TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 525.623 | Formula: C25H31N7O4S
H donors: 3 H acceptors: 6 LogP: 2.67 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CCCCNc1ncc(c(n1)NCc1ccncc1)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1
InChi: 1S/C25H31N7O4S/c1-2-3-10-27-25-29-18-22(23(31-25)28-17-19-8-11-26-12-9-19)24(33)30-20-4-6-21(7-5-20)37(34,35)32-13-15-36-16-14-32/h4-9,11-12,18H,2-3,10,13-17H2,1H3,(H,30,33)(H2,27,28,29,31)
InChiKey: IFGAKKDJKVVCHX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TYRO3 protein tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	MER proto-oncogene, tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_132328	All targets in OG5_132328

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Echinococcus granulosus	tyrosine kinase	0.0019	0.2688	0.3241
Echinococcus granulosus	ephrin type A receptor 4 A	0.0019	0.2688	0.3241
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK protein kinase	0.0019	0.2688	0.2688
Loa Loa (eye worm)	TK/INSR protein kinase	0.0019	0.2688	0.2688
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2647	0.2647
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0019	0.2688	0.3241
Loa Loa (eye worm)	TK/RYK protein kinase	0.0019	0.2688	0.2688
Brugia malayi	hypothetical protein	0.0019	0.2688	0.1905
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0019	0.2688	0.3241
Echinococcus multilocularis	tyrosine protein kinase csk	0.0019	0.2688	0.3241
Echinococcus granulosus	epidermal growth factor receptor	0.0019	0.2688	0.3241
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0022	0.4448	0.6344
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0019	0.2688	0.3241
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0019	0.2688	0.3241
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Echinococcus granulosus	neuroglian	0.0015	0.0967	0.0207
Schistosoma mansoni	protein kinase	0.0019	0.2688	0.3098
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0019	0.2688	0.2688
Trypanosoma brucei	protein kinase, putative	0.0019	0.2688	0.5
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0019	0.2688	0.3098
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.2688	0.5
Giardia lamblia	Kinase	0.0019	0.2688	0.5
Echinococcus granulosus	protein kinase	0.0019	0.2688	0.3241
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0887	0.0066
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0019	0.2688	0.2688
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0019	0.2688	0.3241
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0019	0.2688	0.3098
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0019	0.2688	0.3241
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0019	0.2688	0.3241
Schistosoma mansoni	protein tyrosine kinase	0.0019	0.2688	0.3098
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Echinococcus granulosus	activated cdc42 kinase 1	0.0019	0.2688	0.3241
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.4448	0.3854
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.0967	0.0967
Schistosoma mansoni	ephrin receptor	0.0019	0.2688	0.3098
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.2688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Giardia lamblia	Protein 21.1	0.0019	0.2688	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0019	0.2688	0.3241
Echinococcus granulosus	tyrosine protein kinase csk	0.0019	0.2688	0.3241
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0019	0.2688	0.3241
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0019	0.2688	0.3241
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0019	0.2688	0.3241
Echinococcus granulosus	c src tyrosine kinase	0.0019	0.2688	0.3241
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0019	0.2688	0.3241
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0019	0.2688	0.3241
Schistosoma mansoni	protein kinase	0.0019	0.2688	0.3098
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0019	0.2688	0.1905
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus granulosus	contactin	0.0015	0.0967	0.0207
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.2688	0.3098
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0019	0.2688	0.3241
Echinococcus multilocularis	tyrosine kinase	0.0019	0.2688	0.3241
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0019	0.2688	0.3241
Giardia lamblia	Kinase, NEK	0.0019	0.2688	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0026	0.6522	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0019	0.2688	0.3241
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0019	0.2688	0.3241
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0019	0.2688	0.3241
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Plasmodium falciparum	protein kinase, putative	0.0019	0.2688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Leishmania major	protein kinase, putative	0.0019	0.2688	0.5
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Schistosoma mansoni	serine/threonine RGC	0.0019	0.2688	0.3098
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Plasmodium falciparum	protein kinase, putative	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.2688	0.5
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Loa Loa (eye worm)	TK protein kinase	0.0019	0.2688	0.2688
Echinococcus granulosus	insulin receptor	0.0019	0.2688	0.3241
