Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0034 | 0.0238 | 0.0238 |
Echinococcus multilocularis | muscleblind protein | 0.0158 | 0.2144 | 0.2144 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.0041 | 0.0042 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0664 | 0.9913 | 0.9913 |
Echinococcus multilocularis | peroxidasin | 0.004 | 0.0326 | 0.0326 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.004 | 0.0326 | 0.0326 |
Brugia malayi | Peptidase family M28 containing protein | 0.038 | 0.5554 | 0.5603 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0022 | 0.0041 | 0.0041 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0273 | 0.3904 | 0.3938 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0158 | 0.2144 | 0.2144 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0061 | 0.0639 | 0.0639 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0034 | 0.0238 | 0.0238 |
Brugia malayi | nicalin | 0.0061 | 0.0639 | 0.0644 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0034 | 0.0238 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0314 | 0.4537 | 0.4537 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0034 | 0.0238 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0314 | 0.4537 | 0.4577 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0022 | 0.0041 | 0.0041 |
Leishmania major | glutaminyl cyclase, putative | 0.0061 | 0.0639 | 0.0503 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0034 | 0.0238 | 0.1839 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0639 | 0.0639 |
Brugia malayi | beta-lactamase family protein | 0.0029 | 0.0148 | 0.0149 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0061 | 0.0639 | 0.0908 |
Onchocerca volvulus | 0.004 | 0.0326 | 0.0329 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.0314 | 0.4537 | 0.4577 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0148 | 0.0148 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0022 | 0.0041 | 0.0041 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0061 | 0.0639 | 0.0639 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0022 | 0.0041 | 0.0041 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0034 | 0.0238 | 0.0092 |
Brugia malayi | FXNA | 0.0061 | 0.0639 | 0.0644 |
Loa Loa (eye worm) | animal heme peroxidase | 0.004 | 0.0326 | 0.0326 |
Toxoplasma gondii | exonuclease III APE | 0.0034 | 0.0238 | 0.0206 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.0639 | 1 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0061 | 0.0639 | 0.0503 |
Brugia malayi | SRC-1 | 0.0022 | 0.0041 | 0.0042 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0034 | 0.0238 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0158 | 0.2144 | 0.2163 |
Echinococcus granulosus | c src tyrosine kinase | 0.0022 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0314 | 0.4537 | 0.4537 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0022 | 0.0041 | 0.0041 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.038 | 0.5554 | 0.5603 |
Schistosoma mansoni | ap endonuclease | 0.0034 | 0.0238 | 0.024 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0183 | 0.2516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Brugia malayi | Animal haem peroxidase family protein | 0.004 | 0.0326 | 0.0329 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Toxoplasma gondii | hypothetical protein | 0.0314 | 0.4537 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.004 | 0.0326 | 0.0329 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0406 | 0.5948 | 0.6001 |
Echinococcus multilocularis | carbonic anhydrase | 0.0314 | 0.4537 | 0.4537 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.004 | 0.0326 | 0.0329 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0061 | 0.0639 | 0.0503 |
Onchocerca volvulus | 0.004 | 0.0326 | 0.0329 | |
Echinococcus granulosus | carbonic anhydrase II | 0.0664 | 0.9913 | 0.9913 |
Mycobacterium ulcerans | hypothetical protein | 0.0061 | 0.0639 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0061 | 0.0639 | 0.0908 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.0041 | 0.0042 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0022 | 0.0041 | 0.0041 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.0041 | 0.0042 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0022 | 0.0041 | 0.0041 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0034 | 0.0238 | 0.0092 |
Onchocerca volvulus | Peroxidase homolog | 0.004 | 0.0326 | 0.0329 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2144 | 0.2144 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0034 | 0.0238 | 0.0381 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0022 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | SRC-1 | 0.0022 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0639 | 0.0639 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0148 | 0.0148 |
Brugia malayi | Animal haem peroxidase family protein | 0.004 | 0.0326 | 0.0329 |
Onchocerca volvulus | 0.004 | 0.0326 | 0.0329 | |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0664 | 0.9913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0022 | 0.0041 | 0.0041 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0022 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | animal heme peroxidase | 0.004 | 0.0326 | 0.0326 |
Echinococcus granulosus | carbonic anhydrase | 0.0314 | 0.4537 | 0.4537 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0061 | 0.0639 | 0.0644 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0034 | 0.0238 | 0.0238 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0029 | 0.0148 | 0.0148 |
Echinococcus granulosus | muscleblind protein | 0.0158 | 0.2144 | 0.2144 |
Onchocerca volvulus | 0.0061 | 0.0639 | 0.0908 | |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0034 | 0.0238 | 0.0092 |
Onchocerca volvulus | Peroxidase homolog | 0.004 | 0.0326 | 0.0329 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0314 | 0.4537 | 0.4577 |
Brugia malayi | Peroxidasin | 0.004 | 0.0326 | 0.0329 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0034 | 0.0238 | 0.1839 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0061 | 0.0639 | 0.0639 |
Onchocerca volvulus | Peroxidasin homolog | 0.004 | 0.0326 | 0.0329 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0314 | 0.4537 | 0.4577 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0029 | 0.0148 | 0.0148 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0022 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Schistosoma mansoni | tyrosine kinase | 0.066 | 0.9853 | 0.9939 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0022 | 0.0041 | 0.0041 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0022 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0022 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.4537 | 0.4537 |
Mycobacterium leprae | Probable lipase LipE | 0.0029 | 0.0148 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0029 | 0.0148 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2144 | 0.2144 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.0041 | 0.0042 |
