Detailed information for compound 1840517

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 446.947 | Formula: C22H23ClN2O4S
  • H donors: 1 H acceptors: 3 LogP: 4.64 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(C)NC(=C(C1c1csc(n1)c1ccc(cc1)Cl)C(=O)OCC)C
  • InChi: 1S/C22H23ClN2O4S/c1-5-28-21(26)17-12(3)24-13(4)18(22(27)29-6-2)19(17)16-11-30-20(25-16)14-7-9-15(23)10-8-14/h7-11,19,24H,5-6H2,1-4H3
  • InChiKey: XOBPKDDUMWVPPS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) voltage-dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Muscle calcium channel subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav1 Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent N-type calcium channel subunit alpha-1B, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav2A Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni voltage-gated cation channel Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii transporter, cation channel family protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei gambiense calcium channel protein, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma congolense Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus 60S acidic ribosomal protein P2 homolog Voltage-dependent L-type calcium channel subunit alpha-1C   169 aa 144 aa 24.3 %
Echinococcus multilocularis sodium channel protein Voltage-dependent L-type calcium channel subunit alpha-1C   169 aa 145 aa 25.5 %
Schistosoma mansoni cd63 antigen-like Voltage-dependent L-type calcium channel subunit alpha-1C   169 aa 181 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0106 0 0.5
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0194 0.0218 0.0218
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni tyrosine protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0213 0.0266 0.0414
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.02 0.0234 0.0364
Onchocerca volvulus Tankyrase homolog 0.02 0.0234 0.383
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica cysteine surface protein, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase csk 0.0194 0.0218 0.0218
Schistosoma mansoni alpha-glucosidase 0.0135 0.0073 0.0073
Entamoeba histolytica tyrosin kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus epidermal growth factor receptor 0.0194 0.0218 0.0218
Echinococcus granulosus poly (ADP ribose) polymerase 0.0839 0.1815 0.1815
Loa Loa (eye worm) hypothetical protein 0.2057 0.4827 0.4827
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase Srms 0.0194 0.0218 0.0218
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0194 0.0218 0.0218
Echinococcus multilocularis protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Schistosoma mansoni ephrin receptor 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/RYK protein kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus granulosus kinase suppressor of Ras 1 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0194 0.0218 0.0218
Loa Loa (eye worm) RGC/RGC protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus granulosus retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica receptor protein kinase, putative 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis CMGC family protein kinase 0.2141 0.5035 1
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase HCK 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Brugia malayi ephrin receptor 1 precursor 0.0194 0.0218 0.0218
Brugia malayi MAP kinase sur-1 0.2141 0.5035 0.5035
Echinococcus granulosus poly (ADP ribose) polymerase 0.042 0.0777 0.0777
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein, conserved 0.0194 0.0218 0.0339
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Brugia malayi Raf kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis CMGC family protein kinase 0.2141 0.5035 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0194 0.0218 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus multilocularis natriuretic peptide receptor 1 0.0194 0.0218 0.0218
Echinococcus multilocularis epidermal growth factor receptor 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/Met protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Brugia malayi hypothetical protein 0.0194 0.0218 0.0218
Schistosoma mansoni protein kinase 0.0213 0.0266 0.0266
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.0128 0.0128
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.4149 1 1
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0353 0.0611 0.0611
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Entamoeba histolytica serine/threonine kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) TK/ACK protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0194 0.0218 0.0218
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.1485 0.3411 0.6775
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis protein kinase atn1, putative 0.0194 0.0218 0.0433
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) RGC/RGC protein kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.1485 0.3411 0.3411
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.2703 0.6423 0.6423
Echinococcus multilocularis mitogen activated protein kinase 0.2141 0.5035 0.5035
Entamoeba histolytica zinc finger protein, putative 0.02 0.0234 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus granulosus tyrosine protein kinase HCK 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.02 0.0234 0.0364
Schistosoma mansoni protein kinase 0.0213 0.0266 0.0266
Schistosoma mansoni poly [ADP-ribose] polymerase 0.1284 0.2915 0.2915
Onchocerca volvulus 0.0194 0.0218 0.3567
Echinococcus multilocularis kinase suppressor of Ras 1 0.0194 0.0218 0.0218
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0213 0.0266 0.0398
Loa Loa (eye worm) TK/ALK protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0194 0.0218 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0218 0.0218
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0194 0.0218 0.3567
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica serine/threonine kinase, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis protein KINase family member (kin 25) 0.0194 0.0218 0.0218
