Detailed information for compound 186093

Basic information

Technical information
  • TDR Targets ID: 186093
  • Name: N-(3-phenoxyphenyl)-7-sulfanylheptanamide
  • MW: 329.456 | Formula: C19H23NO2S
  • H donors: 1 H acceptors: 1 LogP: 4.46 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: SCCCCCCC(=O)Nc1cccc(c1)Oc1ccccc1
  • InChi: 1S/C19H23NO2S/c21-19(13-6-1-2-7-14-23)20-16-9-8-12-18(15-16)22-17-10-4-3-5-11-17/h3-5,8-12,15,23H,1-2,6-7,13-14H2,(H,20,21)
  • InChiKey: ROYJJMKEQBVKFP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-phenoxyphenyl)-7-sulfanyl-heptanamide
  • 7-mercapto-N-(3-phenoxyphenyl)heptanamide
  • 7-mercapto-N-(3-phenoxyphenyl)enanthamide
  • N-[3-(phenoxy)phenyl]-7-sulfanylheptanamide
  • N-[3-(phenoxy)phenyl]-7-sulfanyl-heptanamide
  • 7-mercapto-N-[3-(phenoxy)phenyl]heptanamide
  • 7-mercapto-N-[3-(phenoxy)phenyl]enanthamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0183 0.0691 0.0655
Plasmodium vivax casein kinase II beta chain, putative 0.0444 0.1982 0.1951
Trichomonas vaginalis protein kinase ck2-beta, putative 0.013 0.0428 0.0322
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0256 0.105 0.1015
Plasmodium vivax glycogen synthase kinase 3, putative 0.007 0.0134 0.0096
Echinococcus multilocularis cyclin dependent kinase 0.0065 0.011 0.0072
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0074 0.0153 0.0044
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Toxoplasma gondii CMGC kinase, CK2 family 0.2067 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0256 0.105 0.0951
Loa Loa (eye worm) Csnk2b protein 0.0444 0.1982 0.1982
Echinococcus multilocularis dual specificity 0.0256 0.105 0.1015
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0065 0.011 0.0072
Echinococcus granulosus death associated protein kinase 1 0.0679 0.3143 0.3117
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.007 0.0134 0.0096
Echinococcus multilocularis dual specificity 0.0225 0.0896 0.0861
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0444 0.1982 0.1951
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0256 0.105 0.1015
Schistosoma mansoni serine/threonine protein kinase 0.0183 0.0691 0.0655
Trypanosoma cruzi casein kinase II, putative 0.2067 1 1
Trichomonas vaginalis protein kinase ck2-beta, putative 0.013 0.0428 0.0322
Echinococcus multilocularis death associated protein kinase 1 0.0946 0.446 0.4439
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0444 0.1982 1
Plasmodium falciparum casein kinase II beta chain 0.0444 0.1982 0.1951
Trypanosoma brucei protein kinase, putative 0.007 0.0134 0.0096
Giardia lamblia Kinase, CMGC GSK 0.007 0.0134 0.0025
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0079 0.0179 0.0141
Schistosoma mansoni casein kinase II beta subunit 0.0444 0.1982 0.1951
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.011 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.2067 1 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0225 0.0896 0.0896
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0079 0.0179 0.0141
Trichomonas vaginalis CMGC family protein kinase 0.2067 1 1
Trichomonas vaginalis CMGC family protein kinase 0.2067 1 1
Trichomonas vaginalis CMGC family protein kinase 0.007 0.0134 0.0025
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0444 0.1982 0.1951
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.007 0.0134 0.0096
Loa Loa (eye worm) histone deacetylase 7A 0.0051 0.0039 0.0039
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0065 0.011 0.0072
Loa Loa (eye worm) hypothetical protein 0.0202 0.0786 0.0786
Trypanosoma brucei cdc2-related kinase 1 0.0065 0.011 0.0072
Entamoeba histolytica protein kinase domain containing protein 0.2067 1 1
Brugia malayi casein kinase II, putaitve 0.013 0.0428 0.0391
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Echinococcus granulosus homeodomain interacting protein kinase 3 0.077 0.3589 0.3564
Entamoeba histolytica casein kinase, putative 0.2067 1 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0225 0.0896 0.0861
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.007 0.0134 0.0096
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Toxoplasma gondii ck2 beta subunit 0.0444 0.1982 0.1951
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0134 0.0025
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.077 0.3589 0.3589
Echinococcus multilocularis casein kinase ii subunit alpha 0.2067 1 1
Entamoeba histolytica protein kinase, putative 0.007 0.0134 0.0025
Giardia lamblia Casein kinase II beta chain 0.0444 0.1982 0.1893
Echinococcus granulosus casein kinase ii subunit beta 0.0444 0.1982 0.1951
Brugia malayi intracellular kinase 0.007 0.0134 0.0096
Giardia lamblia Kinase, CMGC CK2 0.2067 1 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.007 0.0134 0.0134
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0444 0.1982 0.1951
Trypanosoma cruzi cdc2-related kinase 3 0.0065 0.011 0.0072
Entamoeba histolytica protein kinase, putative 0.0225 0.0896 0.0795
Echinococcus granulosus dual specificity 0.0256 0.105 0.1015
Echinococcus multilocularis dual specificity 0.0256 0.105 0.1015
Trichomonas vaginalis CMGC family protein kinase 0.0256 0.105 0.0951
Brugia malayi Protein kinase domain containing protein 0.0183 0.0691 0.0655
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0444 0.1982 1
