TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 459.534 | Formula: C28H29NO5
H donors: 2 H acceptors: 3 LogP: 5.6 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCN(Cc1ccccc1)CCCCOc1ccc(cc1)c1coc2c(c1=O)c(O)cc(c2)O
InChi: 1S/C28H29NO5/c1-2-29(18-20-8-4-3-5-9-20)14-6-7-15-33-23-12-10-21(11-13-23)24-19-34-26-17-22(30)16-25(31)27(26)28(24)32/h3-5,8-13,16-17,19,30-31H,2,6-7,14-15,18H2,1H3
InChiKey: CAQVZKXGFDSSBX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Acetylcholinesterase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	carboxylesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	Acetylcholinesterase 1 precursor, putative	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	ko:K01049 acetylcholinesterase [EC3.1.1.7], putative	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	acetylcholinesterase 1	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Drosophila melanogaster	CG10175 gene product from transcript CG10175-RE	Acetylcholinesterase	614 aa	547 aa	32.5 %
Onchocerca volvulus	Carnitine O-palmitoyltransferase 2, mitochondrial homolog	Acetylcholinesterase	614 aa	531 aa	39.7 %
Onchocerca volvulus		Acetylcholinesterase	614 aa	583 aa	30.7 %
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	614 aa	573 aa	30.5 %
Echinococcus multilocularis	BC026374 protein (S09 family)	Acetylcholinesterase	614 aa	642 aa	34.0 %
Onchocerca volvulus	Molybdopterin synthase catalytic subunit homolog	Acetylcholinesterase	614 aa	564 aa	29.8 %
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Acetylcholinesterase	614 aa	602 aa	24.3 %
Loa Loa (eye worm)	hypothetical protein	Acetylcholinesterase	614 aa	570 aa	25.4 %
Echinococcus multilocularis	neuroligin	Acetylcholinesterase	614 aa	496 aa	24.0 %
Onchocerca volvulus	Putative nuclear protein	Acetylcholinesterase	614 aa	577 aa	40.7 %
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	614 aa	507 aa	26.4 %
Onchocerca volvulus		Acetylcholinesterase	614 aa	632 aa	25.6 %
Loa Loa (eye worm)	hypothetical protein	Acetylcholinesterase	614 aa	574 aa	24.0 %
Onchocerca volvulus		Acetylcholinesterase	614 aa	581 aa	27.0 %
Echinococcus granulosus	BC026374 protein S09 family	Acetylcholinesterase	614 aa	642 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	jumonji domain containing protein	0.0052	0.0231	0.0231
Trichomonas vaginalis	chromobox protein, putative	0.0061	0.0342	0.0643
Echinococcus multilocularis	lysosomal protective protein	0.0892	1	1
Brugia malayi	RNA binding protein	0.0059	0.0319	0.0319
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0067	0.041	0.041
Schistosoma mansoni	chromobox protein	0.0061	0.0342	0.0342
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0052	0.0231	0.0168
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0257	0.2622	0.5316
Trichomonas vaginalis	chromobox protein, putative	0.0037	0.0059	0.0062
Leishmania major	trypanothione reductase	0.0088	0.0653	0.0593
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0169	0.159	0.159
Echinococcus multilocularis	acetylcholinesterase	0.0082	0.058	0.052
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0319	0.0319
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.036	0.036
Brugia malayi	Pre-SET motif family protein	0.0057	0.0294	0.0294
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0224	0.2227	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0052	0.0231	0.0231
Echinococcus multilocularis	carboxylesterase 5A	0.0082	0.058	0.052
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0063	0.036	0.0298
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0203	0.1984	0.87
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0068	0.0423	0.1406
Trichomonas vaginalis	chromobox protein, putative	0.0037	0.0059	0.0062
Trypanosoma brucei	serine peptidase, Clan SC, Family S10	0.0892	1	1
Echinococcus multilocularis	tar DNA binding protein	0.0059	0.0319	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0029	0.0029
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0423	0.0362
Brugia malayi	RNA recognition motif domain containing protein	0.0059	0.0319	0.0319
Echinococcus granulosus	lysosomal protective protein	0.0892	1	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0068	0.0423	0.0423
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0257	0.2622	0.5316
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0063	0.036	0.0298
Giardia lamblia	Fructose-bisphosphate aldolase	0.0257	0.2622	0.5
Onchocerca volvulus		0.0142	0.1276	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0082	0.058	0.058
Trypanosoma brucei	serine peptidase, Clan SC, Family S10	0.0892	1	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.0082	0.058	0.058
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0064	0.0072
Plasmodium vivax	thioredoxin reductase, putative	0.0088	0.0653	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0063	0.036	0.0298
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0057	0.0294	0.3899
Echinococcus multilocularis	geminin	0.0149	0.1364	0.1308
