TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 322.361 | Formula: C18H18N4O2
H donors: 1 H acceptors: 4 LogP: 1.42 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OCc1cccc(c1)c1nc2cccnc2c(n1)N1CCOCC1
InChi: 1S/C18H18N4O2/c23-12-13-3-1-4-14(11-13)17-20-15-5-2-6-19-16(15)18(21-17)22-7-9-24-10-8-22/h1-6,11,23H,7-10,12H2
InChiKey: XXWFFCFOQNPIOZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	Starlite/ChEMBL	References
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Starlite/ChEMBL	References
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1068 aa	927 aa	29.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1434	0.1669
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Leishmania major	cathepsin L-like protease	0.0119	0.1434	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0263	0.406	0.6529
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.013	0.1637	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trypanosoma cruzi	cysteine peptidase, putative	0.0119	0.1434	0.2219
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.008	0.0729	0.0663
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0297	0.4674	0.4674
Brugia malayi	putative neuropeptide receptor	0.008	0.0729	0.1174
Brugia malayi	Cathepsin L-like precursor	0.0119	0.1434	0.2308
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0053	0.0233	0.0361
Schistosoma mansoni	alpha-1 adrenergic receptor	0.008	0.0729	0.0729
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0054	0.0262	0.0244
Loa Loa (eye worm)	phosphatidylinositol 3	0.0513	0.8595	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.1434	0.8704
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0065	0.0463	0.0745
Loa Loa (eye worm)	phosphatidylinositol 3	0.0065	0.0463	0.0539
Schistosoma mansoni	neuropeptide f receptor 76f	0.008	0.0729	0.0729
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0382	0.6214	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Schistosoma mansoni	amine GPCR	0.008	0.0729	0.0729
Giardia lamblia	Cathepsin B precursor	0.0117	0.1403	0.4287
Echinococcus granulosus	cathepsin b	0.0297	0.4674	0.4636
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0053	0.0233	0.0263
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0729	0.0729
Brugia malayi	cathepsin B-like cysteine proteinase	0.0297	0.4674	0.7521
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.1434	0.8704
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.008	0.0729	0.0729
Brugia malayi	RE15519p	0.008	0.0729	0.1174
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0053	0.0233	0.0374
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0261	0.0407
Entamoeba histolytica	cysteine proteinase, putative	0.0112	0.1302	0.2003
Echinococcus multilocularis	nmda type glutamate receptor	0.0093	0.097	0.097
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.013	0.1637	0.2625
Brugia malayi	hypothetical protein	0.008	0.0729	0.1174
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0048	0.0138	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1302	0.1514
Schistosoma mansoni	neuropeptide receptor	0.008	0.0729	0.0729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0071	0.0101
Brugia malayi	Cathepsin L-like precursor	0.0119	0.1434	0.2308
Echinococcus granulosus	tm gpcr rhodopsin	0.008	0.0729	0.0663
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0261	0.0407
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0053	0.0233	0.0361
Entamoeba histolytica	cysteine proteinase, putative	0.0119	0.1434	0.2219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1302	0.1514
Schistosoma mansoni	amine GPCR	0.008	0.0729	0.0729
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.1434	0.8704
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0729	0.0729
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0729	0.0729
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0729	0.0729
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0119	0.1434	0.2298
Schistosoma mansoni	cathepsin F (C01 family)	0.0119	0.1434	0.1434
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0009	0.0001
Loa Loa (eye worm)	ctsf protein	0.0119	0.1434	0.1669
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.008	0.0729	0.0849
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0053	0.0233	0.0183
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0066	0.0093
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0048	0.0138	0.0067
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0065	0.0463	0.0395
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0009	0.0001
Echinococcus granulosus	g protein coupled receptor	0.008	0.0729	0.0663
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0053	0.0233	0.0263
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.008	0.0729	0.0729
Echinococcus granulosus	serotonin receptor	0.008	0.0729	0.0663
Echinococcus multilocularis	neuropeptides capa receptor	0.008	0.0729	0.0729
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.1434	0.8704
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0053	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1302	0.1514
Leishmania major	cathepsin L-like protease	0.0119	0.1434	1