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0194 0.0218 0.0218
Echinococcus granulosus poly ADP ribose polymerase 1 0.2703 0.6423 0.6423
Entamoeba histolytica ankyrin repeat protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.2141 0.5035 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0194 0.0218 0.0218
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0194 0.0218 0.0433
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Onchocerca volvulus 0.0194 0.0218 0.3567
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Trypanosoma brucei protein kinase, putative 0.2141 0.5035 1
Echinococcus granulosus tyrosine protein kinase csk 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis AGC family protein kinase 0.0194 0.0218 0.0433
Onchocerca volvulus 0.0194 0.0218 0.3567
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0194 0.0218 0.0218
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0194 0.0218 0.0326
Entamoeba histolytica hypothetical protein 0.02 0.0234 0.0364
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.4149 1 1
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0128 0.0128
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0194 0.0218 0.0218
Plasmodium vivax protein kinase, putative 0.0194 0.0218 1
Entamoeba histolytica hypothetical protein 0.042 0.0777 0.1209
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) protein kinase domain-containing protein 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Echinococcus granulosus tyrosine protein kinase pr2 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica receptor protein kinase, putative 0.0194 0.0218 0.0339
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0213 0.0266 0.0266
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trypanosoma cruzi DNA repair protein, putative 0.0353 0.0611 0.1214
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.2141 0.5035 1
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis FL cytokine receptor 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.02 0.0234 0.0364
Trypanosoma cruzi protein kinase, putative 0.0194 0.0218 0.0433
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.2808 0.6685 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Echinococcus multilocularis c src tyrosine kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Echinococcus granulosus activated cdc42 kinase 1 0.0194 0.0218 0.0218
Schistosoma mansoni alpha-glucosidase 0.0135 0.0073 0.0073
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/CSK protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus granulosus natriuretic peptide receptor 1 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis activated cdc42 kinase 1 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Echinococcus granulosus WGR domain containing protein 0.0839 0.1815 0.1815
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0194 0.0218 0.3567
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Tnks protein 0.02 0.0234 0.0234
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.2141 0.5035 1
Toxoplasma gondii protein kinase domain-containing protein 0.0194 0.0218 0.0326
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0194 0.0218 0.0218
Echinococcus multilocularis tankyrase 0.02 0.0234 0.0234
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.2141 0.5035 1
Echinococcus granulosus activated cdc42 kinase 1 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Echinococcus multilocularis protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni ephrin receptor 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Trypanosoma brucei DNA repair protein, putative 0.0353 0.0611 0.1214
Echinococcus granulosus tyrosine protein kinase shark 0.0194 0.0218 0.0218
Echinococcus granulosus mitogen activated protein kinase 0.2141 0.5035 0.5035
Echinococcus multilocularis tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase ABL1 0.0194 0.0218 0.0218
Trypanosoma brucei Pseudokinase, putative 0.0194 0.0218 0.0433
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0194 0.0218 0.0218
Treponema pallidum DNA ligase (lig) 0.0106 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.2141 0.5035 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0213 0.0266 0.0528
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.0128 0.0128
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis CMGC family protein kinase 0.2141 0.5035 1
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0194 0.0218 0.0218
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus c src tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus epidermal growth factor receptor 0.0194 0.0218 0.0218
Loa Loa (eye worm) serine/threonine protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosin kinase, putative 0.0194 0.0218 0.0339
Trypanosoma cruzi protein kinase, putative 0.0194 0.0218 0.0433
Trichomonas vaginalis STE family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase Lyn 0.0213 0.0266 0.0266
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni hypothetical protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TK family protein kinase 0.0194 0.0218 0.0433
Echinococcus granulosus mitogen activated protein kinase 3 0.2141 0.5035 0.5035
Echinococcus granulosus tyrosine protein kinase Src64B 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis mitogen activated protein kinase 3 0.2141 0.5035 0.5035
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0213 0.0266 0.0528
Brugia malayi Immunoglobulin I-set domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Brugia malayi WGR domain containing protein 0.1485 0.3411 0.3411
Trypanosoma brucei Flagellum attachment zone protein 20 0.0194 0.0218 0.0433
Chlamydia trachomatis DNA ligase 0.0106 0 0.5
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Entamoeba histolytica serine/threonine kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0213 0.0266 0.0266
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica tyrosin kinase, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase csk 0.0194 0.0218 0.0218
