Detailed information for compound 18374

Basic information

Technical information
  • TDR Targets ID: 18374
  • Name: 5-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl ]-1,3-oxazine-2,4-dione
  • MW: 245.186 | Formula: C9H11NO7
  • H donors: 4 H acceptors: 5 LogP: -2.23 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)O)c1coc(=O)[nH]c1=O
  • InChi: 1S/C9H11NO7/c11-1-4-5(12)6(13)7(17-4)3-2-16-9(15)10-8(3)14/h2,4-7,11-13H,1H2,(H,10,14,15)
  • InChiKey: REFHNSOTFKKRAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,3-oxazine-2,4-dione
  • 5-[3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-1,3-oxazine-2,4-dione
  • 5-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)-1,3-oxazine-2,4-quinone
  • minimycin
  • NSC166064
  • Minimycin: Oxazinomycin

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0156 0.1679 0.5855
Schistosoma mansoni ap endonuclease 0.0019 0.0031 0.0184
Echinococcus granulosus vacuolar ATP synthase subunit b 0.0033 0.0203 0.0707
Toxoplasma gondii vacuolar ATP synthase subunit b, putative 0.0033 0.0203 0.1862
Mycobacterium leprae PROBABLE ATP SYNTHASE BETA CHAIN ATPD 0.0033 0.02 0.0769
Treponema pallidum V-type ATP synthase subunit B 0.0033 0.0203 0.0506
Echinococcus granulosus dna polymerase kappa 0.0041 0.0296 0.1033
Brugia malayi Cathepsin L-like precursor 0.0017 0.0014 0.0049
Echinococcus granulosus tar DNA binding protein 0.0065 0.0592 0.2062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0173 0.0602
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0592 0.2062
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0621 0.371
Onchocerca volvulus 0.0082 0.0798 0.4709
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0798
Echinococcus granulosus GPCR family 2 0.0016 0.0002 0.0007
Mycobacterium ulcerans F0F1 ATP synthase subunit alpha 0.0033 0.02 0.0968
Brugia malayi Cathepsin L-like precursor 0.0017 0.0014 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3429 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0296 0.0824
Brugia malayi nuclear hormone receptor 0.003 0.0173 0.0602
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0173 0.0602
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0012
Trypanosoma brucei ATP synthase F1, alpha subunit 0.0027 0.013 0.0356
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0085 0.0312
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0333 0.0902
Loa Loa (eye worm) vacuolar ATP synthase subunit B 0.0033 0.0203 0.0707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0597 0.1672
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.3429 1
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0173 0.0173
Plasmodium vivax vacuolar ATP synthase subunit b, putative 0.0033 0.0203 1
Schistosoma mansoni ATP synthase alpha subunit mitochondrial 0.0033 0.02 0.1194
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0173 0.1032
Schistosoma mansoni thyroid hormone receptor 0.0155 0.1674 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0173 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0597 0.1672
Echinococcus multilocularis vacuolar ATP synthase subunit b 0.0033 0.0203 0.0203
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0173 0.0173
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0528 0.1455
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0085 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0173 0.0602
Echinococcus multilocularis GPCR, family 2 0.0016 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0173 0.0602
Entamoeba histolytica V-type ATPase, B subunit, putative 0.0033 0.0203 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0296 0.0824
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0014 0.0049
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0085 0.3779
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0002 0.0002
Schistosoma mansoni survival motor neuron protein 0.005 0.0413 0.2466
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0173 0.0602
Schistosoma mansoni nuclear hormone receptor 0.003 0.0173 0.1032
Echinococcus multilocularis cysteine protease 0.0017 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0177 0.0488
Loa Loa (eye worm) hypothetical protein 0.0031 0.0177 0.0618
Echinococcus granulosus ATP synthase subunit alpha mitochondrial 0.0033 0.02 0.0697
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0014 0.0084
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.1028 0.614
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0333 0.0927
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0173 0.0602
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0002 0.0007
Onchocerca volvulus ATP synthase subunit alpha, mitochondrial homolog 0.0033 0.02 0.1117
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0173 0.0602
Brugia malayi TAR-binding protein 0.0065 0.0592 0.2062
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0218 0.0602
Brugia malayi Cathepsin L-like precursor 0.0017 0.0014 0.0049
Echinococcus multilocularis cysteine protease 0.0017 0.0014 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0173 0.1032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0014 0.0014
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0594 0.207
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0594 0.0594
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1286 0.4484
Onchocerca volvulus 0.003 0.0173 0.0954
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0002 0.0007
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0333 0.0902
Loa Loa (eye worm) ctsf protein 0.0017 0.0014 0.0049
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0333 0.0902
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0173 0.1032
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1576 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0594 0.164
Leishmania major cathepsin L-like protease 0.0066 0.0597 0.1649
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0594 0.3546
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0296 0.0824
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.2779 0.969
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1576 0.8843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3429 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0798 0.0798
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0296 0.0824
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0058 0.0124
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0058 0.0155
Leishmania major cathepsin L-like protease 0.0066 0.0597 0.1649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0597 0.1672
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0173 0.0173
Giardia lamblia Vacuolar ATP synthase subunit B 0.0033 0.0203 0.0506
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0592 0.3533
Trypanosoma brucei unspecified product 0.0034 0.0218 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0173 0.0602
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0229 0.0798
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0085 0.0312
Entamoeba histolytica hypothetical protein 0.0023 0.0085 0.0209
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0173 0.0954
Brugia malayi nuclear receptor NHR-88 0.003 0.0173 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0597 0.1672
