Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0351 | 0.0267 | 0.0356 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1022 | 0.4383 | 0.5834 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0851 | 0.3337 | 0.4398 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0822 | 0.3157 | 0.4188 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1527 | 0.7486 | 1 |
Onchocerca volvulus | 0.1778 | 0.9028 | 0.9285 | |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0321 | 0.0081 | 0.0056 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0676 | 0.2258 | 0.2981 |
Brugia malayi | AMP-binding enzyme family protein | 0.0314 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1527 | 0.7486 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1527 | 0.7486 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1085 | 0.4773 | 0.6357 |
Mycobacterium ulcerans | thioesterase | 0.0851 | 0.3337 | 0.443 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1527 | 0.7486 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0314 | 0.0039 | 0.0052 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.1085 | 0.4773 | 0.6337 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.1085 | 0.4773 | 0.6337 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1085 | 0.4773 | 0.6376 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.1022 | 0.4383 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.1085 | 0.4773 | 0.6376 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0954 | 0.3971 | 0.3889 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0676 | 0.2258 | 0.2981 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1085 | 0.4773 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0734 | 0.2616 | 0.3495 |
Leishmania major | hypothetical protein, conserved | 0.0308 | 0 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0727 | 0.2576 | 0.3708 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0321 | 0.0081 | 0.0108 |
Brugia malayi | AMP-binding enzyme family protein | 0.0954 | 0.3971 | 0.3971 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.1085 | 0.4773 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1022 | 0.4383 | 0.5856 |
Loa Loa (eye worm) | hypothetical protein | 0.1716 | 0.8648 | 1 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0663 | 0.218 | 0.2574 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.1085 | 0.4773 | 0.6376 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1022 | 0.4383 | 0.5856 |
Giardia lamblia | Methyltransferase like 2 | 0.0308 | 0 | 0.5 |
Loa Loa (eye worm) | fatty acid synthase | 0.1008 | 0.43 | 0.4318 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0851 | 0.3337 | 0.4459 |
Mycobacterium ulcerans | polyketide synthase | 0.1022 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0413 | 0.0647 | 0.0864 |
Schistosoma mansoni | methyltransferase-related | 0.0308 | 0 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1022 | 0.4383 | 0.5834 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1022 | 0.4383 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0676 | 0.2258 | 0.2941 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1022 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0835 | 0.324 | 0.4329 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0308 | 0 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.1022 | 0.4383 | 0.581 |
Mycobacterium ulcerans | thioesterase TesA | 0.0851 | 0.3337 | 0.443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0822 | 0.3157 | 0.4188 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1085 | 0.4773 | 0.6357 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1842 | 0.9418 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.099 | 0.4191 | 0.5599 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.099 | 0.4191 | 0.5599 |
Mycobacterium ulcerans | polyketide synthase | 0.1085 | 0.4773 | 0.6357 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.1022 | 0.4383 | 0.4383 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0954 | 0.3971 | 0.5305 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 0.1625 | 0.0823 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0822 | 0.3157 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0581 | 0.1676 | 0.224 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1022 | 0.4383 | 0.5856 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.