Brugia malayi | Animal haem peroxidase family protein | 0.004 | 0.0326 | 0.0329 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0022 | 0.0041 | 0.0042 |
Brugia malayi | Blistered cuticle protein 3 | 0.004 | 0.0326 | 0.0329 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0022 | 0.0041 | 0.0041 |
Schistosoma mansoni | peroxidasin | 0.004 | 0.0326 | 0.0329 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0061 | 0.0639 | 0.1118 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.3613 | 0.3613 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.038 | 0.5554 | 0.5554 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0029 | 0.0148 | 0.0149 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0061 | 0.0639 | 1 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.038 | 0.5554 | 0.5554 |
Loa Loa (eye worm) | beta-lactamase | 0.0029 | 0.0148 | 0.0148 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.4537 | 0.4537 |
Leishmania major | carbonic anhydrase-like protein | 0.0664 | 0.9913 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0034 | 0.0238 | 0.024 |
Mycobacterium tuberculosis | Conserved protein | 0.0061 | 0.0639 | 0.2073 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0022 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0061 | 0.0639 | 0.0639 |
Schistosoma mansoni | carbonic anhydrase | 0.0314 | 0.4537 | 0.4577 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0664 | 0.9913 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0314 | 0.4537 | 0.4577 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0314 | 0.4537 | 0.4577 |
Onchocerca volvulus | 0.0333 | 0.4833 | 0.8665 | |
Toxoplasma gondii | hypothetical protein | 0.0061 | 0.0639 | 0.1118 |
Echinococcus multilocularis | carbonic anhydrase | 0.0314 | 0.4537 | 0.4537 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0664 | 0.9913 | 1 |
Brugia malayi | leucyl aminopeptidase | 0.0061 | 0.0639 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.4537 | 0.4537 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0148 | 0.0148 |
Brugia malayi | beta-lactamase family protein | 0.0029 | 0.0148 | 0.0149 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0061 | 0.0639 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0029 | 0.0148 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0148 | 0.0148 |
Leishmania major | hypothetical protein, conserved | 0.0061 | 0.0639 | 0.0503 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0664 | 0.9913 | 0.9913 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0664 | 0.9913 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0664 | 0.9913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.5554 | 0.5554 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0029 | 0.0148 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0664 | 0.9913 | 0.9913 |
Brugia malayi | Animal haem peroxidase family protein | 0.004 | 0.0326 | 0.0329 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0034 | 0.0238 | 0.1839 |
Loa Loa (eye worm) | animal heme peroxidase | 0.004 | 0.0326 | 0.0326 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0029 | 0.0148 | 0.0148 |
Echinococcus granulosus | peroxidasin | 0.004 | 0.0326 | 0.0326 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0639 | 0.0639 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0061 | 0.0639 | 0.0644 |
Schistosoma mansoni | hypothetical protein | 0.0314 | 0.4537 | 0.4577 |
Schistosoma mansoni | peroxidasin | 0.004 | 0.0326 | 0.0329 |
Onchocerca volvulus | Peroxidasin homolog | 0.004 | 0.0326 | 0.0329 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0061 | 0.0639 | 0.0639 |
Echinococcus granulosus | carbonic anhydrase | 0.0314 | 0.4537 | 0.4537 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0022 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | animal heme peroxidase | 0.004 | 0.0326 | 0.0326 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0022 | 0.0041 | 0.0041 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0022 | 0.0041 | 0.0041 |
Schistosoma mansoni | nicalin (M28 family) | 0.0061 | 0.0639 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0326 | 0.0326 |
Plasmodium falciparum | carbonic anhydrase | 0.0314 | 0.4537 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0034 | 0.0238 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.038 | 0.5554 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0148 | 0.0148 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0314 | 0.4537 | 0.4577 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0333 | 0.4833 | 0.4833 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0061 | 0.0639 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0273 | 0.3904 | 0.3904 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.0639 | 1 |
Onchocerca volvulus | 0.0333 | 0.4833 | 0.8665 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0314 | 0.4537 | 0.4577 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0034 | 0.0238 | 0.0092 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0333 | 0.4833 | 0.4875 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.0639 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0314 | 0.4537 | 0.4537 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0664 | 0.9913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0148 | 0.0148 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0061 | 0.0639 | 0.0639 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0022 | 0.0041 | 0.0041 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0034 | 0.0238 | 0.024 |
Brugia malayi | beta-lactamase | 0.0029 | 0.0148 | 0.0149 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0664 | 0.9913 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0326 | 0.0329 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0034 | 0.0238 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0061 | 0.0639 | 0.0503 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0061 | 0.0639 | 0.2073 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0639 | 0.0639 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0061 | 0.0639 | 0.0908 |
Brugia malayi | Animal haem peroxidase family protein | 0.004 | 0.0326 | 0.0329 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Modulation of human muscarinic M1 receptor expressed in mouse A9 L cells assessed as effect on carbachol-induced phosphoinositide metabolism at 1 to 100 uM after 1 hr by topcount analysis | ChEMBL. | 24582400 | |
Activity (binding) | Stimulation of human muscarinic M1 receptor expressed in mouse A9 L cells at 1 to 100 uM after 1 hr by topcount analysis | ChEMBL. | 24582400 | |
Activity (binding) | Stimulation of human muscarinic M5 receptor expressed in mouse A9 L cells at 1 to 100 uM after 1 hr by topcount analysis | ChEMBL. | 24582400 | |
Activity (binding) | Modulation of human muscarinic M5 receptor expressed in mouse A9 L cells assessed as effect on carbachol-induced phosphoinositide metabolism at 1 to 100 uM after 1 hr by topcount analysis | ChEMBL. | 24582400 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.