Brugia malayi	G-protein coupled receptor	0.008	0.0729	0.1174
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0186	0.2656	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0729	0.0729
Echinococcus granulosus	orexin receptor type 2	0.008	0.0729	0.0663
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.008	0.0729	0.0849
Echinococcus granulosus	biogenic amine 5HT receptor	0.008	0.0729	0.0663
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0729	0.0729
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.008	0.0729	0.0663
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.008	0.0729	0.1174
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0729	0.0729
Echinococcus multilocularis	g protein coupled receptor	0.008	0.0729	0.0729
Schistosoma mansoni	opsin-like receptor	0.008	0.0729	0.0729
Echinococcus granulosus	glutamate receptor 2	0.0048	0.0138	0.0067
Brugia malayi	hypothetical protein	0.008	0.0729	0.1174
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0044	0.0071	0.0071
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0009	0.0001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.1434	0.8704
Loa Loa (eye worm)	hypothetical protein	0.0249	0.3791	0.4411
Loa Loa (eye worm)	neuropeptide F receptor	0.008	0.0729	0.0849
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.008	0.0729	0.0663
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Plasmodium vivax	vivapain-2	0.0119	0.1434	1
Echinococcus granulosus	allatostatin A receptor	0.008	0.0729	0.0663
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0053	0.0233	0.0163
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0729	0.0729
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.008	0.0729	0.0729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0261	0.0407
Echinococcus multilocularis	glutamate receptor 2	0.0048	0.0138	0.0138
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0208	0.3059	0.4923
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0119	0.1434	0.2298
Brugia malayi	hypothetical protein	0.008	0.0729	0.1174
Schistosoma mansoni	growth hormone secretagogue receptor	0.008	0.0729	0.0729
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0112	0.1302	0.2003
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.008	0.0729	0.1174
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.021	0.0325
Loa Loa (eye worm)	G-protein coupled receptor	0.008	0.0729	0.0849
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0044	0.0071	0.0071
Onchocerca volvulus		0.0119	0.1434	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.008	0.0729	0.0729
Schistosoma mansoni	biogenic amine receptor	0.008	0.0729	0.0729
Brugia malayi	Cathepsin L-like precursor	0.0119	0.1434	0.2308
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0297	0.4674	0.7493
Onchocerca volvulus		0.0112	0.1302	0.8118
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0463	0.0732
Brugia malayi	hypothetical protein	0.008	0.0729	0.1174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0729	0.0729
Schistosoma mansoni	biogenic amine receptor	0.008	0.0729	0.0729
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0119	0.1434	0.1434
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0382	0.6214	1
Echinococcus granulosus	tm gpcr rhodopsin	0.008	0.0729	0.0663
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0065	0.0463	0.0463
Echinococcus granulosus	hypothetical protein	0.008	0.0729	0.0663
Schistosoma mansoni	amine GPCR	0.008	0.0729	0.0729
Echinococcus granulosus	neuropeptide Y receptor	0.008	0.0729	0.0663
Schistosoma mansoni	hypothetical protein	0.008	0.0729	0.0729
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.008	0.0729	0.0849
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0053	0.0233	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1696	0.1973
Echinococcus multilocularis	glutamate receptor NMDA	0.0079	0.0701	0.0701
Echinococcus multilocularis	dro:myosuppressin receptor	0.008	0.0729	0.0729
Brugia malayi	ORL1-like opioid receptor	0.008	0.0729	0.1174
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0053	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Echinococcus multilocularis	g-protein coupled receptor	0.008	0.0729	0.0729
Echinococcus granulosus	sex peptide receptor	0.008	0.0729	0.0663
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Echinococcus granulosus	somatostatin receptor	0.008	0.0729	0.0663
Echinococcus granulosus	g-protein coupled receptor	0.008	0.0729	0.0663
Brugia malayi	Serotonin receptor	0.008	0.0729	0.1174
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0119	0.1434	0.1669
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0729	0.0663
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0048	0.0138	0.0138
Echinococcus granulosus	neuropeptides capa receptor	0.008	0.0729	0.0663
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0048	0.0138	0.0138
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.008	0.0729	0.0729
Echinococcus multilocularis	allatostatin A receptor	0.008	0.0729	0.0729
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0065	0.0463	0.0638
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0065	0.0463	0.2502