Brugia malayi	chromobox protein homolog 3	0.0034	0.0029	0.0029
Echinococcus multilocularis	lysine specific demethylase 5A	0.0052	0.0231	0.0168
Plasmodium vivax	glutathione reductase, putative	0.0088	0.0653	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0224	0.2227	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0064	0.0072
Echinococcus granulosus	transcription factor Dp 1	0.004	0.0089	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0082	0.058	0.058
Plasmodium falciparum	thioredoxin reductase	0.0088	0.0653	0.5
Onchocerca volvulus		0.0067	0.041	0.0383
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0057	0.0294	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0294	0.0294
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0059	0.0319	0.0319
Brugia malayi	Thioredoxin reductase	0.0088	0.0653	0.0653
Toxoplasma gondii	thioredoxin reductase	0.0088	0.0653	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0064	0.0064
Brugia malayi	jmjC domain containing protein	0.0052	0.0231	0.0231
Schistosoma mansoni	hypothetical protein	0.0149	0.1364	0.1364
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0257	0.2622	0.5316
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0064	0.0072
Toxoplasma gondii	aldehyde dehydrogenase	0.0063	0.036	0.5018
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0169	0.159	0.159
Echinococcus multilocularis	chromobox protein 1	0.0061	0.0342	0.028
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0319	0.0319
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.084	0.9392	0.9388
Echinococcus granulosus	lysosomal alpha glucosidase	0.0169	0.159	0.1536
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0055	0.0269	0.0207
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0068	0.0423	0.0423
Schistosoma mansoni	family S10 unassigned peptidase (S10 family)	0.0892	1	1
Echinococcus multilocularis	family S10 non peptidase ue (S10 family)	0.0804	0.8975	0.8968
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0423	0.0362
Trypanosoma brucei	trypanothione reductase	0.0088	0.0653	0.0593
Schistosoma mansoni	hypothetical protein	0.0149	0.1364	0.1364
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0201	0.1966	0.8603
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0057	0.0294	0.0294
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.036	0.036
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0052	0.0231	0.0168
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0257	0.2622	0.5316
Brugia malayi	Carboxylesterase family protein	0.0082	0.058	0.058
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0057	0.0294	0.0294
Mycobacterium tuberculosis	Probable oxidoreductase	0.0224	0.2227	1
Brugia malayi	glutathione reductase	0.0088	0.0653	0.0653
Echinococcus granulosus	acetylcholinesterase	0.0082	0.058	0.052
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0064	0.0064
Loa Loa (eye worm)	jmjC domain-containing protein	0.0052	0.0231	0.0231
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0068	0.0423	0.0362
Schistosoma mansoni	lysosomal protective protein precursor (cathepsin A) (carboxypeptidase	0.0088	0.0654	0.0654
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0064	0.0072
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0201	0.1966	0.8603
Brugia malayi	jmjC domain containing protein	0.0052	0.0231	0.0231
Echinococcus granulosus	microtubule associated protein 2	0.0715	0.7937	0.7924
Mycobacterium tuberculosis	Probable dehydrogenase	0.0201	0.1966	0.8603
Plasmodium falciparum	glutathione reductase	0.0088	0.0653	0.5
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0399	0.4266	0.4266
Onchocerca volvulus		0.0098	0.0763	0.0737
Mycobacterium tuberculosis	Probable reductase	0.0201	0.1966	0.8603
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0057	0.0294	0.0294
Trichomonas vaginalis	set domain proteins, putative	0.0454	0.4906	1
Onchocerca volvulus		0.0454	0.4906	0.4892
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0224	0.2227	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0089	0.0659	0.0599
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0047	0.0172	0.0172
Trypanosoma cruzi	serine carboxypeptidase (CBP1), putative	0.0892	1	1
Schistosoma mansoni	alpha-glucosidase	0.0145	0.1317	0.1317
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0057	0.0294	0.0231
Echinococcus granulosus	lysine specific demethylase 5A	0.0052	0.0231	0.0168
Trypanosoma cruzi	serine carboxypeptidase (CBP1), putative	0.0892	1	1
Loa Loa (eye worm)	RNA binding protein	0.0059	0.0319	0.0319
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0319	0.0319
Echinococcus granulosus	geminin	0.0149	0.1364	0.1308
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1276	0.1276
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0126	0.1091	0.3915
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0089	0.0659	0.0599
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0319	0.0319
Echinococcus granulosus	tar DNA binding protein	0.0059	0.0319	0.0257
