Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | recQ family helicase, putative | 0.0021 | 0.0459 | 0.3847 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1193 | 0.1246 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1193 | 0.1246 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0007 | 0.0007 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.0459 | 0.0474 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0061 | 0.2247 | 0.2352 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0007 | 0.0007 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.2315 | 0.1274 |
Echinococcus granulosus | bloom syndrome protein | 0.0021 | 0.0459 | 0.0474 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0007 | 0.0007 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.1193 | 0.1246 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.2315 | 0.2424 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.1193 | 0.1246 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0017 | 0.0146 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0017 | 0.0146 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1192 | 1 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0121 | 0.4855 | 0.5094 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.1193 | 0.1252 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2315 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0017 | 0.0011 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.1193 | 0.5 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0021 | 0.0459 | 0.0474 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.1193 | 0.1246 |
Onchocerca volvulus | 0.0037 | 0.1193 | 1 | |
Schistosoma mansoni | DNA helicase recq5 | 0.0021 | 0.0459 | 0.0481 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0459 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1193 | 1 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0227 | 0.9531 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.1193 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.4855 | 0.5091 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.9531 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1192 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2315 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.1193 | 0.1246 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0007 | 0.0007 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0121 | 0.4855 | 0.5091 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.2315 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0007 | 0.0007 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.1192 | 0.1251 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1193 | 0.1246 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.1193 | 0.1246 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0227 | 0.9531 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.1193 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0017 | 0.0075 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.1193 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.0459 | 0.1981 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0227 | 0.9531 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.1193 | 0.1246 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1192 | 0.1251 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0007 | 0.0007 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.1193 | 1 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0007 | 0.0007 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.1193 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0021 | 0.0459 | 0.0474 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0021 | 0.0459 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.1192 | 0.1244 |
Brugia malayi | beta-lactamase | 0.0037 | 0.1193 | 0.1246 |
Echinococcus multilocularis | bloom syndrome protein | 0.0021 | 0.0459 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0017 | 0.0011 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.1193 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0021 | 0.0459 | 0.0474 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0007 | 0.0007 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0017 | 0.0018 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2315 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1192 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0021 | 0.0459 | 0.0474 |
Loa Loa (eye worm) | RecQ helicase | 0.0021 | 0.0459 | 0.0474 |
Onchocerca volvulus | 0.0037 | 0.1193 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.1193 | 0.3957 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.1192 | 0.1244 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0007 | 0.0007 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0007 | 0.0007 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.2315 | 0.2429 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.0017 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0459 | 0.0474 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0121 | 0.4855 | 0.5094 |
Schistosoma mansoni | DNA helicase recq1 | 0.0021 | 0.0459 | 0.0481 |
Brugia malayi | hypothetical protein | 0.0037 | 0.1192 | 0.1244 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1193 | 0.1246 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.0459 | 0.0474 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1193 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0021 | 0.0459 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.2315 | 0.2429 |
Onchocerca volvulus | 0.0037 | 0.1193 | 1 | |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.2315 | 0.2424 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.0459 | 0.3751 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.1193 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.1193 | 0.1252 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.2315 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.0459 | 0.1981 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0059 | 0.2167 | 0.2269 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.1193 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0021 | 0.0459 | 0.0474 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1192 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.1193 | 0.1246 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1193 | 0.1246 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0007 | 0.0007 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.1193 | 0.5 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0021 | 0.0459 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1193 | 0.1246 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0227 | 0.9531 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.1193 | 0.5154 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.