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0119	0.1434	0.2298
Brugia malayi	Cathepsin L-like precursor	0.0119	0.1434	0.2308
Leishmania major	cathepsin L-like protease	0.0119	0.1434	1
Brugia malayi	GnHR receptor homolog	0.008	0.0729	0.1174
Echinococcus granulosus	neuropeptide receptor	0.008	0.0729	0.0663
Schistosoma mansoni	neuropeptide receptor	0.008	0.0729	0.0729
Brugia malayi	Cathepsin L-like precursor	0.0119	0.1434	0.2308
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.013	0.1637	0.2625
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0117	0.1403	0.2168
Echinococcus granulosus	neuropeptide Y receptor	0.008	0.0729	0.0663
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0305	0.4809	0.7713
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0119	0.1434	0.2298
Trypanosoma cruzi	cysteine peptidase, putative	0.0119	0.1434	0.2219
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.021	0.0325
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.1434	0.8704
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.006	0.0083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0261	0.0407
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0463	0.0732
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0053	0.0233	0.1185
Brugia malayi	G protein-coupled receptor	0.008	0.0729	0.1174
Echinococcus multilocularis	serotonin receptor	0.008	0.0729	0.0729
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0048	0.0138	0.0067
Schistosoma mansoni	myosin xvIII	0.008	0.0729	0.0729
Brugia malayi	neuropeptide F receptor	0.008	0.0729	0.1174
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.008	0.0729	0.1174
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0066	0.0093
Echinococcus multilocularis	fmrfamide receptor	0.008	0.0729	0.0729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0319	0.05
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0729	0.0729
Echinococcus multilocularis	neuropeptides capa receptor	0.008	0.0729	0.0729
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0044	0.0071	0.0071
Echinococcus multilocularis	nmda type glutamate receptor	0.0086	0.0839	0.0839
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.1302	0.2084
Schistosoma mansoni	opsin-like receptor	0.008	0.0729	0.0729
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.008	0.0729	0.0729
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0119	0.1434	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0112	0.1302	0.2095
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.008	0.0729	0.0663
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0065	0.0463	0.2502
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0119	0.1434	0.2298
Schistosoma mansoni	opsin-like receptor	0.008	0.0729	0.0729
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0729	0.0663
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.008	0.0729	0.0729
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0119	0.1434	0.1669
Brugia malayi	hypothetical protein	0.008	0.0729	0.1174
Brugia malayi	hypothetical protein	0.008	0.0729	0.1174
Brugia malayi	Dopamine receptor protein 1	0.008	0.0729	0.1174
Loa Loa (eye worm)	cathepsin B	0.0117	0.1403	0.1632
Brugia malayi	hypothetical protein	0.008	0.0729	0.1174
Echinococcus granulosus	cathepsin l1	0.0112	0.1302	0.1239
Loa Loa (eye worm)	hypothetical protein	0.0297	0.4674	0.5438
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.008	0.0729	0.0729
Schistosoma mansoni	hypothetical protein	0.008	0.0729	0.0729
Echinococcus granulosus	alpha 1A adrenergic receptor	0.008	0.0729	0.0663
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0729	0.0663
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0729	0.0663
Brugia malayi	hypothetical protein	0.008	0.0729	0.1174
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Echinococcus granulosus	g protein coupled receptor	0.008	0.0729	0.0663
Schistosoma mansoni	cathepsin F (C01 family)	0.0112	0.1302	0.1302
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0053	0.0233	0.1032
Echinococcus multilocularis	serotonin receptor	0.008	0.0729	0.0729
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0367	0.5947	0.9565
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0729	0.0663
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0729	0.0663
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0053	0.0233	0.0233
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.008	0.0729	0.0729
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.1434	0.8704
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.008	0.0729	0.0729
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0263	0.406	0.6529
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.013	0.1637	0.255
Echinococcus granulosus	cathepsin l1	0.0119	0.1434	0.1373
Trypanosoma cruzi	cysteine peptidase, putative	0.0119	0.1434	0.2219
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0117	0.1403	0.1403
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.1434	0.8704
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0065	0.0463	0.1916
Schistosoma mansoni	amine GPCR	0.008	0.0729	0.0729
Brugia malayi	sulfakinin receptor protein	0.008	0.0729	0.1174
