Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0002 | 0.0012 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0147 | 0.1578 | 0.4424 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.003 | 0.0173 | 0.0602 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0311 | 0.3549 | 1 |
Trichomonas vaginalis | ATP synthase alpha subunit mitochondrial, putative | 0.0033 | 0.0203 | 0.0553 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0594 | 0.164 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0052 | 0.0428 | 0.1171 |
Loa Loa (eye worm) | ctsf protein | 0.0017 | 0.0014 | 0.0049 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.003 | 0.0173 | 0.0602 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0597 | 0.1672 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0424 | 0.1479 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.1286 | 0.4484 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0824 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0002 | 0.0007 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0017 | 0.0014 | 0.0049 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0031 | 0.0166 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0014 | 0.0084 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0101 | 0.1028 | 0.1028 |
Schistosoma mansoni | coup transcription factor | 0.003 | 0.0173 | 0.1032 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.003 | 0.0173 | 0.0954 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0031 | 0.0047 |
Onchocerca volvulus | 0.003 | 0.0173 | 0.0954 | |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0085 | 0.3779 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0014 | 0.0049 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.0085 | 0.0229 |
Echinococcus granulosus | FTZ F1 alpha | 0.003 | 0.0173 | 0.0602 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.003 | 0.0173 | 0.0602 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0002 | 0.0007 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0033 | 0.02 | 0.0968 |
Trypanosoma cruzi | V-type proton ATPase subunit B, putative | 0.0033 | 0.0203 | 0.0534 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0031 | 0.0889 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.0333 | 0.0902 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0033 | 0.02 | 0.1194 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0031 | 0.0177 | 0.0488 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0023 | 0.0085 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0602 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.003 | 0.0173 | 0.0602 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0014 | 0.0049 |
Loa Loa (eye worm) | vacuolar ATP synthase subunit B | 0.0033 | 0.0203 | 0.0707 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.3429 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0824 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0296 | 0.1519 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.003 | 0.0173 | 0.1032 |
Onchocerca volvulus | 0.005 | 0.0413 | 0.2395 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0597 | 0.1672 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0296 | 0.1033 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.0058 | 0.0124 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0164 | 0.1778 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.0173 | 0.0602 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.3429 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0592 | 0.3533 |
Toxoplasma gondii | hypothetical protein | 0.005 | 0.041 | 0.3907 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0101 | 0.1028 | 0.614 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.1286 | 0.4484 |
Echinococcus granulosus | cathepsin l1 | 0.0017 | 0.0014 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0002 | 0.0012 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0247 | 0.2779 | 0.969 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.003 | 0.0173 | 0.1032 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0085 | 0.3779 |
Chlamydia trachomatis | V-type ATP synthase subunit B | 0.0033 | 0.0203 | 1 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0033 | 0.02 | 0.9848 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0041 | 0.0296 | 0.0827 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.0592 | 0.2062 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0066 | 0.0597 | 0.1649 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.003 | 0.0173 | 0.0602 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0301 | 0.3429 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0296 | 0.1519 |
Brugia malayi | nuclear receptor NHR-88 | 0.003 | 0.0173 | 0.0602 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.003 | 0.0173 | 0.0173 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0031 | 0.0047 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0262 | 0.0262 |
Brugia malayi | ecdysteroid receptor | 0.003 | 0.0173 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.2779 | 0.969 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0798 |
Leishmania major | ATPase alpha subunit | 0.0027 | 0.013 | 0.0329 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0311 | 0.3549 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0301 | 0.3429 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0002 | 0.0007 |
Brugia malayi | polk-prov protein | 0.0031 | 0.0177 | 0.0618 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0413 | 0.2466 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0014 | 0.0014 |
Mycobacterium ulcerans | hypothetical protein | 0.0164 | 0.1778 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.0058 | 0.0079 |
Toxoplasma gondii | melibiase subfamily protein | 0.0101 | 0.1028 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0594 | 0.207 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0147 | 0.1578 | 0.4439 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0002 | 0.0007 |
Echinococcus multilocularis | ATPase, H+ transporting, lysosomal accessory | 0.0254 | 0.2868 | 0.2868 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.006 | 0.0528 | 0.1455 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0101 | 0.1028 | 0.1028 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0002 | 0.0012 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0065 | 0.0594 | 0.1698 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.0058 | 0.0155 |
Brugia malayi | Melibiase family protein | 0.0068 | 0.0621 | 0.2165 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0177 | 0.0618 |
Echinococcus granulosus | vacuolar ATP synthase subunit b | 0.0033 | 0.0203 | 0.0707 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0592 | 0.3533 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0017 | 0.0014 | 0.0049 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0824 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0424 | 0.1479 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0027 | 0.013 | 0.0356 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.0592 | 0.0592 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0014 | 0.0014 |
Toxoplasma gondii | vacuolar ATP synthase subunit b, putative | 0.0033 | 0.0203 | 0.1862 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0033 | 0.0203 | 0.0506 |
Plasmodium vivax | vacuolar ATP synthase subunit b, putative | 0.0033 | 0.0203 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0017 | 0.0014 | 0.0049 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0147 | 0.1576 | 1 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0085 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0014 | 0.0049 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0824 |
