Detailed information for compound 1850516

Basic information

Technical information
  • TDR Targets ID: 1850516
  • Name: (2R,3S,5R)-5-(6-amino-8-ethynylpurin-9-yl)-2- (hydroxymethyl)oxolan-3-ol
  • MW: 275.263 | Formula: C12H13N5O3
  • H donors: 3 H acceptors: 5 LogP: -0.65 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1c(C#C)nc2c1ncnc2N
  • InChi: 1S/C12H13N5O3/c1-2-8-16-10-11(13)14-5-15-12(10)17(8)9-3-6(19)7(4-18)20-9/h1,5-7,9,18-19H,3-4H2,(H2,13,14,15)/t6-,7+,9+/m0/s1
  • InChiKey: VRKPVSVQAAYZAY-LKEWCRSYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3S,5R)-5-(6-amino-8-ethynyl-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
  • (2R,3S,5R)-5-(6-amino-8-ethynyl-9-purinyl)-2-(hydroxymethyl)-3-tetrahydrofuranol
  • (2R,3S,5R)-5-(6-amino-8-ethynyl-purin-9-yl)-2-methylol-tetrahydrofuran-3-ol
  • (2R,3S,5R)-5-(6-amino-8-ethynyl-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
  • 2'-Deoxy-8-ethynyladenosine
  • AIDS-187018
  • AIDS187018

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide receptor 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0298 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0164 0.0197
Loa Loa (eye worm) hypothetical protein 0.0027 0.0409 0.04
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622
Trichomonas vaginalis rheb, putative 0.0298 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0071 0.1967 0.196
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0744 0.0735
Brugia malayi follicle stimulating hormone receptor 0.0046 0.1079 0.1079
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1019 0.1019
Mycobacterium tuberculosis Conserved protein 0.0037 0.0744 0.0943
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Mycobacterium leprae Probable lipase LipE 0.0037 0.0744 0.1426
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0409 0.4237
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0409 0.5428
Loa Loa (eye worm) hypothetical protein 0.0038 0.0774 0.0765
Schistosoma mansoni hypothetical protein 0.0046 0.1079 0.2957
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0744 0.0735
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.1079 0.2957
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0409 0.5428
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.1967 0.1967
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.1079 0.1071
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0071 0.1967 0.196
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0409 0.4237
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0046 0.1079 0.1071
Loa Loa (eye worm) beta-lactamase 0.0037 0.0744 0.0735
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Brugia malayi photoreceptor-specific nuclear receptor 0.0071 0.1967 0.1967
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Brugia malayi beta-lactamase 0.0037 0.0744 0.0744
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.1079 0.1079
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1079 0.1071
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.1079 0.2957
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Schistosoma mansoni amine GPCR 0.0046 0.1079 0.2957
Schistosoma mansoni amine GPCR 0.0046 0.1079 0.2957
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Schistosoma mansoni thyroid hormone receptor 0.0071 0.1967 0.5412
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0071 0.1967 0.1967
Loa Loa (eye worm) hypothetical protein 0.0146 0.4603 0.4598
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.1967 0.1967
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0071 0.1967 0.196
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.1079 0.1071
Brugia malayi Serotonin receptor 0.0046 0.1079 0.1079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.1967 0.196
Onchocerca volvulus 0.0046 0.1079 0.1485
Brugia malayi Ras-related protein R-Ras2 0.0298 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1079 0.2957
Onchocerca volvulus 0.0046 0.1079 0.1485
Onchocerca volvulus Bile acid receptor homolog 0.0071 0.1967 0.3453
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0071 0.1967 0.5412
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis allatostatin A receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1079 0.1071
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0309 0.03
Echinococcus multilocularis sex peptide receptor 0.0046 0.1079 0.1071
Brugia malayi sulfakinin receptor protein 0.0046 0.1079 0.1079
Echinococcus granulosus g-protein coupled receptor 0.0046 0.1079 0.1071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0124 0.0146
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1079 0.1071
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0631 0.0622
Brugia malayi beta-lactamase family protein 0.0037 0.0744 0.0744
Loa Loa (eye worm) hypothetical protein 0.0071 0.1967 0.196
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.377 0.3764
Echinococcus multilocularis orexin receptor type 2 0.0046 0.1079 0.1071
Brugia malayi hypothetical protein 0.0046 0.1079 0.1079
Onchocerca volvulus 0.0034 0.0631 0.0491
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Schistosoma mansoni nuclear receptor 0.0034 0.0631 0.1717
Brugia malayi hypothetical protein 0.0025 0.0309 0.0309
Brugia malayi hypothetical protein 0.0154 0.4921 0.4921
Brugia malayi hypothetical protein 0.0034 0.0631 0.0631
Plasmodium falciparum thioredoxin reductase 0.0037 0.0745 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0071 0.1967 0.3453