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus granulosus	protein tyrosine kinase	0.0019	0.2688	0.3241
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0019	0.2688	0.3241
Loa Loa (eye worm)	TK protein kinase	0.0019	0.2688	0.2688
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0019	0.2688	0.3241
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0019	0.2688	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0019	0.2688	0.3241
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0019	0.2688	0.2688
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0019	0.2688	0.3241
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0019	0.2688	0.3098
Brugia malayi	hypothetical protein	0.0019	0.2688	0.1905
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0019	0.2688	0.3241
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0019	0.2688	0.2688
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0019	0.2688	0.3241
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.2688	0.5
Brugia malayi	Receptor family ligand binding region containing protein	0.0019	0.2688	0.1905
Echinococcus multilocularis	neuroglian	0.0015	0.0967	0.0207
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.2688	0.3098
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0019	0.2688	0.3241
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0019	0.2688	0.3098
Echinococcus multilocularis	transfer RNA-Thr	0.0019	0.2688	0.3241
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0019	0.2688	0.3241
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0019	0.2688	0.3241
Echinococcus granulosus	tyrosine protein kinase csk	0.0019	0.2688	0.3241
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0019	0.2688	0.3241
Toxoplasma gondii	protein kinase domain-containing protein	0.0019	0.2688	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0019	0.2688	0.2688
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0019	0.2688	0.2688
Entamoeba histolytica	hypothetical protein	0.002	0.3599	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0019	0.2688	0.2688
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0019	0.2688	0.3241
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0019	0.2688	0.1905
Loa Loa (eye worm)	SRC-1	0.0019	0.2688	0.2688
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0019	0.2688	0.2688
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK protein kinase	0.0019	0.2688	0.2688
Trypanosoma brucei	Pseudokinase, putative	0.0019	0.2688	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0019	0.2688	0.3241
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2647	0.2647
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Schistosoma mansoni	protein kinase	0.0019	0.2688	0.3098
Brugia malayi	hypothetical protein	0.0019	0.2688	0.1905
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0019	0.2688	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0019	0.2688	0.3241
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.0967	0.0207
Echinococcus multilocularis	protein tyrosine kinase	0.0019	0.2688	0.3241
Trichomonas vaginalis	STE family protein kinase	0.0019	0.2688	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0022	0.4448	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0019	0.2688	0.3241
Echinococcus granulosus	tyrosine kinase	0.0019	0.2688	0.3241
Echinococcus multilocularis	roundabout 2	0.0015	0.0967	0.0207
Loa Loa (eye worm)	TK protein kinase	0.0019	0.2688	0.2688
Echinococcus multilocularis	tyrosine protein kinase csk	0.0019	0.2688	0.3241
Loa Loa (eye worm)	TK protein kinase	0.0019	0.2688	0.2688
Leishmania major	hypothetical protein, conserved	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0019	0.2688	0.2688
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Schistosoma mansoni	protein kinase	0.0019	0.2688	0.3098
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0019	0.2688	0.1905
Entamoeba histolytica	protein kinase, putative	0.002	0.3599	1
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0019	0.2688	0.5
Schistosoma mansoni	protein kinase	0.0019	0.2688	0.3098
Echinococcus multilocularis	roundabout 2	0.0026	0.6481	0.9928
Echinococcus multilocularis	heat shock protein 70	0.0019	0.2688	0.3241
Echinococcus granulosus	tyrosine protein kinase Srms	0.0019	0.2688	0.3241
Echinococcus granulosus	roundabout 2	0.0015	0.0967	0.0207
Schistosoma mansoni	tyrosine kinase	0.0026	0.6246	0.9503
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Schistosoma mansoni	hypothetical protein	0.0019	0.2688	0.3098
Echinococcus multilocularis	tyrosine protein kinase	0.0019	0.2688	0.3241
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.2688	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0019	0.2688	0.1905
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0019	0.2688	0.3241
Brugia malayi	protein-tyrosine kinase	0.0019	0.2688	0.1905
Loa Loa (eye worm)	TK protein kinase	0.0019	0.2688	0.2688
Brugia malayi	C-terminal src kinase protein 1	0.0019	0.2688	0.1905
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2923	0.2923
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0019	0.2688	0.2688
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0019	0.2688	0.3241
Echinococcus multilocularis	integrin linked protein kinase	0.0019	0.2688	0.3241
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.0967	0.0207
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0019	0.2688	0.3241