Onchocerca volvulus | 0.0156 | 0.1679 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.003 | 0.0173 | 0.0602 |
Schistosoma mansoni | thyroid hormone receptor | 0.0155 | 0.1674 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.003 | 0.0173 | 0.0602 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0031 | 0.0049 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0798 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.003 | 0.0173 | 0.0602 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.0592 | 0.2062 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0033 | 0.02 | 0.0697 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0017 | 0.0014 | 0.0049 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0101 | 0.1028 | 0.614 |
Echinococcus multilocularis | FTZ F1 alpha | 0.003 | 0.0173 | 0.0173 |
Brugia malayi | hypothetical protein | 0.0254 | 0.2868 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0044 | 0.0333 | 0.0927 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0014 | 0.0014 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.003 | 0.0173 | 0.0602 |
Giardia lamblia | Vacuolar ATP synthase subunit B | 0.0033 | 0.0203 | 0.0506 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.003 | 0.0173 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0602 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.003 | 0.0173 | 0.0602 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0023 | 0.0085 | 0.0312 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0592 | 0.3533 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0002 | 0.0007 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0597 | 0.1672 |
Schistosoma mansoni | thyroid hormone receptor | 0.0155 | 0.1674 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0082 | 0.0798 | 0.2782 |
Schistosoma mansoni | nuclear hormone receptor | 0.003 | 0.0173 | 0.1032 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0014 | 0.0014 |
Trypanosoma cruzi | Vacuolar proton pump subunit B, putative | 0.0033 | 0.0203 | 0.0534 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0044 | 0.0333 | 0.0902 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0014 | 0.0049 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.003 | 0.0173 | 0.1032 |
Brugia malayi | hypothetical protein | 0.0247 | 0.2779 | 0.969 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0068 | 0.0621 | 0.1778 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.003 | 0.0173 | 0.0602 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0262 | 0.0914 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0033 | 0.0203 | 0.0506 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0798 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0068 | 0.0621 | 0.371 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.3429 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.003 | 0.0173 | 0.1032 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0033 | 0.02 | 0.1117 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.0592 | 0.2062 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0296 | 0.0296 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.3429 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0014 | 0.0049 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0002 | 0.0007 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0014 | 0.0049 |
Trichomonas vaginalis | ATP synthase, putative | 0.0033 | 0.0203 | 0.0553 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0031 | 0.0031 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.003 | 0.0173 | 0.0602 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0082 | 0.0798 | 0.2782 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.0173 | 0.0173 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.003 | 0.0173 | 0.0602 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0033 | 0.02 | 0.0769 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.003 | 0.0173 | 0.1032 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0033 | 0.02 | 0.0968 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.3429 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.0597 | 0.1649 |
Loa Loa (eye worm) | fibroinase | 0.0017 | 0.0014 | 0.0049 |
Leishmania major | ATPase alpha subunit | 0.0027 | 0.013 | 0.0329 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0824 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.003 | 0.0173 | 0.0602 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.003 | 0.0173 | 0.0173 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.003 | 0.0173 | 0.1032 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.003 | 0.0173 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.2868 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0597 | 0.1672 |
Brugia malayi | steroid hormone receptor | 0.003 | 0.0173 | 0.0602 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0597 | 0.1672 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0101 | 0.1028 | 0.614 |
Trypanosoma brucei | Vacuolar proton pump subunit B, putative | 0.0033 | 0.0203 | 0.056 |
Brugia malayi | hypothetical protein | 0.0156 | 0.1679 | 0.5855 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0034 | 0.0218 | 0.0602 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.0592 | 0.2062 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0002 | 0.0012 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.003 | 0.0173 | 0.0954 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0082 | 0.0798 | 0.4767 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0002 | 0.0002 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0002 | 0.0007 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0065 | 0.0594 | 0.164 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0597 | 0.1672 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0031 | 0.0889 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.3429 | 1 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0027 | 0.013 | 0.0356 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0101 | 0.1028 | 0.614 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0033 | 0.02 | 0.0697 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.3429 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0594 | 0.207 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0033 | 0.02 | 0.0968 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0031 | 0.0075 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0594 | 0.3546 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.003 | 0.0173 | 0.0173 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0247 | 0.2779 | 0.2779 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0424 | 0.1479 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0002 | 0.0002 |
Plasmodium falciparum | V-type proton ATPase subunit B | 0.0033 | 0.0203 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.003 | 0.0173 | 0.0602 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.003 | 0.0173 | 0.1032 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0597 | 0.1672 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.003 | 0.0173 | 0.0602 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0014 | 0.0014 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0824 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0031 | 0.0049 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0424 | 0.1479 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0014 | 0.0049 |
Onchocerca volvulus | Bile acid receptor homolog | 0.003 | 0.0173 | 0.0954 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.0597 | 0.1649 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0413 | 0.2466 |