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1019 0.1011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus multilocularis serotonin receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0631 0.0622
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1079 0.1071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Echinococcus granulosus neuropeptide s receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0631 0.0622
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0744 0.0943
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0001
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.2754 0.353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0071 0.1967 0.196
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1079 0.2957
Loa Loa (eye worm) hypothetical protein 0.0071 0.1967 0.196
Schistosoma mansoni myosin xvIII 0.0046 0.1079 0.2957
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Schistosoma mansoni amine GPCR 0.0046 0.1079 0.2957
Trypanosoma brucei trypanothione reductase 0.0037 0.0745 1
Mycobacterium tuberculosis Probable reductase 0.0084 0.2421 0.3101
Brugia malayi beta-lactamase family protein 0.0037 0.0744 0.0744
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622
Brugia malayi Thioredoxin reductase 0.0037 0.0745 0.0745
Trichomonas vaginalis rap1 and, putative 0.0298 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0744 0.0735
Echinococcus multilocularis serotonin receptor 0.0046 0.1079 0.1071
Trichomonas vaginalis GTP-binding protein rit, putative 0.0298 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0631 0.1717
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0744 0.9977
Mycobacterium ulcerans hypothetical protein 0.0027 0.0409 0.4237
Schistosoma mansoni neuropeptide receptor 0.0046 0.1079 0.2957
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.1079 0.1071
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.1079 0.2957
Schistosoma mansoni RAR-like nuclear receptor 0.0071 0.1967 0.5412
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0745 0.0737
Loa Loa (eye worm) hypothetical protein 0.0146 0.4603 0.4598
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1246 0.1246
Brugia malayi hypothetical protein 0.0046 0.1079 0.1079
Brugia malayi MH2 domain containing protein 0.0122 0.377 0.377
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1019 0.1011
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0631 0.0622
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.1967 0.1967
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.1967 0.196
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.1079 0.1079
Brugia malayi neuropeptide F receptor 0.0046 0.1079 0.1079
Onchocerca volvulus 0.0046 0.1079 0.1485
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.0774 0.0765
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.1079 0.1071
Schistosoma mansoni amine GPCR 0.0046 0.1079 0.2957
Brugia malayi hypothetical protein 0.0038 0.0774 0.0774
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1019 0.2791
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0409 0.4237
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0409 0.4237
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1079 0.1071
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.1079 0.1071
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.1079 0.1071
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0409 0.4237
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0124 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0164 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0409 0.04
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0124 0.0146
Loa Loa (eye worm) hypothetical protein 0.0071 0.1967 0.196
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.0774 0.0765
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0409 0.4237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1019 0.2791
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0774 0.0774
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0744 0.9977
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.2421 0.3101
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0071 0.1967 0.5412
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0011 0.0003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.1079 0.2957
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0631 0.1717
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0631 0.0622
Echinococcus granulosus allatostatin A receptor 0.0046 0.1079 0.1071
Brugia malayi nuclear hormone receptor 0.0071 0.1967 0.1967
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1246 0.1238
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0071 0.1967 0.196
Brugia malayi hypothetical protein 0.0046 0.1079 0.1079
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Loa Loa (eye worm) Ras protein let-60 0.0298 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0744 0.0943
Brugia malayi G-protein coupled receptor 0.0046 0.1079 0.1079
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0409 0.0513
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0763 0.0754
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.1079 0.2957
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0071 0.1967 0.196
Entamoeba histolytica Ras family GTPase 0.0298 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0071 0.1967 0.1967
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0744 0.0943
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622
Onchocerca volvulus 0.0046 0.1079 0.1485
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1079 0.1071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1079 0.2957
