TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 325.405 | Formula: C19H23N3O2
H donors: 2 H acceptors: 3 LogP: 3.28 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN1C2CCC1CC(C2)NC(=O)c1c(C)nc2c(c1O)cccc2
InChi: 1S/C19H23N3O2/c1-11-17(18(23)15-5-3-4-6-16(15)20-11)19(24)21-12-9-13-7-8-14(10-12)22(13)2/h3-6,12-14H,7-10H2,1-2H3,(H,20,23)(H,21,24)
InChiKey: ZKSNSGVNASDNFY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic		References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic		References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic		References
Rattus norvegicus	Serotonin 3 (5-HT3) receptor	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic		References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-3 precursor, putative	Serotonin 3 (5-HT3) receptor	483 aa	505 aa	21.2 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	477 aa	26.6 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	461 aa	24.3 %
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	Serotonin 3 (5-HT3) receptor	483 aa	445 aa	25.6 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	Serotonin 3 (5-HT3) receptor	483 aa	478 aa	25.1 %
Brugia malayi	Cation transporter family protein	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	484 aa	469 aa	28.6 %
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	Serotonin 3 (5-HT3) receptor	483 aa	445 aa	25.4 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	489 aa	31.3 %
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	484 aa	26.0 %
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	Serotonin 3 (5-HT3) receptor	483 aa	514 aa	23.2 %
Brugia malayi	Cation transporter family protein	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	404 aa	445 aa	22.0 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	Serotonin 3 (5-HT3) receptor	483 aa	388 aa	21.9 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	452 aa	29.2 %
Onchocerca volvulus	Large subunit GTPase 1 homolog	Serotonin 3 (5-HT3) receptor	483 aa	394 aa	19.3 %
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative	Serotonin 3 (5-HT3) receptor	483 aa	457 aa	24.7 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type des-2 homolog	Serotonin 3 (5-HT3) receptor	483 aa	464 aa	24.8 %
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	470 aa	27.7 %
Brugia malayi	Cation transporter family protein	Serotonin 3 (5-HT3) receptor	483 aa	507 aa	28.2 %
Drosophila melanogaster	nicotinic Acetylcholine Receptor alpha2	Serotonin 3 (5-HT3) receptor	483 aa	541 aa	25.5 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Serotonin 3 (5-HT3) receptor	483 aa	465 aa	27.3 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	457 aa	26.7 %
Onchocerca volvulus	Putative zinc finger protein	Serotonin 3 (5-HT3) receptor	483 aa	489 aa	25.8 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	473 aa	27.5 %
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	Serotonin 3 (5-HT3) receptor	483 aa	457 aa	26.9 %
Onchocerca volvulus	39S ribosomal protein L13, mitochondrial homolog	Serotonin 3 (5-HT3) receptor	483 aa	490 aa	31.0 %
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	Serotonin 3 (5-HT3) receptor	483 aa	503 aa	22.3 %
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	Serotonin 3 (5-HT3) receptor	483 aa	463 aa	26.8 %
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	470 aa	26.8 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Serotonin 3 (5-HT3) receptor	483 aa	465 aa	27.3 %
Echinococcus multilocularis	nAChR subunit	Serotonin 3 (5-HT3) receptor	483 aa	495 aa	24.2 %
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	Serotonin 3 (5-HT3) receptor	483 aa	387 aa	25.6 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Serotonin 3 (5-HT3) receptor	483 aa	482 aa	25.1 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	482 aa	23.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	STE kinase	0.0236	0	0.5
Schistosoma mansoni	hypothetical protein	0.0346	0.3176	0.3176
Loa Loa (eye worm)	TK/FER protein kinase	0.0583	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0583	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0583	1	1
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0583	1	1
Loa Loa (eye worm)	TK protein kinase	0.0583	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus multilocularis	tensin	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0236	0	0.5
Schistosoma mansoni	tensin	0.0346	0.3176	0.3176
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Schistosoma mansoni	vav2	0.0346	0.3176	0.3176
Brugia malayi	SRC-1	0.0583	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0346	0.3176	0.3176
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0583	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0583	1	1
Loa Loa (eye worm)	SRC-1	0.0583	1	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0346	0.3176	0.3176
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0346	0.3176	0.3176
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	AGC family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Brugia malayi	hypothetical protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Brugia malayi	SH2 domain containing protein	0.0583	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0346	0.3176	0.3176
Onchocerca volvulus		0.0583	1	1
Echinococcus granulosus	tensin	0.0346	0.3176	0.3176
Trypanosoma brucei	Pseudokinase, putative	0.0236	0	0.5
Trypanosoma brucei	protein kinase, putative	0.0236	0	0.5
Brugia malayi	RhoGAP domain containing protein	0.0346	0.3176	0.3176
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0583	1	1
Echinococcus granulosus	hypothetical protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0236	0	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0346	0.3176	0.3176
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0346	0.3176	0.3176
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Brugia malayi	SH2 domain containing protein	0.0346	0.3176	0.3176
Trypanosoma cruzi	protein kinase, putative	0.0236	0	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0346	0.3176	0.3176
