Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | intermediate filament protein | 0.0029 | 0.005 | 0.005 |
Mycobacterium tuberculosis | Conserved protein | 0.0423 | 0.1542 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.2656 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0423 | 0.1542 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0159 | 0.0543 | 0.0495 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0543 | 0.0543 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.2656 | 1 | 1 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0423 | 0.1542 | 0.1542 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0423 | 0.1542 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0423 | 0.1542 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.0096 | 0.0046 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.005 | 0.005 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.2656 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.0186 | 0.0137 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0423 | 0.1542 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.2656 | 1 | 1 |
Brugia malayi | FXNA | 0.0423 | 0.1542 | 0.1542 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0423 | 0.1542 | 0.1499 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.007 | 0.0208 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.1542 | 0.1542 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0423 | 0.1542 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.007 | 0.0208 | 0.0208 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0423 | 0.1542 | 0.1499 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0423 | 0.1542 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.007 | 0.0208 | 0.0157 |
Onchocerca volvulus | 0.0423 | 0.1542 | 0.1499 | |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.0208 | 0.0158 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.007 | 0.0208 | 0.0208 |
Leishmania major | hypothetical protein, conserved | 0.0423 | 0.1542 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.007 | 0.0208 | 0.0158 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0423 | 0.1542 | 0.1499 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0423 | 0.1542 | 0.1499 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0423 | 0.1542 | 0.1499 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0423 | 0.1542 | 0.5 |
Brugia malayi | nicalin | 0.0423 | 0.1542 | 0.1542 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0543 | 0.0543 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0423 | 0.1542 | 0.1499 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0423 | 0.1542 | 0.1499 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.1542 | 0.1542 |
Brugia malayi | Muscleblind-like protein | 0.0159 | 0.0543 | 0.0543 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.005 | 0.005 |
Echinococcus multilocularis | muscleblind protein | 0.0159 | 0.0543 | 0.0495 |
Mycobacterium ulcerans | hypothetical protein | 0.0423 | 0.1542 | 1 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0423 | 0.1542 | 1 |
Brugia malayi | leucyl aminopeptidase | 0.0423 | 0.1542 | 0.1542 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0423 | 0.1542 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.0208 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.2656 | 1 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0423 | 0.1542 | 0.1499 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.0186 | 0.0137 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0423 | 0.1542 | 0.1499 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.0186 | 0.0137 |
Leishmania major | glutaminyl cyclase, putative | 0.0423 | 0.1542 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.005 | 0.005 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.005 | 0.005 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0423 | 0.1542 | 0.1499 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.1542 | 0.1542 |
Schistosoma mansoni | nicalin (M28 family) | 0.0423 | 0.1542 | 0.1499 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0423 | 0.1542 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.0096 | 0.0046 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0423 | 0.1542 | 0.1499 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.1542 | 0.1542 |
Toxoplasma gondii | hypothetical protein | 0.0423 | 0.1542 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.0186 | 0.0137 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0159 | 0.0543 | 0.0495 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.