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0798 0.4767
Chlamydia trachomatis V-type ATP synthase subunit B 0.0033 0.0203 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0085 0.0229
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.1028 0.614
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0262 0.0262
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.1674 0.1674
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0085 0.0704
Toxoplasma gondii melibiase subfamily protein 0.0101 0.1028 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0014 0.0014
Plasmodium falciparum ATP synthase F1, alpha subunit 0.0033 0.02 0.9848
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0296 0.0798
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0597 0.1649
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0031 0.0031
Mycobacterium ulcerans hypothetical protein 0.0164 0.1778 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0031 0.0049
Brugia malayi steroid hormone receptor 0.003 0.0173 0.0602
Leishmania major DNA polymerase kappa, putative 0.0021 0.0058 0.0124
Onchocerca volvulus 0.0156 0.1679 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0597 0.1672
Leishmania major vacuolar ATP synthase subunit b, putative 0.0033 0.0203 0.0534
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.3429 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0173 0.0602
Loa Loa (eye worm) hypothetical protein 0.003 0.0173 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0597 0.1672
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0014 0.0049
Brugia malayi Cathepsin L-like precursor 0.0017 0.0014 0.0049
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1308 0.1308
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0049
Leishmania major ATPase alpha subunit 0.0027 0.013 0.0329
Trichomonas vaginalis ATP synthase alpha subunit mitochondrial, putative 0.0033 0.0203 0.0553
Schistosoma mansoni ATP synthase subunit beta vacuolar 0.0033 0.0203 0.1211
Trypanosoma cruzi Vacuolar proton pump subunit B, putative 0.0033 0.0203 0.0534
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0296 0.0827
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1778 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0173 0.0602
Loa Loa (eye worm) hypothetical protein 0.0051 0.0424 0.1479
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0031 0.0047
Brugia malayi hypothetical protein 0.0247 0.2779 0.969
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0424 0.1479
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0173 0.0602
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0597 0.1649
Echinococcus granulosus ATPase H transporting lysosomal accessory 0.0254 0.2868 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0014 0.0014
Brugia malayi RNA binding protein 0.0065 0.0592 0.2062
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0621 0.371
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0173 0.0602
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0031 0.0047
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit alpha 0.0033 0.02 1
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0012
Schistosoma mansoni hypothetical protein 0.005 0.0413 0.2466
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0798 0.2782
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1578 0.4424
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0173 0.0602
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.3549 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0173 0.0602
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3429 1
Echinococcus granulosus cathepsin l1 0.0017 0.0014 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3429 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0296 0.0824
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0296 0.0798
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0597 0.1649
Loa Loa (eye worm) hypothetical protein 0.003 0.0173 0.0602
Loa Loa (eye worm) RNA binding protein 0.0065 0.0592 0.2062
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0173 0.1032
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0597 0.1649
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1286 0.4484
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0002 0.0007
Schistosoma mansoni thyroid hormone receptor 0.0155 0.1674 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3429 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0424 0.1479
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0592 0.3533
Treponema pallidum V-type ATP synthase subunit B 0.0033 0.0203 0.0506
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0592 0.3533
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0296 0.0827
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1578 0.4424
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3549 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0173 0.0602
Toxoplasma gondii exonuclease III APE 0.0019 0.0031 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.0151
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0031 0.0047
Loa Loa (eye worm) hypothetical protein 0.0068 0.0621 0.2165
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.1028 0.614
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1576 0.8843
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0031 0.0049
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0085 0.0161
Loa Loa (eye worm) fibroinase 0.0017 0.0014 0.0049
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0173 0.1032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0173 0.0602
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0012
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0173 0.0602
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0031 0.0075
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0594 0.207
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0173 0.0602
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0594 0.207
Brugia malayi Melibiase family protein 0.0068 0.0621 0.2165
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0012
Plasmodium vivax ATP synthase alpha chain, putative 0.0033 0.02 0.9848
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0031 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0296 0.0824
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0296 0.0798
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0594 0.1663
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0296 0.0824
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.3429 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0014 0.0049
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0594 0.164
Leishmania major ATPase alpha subunit 0.0027 0.013 0.0329
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0101 0.1028 0.1028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0424 0.1479
Brugia malayi hypothetical protein 0.0254 0.2868 1
Onchocerca volvulus 0.005 0.0413 0.2395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0173 0.0602
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0798 0.2782
Loa Loa (eye worm) hypothetical protein 0.0082 0.0798 0.2782
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0085 0.0704
Brugia malayi Cathepsin L-like precursor 0.0017 0.0014 0.0049
