1527 | 0.7486 | 1 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0321 | 0.0081 | 0.0056 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1527 | 0.7486 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1022 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0835 | 0.324 | 0.4329 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1085 | 0.4773 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1527 | 0.7486 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0954 | 0.3971 | 0.5305 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1022 | 0.4383 | 0.5856 |
Brugia malayi | AMP-binding enzyme family protein | 0.0314 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | thioesterase TesA | 0.0851 | 0.3337 | 0.443 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1085 | 0.4773 | 0.6376 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0954 | 0.3971 | 0.3889 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.1022 | 0.4383 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0314 | 0.0039 | 0.0052 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.099 | 0.4191 | 0.5599 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0851 | 0.3337 | 0.4459 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0663 | 0.218 | 0.2574 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0822 | 0.3157 | 0.4188 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.099 | 0.4191 | 0.5599 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0351 | 0.0267 | 0.0356 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1022 | 0.4383 | 0.5834 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.1022 | 0.4383 | 0.4383 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0727 | 0.2576 | 0.3708 |
Brugia malayi | AMP-binding enzyme family protein | 0.0954 | 0.3971 | 0.3971 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1085 | 0.4773 | 0.6357 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0321 | 0.0081 | 0.0108 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1085 | 0.4773 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1022 | 0.4383 | 0.5834 |
Giardia lamblia | Methyltransferase like 2 | 0.0308 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0734 | 0.2616 | 0.3495 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.1085 | 0.4773 | 0.6376 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1022 | 0.4383 | 0.5856 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.1085 | 0.4773 | 0.6337 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1527 | 0.7486 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.1008 | 0.43 | 0.4318 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.1085 | 0.4773 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.1716 | 0.8648 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0851 | 0.3337 | 0.443 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0676 | 0.2258 | 0.2941 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1022 | 0.4383 | 0.5856 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0822 | 0.3157 | 0.4188 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.1022 | 0.4383 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0822 | 0.3157 | 0.4155 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.1085 | 0.4773 | 0.6376 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.1085 | 0.4773 | 0.6337 |
Schistosoma mansoni | methyltransferase-related | 0.0308 | 0 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1022 | 0.4383 | 0.5834 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0308 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0851 | 0.3337 | 0.4398 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0413 | 0.0647 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 0.1625 | 0.0823 |
Onchocerca volvulus | 0.1778 | 0.9028 | 0.9285 | |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1842 | 0.9418 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0308 | 0 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.1022 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0581 | 0.1676 | 0.224 |
Mycobacterium ulcerans | polyketide synthase | 0.1085 | 0.4773 | 0.6357 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.