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0583	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0236	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0346	0.3176	0.3176
Echinococcus multilocularis	SH2 motif	0.0346	0.3176	0.3176
Loa Loa (eye worm)	TK/FER protein kinase	0.0583	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0346	0.3176	0.3176
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0583	1	1
Plasmodium falciparum	protein kinase, putative	0.0236	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0583	1	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0346	0.3176	0.3176
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0583	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0346	0.3176	0.3176
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0583	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0583	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Echinococcus multilocularis	N chimaerin	0.0346	0.3176	0.3176
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0346	0.3176	0.3176
Echinococcus granulosus	growth factor receptor bound protein 2	0.0346	0.3176	0.3176
Schistosoma mansoni	tyrosine kinase	0.0583	1	1
Brugia malayi	Protein kinase domain containing protein	0.0583	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0236	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0346	0.3176	0.3176
Echinococcus granulosus	SH2 domain containing protein 7	0.0346	0.3176	0.3176
Trichomonas vaginalis	conserved hypothetical protein	0.0236	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0346	0.3176	0.3176
Giardia lamblia	Protein 21.1	0.0236	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Giardia lamblia	Kinase	0.0236	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0236	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0236	0	0.5
Brugia malayi	SH2 domain containing protein	0.0346	0.3176	0.3176
Brugia malayi	Protein kinase domain containing protein	0.0583	1	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0583	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0346	0.3176	0.3176
Loa Loa (eye worm)	SH2 domain-containing protein	0.0346	0.3176	0.3176
Brugia malayi	Variant SH3 domain containing protein	0.0346	0.3176	0.3176
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0346	0.3176	0.3176
Echinococcus granulosus	NCK adaptor protein	0.0346	0.3176	0.3176
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0583	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0236	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0583	1	1
Echinococcus granulosus	N chimaerin	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0346	0.3176	0.3176
Brugia malayi	Variant SH3 domain containing protein	0.0346	0.3176	0.3176
Entamoeba histolytica	protein kinase, putative	0.0346	0.3176	0.3176
Schistosoma mansoni	tyrosine kinase	0.0583	1	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0583	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Giardia lamblia	Kinase, NEK	0.0236	0	0.5
Brugia malayi	SH2 domain containing protein	0.0346	0.3176	0.3176
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0583	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0583	1	1
Trichomonas vaginalis	STE family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0583	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0583	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0583	1	1
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Onchocerca volvulus		0.0583	1	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0346	0.3176	0.3176
Toxoplasma gondii	protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0236	0	0.5
Onchocerca volvulus		0.0583	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0236	0	0.5
Onchocerca volvulus		0.0583	1	1
Brugia malayi	SH2 domain containing protein	0.0346	0.3176	0.3176
Plasmodium falciparum	protein kinase, putative	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Brugia malayi	hypothetical protein	0.0583	1	1
Brugia malayi	Tensin	0.0346	0.3176	0.3176
Onchocerca volvulus		0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Schistosoma mansoni	tensin	0.0346	0.3176	0.3176
Schistosoma mansoni	nck2/grb4	0.0346	0.3176	0.3176
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Echinococcus multilocularis	c src tyrosine kinase	0.0583	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0346	0.3176	0.3176
Echinococcus multilocularis	SH2 motif	0.0346	0.3176	0.3176
Echinococcus granulosus	tyrosine kinase	0.0583	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus multilocularis	tensin	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TK family protein kinase	0.0236	0	0.5
Brugia malayi	protein-tyrosine kinase	0.0583	1	1
Schistosoma mansoni	adapter molecule crk	0.0346	0.3176	0.3176
Brugia malayi	Protein kinase domain containing protein	0.0583	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Schistosoma mansoni	GTPase activating protein	0.0346	0.3176	0.3176
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0583	1	1
Echinococcus granulosus	expressed conserved protein	0.0346	0.3176	0.3176
Loa Loa (eye worm)	TK/FER protein kinase	0.0583	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0346	0.3176	0.3176
Onchocerca volvulus		0.0346	0.3176	0.3176
Echinococcus multilocularis	signal transduction protein lnk realted	0.0346	0.3176	0.3176
Onchocerca volvulus		0.0583	1	1
Loa Loa (eye worm)	STAT protein	0.0346	0.3176	0.3176
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0236	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus granulosus	SH2 motif	0.0346	0.3176	0.3176
Onchocerca volvulus		0.0346	0.3176	0.3176
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0583	1	1
Echinococcus multilocularis	SH2 motif	0.0346	0.3176	0.3176
Echinococcus multilocularis		0.0346	0.3176	0.3176
Echinococcus multilocularis	NCK adaptor protein	0.0346	0.3176	0.3176
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0583	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0583	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0346	0.3176	0.3176
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0346	0.3176	0.3176
