Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | type I fatty acid synthase, putative | 0.01 | 0.3212 | 0.2993 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0025 | 0.0487 | 0.0425 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.002 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0288 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0025 | 0.0487 | 0.0381 |
Onchocerca volvulus | 0.0045 | 0.1203 | 0.263 | |
Echinococcus granulosus | serine/threonine protein kinase | 0.0015 | 0.0114 | 0.0098 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.5288 | 0.5236 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0046 | 0.1258 | 0.1201 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.011 | 0.0093 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3212 | 0.3212 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0288 | 1 | 1 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0013 | 0.0061 | 0.0044 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0015 | 0.0114 | 0.164 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.011 | 0.011 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0046 | 0.1258 | 0.1201 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0013 | 0.0066 | 0.0049 |
Schistosoma mansoni | lamin | 0.0025 | 0.0487 | 0.0381 |
Trichomonas vaginalis | AGC family protein kinase | 0.0022 | 0.036 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0025 | 0.0487 | 0.0487 |
Echinococcus multilocularis | nervana 2 | 0.0013 | 0.0061 | 0.0044 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.002 | 0.0312 | 0.0249 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.011 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0726 | 0.0726 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0023 | 0.0427 | 0.0119 |
Echinococcus multilocularis | nervana 2 | 0.0013 | 0.0061 | 0.0044 |
Echinococcus granulosus | lamin dm0 | 0.0025 | 0.0487 | 0.0471 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.022 | 0.7547 | 0.7543 |
Trichomonas vaginalis | AGC family protein kinase | 0.0022 | 0.036 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.011 | 0.0093 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0013 | 0.0061 | 0.0044 |
Echinococcus granulosus | geminin | 0.0158 | 0.5288 | 0.528 |
Trichomonas vaginalis | AGC family protein kinase | 0.0022 | 0.036 | 0.5 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.01 | 0.3212 | 0.2993 |
Trichomonas vaginalis | AGC family protein kinase | 0.0022 | 0.036 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0013 | 0.0066 | 0.0049 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0046 | 0.1258 | 0.1258 |
Echinococcus granulosus | nervana 2 | 0.0013 | 0.0061 | 0.0044 |
Onchocerca volvulus | 0.01 | 0.3212 | 1 | |
Leishmania major | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0427 | 0.0427 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.01 | 0.3212 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.7547 | 0.7547 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0013 | 0.0061 | 0.0044 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0023 | 0.0427 | 0.007 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3212 | 0.3212 |
Mycobacterium leprae | 3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) | 0.0188 | 0.6366 | 1 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0288 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0025 | 0.0487 | 0.0471 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) | 0.0188 | 0.6366 | 1 |
Echinococcus multilocularis | lamin | 0.0025 | 0.0487 | 0.0471 |
Schistosoma mansoni | intermediate filament proteins | 0.0025 | 0.0487 | 0.0381 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0015 | 0.0114 | 0.0005 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.01 | 0.3212 | 0.3168 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.01 | 0.3212 | 0.2993 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0427 | 0.0364 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) | 0.0188 | 0.6366 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0288 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0487 | 0.0487 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0288 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.011 | 0.0045 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0427 | 0.0364 |
Giardia lamblia | Kinase, AGC PKA | 0.0013 | 0.0066 | 0.5 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.01 | 0.3212 | 0.3168 |
Echinococcus multilocularis | lamin dm0 | 0.0025 | 0.0487 | 0.0471 |
Mycobacterium leprae | 3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I) | 0.0188 | 0.6366 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.011 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0017 | 0.0017 |
Trichomonas vaginalis | AGC family protein kinase | 0.0022 | 0.036 | 0.5 |
Brugia malayi | hypothetical protein | 0.022 | 0.7547 | 0.7531 |
Entamoeba histolytica | protein kinase, putative | 0.0022 | 0.036 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.011 | 0.0045 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0045 | 0.1203 | 0.1146 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0288 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0288 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0025 | 0.0487 | 0.0471 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0013 | 0.0066 | 0.0049 |
Trichomonas vaginalis | AGC family protein kinase | 0.0022 | 0.036 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0032 | 0.0726 | 0.0666 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0023 | 0.0427 | 0.0364 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.5288 | 0.5236 |
Brugia malayi | intermediate filament protein | 0.0025 | 0.0487 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.011 | 0.011 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0025 | 0.0487 | 0.0487 |
Echinococcus granulosus | nervana 2 | 0.0013 | 0.0061 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1258 | 0.1258 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0015 | 0.0114 | 0.164 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0427 | 0.0365 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0126 | 0.0062 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.011 | 0.0093 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.1203 | 0.1106 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0022 | 0.036 | 0.036 |
Trypanosoma cruzi | Protein kinase B | 0.0015 | 0.0114 | 0.0049 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0015 | 0.0114 | 0.0049 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0288 | 1 | 0.5 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.01 | 0.3212 | 0.2993 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0427 | 0.0364 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0015 | 0.0114 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0726 | 0.0624 |
Echinococcus granulosus | intermediate filament protein | 0.0025 | 0.0487 | 0.0471 |
Entamoeba histolytica | protein kinase, putative | 0.0022 | 0.036 | 1 |
Echinococcus multilocularis | geminin | 0.0158 | 0.5288 | 0.528 |
Entamoeba histolytica | protein kinase, putative | 0.002 | 0.0312 | 0.836 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0427 | 0.0364 |
Brugia malayi | Protein kinase domain containing protein | 0.0022 | 0.036 | 0.0297 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0013 | 0.0061 | 0.0044 |
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.0288 | 1 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0015 | 0.0114 | 0.0098 |
Schistosoma mansoni | survival motor neuron protein | 0.0045 | 0.1203 | 0.1106 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0013 | 0.0065 | 0.0065 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.011 | 0.0093 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.022 | 0.7547 | 0.7543 |
Trichomonas vaginalis | AGC family protein kinase | 0.0022 | 0.036 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0288 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.