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.3429 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0173 0.1032
Brugia malayi vacuolar ATP synthase subunit B 0.0033 0.0203 0.0707
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0031 0.0107
Echinococcus multilocularis ATP synthase subunit alpha, mitochondrial 0.0033 0.02 0.02
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0173 0.0602
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3429 1
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0173 0.1032
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0594 0.1698
Loa Loa (eye worm) hypothetical protein 0.003 0.0173 0.0602
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0173 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0597 0.1672
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3549 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.1028 0.614
Trypanosoma brucei ATP synthase F1, alpha subunit 0.0027 0.013 0.0356
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0031 0.0889
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0597 0.1672
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0031 0.0107
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0296 0.0296
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0428 0.1171
Echinococcus multilocularis ATPase, H+ transporting, lysosomal accessory 0.0254 0.2868 0.2868
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.1578 0.4439
Brugia malayi polk-prov protein 0.0031 0.0177 0.0618
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0031 0.0049
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0002 0.0007
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0173 0.0602
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0014 0.0049
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0125 0.1308 0.7812
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0173 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0177 0.0488
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0296 0.1519
Mycobacterium leprae PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA 0.0033 0.02 0.0769
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0597 0.1672
Loa Loa (eye worm) hypothetical protein 0.0254 0.2868 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3429 1
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0592 0.0592
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0592 0.2062
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0173 0.0173
Brugia malayi ATP synthase alpha chain, mitochondrial precursor, putative 0.0033 0.02 0.0697
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0592 0.3533
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0173 0.0602
Loa Loa (eye worm) hypothetical protein 0.003 0.0173 0.0602
Loa Loa (eye worm) hypothetical protein 0.003 0.0173 0.0602
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.2779 0.2779
Mycobacterium tuberculosis Probable ATP synthase beta chain AtpD 0.0033 0.02 0.0968
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0621 0.1778
Loa Loa (eye worm) cysteine protease 0.0017 0.0014 0.0049
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0592 0.2062
Trypanosoma cruzi V-type proton ATPase subunit B, putative 0.0033 0.0203 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0173 0.0602
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0173 0.0954
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0173 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0173 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0597 0.1672
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1308 0.456
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0597 0.1672
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0262 0.0914
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0173 0.1032
Mycobacterium tuberculosis Probable ATP synthase alpha chain AtpA 0.0033 0.02 0.0968
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0413 0.1439
Plasmodium falciparum V-type proton ATPase subunit B 0.0033 0.0203 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0173 0.0602
Trypanosoma brucei Vacuolar proton pump subunit B, putative 0.0033 0.0203 0.056
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0014 0.0049
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.0156 0.1679 0.5855
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0296 0.0798
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0085 0.3226
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0085 0.0202
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0173 0.0602
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0592 0.3533
Brugia malayi MH2 domain containing protein 0.0123 0.1286 0.4484
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3429 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0173 0.0173
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0031 0.0889
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0448 0.1227
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0173 0.0602
Loa Loa (eye worm) hypothetical protein 0.003 0.0173 0.0602
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0002 0.0007
Giardia lamblia DINP protein human, muc B family 0.0021 0.0058 0.0079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0173 0.1032
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0296 0.0824
Echinococcus granulosus FTZ F1 alpha 0.003 0.0173 0.0602
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0014 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0296 0.0824
Brugia malayi ecdysteroid receptor 0.003 0.0173 0.0602
Schistosoma mansoni coup transcription factor 0.003 0.0173 0.1032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0173 0.0602
Schistosoma mansoni hypothetical protein 0.0035 0.0229 0.1367
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0296 0.0824
Loa Loa (eye worm) hypothetical protein 0.0247 0.2779 0.969
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0085 0.3779
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0594 0.164
Schistosoma mansoni ap endonuclease 0.0019 0.0031 0.0184
Toxoplasma gondii hypothetical protein 0.005 0.041 0.3907
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0173 0.0602
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0173 0.0954
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0101 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.003 0.0173 0.0602
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0173 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0296 0.0824
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0296 0.1519
Leishmania major cathepsin L-like protease 0.0066 0.0597 0.1649
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0173 0.0602
Trichomonas vaginalis ATP synthase, putative 0.0033 0.0203 0.0553
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.3549 1
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0101 0.1028 0.3584

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.0000003 M Antitumor activity against L1210 cells ChEMBL. 6276541
IC50 (functional) = 0.0000005 M Antitumor activity against HeLa cells ChEMBL. 6276541
Inhibition (functional) = 5 % Inhibition against L1210 cells growth at 8*10e-7 M. ChEMBL. 6276541

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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