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.1079 0.2957
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.1079 0.1079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1079 0.2957
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0071 0.1967 0.1967
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1079 0.2957
Brugia malayi hypothetical protein 0.0046 0.1079 0.1079
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.1967 0.1967
Loa Loa (eye worm) hypothetical protein 0.0037 0.0744 0.0735
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0409 0.5428
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.7785 1
Onchocerca volvulus 0.0046 0.1079 0.1485
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622
Onchocerca volvulus 0.0154 0.4921 1
Brugia malayi nuclear receptor NHR-88 0.0071 0.1967 0.1967
Echinococcus multilocularis fmrfamide receptor 0.0046 0.1079 0.1071
Schistosoma mansoni biogenic amine receptor 0.0046 0.1079 0.2957
Schistosoma mansoni nuclear hormone receptor 0.0071 0.1967 0.5412
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Brugia malayi Dopamine receptor protein 1 0.0046 0.1079 0.1079
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0071 0.1967 0.5412
Echinococcus granulosus FTZ F1 alpha 0.0071 0.1967 0.196
Loa Loa (eye worm) hypothetical protein 0.0051 0.1246 0.1238
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0409 0.0409
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Brugia malayi hypothetical protein 0.0046 0.1079 0.1079
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.1079 0.1071
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0631 0.0631
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.2421 0.3101
Onchocerca volvulus Protein ultraspiracle homolog 0.0071 0.1967 0.3453
Loa Loa (eye worm) hypothetical protein 0.0038 0.0774 0.0765
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Schistosoma mansoni neuropeptide receptor 0.0046 0.1079 0.2957
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.1079 0.1071
Brugia malayi Latrophilin receptor protein 2 0.0016 0.001 0.001
Brugia malayi ORL1-like opioid receptor 0.0046 0.1079 0.1079
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.1079 0.1071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0071 0.1967 0.5412
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0631 0.0622
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0071 0.1967 0.196
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0037 0.0744 0.0735
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0071 0.1967 0.1967
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0071 0.1967 0.196
Trichomonas vaginalis ras-dva small GTPase, putative 0.0298 1 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.4921 0.4916
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1019 0.1011
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1019 0.1011
Schistosoma mansoni hypothetical protein 0.0046 0.1079 0.2957
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.1079 0.1071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1246 0.1246
Brugia malayi hypothetical protein 0.0046 0.1079 0.1079
Echinococcus multilocularis muscleblind protein 0.0146 0.4603 0.4598
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0631 0.0622
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.1079 0.2957
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0071 0.1967 0.1967
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0124 0.0146
Loa Loa (eye worm) hypothetical protein 0.0038 0.0774 0.0765
Trichomonas vaginalis dexras1, putative 0.0298 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.001 0.001
Brugia malayi nuclear hormone receptor 0.0034 0.0631 0.0631
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.1967 0.196
Brugia malayi glutathione reductase 0.0037 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.2754 0.353
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.1079 0.2957
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0631 0.1717
Entamoeba histolytica Ras family GTPase 0.0298 1 1
Echinococcus granulosus somatostatin receptor 0.0046 0.1079 0.1071
Onchocerca volvulus 0.0046 0.1079 0.1485
Loa Loa (eye worm) hypothetical protein 0.002 0.0164 0.0154
Onchocerca volvulus 0.0046 0.1079 0.1485
Brugia malayi neuropeptide F receptor 0.0046 0.1079 0.1079
Schistosoma mansoni zinc finger protein 0.0034 0.0631 0.1717
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0674 0.0674
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0011 0.0001
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.1079 0.2957
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1079 0.2957
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0745 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Brugia malayi larval opioid receptor 0.0046 0.1079 0.1079
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.1079 0.1071
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus multilocularis neuropeptide receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0011 0.0001
Onchocerca volvulus 0.0046 0.1079 0.1485
Echinococcus granulosus serotonin receptor 0.0046 0.1079 0.1071
Mycobacterium tuberculosis Conserved protein 0.0037 0.0744 0.0943
Leishmania major trypanothione reductase 0.0037 0.0745 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.2754 1
Brugia malayi ecdysone receptor 0.0034 0.0631 0.0631
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Mycobacterium ulcerans lipase LipD 0.0037 0.0744 1
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0164 0.2083
