Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0279 | 0.0786 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0279 | 0.0786 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0279 | 0.0786 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 0.0786 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0279 | 0.0786 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.0786 | 0.0786 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.0786 | 0.0786 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0279 | 0.0786 | 1 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0279 | 0.0786 | 0.0786 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0279 | 0.0786 | 0.0786 |
Brugia malayi | nicalin | 0.0279 | 0.0786 | 0.0786 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0279 | 0.0786 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0279 | 0.0786 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0279 | 0.0786 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.1754 | 1 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0279 | 0.0786 | 0.0786 |
Schistosoma mansoni | nicalin (M28 family) | 0.0279 | 0.0786 | 0.0786 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0279 | 0.0786 | 0.0786 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.0786 | 0.0786 |
Mycobacterium tuberculosis | Conserved protein | 0.0279 | 0.0786 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0153 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.1754 | 1 | 1 |
Brugia malayi | leucyl aminopeptidase | 0.0279 | 0.0786 | 0.0786 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0279 | 0.0786 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0279 | 0.0786 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0279 | 0.0786 | 0.0786 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0279 | 0.0786 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0279 | 0.0786 | 0.0786 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0153 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1754 | 1 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0279 | 0.0786 | 0.0786 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.1754 | 1 | 1 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.1754 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0279 | 0.0786 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0279 | 0.0786 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.0786 | 0.0786 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0279 | 0.0786 | 0.0786 |
Brugia malayi | FXNA | 0.0279 | 0.0786 | 0.0786 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0279 | 0.0786 | 0.0786 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fu (ADMET) | = 20.6 % | Fraction unbound in human plasma | ChEMBL. | No reference |
IC50 (binding) | = 7.5 | Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation counting | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.