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0071	0.0101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0729	0.0729
Brugia malayi	Serotonin receptor	0.008	0.0729	0.1174
Toxoplasma gondii	cathepsin B	0.0117	0.1403	0.9744
Schistosoma mansoni	glutamate receptor NMDA	0.0095	0.1	0.1
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0071	0.0114
Echinococcus granulosus	dro:myosuppressin receptor	0.008	0.0729	0.0663
Schistosoma mansoni	biogenic amine (5HT) receptor	0.008	0.0729	0.0729
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0117	0.1403	0.2247
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0053	0.0233	0.0163
Echinococcus multilocularis	neuropeptide receptor A26	0.008	0.0729	0.0729
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.008	0.0729	0.0729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.059	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Brugia malayi	putative neuropeptide receptor NPR1	0.008	0.0729	0.1174
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.059	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.008	0.0729	0.0663
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0729	0.0729
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0065	0.0463	0.0638
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0048	0.0138	0.0067
Echinococcus multilocularis	neuropeptide receptor	0.008	0.0729	0.0729
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.008	0.0729	0.0729
Schistosoma mansoni	hypothetical protein	0.008	0.0729	0.0729
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0249	0.3791	0.6101
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0066	0.0093
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.008	0.0729	0.0729
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.008	0.0729	0.0729
Schistosoma mansoni	cathepsin F (C01 family)	0.0119	0.1434	0.1434
Plasmodium vivax	vivapain-2	0.0119	0.1434	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0065	0.0463	0.0463
Echinococcus granulosus	biogenic amine 5HT receptor	0.008	0.0729	0.0663
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0729	0.0729
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0117	0.1403	0.9739
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0117	0.1403	0.8504
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Echinococcus granulosus	cathepsin b	0.0297	0.4674	0.4636
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0048	0.0138	0.0138
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0065	0.0463	0.0638
Onchocerca volvulus	Cathepsin F homolog	0.0119	0.1434	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.013	0.1637	0.255
Echinococcus multilocularis	cysteine protease	0.0119	0.1434	0.1434
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.013	0.1637	0.2625
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Echinococcus multilocularis	neuropeptide Y receptor	0.008	0.0729	0.0729
Entamoeba histolytica	cysteine proteinase, putative	0.0119	0.1434	0.2219
Brugia malayi	Melatonin receptor type 1A	0.008	0.0729	0.1174
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.008	0.0729	0.0729
Onchocerca volvulus		0.0119	0.1434	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0119	0.1434	0.2298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Leishmania major	cysteine peptidase A (CPA)	0.0119	0.1434	1
Schistosoma mansoni	glutamate receptor NMDA	0.0126	0.1566	0.1566
Onchocerca volvulus	Cathepsin L homolog	0.0119	0.1434	1
Loa Loa (eye worm)	G-protein coupled receptor	0.008	0.0729	0.0849
Brugia malayi	follicle stimulating hormone receptor	0.008	0.0729	0.1174
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0119	0.1434	0.1373
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.0138	0.0209
Brugia malayi	Dopamine receptor	0.008	0.0729	0.1174
Onchocerca volvulus		0.0119	0.1434	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.1434	0.8704
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.008	0.0729	0.0729
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0065	0.0463	0.0638
Echinococcus granulosus	neuropeptides capa receptor	0.008	0.0729	0.0663
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.008	0.0729	0.0729
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0729	0.0663
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.008	0.0729	0.0729
Loa Loa (eye worm)	melatonin receptor type 1A	0.008	0.0729	0.0849
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.021	0.0325
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Brugia malayi	hypothetical protein	0.008	0.0729	0.1174
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0249	0.3791	0.3791
Echinococcus multilocularis	g protein coupled receptor	0.008	0.0729	0.0729
Brugia malayi	neuropeptide F receptor	0.008	0.0729	0.1174
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0119	0.1434	0.2298
Echinococcus granulosus	fmrfamide receptor	0.008	0.0729	0.0663
Brugia malayi	Tachykinin-like peptides receptor 99D	0.008	0.0729	0.1174
Echinococcus multilocularis	somatostatin receptor	0.008	0.0729	0.0729
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Brugia malayi	G-protein coupled receptor	0.008	0.0729	0.1174