Echinococcus granulosus fmrfamide receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.1079 0.1071
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.2754 0.353
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.1079 0.1071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0071 0.1967 0.196
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0744 0.203
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.1079 0.1071
Onchocerca volvulus 0.0037 0.0744 0.0741
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1079 0.2957
Leishmania major hypothetical protein, conserved 0.0037 0.0744 0.9977
Loa Loa (eye worm) hypothetical protein 0.0071 0.1967 0.196
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0774 0.2113
Schistosoma mansoni biogenic amine receptor 0.0046 0.1079 0.2957
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.0774 0.2113
Brugia malayi hypothetical protein 0.0038 0.0774 0.0774
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.1079 0.1071
Brugia malayi G protein-coupled receptor 0.0046 0.1079 0.1079
Brugia malayi isocitrate dehydrogenase 0.0016 0.0011 0.0011
Schistosoma mansoni opsin-like receptor 0.0046 0.1079 0.2957
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0631 0.0622
Brugia malayi steroid hormone receptor 0.0071 0.1967 0.1967
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0744 0.1426
Brugia malayi nuclear receptor RXR 0.0038 0.0774 0.0774
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1079 0.2957
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0631 0.0631
Loa Loa (eye worm) steroid hormone receptor 0.0071 0.1967 0.196
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.1079 0.1071
Echinococcus multilocularis neuropeptide receptor 0.0046 0.1079 0.1071
Brugia malayi G-protein coupled receptor 0.0046 0.1079 0.1079
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0071 0.1967 0.1967
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.2421 0.3101
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.1079 0.1071
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0071 0.1967 0.196
Onchocerca volvulus 0.0034 0.0631 0.0491
Onchocerca volvulus 0.0046 0.1079 0.1485
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.1079 0.1071
Onchocerca volvulus 0.0037 0.0744 0.0741
Schistosoma mansoni retinoic acid receptor RXR 0.0071 0.1967 0.5412
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.2421 0.3101
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Brugia malayi Melatonin receptor type 1A 0.0046 0.1079 0.1079
Echinococcus granulosus g protein coupled receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.1079 0.1071
Mycobacterium tuberculosis Conserved protein 0.0037 0.0744 0.0943
Brugia malayi tailless protein 0.0034 0.0631 0.0631
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.1079 0.1071
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0744 0.0943
Loa Loa (eye worm) hypothetical protein 0.0037 0.0744 0.0735
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.1079 0.1071
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.1079 0.2957
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0744 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0631 0.0622
Onchocerca volvulus 0.0046 0.1079 0.1485
Plasmodium falciparum glutathione reductase 0.0037 0.0745 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1079 0.2957
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.1079 0.1485
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0631 0.0622
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0071 0.1967 0.196
Loa Loa (eye worm) hypothetical protein 0.0037 0.0744 0.0735
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.1079 0.1071
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0001
Loa Loa (eye worm) glutathione reductase 0.0037 0.0745 0.0737
Brugia malayi hypothetical protein 0.0046 0.1079 0.1079
Onchocerca volvulus 0.0046 0.1079 0.1485
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.377 0.3764
Brugia malayi Dopamine receptor 0.0046 0.1079 0.1079
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0631 0.0491
Schistosoma mansoni thyroid hormone receptor 0.0071 0.1967 0.5412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0744 1
Echinococcus granulosus ecdysone induced protein 78C 0.0071 0.1967 0.196
Echinococcus multilocularis somatostatin receptor 0.0046 0.1079 0.1071
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Onchocerca volvulus 0.0046 0.1079 0.1485
Onchocerca volvulus 0.0046 0.1079 0.1485
Schistosoma mansoni hypothetical protein 0.0035 0.0674 0.1836
Toxoplasma gondii thioredoxin reductase 0.0037 0.0745 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0071 0.1967 0.196
Loa Loa (eye worm) hypothetical protein 0.0035 0.0674 0.0665
Schistosoma mansoni biogenic amine receptor 0.0046 0.1079 0.2957
Schistosoma mansoni histamine h1 receptor 0.0046 0.1079 0.2957
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0309 0.406
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.1079 0.1071
Onchocerca volvulus 0.0046 0.1079 0.1485
Loa Loa (eye worm) hypothetical protein 0.0071 0.1967 0.196
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0763 0.0754
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Onchocerca volvulus 0.0046 0.1079 0.1485
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0011 0.0011
Brugia malayi hypothetical protein 0.0046 0.1079 0.1079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1019 0.1011
Schistosoma mansoni amine GPCR 0.0046 0.1079 0.2957
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0631 0.0622
Onchocerca volvulus 0.0037 0.0744 0.0741
