Detailed information for compound 1839757

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 305.306 | Formula: C14H11NO5S
  • H donors: 2 H acceptors: 5 LogP: 1.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C=C/CN1C(=O)S/C(=C/c2ccc(cc2)O)/C1=O
  • InChi: 1S/C14H11NO5S/c16-10-5-3-9(4-6-10)8-11-13(19)15(14(20)21-11)7-1-2-12(17)18/h1-6,8,16H,7H2,(H,17,18)/b2-1+,11-8+
  • InChiKey: ZIPYNFLCSAMPBV-ZSZCRNLOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldo-keto reductase family 1, member B1 (aldose reductase) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Conserved protein aldo-keto reductase family 1, member B1 (aldose reductase) 316 aa 325 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldo keto reductase 0.0038 0.1277 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.1277 0.0413
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.1277 0.5
Mycobacterium tuberculosis Polyketide synthase Pks12 0.008 0.4752 0.6357
Schistosoma mansoni aldo-keto reductase 0.0038 0.1277 0.5
Entamoeba histolytica aldose reductase, putative 0.0038 0.1277 0.5
Mycobacterium ulcerans fatty acid synthase Fas 0.0024 0.0042 0.0056
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1277 0.5
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.1277 0.5
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0075 0.4361 0.5834
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.008 0.4752 0.6357
Mycobacterium ulcerans Type I modular polyketide synthase 0.0075 0.4361 0.5834
Mycobacterium ulcerans Type I modular polyketide synthase 0.0075 0.4361 0.5834
Echinococcus granulosus aldo keto reductase 0.0038 0.1277 1
Onchocerca volvulus Fatty acid synthase homolog 0.0135 0.9416 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1277 1
Echinococcus multilocularis aldo keto reductase 0.0038 0.1277 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.1277 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.1592 0.0823
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1277 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.1277 0.0413
Mycobacterium ulcerans polyketide synthase Pks9 0.005 0.2228 0.2981
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.007 0.3948 0.528
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.005 0.2228 0.2941
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0112 0.7476 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.1277 0.1277
Schistosoma mansoni pol-related 0.0038 0.1277 0.5
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.005 0.2228 0.2981
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0073 0.4168 0.5576
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1277 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0075 0.4361 0.5834
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.1277 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1277 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.1277 0.1661
Onchocerca volvulus 0.0131 0.9025 0.9519
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1277 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1277 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0062 0.3311 0.443
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.006 0.3131 0.4188
Echinococcus multilocularis aldo keto reductase 0.0038 0.1277 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1277 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1277 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1277 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.003 0.061 0.0817
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.008 0.4752 0.6357
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1277 1
Schistosoma mansoni aldo-keto reductase 0.0038 0.1277 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1277 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1277 1
Mycobacterium leprae Polyketide synthase Pks13 0.0112 0.7476 1
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.008 0.4752 0.6357
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1277 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1277 0.5
Loa Loa (eye worm) hypothetical protein 0.0126 0.8643 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.1277 0.1277
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0054 0.2588 0.3461
Mycobacterium ulcerans thioesterase 0.0062 0.3311 0.443
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0062 0.3311 0.4398
Loa Loa (eye worm) AMP-binding enzyme family protein 0.007 0.3948 0.3889
Mycobacterium ulcerans polyketide synthase Pks13 0.0112 0.7476 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1277 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.1277 0.1708
Trypanosoma brucei prostaglandin f synthase 0.0038 0.1277 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0073 0.4168 0.5576
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.008 0.4752 0.6357
Mycobacterium ulcerans polyketide synthase 0.0075 0.4361 0.5834
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.1277 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1277 0.5
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.008 0.4752 0.6337
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1277 0.5
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.1277 0.5
Entamoeba histolytica aldose reductase, putative 0.0038 0.1277 0.5
Leishmania major aldo-keto reductase-like protein 0.0038 0.1277 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0043 0.1644 0.2199
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.1277 0.1277
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1277 0.5
Giardia lamblia Aldose reductase 0.0038 0.1277 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1277 1
Brugia malayi AMP-binding enzyme family protein 0.007 0.3948 0.3948
Leishmania major prostaglandin f synthase, putative 0.0038 0.1277 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.1277 0.0413
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0026 0.0229 0.0306
Loa Loa (eye worm) oxidoreductase 0.0038 0.1277 0.0413
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0049 0.2149 0.2574
Mycobacterium ulcerans Type I modular polyketide synthase 0.0075 0.4361 0.5834
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.006 0.3131 0.4188
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1277 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1277 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.008 0.4752 0.6337
Onchocerca volvulus 0.007 0.3948 0.3281
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1277 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1277 0.5
Toxoplasma gondii type I fatty acid synthase, putative 0.008 0.4752 1
Toxoplasma gondii aldose reductase, putative 0.0038 0.1277 0.0086
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.1277 0.5
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.1277 0.1277
Loa Loa (eye worm) fatty acid synthase 0.0074 0.4277 0.4318
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.1277 0.5
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.1277 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1277 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0075 0.4361 0.4361
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.1277 0.5
Loa Loa (eye worm) oxidoreductase 0.0038 0.1277 0.0413
Mycobacterium ulcerans oxidoreductase 0.0038 0.1277 0.1708
Loa Loa (eye worm) oxidoreductase 0.0038 0.1277 0.0413
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1277 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0075 0.4361 0.5834
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1277 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0075 0.4361 0.581
Entamoeba histolytica aldose reductase, putative 0.0038 0.1277 0.5
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.0346 0.0409
Mycobacterium ulcerans thioesterase TesA 0.0062 0.3311 0.443
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1277 0.5
Toxoplasma gondii type I fatty acid synthase, putative 0.0053 0.2547 0.3708
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0024 0.0042 0.0056
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0075 0.4361 0.5834
Echinococcus granulosus hypothetical protein 0.0038 0.1277 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0075 0.4361 0.581
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1277 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.006 0.3131 0.4155
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1277 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0061 0.3214 0.4299
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1277 1
Echinococcus granulosus aldo keto reductase 0.0038 0.1277 1
Giardia lamblia Aldose reductase 0.0038 0.1277 0.5
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0112 0.7476 1
Mycobacterium ulcerans polyketide synthase 0.008 0.4752 0.6357
Trypanosoma cruzi aldo-keto reductase 0.0038 0.1277 0.5
Echinococcus multilocularis aldo keto reductase 0.0038 0.1277 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1277 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.008 0.4752 0.6337
Echinococcus granulosus aldo keto reductase 0.0038 0.1277 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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