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.4149 1 1
Brugia malayi Furin-like cysteine rich region family protein 0.0194 0.0218 0.0218
Echinococcus granulosus retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.2703 0.6423 1
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Brugia malayi Tyrosine-protein kinase PR2 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus granulosus tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus activin receptor type 0.0213 0.0266 0.0266
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/EPH protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.2141 0.5035 0.5035
Echinococcus granulosus poly (ADP ribose) polymerase 0.042 0.0777 0.0777
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Schistosoma mansoni poly [ADP-ribose] polymerase 0.1485 0.3411 0.3411
Onchocerca volvulus 0.0194 0.0218 0.3567
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0194 0.0218 0.0218
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.1485 0.3411 0.3411
Echinococcus multilocularis raf serine:threonine protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.4149 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0128 0.0128
Trypanosoma brucei protein kinase, putative 0.0213 0.0266 0.0528
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Brugia malayi Guanylyl cyclase protein 23 0.0194 0.0218 0.0218
Echinococcus multilocularis protein tyrosine kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FAK protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Plasmodium falciparum tyrosine kinase-like protein 0.0194 0.0218 0.8198
Schistosoma mansoni protein kinase 0.0213 0.0266 0.0266
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Echinococcus granulosus protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus geminin 0.0164 0.0143 0.0143
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Onchocerca volvulus DNA ligase 3 homolog 0.0353 0.0611 1
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0353 0.0611 0.1214
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.0128 0.0128
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) SRC-1 0.0194 0.0218 0.0218
Brugia malayi WGR domain containing protein 0.2703 0.6423 0.6423
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0194 0.0218 0.0218
Brugia malayi protein-tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus multilocularis transfer RNA-Thr 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni hypothetical protein 0.0164 0.0143 0.0143
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Loa Loa (eye worm) RGC/RGC protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK/DDR protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0194 0.0218 0.0339
Plasmodium falciparum protein kinase, putative 0.0213 0.0266 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Echinococcus multilocularis geminin 0.0164 0.0143 0.0143
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0194 0.0218 0.0433
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0194 0.0218 0.0218
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.2141 0.5035 0.7532
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica ankyrin repeat protein 0.0194 0.0218 0.0339
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0194 0.0218 0.0218
Echinococcus granulosus insulin receptor 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0213 0.0266 0.0528
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Giardia lamblia Kinase, CMGC MAPK 0.2141 0.5035 1
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Plasmodium vivax tyrosine kinase-like protein, putative 0.0194 0.0218 1
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Echinococcus multilocularis integrin linked protein kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Echinococcus multilocularis receptor type guanylyl cyclase 0.0194 0.0218 0.0218
Brugia malayi SH2 domain containing protein 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase shark 0.0194 0.0218 0.0218
Brugia malayi Receptor family ligand binding region containing protein 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Echinococcus granulosus tankyrase 0.02 0.0234 0.0234
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.1065 0.2373 0.2373
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica serine/threonine kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica serine/threonine kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0194 0.0218 0.0433
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0194 0.0218 0.0218
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Echinococcus multilocularis insulin receptor 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Onchocerca volvulus 0.0194 0.0218 0.3567
Onchocerca volvulus 0.0194 0.0218 0.3567
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase csk 0.0194 0.0218 0.0218
Echinococcus granulosus poly (ADP ribose) polymerase 0.042 0.0777 0.0777
Echinococcus granulosus raf serine:threonine protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0194 0.0218 0.0218
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0106 0 0.5
Loa Loa (eye worm) TK/ROR protein kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Plasmodium falciparum protein kinase, putative 0.0194 0.0218 0.8198
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.2141 0.5035 0.5035
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) TK/INSR protein kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Schistosoma mansoni hypothetical protein 0.0164 0.0143 0.0143
Schistosoma mansoni serine/threonine RGC 0.0194 0.0218 0.0218
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase csk 0.0194 0.0218 0.0218
Echinococcus granulosus ephrin type A receptor 4 A 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0194 0.0218 0.0218
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0106 0 0.5
Onchocerca volvulus Tyrosine kinase homolog 0.0194 0.0218 0.3567
Echinococcus multilocularis epidermal growth factor receptor 0.0194 0.0218 0.0218