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0745 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0309 0.406
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0744 0.0943
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1079 0.2957
Brugia malayi Serotonin receptor 0.0046 0.1079 0.1079
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1079 0.1071
Echinococcus multilocularis ras gtpase 0.0298 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1079 0.2957
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0071 0.1967 0.1967
Schistosoma mansoni neuropeptide receptor 0.0046 0.1079 0.2957
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0164 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Schistosoma mansoni opsin-like receptor 0.0046 0.1079 0.2957
Brugia malayi Dopamine receptor protein 2 0.0046 0.1079 0.1079
Loa Loa (eye worm) hypothetical protein 0.0038 0.0774 0.0765
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.1079 0.2957
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0409 0.4237
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.1079 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.1967 0.1967
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622
Echinococcus granulosus sex peptide receptor 0.0046 0.1079 0.1071
Brugia malayi GnHR receptor homolog 0.0046 0.1079 0.1079
Echinococcus multilocularis muscleblind protein 1 0.0146 0.4603 0.4598
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.1967 0.196
Onchocerca volvulus 0.0046 0.1079 0.1485
Echinococcus granulosus hypothetical protein 0.0046 0.1079 0.1071
Entamoeba histolytica ras-1, putative 0.0298 1 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.2421 0.858
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.1079 0.1071
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.1079 0.2957
Onchocerca volvulus 0.0046 0.1079 0.1485
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.2421 0.3101
Brugia malayi putative neuropeptide receptor 0.0046 0.1079 0.1079
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0071 0.1967 0.1967
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0744 0.9977
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0071 0.1967 0.196
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1079 0.1071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1079 0.2957
Brugia malayi conserved hypotetical protein 0.0034 0.0631 0.0631
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0631 0.0622
Loa Loa (eye worm) hypothetical protein 0.002 0.0164 0.0154
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0011 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0744 0.9977
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.1967 0.1967
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0309 0.406
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622
Mycobacterium ulcerans beta-lactamase 0.0037 0.0744 1
Brugia malayi hypothetical protein 0.0034 0.0631 0.0631
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0631 0.0631
Schistosoma mansoni opsin-like receptor 0.0046 0.1079 0.2957
Onchocerca volvulus 0.0071 0.1967 0.3453
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.1079 0.1071
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0631 0.0631
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.0774 0.0765
Echinococcus granulosus ras gtpase 0.0298 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0745 0.0945
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.1079 0.2957
Schistosoma mansoni steroid hormone receptor ad4bp 0.0071 0.1967 0.5412
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0631 0.0622
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0631 0.1717
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Brugia malayi hypothetical protein 0.0046 0.1079 0.1079
Leishmania major hypothetical protein, conserved 0.0025 0.0309 0.406
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.1079 0.1079
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.1967 0.1967
Loa Loa (eye worm) hypothetical protein 0.002 0.0164 0.0154
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0309 0.406
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0744 0.203
Trichomonas vaginalis ral, putative 0.0298 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.1079 0.1071
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0164 0.2083
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.1079 0.2957
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.1079 0.1071
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0071 0.1967 0.5412
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.1079 0.1071
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0631 0.0491
Loa Loa (eye worm) DR-78 0.0034 0.0631 0.0622
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0071 0.1967 0.196
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0744 0.0943
Loa Loa (eye worm) hypothetical protein 0.0027 0.0409 0.04
Echinococcus granulosus orexin receptor type 2 0.0046 0.1079 0.1071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0071 0.1967 0.196
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.1079 0.2957
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Schistosoma mansoni neuropeptide receptor 0.0046 0.1079 0.2957
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0071 0.1967 0.196
Loa Loa (eye worm) hypothetical protein 0.0071 0.1967 0.196
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Schistosoma mansoni hypothetical protein 0.0046 0.1079 0.2957
Schistosoma mansoni hypothetical protein 0.0046 0.1079 0.2957