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.013	0.1637	0.1637
Trypanosoma cruzi	cysteine peptidase, putative	0.0119	0.1434	0.2219
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0065	0.0463	0.1916
Loa Loa (eye worm)	neuropeptide F receptor	0.008	0.0729	0.0849
Echinococcus multilocularis	fmrfamide receptor	0.008	0.0729	0.0729
Schistosoma mansoni	adenoreceptor	0.008	0.0729	0.0729
Echinococcus multilocularis	cysteine protease	0.0119	0.1434	0.1434
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.1434	0.8704
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0117	0.0175
Toxoplasma gondii	cathepsin CPL	0.0119	0.1434	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0171	0.2386	0.3769
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0297	0.4674	0.4674
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0119	0.1434	0.1373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.021	0.0325
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0053	0.0233	0.0361
Onchocerca volvulus	Cathepsin L homolog	0.0119	0.1434	1
Echinococcus granulosus	neuropeptide receptor A26	0.008	0.0729	0.0663
Echinococcus multilocularis	cathepsin L	0.0044	0.0071	0.0071
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.008	0.0729	0.0729
Echinococcus granulosus	nmda type glutamate receptor	0.0093	0.097	0.0906
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.1302	0.2084
Echinococcus multilocularis	neuropeptide s receptor	0.008	0.0729	0.0729
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.021	0.0325
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Schistosoma mansoni	neuropeptide receptor	0.008	0.0729	0.0729
Echinococcus multilocularis	cathepsin L cysteine protease	0.0119	0.1434	0.1434
Echinococcus multilocularis	orexin receptor type 2	0.008	0.0729	0.0729
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0382	0.6214	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Loa Loa (eye worm)	TYRA-2 protein	0.008	0.0729	0.0849
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0092	0.0945	0.2198
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Schistosoma mansoni	biogenic amine receptor	0.008	0.0729	0.0729
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.008	0.0729	0.0729
Echinococcus granulosus	7tm_1 domain containing protein	0.008	0.0729	0.0663
Brugia malayi	larval opioid receptor	0.008	0.0729	0.1174
Leishmania major	cathepsin L-like protease	0.0119	0.1434	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0119	0.1434	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0382	0.6214	1
Brugia malayi	Cathepsin L-like precursor	0.0112	0.1302	0.2095
Schistosoma mansoni	histamine h1 receptor	0.008	0.0729	0.0729
Echinococcus granulosus	neuropeptide s receptor	0.008	0.0729	0.0663
Schistosoma mansoni	neuropeptide F-like receptor	0.008	0.0729	0.0729
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.1434	0.8704
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0115	0.137	0.2115
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0382	0.6214	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0729	0.0729
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0729	0.0729
Echinococcus granulosus	tachykinin peptides receptor 99D	0.008	0.0729	0.0663
Onchocerca volvulus		0.0119	0.1434	1
Loa Loa (eye worm)	fibroinase	0.0119	0.1434	0.1669
Echinococcus granulosus	neuropeptide FF receptor 2	0.008	0.0729	0.0663
Giardia lamblia	Cathepsin B precursor	0.0117	0.1403	0.4287
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.008	0.0729	0.0729
Echinococcus multilocularis	cathepsin b	0.0297	0.4674	0.4674
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0119	0.1434	0.1434
Schistosoma mansoni	neuropeptide F-like receptor	0.008	0.0729	0.0729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.021	0.0325
Brugia malayi	G protein-coupled receptor F59B2.13	0.008	0.0729	0.1174
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0382	0.6214	1
Schistosoma mansoni	amine GPCR	0.008	0.0729	0.0729
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.008	0.0729	0.0729
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0053	0.0233	0.0263
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0053	0.0233	0.1185
Leishmania major	cathepsin L-like protease	0.0119	0.1434	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Echinococcus granulosus	tm gpcr rhodopsin	0.008	0.0729	0.0663
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0249	0.3791	0.3747
Loa Loa (eye worm)	phosphatidylinositol 3	0.0115	0.137	0.1594
Echinococcus granulosus	glutamate receptor NMDA	0.0079	0.0701	0.0635
Echinococcus multilocularis	G-protein coupled receptor, putative	0.008	0.0729	0.0729
Schistosoma mansoni	neuropeptide receptor	0.008	0.0729	0.0729
Echinococcus multilocularis	Zinc finger, PHD finger	0.0053	0.0233	0.0233
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.008	0.0729	0.0729
Leishmania major	cathepsin L-like protease	0.0119	0.1434	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0119	0.1434	0.2298
Brugia malayi	AKH receptor	0.008	0.0729	0.1174
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Echinococcus multilocularis	sex peptide receptor	0.008	0.0729	0.0729