Echinococcus multilocularis	chromobox protein 1	0.0061	0.0342	0.028
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0047	0.0172	0.0172
Trypanosoma cruzi	trypanothione reductase, putative	0.0088	0.0653	0.0593
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0088	0.0653	0.1573
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0257	0.2622	0.5316
Loa Loa (eye worm)	heterochromatin protein 1	0.0061	0.0342	0.0342
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0068	0.0423	0.0423
Echinococcus granulosus	acetylcholinesterase	0.0082	0.058	0.052
Schistosoma mansoni	chromobox protein	0.0061	0.0342	0.0342
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0257	0.2622	0.5316
Schistosoma mansoni	alpha glucosidase	0.0037	0.0064	0.0064
Echinococcus granulosus	chromobox protein 1	0.0061	0.0342	0.028
Loa Loa (eye worm)	thioredoxin reductase	0.0088	0.0653	0.0653
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0068	0.0423	0.0362
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0201	0.1966	0.7704
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0423	0.0362
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0126	0.1091	1
Loa Loa (eye worm)	carboxylesterase	0.0082	0.058	0.058
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0257	0.2622	0.5316
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0201	0.1966	0.8603
Trypanosoma cruzi	serine peptidase, Clan SC, Family S10, putative	0.0892	1	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0201	0.1966	0.8603
Onchocerca volvulus	Uncharacterized serine carboxypeptidase homolog	0.0892	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0082	0.058	0.058
Brugia malayi	Pre-SET motif family protein	0.0399	0.4266	0.4266
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0257	0.2622	0.5316
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0064	0.0072
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0257	0.2622	1
Echinococcus multilocularis	acetylcholinesterase	0.0082	0.058	0.052
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0047	0.0172	0.0172
Schistosoma mansoni	alpha-glucosidase	0.0145	0.1317	0.1317
Brugia malayi	Heterochromatin protein 1	0.0061	0.0342	0.0342
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0052	0.0231	0.0231
Leishmania major	serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10	0.0892	1	1
Brugia malayi	hypothetical protein	0.0142	0.1276	0.1276
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0064	0.0072
Trypanosoma cruzi	serine peptidase, Clan SC, Family S10, putative	0.0892	1	1
Trypanosoma brucei	serine peptidase, Clan SC, Family S10	0.0892	1	1
Echinococcus granulosus	family S10 non peptidase ue S10 family	0.0804	0.8975	0.8968
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0064	0.0072
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0068	0.0423	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0892	1	1
Echinococcus granulosus	chromobox protein 1	0.0061	0.0342	0.028
Loa Loa (eye worm)	TAR-binding protein	0.0059	0.0319	0.0319
Echinococcus granulosus	carboxylesterase 5A	0.0082	0.058	0.052
Treponema pallidum	fructose-bisphosphate aldolase	0.0257	0.2622	0.5
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0169	0.159	0.1536
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0037	0.0059	0.003
Echinococcus multilocularis	transcription factor Dp 1	0.004	0.0089	0.0025
Trichomonas vaginalis	chromobox protein, putative	0.0061	0.0342	0.0643
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0064	0.0072
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0319	0.0319
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0169	0.159	0.1536
Loa Loa (eye worm)	glutathione reductase	0.0088	0.0653	0.0653
Brugia malayi	TAR-binding protein	0.0059	0.0319	0.0319
Brugia malayi	Carboxylesterase family protein	0.0082	0.058	0.058
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0172	0.0172
Echinococcus multilocularis	microtubule associated protein 2	0.0715	0.7937	0.7924
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0064	0.0072
Schistosoma mansoni	microtubule-associated protein tau	0.0715	0.7937	0.7937
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0257	0.2622	1
Schistosoma mansoni	family S10 non-peptidase homologue (S10 family)	0.0892	1	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0057	0.0294	0.0231

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of human erythrocytes AchE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method	ChEMBL.	24589487
IC50 (binding)		Inhibition of electric eel AchE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method	ChEMBL.	24589487
IC50 (binding)	= 12.8 uM	Inhibition of rat cortex homogenate AchE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method	ChEMBL.	24589487
Inhibition (binding)	< 5 %	Inhibition of rat serum BuChE using butyrylthiocholine iodide as substrate at 50 uM after 15 mins by Ellman's method	ChEMBL.	24589487

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3127014

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1828160