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Echinococcus granulosus	tyrosine protein kinase csk	0.0019	0.2688	0.3241
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.2688	0.3098
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus granulosus	roundabout 2	0.0015	0.0967	0.0207
Plasmodium falciparum	protein kinase, putative	0.0019	0.2688	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0022	0.4448	0.4448
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0019	0.2688	0.3241
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0019	0.2688	0.2688
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0019	0.2688	0.2688
Trypanosoma cruzi	protein kinase, putative	0.0019	0.2688	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0019	0.2688	0.3241
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0019	0.2688	0.2688
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0967	0.0207
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0019	0.2688	0.3241
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0019	0.2688	0.3241
Brugia malayi	Raf kinase	0.0019	0.2688	0.1905
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Brugia malayi	SH2 domain containing protein	0.0019	0.2688	0.1905
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0019	0.2688	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0019	0.2688	0.1905
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0019	0.2688	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0019	0.2688	0.3241
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0019	0.2688	0.3241
Echinococcus multilocularis	tyrosine protein kinase shark	0.0019	0.2688	0.3241
Entamoeba histolytica	hypothetical protein	0.002	0.3599	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Trichomonas vaginalis	TK family protein kinase	0.0019	0.2688	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0019	0.2688	0.3241
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0015	0.0967	0.0967
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0019	0.2688	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0019	0.2688	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0019	0.2688	0.3241
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0019	0.2688	0.3241
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0015	0.0967	0.0207
Schistosoma mansoni	cell adhesion molecule	0.0023	0.4721	0.6758
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0019	0.2688	0.3241
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0019	0.2688	0.3241
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0019	0.2688	0.2688
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0026	0.6522	1
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0019	0.2688	0.3241
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0019	0.2688	0.5
Echinococcus multilocularis	activated cdc42 kinase 1	0.0019	0.2688	0.3241
Toxoplasma gondii	STE kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0019	0.2688	0.2688
Echinococcus granulosus	tyrosine kinase	0.0019	0.2688	0.3241
Echinococcus multilocularis	protein kinase	0.0019	0.2688	0.3241
Brugia malayi	SRC-1	0.0019	0.2688	0.1905
Trichomonas vaginalis	CAMK family protein kinase	0.0019	0.2688	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0019	0.2688	0.1905
Echinococcus granulosus	natriuretic peptide receptor 1	0.0019	0.2688	0.3241
Loa Loa (eye worm)	TK/ACK protein kinase	0.0019	0.2688	0.2688
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0019	0.2688	0.1905
Echinococcus granulosus	tyrosine protein kinase shark	0.0019	0.2688	0.3241
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0019	0.2923	0.2166
Loa Loa (eye worm)	TK protein kinase	0.0019	0.2688	0.2688
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0022	0.4448	0.6344
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0019	0.2688	0.3241
Schistosoma mansoni	nephrin	0.0023	0.4684	0.6691
Brugia malayi	Tyrosine-protein kinase PR2	0.0019	0.2688	0.1905
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0019	0.2688	0.3241
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0019	0.2688	0.1905
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Echinococcus multilocularis	epidermal growth factor receptor	0.0019	0.2688	0.3241
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0019	0.2688	0.3241
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0019	0.2688	0.3241
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0019	0.2688	0.3241
Schistosoma mansoni	protein kinase	0.0019	0.2688	0.3098
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Echinococcus multilocularis	c src tyrosine kinase	0.0019	0.2688	0.3241
Entamoeba histolytica	hypothetical protein	0.002	0.3599	1
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Brugia malayi	hypothetical protein	0.0019	0.2923	0.2166
Echinococcus multilocularis	roundabout 2	0.0015	0.0967	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0887	0.0887
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0019	0.2688	0.3098
Schistosoma mansoni	ephrin receptor	0.0026	0.6522	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0019	0.2688	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0019	0.2688	0.3241
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0019	0.2688	0.3241
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0019	0.2688	0.3241