Leishmania major | vacuolar ATP synthase subunit b, putative | 0.0033 | 0.0203 | 0.0534 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.003 | 0.0173 | 0.0602 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0031 | 0.0184 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0068 | 0.0621 | 0.371 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0824 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0033 | 0.02 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0301 | 0.3429 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0602 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0147 | 0.1576 | 0.8843 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0031 | 0.0049 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0147 | 0.1576 | 0.8843 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.0058 | 0.0124 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.3429 | 1 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0101 | 0.1028 | 0.3584 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0621 | 0.2165 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.003 | 0.0173 | 0.1032 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.0592 | 0.2062 |
Echinococcus multilocularis | vacuolar ATP synthase subunit b | 0.0033 | 0.0203 | 0.0203 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0023 | 0.0085 | 0.0704 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0594 | 0.0594 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0594 | 0.1663 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0602 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.003 | 0.0173 | 0.0602 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0033 | 0.02 | 0.02 |
Brugia malayi | vacuolar ATP synthase subunit B | 0.0033 | 0.0203 | 0.0707 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.0597 | 0.1649 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0311 | 0.3549 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0065 | 0.0594 | 0.207 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.003 | 0.0173 | 0.0602 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0014 | 0.0014 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0311 | 0.3549 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0023 | 0.0085 | 0.0704 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0798 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0031 | 0.0047 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0229 | 0.0798 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0296 | 0.0824 |
Trypanosoma brucei | unspecified product | 0.0034 | 0.0218 | 0.0602 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0033 | 0.02 | 0.9848 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.003 | 0.0173 | 0.0602 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0031 | 0.0184 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0296 | 0.0824 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.003 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0229 | 0.0798 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0229 | 0.1367 |
Echinococcus granulosus | ATPase H transporting lysosomal accessory | 0.0254 | 0.2868 | 1 |
Onchocerca volvulus | 0.0082 | 0.0798 | 0.4709 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0597 | 0.1672 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.003 | 0.0173 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1679 | 0.5855 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0014 | 0.0084 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.003 | 0.0173 | 0.0602 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0058 | 0.0151 |
Loa Loa (eye worm) | cysteine protease | 0.0017 | 0.0014 | 0.0049 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0155 | 0.1674 | 0.1674 |
Schistosoma mansoni | ATP synthase subunit beta vacuolar | 0.0033 | 0.0203 | 0.1211 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0085 | 0.3226 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.003 | 0.0173 | 0.1032 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.003 | 0.0173 | 0.0602 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0597 | 0.1672 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0017 | 0.0014 | 0.0049 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0597 | 0.1672 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.003 | 0.0173 | 0.0602 |
Brugia malayi | RNA binding protein | 0.0065 | 0.0592 | 0.2062 |
Brugia malayi | nuclear hormone receptor | 0.003 | 0.0173 | 0.0602 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.003 | 0.0173 | 0.0602 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0824 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.0333 | 0.0902 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0031 | 0.0107 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.0597 | 0.1649 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0594 | 0.164 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.0597 | 0.1649 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0031 | 0.0107 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.003 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.1286 | 0.4484 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0592 | 0.3533 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0597 | 0.1672 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0082 | 0.0798 | 0.0798 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0085 | 0.0312 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0125 | 0.1308 | 0.1308 |
Loa Loa (eye worm) | steroid hormone receptor | 0.003 | 0.0173 | 0.0602 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.1308 | 0.7812 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0592 | 0.3533 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0602 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.0173 | 0.0602 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.003 | 0.0173 | 0.0602 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0085 | 0.0209 |
Entamoeba histolytica | V-type ATPase, B subunit, putative | 0.0033 | 0.0203 | 0.0553 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0033 | 0.02 | 0.0769 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.0592 | 0.2062 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0147 | 0.1578 | 0.4424 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0301 | 0.3429 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0798 | 0.2782 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.0597 | 0.1649 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0053 | 0.0448 | 0.1227 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0413 | 0.1439 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0125 | 0.1308 | 0.456 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0023 | 0.0085 | 0.0312 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.0173 | 0.0173 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0031 | 0.0107 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0041 | 0.0296 | 0.0827 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0296 | 0.0824 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.003 | 0.0173 | 0.0602 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0031 | 0.0177 | 0.0488 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.0000003 M | Antitumor activity against L1210 cells | ChEMBL. | 6276541 |
IC50 (functional) | = 0.0000005 M | Antitumor activity against HeLa cells | ChEMBL. | 6276541 |
Inhibition (functional) | = 5 % | Inhibition against L1210 cells growth at 8*10e-7 M. | ChEMBL. | 6276541 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.