Onchocerca volvulus		0.0119	0.1434	1
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0095	0.1	0.1
Echinococcus granulosus	G protein coupled receptor 139	0.008	0.0729	0.0663
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0053	0.0233	0.0271
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.008	0.0729	0.1174
Giardia lamblia	Cathepsin B precursor	0.0117	0.1403	0.4287
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.008	0.0729	0.0849
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0119	0.1434	0.2298
Echinococcus granulosus	7TM GPCR rhodopsin	0.008	0.0729	0.0663
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0297	0.4674	0.4674
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0463	0.0732
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.008	0.0729	0.0663
Leishmania major	cathepsin L-like protease	0.0119	0.1434	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0053	0.0233	0.0183
Onchocerca volvulus		0.0119	0.1434	1
Schistosoma mansoni	hypothetical protein	0.008	0.0729	0.0729
Brugia malayi	hypothetical protein	0.008	0.0729	0.1174
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.008	0.0729	0.0663
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0729	0.0729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0119	0.1434	0.2298
Trypanosoma cruzi	target of rapamycin kinase 3	0.0054	0.0262	0.0311
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0119	0.1434	0.2298
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0729	0.0729
Echinococcus multilocularis	cathepsin L cysteine protease	0.0119	0.1434	0.1434
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.008	0.0729	0.1174
Echinococcus multilocularis	neuropeptide receptor	0.008	0.0729	0.0729
Echinococcus granulosus	g protein coupled receptor	0.008	0.0729	0.0663
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0095	0.1	0.0935
Entamoeba histolytica	hypothetical protein	0.0305	0.4809	0.7713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.008	0.0729	0.0729
Onchocerca volvulus		0.0119	0.1434	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0297	0.4674	0.4674
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.008	0.0729	0.0729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.021	0.0325
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.008	0.0729	0.0849
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Entamoeba histolytica	cysteine protease, putative	0.0119	0.1434	0.2219
Loa Loa (eye worm)	cysteine protease	0.0119	0.1434	0.1669
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0054	0.0262	0.1219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1434	0.2298
Echinococcus granulosus	nmda type glutamate receptor	0.0086	0.0839	0.0774
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0119	0.1434	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Echinococcus multilocularis	neuropeptide FF receptor 2	0.008	0.0729	0.0729
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.008	0.0729	0.0729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0009	0.0001
Echinococcus multilocularis	g protein coupled receptor	0.008	0.0729	0.0729
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0048	0.0138	0.0138
Leishmania major	cathepsin L-like protease	0.0119	0.1434	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.013	0.1637	0.255
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.013	0.1637	0.2635
Schistosoma mansoni	biogenic amine (5HT) receptor	0.008	0.0729	0.0729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0261	0.0407
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0382	0.6214	1
Echinococcus multilocularis	neuropeptide Y receptor	0.008	0.0729	0.0729
Brugia malayi	Dopamine receptor protein 2	0.008	0.0729	0.1174
Brugia malayi	cathepsin L-like precursor	0.0112	0.1302	0.2095
Echinococcus multilocularis	cathepsin b	0.0297	0.4674	0.4674
Brugia malayi	Papain family cysteine protease containing protein	0.0119	0.1434	0.2308
Brugia malayi	Cathepsin L-like precursor	0.0119	0.1434	0.2308
Echinococcus granulosus	neuropeptide receptor	0.008	0.0729	0.0663
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.006	0.0083
Echinococcus multilocularis	G protein coupled receptor 139	0.008	0.0729	0.0729
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0071	0.0114
Trypanosoma cruzi	cruzipain precursor, putative	0.0119	0.1434	0.2219
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.008	0.0729	0.0729
Loa Loa (eye worm)	hypothetical protein	0.008	0.0729	0.0849
Brugia malayi	Cathepsin L-like precursor	0.0112	0.1302	0.2095

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.024 uM	Inhibition of PI3Kdelta (unknown origin) after 1 hr by TR-FRET assay	ChEMBL.	24345273
IC50 (binding)	= 0.061 uM	Inhibition of PI3Kalpha (unknown origin) after 1 hr by TR-FRET assay	ChEMBL.	24345273
IC50 (binding)	= 0.183 uM	Inhibition of PI3Kgamma (unknown origin) after 1 hr by TR-FRET assay	ChEMBL.	24345273
IC50 (binding)	= 0.336 uM	Inhibition of mTOR (unknown origin) after 2 hrs by TR-FRET assay	ChEMBL.	24345273

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3109126

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1829603