Brugia malayi	SH2 domain containing protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0583	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0583	1	1
Echinococcus multilocularis	tyrosine kinase	0.0583	1	1
Onchocerca volvulus		0.0346	0.3176	0.3176
Brugia malayi	SH2 domain containing protein	0.0346	0.3176	0.3176
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0583	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0346	0.3176	0.3176
Toxoplasma gondii	protein kinase domain-containing protein	0.0236	0	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0346	0.3176	0.3176
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0583	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0236	0	0.5
Brugia malayi	SH2 domain containing protein	0.0583	1	1
Schistosoma mansoni	tensin	0.0346	0.3176	0.3176
Schistosoma mansoni	SH2A	0.0346	0.3176	0.3176
Echinococcus granulosus	tyrosine kinase	0.0583	1	1
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0346	0.3176	0.3176
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0346	0.3176	0.3176
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0236	0	0.5
Plasmodium vivax	protein kinase, putative	0.0236	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0236	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0583	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0346	0.3176	0.3176
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0583	1	1
Giardia lamblia	Kinase, NEK	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0346	0.3176	0.3176
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0236	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0236	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0583	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0583	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0346	0.3176	0.3176
Onchocerca volvulus		0.0346	0.3176	0.3176
Schistosoma mansoni	tyrosine kinase	0.0583	1	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0583	1	1
Schistosoma mansoni	tensin-related	0.0346	0.3176	0.3176
Trypanosoma cruzi	protein kinase, putative	0.0236	0	0.5
Onchocerca volvulus		0.0583	1	1
Brugia malayi	SH2 domain containing protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0236	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0346	0.3176	0.3176
Schistosoma mansoni	tyrosine kinase	0.0583	1	1
Schistosoma mansoni	shc transforming protein	0.0346	0.3176	0.3176
Leishmania major	protein kinase, putative	0.0236	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0346	0.3176	0.3176
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0346	0.3176	0.3176
Schistosoma mansoni	tensin-related	0.0346	0.3176	0.3176
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0583	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0583	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0583	1	1
Echinococcus granulosus	SH2 motif	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Schistosoma mansoni	hypothetical protein	0.0346	0.3176	0.3176
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0346	0.3176	0.3176
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0346	0.3176	0.3176
Echinococcus granulosus	tyrosine protein kinase shark	0.0583	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0583	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0583	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0346	0.3176	0.3176
Loa Loa (eye worm)	TK/FER protein kinase	0.0583	1	1
Leishmania major	hypothetical protein, conserved	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0583	1	1
Onchocerca volvulus		0.0346	0.3176	0.3176
Schistosoma mansoni	growth factor receptor-bound protein	0.0346	0.3176	0.3176
Loa Loa (eye worm)	SH2 domain-containing protein	0.0346	0.3176	0.3176
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0583	1	1
Leishmania major	protein kinase, putative	0.0236	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0583	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0583	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0583	1	1
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0236	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0583	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0346	0.3176	0.3176
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3176	0.3176
Echinococcus granulosus	c src tyrosine kinase	0.0583	1	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0346	0.3176	0.3176
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0346	0.3176	0.3176

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 0.015 mg kg-1	In vivo inhibitory concentration after 5 minutes against 5-hydroxytryptamine 3 receptor induced bradycardia [bezold-jarisch (B-J) reflex test] in rat by intravenous administration	ChEMBL.	8496941
ED50 (functional)	= 0.015 mg kg-1	Effective dose causing reduction of serotonin effect at 5 min administered iv in Bezold-Jarisch reflex test	ChEMBL.	8230119
ED50 (functional)	= 0.015 mg kg-1	In vivo inhibitory concentration after 5 minutes against 5-hydroxytryptamine 3 receptor induced bradycardia [bezold-jarisch (B-J) reflex test] in rat by intravenous administration	ChEMBL.	8496941
ID50 (functional)	= 41 mg kg-1	Inhibitory dose causing inhibition of restraint stress induced defecation by oral administration (inhibition at 1 mg/kg)	ChEMBL.	8230119
Ki (binding)	= 7.2 nM	Binding affinity against radioligand [3H]-quipazine labeled 5-hydroxytryptamine 3 receptor sites in neuroblastoma-glioma (NG108-15) cells.	ChEMBL.	8496941
Ki (binding)	= 7.2 nM	Binding affinity towards [3H]-quipazine labeled 5-hydroxytryptamine 3 receptor sites in HG108-15	ChEMBL.	8230119
Ki (binding)	= 7.2 nM	Binding affinity against radioligand [3H]-quipazine labeled 5-hydroxytryptamine 3 receptor sites in neuroblastoma-glioma (NG108-15) cells.	ChEMBL.	8496941
Ki (binding)	= 7.2 nM	Binding affinity towards [3H]-quipazine labeled 5-hydroxytryptamine 3 receptor sites in HG108-15	ChEMBL.	8230119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL113045

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 184257