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.1079 0.1071
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.1079 0.1071
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.1079 0.1079
Echinococcus multilocularis FTZ F1 alpha 0.0071 0.1967 0.196
Brugia malayi nuclear receptor NHR-67 0.0034 0.0631 0.0631
Echinococcus granulosus muscleblind protein 0.0146 0.4603 0.4598
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.1079 0.2957
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0744 0.0943
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0071 0.1967 0.5412
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.1079 0.1071
Brugia malayi AKH receptor 0.0046 0.1079 0.1079
Mycobacterium ulcerans hypothetical protein 0.0037 0.0744 1
Brugia malayi nuclear receptor NHR-88 0.0034 0.0631 0.0631
Brugia malayi nuclear receptor RXR 0.0034 0.0631 0.0631
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.1079 0.1079
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0631 0.1717
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0409 0.0513
Loa Loa (eye worm) hypothetical protein 0.002 0.0164 0.0154
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622
Brugia malayi Muscleblind-like protein 0.0146 0.4603 0.4603
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0631 0.0622
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1019 0.2791
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.1079 0.2957
Toxoplasma gondii ABC1 family protein 0.0037 0.0744 0.9977
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Schistosoma mansoni adenoreceptor 0.0046 0.1079 0.2957
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0774 0.0774
Loa Loa (eye worm) hypothetical protein 0.0038 0.0774 0.0765
Brugia malayi ecdysteroid receptor 0.0071 0.1967 0.1967
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0037 0.0744 0.0735
Schistosoma mansoni nuclear receptor 0.0034 0.0631 0.1717
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0309 0.406
Brugia malayi hypothetical protein 0.0046 0.1079 0.1079
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.1079 0.1071
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0631 0.0631
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.1079 0.1071
Echinococcus granulosus neuropeptide receptor 0.0046 0.1079 0.1071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0071 0.1967 0.196
Brugia malayi RE15519p 0.0046 0.1079 0.1079
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0744 0.0744
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.1079 0.1071
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0001
Schistosoma mansoni coup transcription factor 0.0071 0.1967 0.5412
Echinococcus granulosus g protein coupled receptor 0.0046 0.1079 0.1071
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.1079 0.1071
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.1079 0.1071
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0309 0.406
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.1079 0.1071
Plasmodium vivax glutathione reductase, putative 0.0037 0.0745 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1079 0.1071
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.1079 0.1071
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0631 0.0622
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0071 0.1967 0.196
Loa Loa (eye worm) hypothetical protein 0.0071 0.1967 0.196
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0309 0.406
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.1079 0.1079
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0744 0.0735
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.1079 0.1485
Echinococcus multilocularis fmrfamide receptor 0.0046 0.1079 0.1071
Echinococcus granulosus g protein coupled receptor 0.0046 0.1079 0.1071
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.1079 0.1079
Loa Loa (eye worm) hypothetical protein 0.0071 0.1967 0.196
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.1079 0.1071
Loa Loa (eye worm) hypothetical protein 0.0034 0.0631 0.0622

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 2 ug ml-1 Minimum inhibitory concentration required for antiviral activity to reduce Cytomegalovirus (CMV) (AD-169) induced cytopathicity in human embryonic lung cells (HEL) ChEMBL. 8176708
MIC (functional) = 2 ug ml-1 Minimum inhibitory concentration to reduce cytopathicity by 50% in proliferation of human embryonic lung cells (HEL) ChEMBL. 8176708
MIC (functional) = 4 ug ml-1 Minimum inhibitory concentration required for antiviral activity to reduce TK Varicella Zoster virus (VZV) (07/1) induced cytopathicity in human embryonic lung cells (HEL) ChEMBL. 8176708
MIC (functional) = 4 ug ml-1 Minimum inhibitory concentration required for antiviral activity to reduce Cytomegalovirus (CMV) (Davis) induced cytopathicity in human embryonic lung cells (HEL) ChEMBL. 8176708
MIC (functional) > 4 ug ml-1 Minimum inhibitory concentration required for antiviral activity to reduce Respiratory syncytial virus (RSV) (Long) induced cytopathicity in human carcinoma cells (HeLa) ChEMBL. 8176708
MIC (functional) = 4 ug ml-1 Minimum inhibitory concentration to reduce cytopathicity by 50% in morphology of human carcinoma cells (HeLa) ChEMBL. 8176708
MIC (functional) = 7 ug ml-1 Minimum inhibitory concentration required for antiviral activity to reduce Varicella Zoster virus (VZV) (Oka) induced cytopathicity in human embryonic lung cells (HEL) ChEMBL. 8176708

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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