Brugia malayi Immunoglobulin I-set domain containing protein 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.2141 0.5035 1
Brugia malayi C-terminal src kinase protein 1 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase Blk 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Loa Loa (eye worm) RGC/RGC protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus protein tyrosine kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis protein tyrosine kinase, putative 0.0194 0.0218 0.0433
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0194 0.0218 0.0218
Brugia malayi integrin-linked kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica serine/threonine kinase, putative 0.0194 0.0218 0.0339
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Toxoplasma gondii STE kinase 0.0194 0.0218 0.0326
Onchocerca volvulus 0.0194 0.0218 0.3567
Plasmodium falciparum tyrosine kinase-like protein 0.0194 0.0218 0.8198
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0194 0.0218 0.0218
Giardia lamblia Protein 21.1 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0194 0.0218 0.0218
Schistosoma mansoni protein tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/EGFR protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Toxoplasma gondii protein kinase 0.0194 0.0218 0.0326
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus fibroblast growth factor receptor 4 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Leishmania major DNA repair protein, putative 0.0353 0.0611 0.0816
Brugia malayi bone morphogenetic protein type 1 receptor 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase csk 0.0194 0.0218 0.0218
Echinococcus granulosus integrin linked protein kinase 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0353 0.0611 0.1214
Trypanosoma brucei poly(adp-ribose) polymerase 0.1485 0.3411 0.6775
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0194 0.0218 0.0218
Brugia malayi hypothetical protein 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tankyrase 0.02 0.0234 0.0234
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus multilocularis tyrosine protein kinase Srms 0.0194 0.0218 0.0218
Echinococcus granulosus poly adp ribose polymerase 2 0.1485 0.3411 0.3411
Echinococcus granulosus tyrosine protein kinase Src42A 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Entamoeba histolytica tyrosin kinase, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase Blk 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Echinococcus multilocularis activin receptor type 0.0213 0.0266 0.0266
Plasmodium vivax tyrosine kinase-like protein, putative 0.0194 0.0218 1
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Leishmania major hypothetical protein, conserved 0.0353 0.0611 0.0816
Echinococcus multilocularis tyrosine protein kinase Abl 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Giardia lamblia Kinase, NEK 0.0194 0.0218 0.0433
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis poly (ADP ribose) polymerase 0.062 0.1272 0.1272
Brugia malayi SH2 domain containing protein 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.2141 0.5035 1
Onchocerca volvulus 0.0194 0.0218 0.3567
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0194 0.0218 0.0218
Giardia lamblia Kinase, NEK 0.0194 0.0218 0.0433
Brugia malayi SRC-1 0.0194 0.0218 0.0218
Leishmania major protein kinase, putative 0.0213 0.0266 0.0099
Loa Loa (eye worm) tnks protein 0.02 0.0234 0.0234
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Giardia lamblia Kinase 0.0194 0.0218 0.0433
Onchocerca volvulus 0.0194 0.0218 0.3567
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0194 0.0218 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus granulosus tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/ABL protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.1485 0.3411 0.6775
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis CMGC family protein kinase 0.2141 0.5035 1
Onchocerca volvulus 0.0194 0.0218 0.3567
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Echinococcus granulosus tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0194 0.0218 0.0326
Echinococcus multilocularis tyrosine protein kinase pr2 0.0194 0.0218 0.0218
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0194 0.0218 0.0218
Echinococcus multilocularis ephrin type A receptor 4 A 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0194 0.0218 0.0339
Echinococcus granulosus tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0194 0.0218 0.0218
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Schistosoma mansoni poly [ADP-ribose] polymerase 0.2703 0.6423 0.6423
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi hypothetical protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Plasmodium falciparum protein kinase, putative 0.0194 0.0218 0.8198
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis heat shock protein 70 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase csk 0.0194 0.0218 0.0218

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.65 10'-6M Antagonist activity at Calcium channel in Cavia porcellus (guinea pig) ileal smooth muscle assessed as inhibition of 40 mM KCl-induced contraction compound pretreated for 15 min before KCl treatment ChEMBL. No reference
TIME (functional) = 27.76 min Anticonvulsant activity against pentylenetetrazole-induced seizures in Mus musculus NMRI (mouse) assessed as time of maximal effect at 5 mg/kg, ip administered 30 min before PTZ challenge ChEMBL. No reference
TIME (functional) = 32.64 min Anticonvulsant activity against pentylenetetrazole-induced seizures in Mus musculus NMRI (mouse) assessed as time of maximal effect at 10 mg/kg, ip administered 30 min before PTZ challenge (Rvb = 24.86 +/- 0.96 min) ChEMBL. No reference
Time (functional) = 39.07 min Anticonvulsant activity against pentylenetetrazole-induced seizures in Mus musculus NMRI (mouse) assessed as time of maximal effect at 20 mg/kg, ip administered 30 min before PTZ challenge ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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