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0019	0.2688	0.3241
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0967	0.0967
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0019	0.2688	0.1905
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Toxoplasma gondii	protein kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0019	0.2688	0.1905
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0019	0.2688	0.3241
Giardia lamblia	Kinase, NEK	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Leishmania major	protein kinase, putative	0.0019	0.2688	0.5
Echinococcus multilocularis	tyrosine kinase	0.0019	0.2688	0.3241
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0019	0.2688	0.3241
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Schistosoma mansoni	protein kinase	0.0019	0.2688	0.3098
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0019	0.2688	0.3098
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0019	0.2688	0.3241
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2923	0.2923
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0019	0.2688	0.3098
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0019	0.2688	0.1905
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0019	0.2688	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.0019	0.2688	0.3241
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Schistosoma mansoni	protein kinase	0.0019	0.2688	0.3098
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0019	0.2688	0.2688
Loa Loa (eye worm)	TK protein kinase	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.2688	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0019	0.2688	0.3241
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0019	0.2688	0.3241
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2923	0.2923
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0019	0.2688	0.3241
Brugia malayi	integrin-linked kinase	0.0019	0.2688	0.1905
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0019	0.2688	0.3241
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0019	0.2688	0.3241
Loa Loa (eye worm)	TK/DDR protein kinase	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Plasmodium vivax	protein kinase, putative	0.0019	0.2688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0019	0.2688	0.3241
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0019	0.2688	0.3241
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Echinococcus granulosus	kinase suppressor of Ras 1	0.0019	0.2688	0.3241
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2688	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK protein kinase	0.0022	0.4448	0.4448
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0015	0.0967	0.0207
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0033	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0019	0.2688	0.2688
Plasmodium falciparum	tyrosine kinase-like protein	0.0019	0.2688	0.5
Echinococcus granulosus	roundabout 2	0.0026	0.6481	0.9928
Schistosoma mansoni	tyrosine protein kinase	0.0019	0.2688	0.3098
Echinococcus granulosus	tyrosine protein kinase	0.0019	0.2688	0.3241
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Loa Loa (eye worm)	TK/ALK protein kinase	0.0019	0.2688	0.2688
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0019	0.2688	0.2688
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.2688	0.3098
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0019	0.2923	0.2166
Echinococcus multilocularis	activin receptor type	0.0019	0.2688	0.3241
Echinococcus multilocularis	protein kinase	0.0019	0.2688	0.3241
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0019	0.2688	0.3241
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0019	0.2688	0.3241
Schistosoma mansoni	protein kinase	0.0019	0.2688	0.3098
Trypanosoma cruzi	protein kinase, putative	0.0019	0.2688	0.5
Brugia malayi	Protein kinase domain containing protein	0.0019	0.2688	0.1905
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0019	0.2688	0.3241
Schistosoma mansoni	protein kinase	0.0019	0.2688	0.3098
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0019	0.2688	0.3241
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.2688	0.2688
Echinococcus multilocularis	insulin receptor	0.0019	0.2688	0.3241
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0019	0.2688	0.3241
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.002	0.3599	1
Echinococcus granulosus	activin receptor type	0.0019	0.2688	0.3241
Echinococcus multilocularis	epidermal growth factor receptor	0.0019	0.2688	0.3241
Brugia malayi	SH2 domain containing protein	0.0019	0.2688	0.1905
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0019	0.2688	0.3241
Echinococcus multilocularis	tyrosine protein kinase csk	0.0019	0.2688	0.3241
Schistosoma mansoni	tyrosine kinase	0.0019	0.2688	0.3098
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0019	0.2688	0.5
Schistosoma mansoni	protein kinase	0.0019	0.2688	0.3098

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.62 uM	Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay	ChEMBL.	24219778
IC50 (binding)	= 4.1 uM	Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay	ChEMBL.	24219778
IC50 (binding)	= 21 uM	Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay	ChEMBL.	24219778

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3093642

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1830356