Trypanosoma cruzi cdc2-related kinase 1 0.0065 0.011 0.0072
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.007 0.0134 0.0096
Plasmodium vivax protein kinase Crk2 0.0065 0.011 0.0072
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Echinococcus multilocularis cyclin dependent kinase 1 0.0065 0.011 0.0072
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0065 0.011 0.011
Brugia malayi Protein kinase domain containing protein 0.0225 0.0896 0.0861
Echinococcus granulosus casein kinase ii subunit alpha 0.2067 1 1
Trypanosoma cruzi cdc2-related kinase 3 0.0065 0.011 0.0072
Loa Loa (eye worm) hypothetical protein 0.0051 0.0039 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.105 0.1015
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.2067 1 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0183 0.0691 0.0655
Echinococcus granulosus cyclin dependent kinase 5 0.0065 0.011 0.0072
Entamoeba histolytica protein kinase domain containing protein 0.0256 0.105 0.0951
Echinococcus granulosus cyclin dependent kinase 0.0065 0.011 0.0072
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.2067 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0079 0.0179 0.0141
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0074 0.0153 0.0044
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0183 0.0691 0.3014
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.0215 0.0177
Giardia lamblia Kinase, CMGC DYRK 0.0256 0.105 0.0951
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Echinococcus granulosus dual specificity 0.0256 0.105 0.1015
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0225 0.0896 0.0861
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0065 0.011 0.0072
Brugia malayi Csnk2b protein 0.0444 0.1982 0.1951
Echinococcus granulosus cyclin dependent kinase 1 0.0065 0.011 0.0072
Echinococcus multilocularis protein kinase shaggy 0.007 0.0134 0.0096
Echinococcus granulosus protein kinase shaggy 0.007 0.0134 0.0096
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0256 0.105 0.105
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0134 0.0025
Plasmodium falciparum casein kinase 2, alpha subunit 0.2067 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0183 0.0691 0.0655
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0444 0.1982 0.1951
Echinococcus multilocularis dual specificity 0.0256 0.105 0.1015
Trichomonas vaginalis CMGC family protein kinase 0.0256 0.105 0.0951
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.011 0.0072
Plasmodium falciparum glycogen synthase kinase 3 0.007 0.0134 0.0096
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.077 0.3589 0.3564
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0065 0.011 0.011
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Trichomonas vaginalis CMGC family protein kinase 0.2067 1 1
Trypanosoma cruzi cdc2-related kinase 1 0.0065 0.011 0.0072
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Brugia malayi cell division control protein 2 homolog 0.0065 0.011 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0256 0.105 0.0951
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0256 0.105 0.1015
Echinococcus granulosus glycogen synthase kinase 3 beta 0.007 0.0134 0.0096
Plasmodium vivax unspecified product 0.2067 1 1
Leishmania major casein kinase II, putative 0.2067 1 1
Schistosoma mansoni serine/threonine protein kinase 0.077 0.3589 0.3564
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0079 0.0179 0.0179
Trichomonas vaginalis CMGC family protein kinase 0.2067 1 1
Trichomonas vaginalis CMGC family protein kinase 0.2067 1 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.007 0.0134 0.0134
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0065 0.011 0.011
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.007 0.0134 0.0096
Entamoeba histolytica protein kinase domain containing protein 0.077 0.3589 0.3518
Entamoeba histolytica protein kinase domain containing protein 0.0225 0.0896 0.0795
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0065 0.011 0.0072
Giardia lamblia Kinase, CMGC GSK 0.007 0.0134 0.0025
Trypanosoma brucei Casein kinase II 0.2067 1 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0183 0.0691 0.0691
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Schistosoma mansoni protein kinase 0.2067 1 1
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.013 0.0428 0.0322
Loa Loa (eye worm) hypothetical protein 0.0069 0.0127 0.0127
Echinococcus multilocularis cyclin dependent kinase 1 0.0065 0.011 0.0072
Echinococcus multilocularis cyclin dependent kinase 5 0.0065 0.011 0.0072
Loa Loa (eye worm) histone deacetylase 0.0051 0.0039 0.0039
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0225 0.0896 0.0861
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0444 0.1982 0.1893
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.0896 0.0861
Trichomonas vaginalis CMGC family protein kinase 0.2067 1 1
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0444 0.1982 0.1951
Entamoeba histolytica protein kinase, putative 0.0256 0.105 0.0951
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0256 0.105 0.1015
Echinococcus multilocularis casein kinase ii subunit beta 0.0444 0.1982 0.1951
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0183 0.0691 0.0691
Plasmodium vivax casein kinase II beta chain, putative 0.0444 0.1982 0.1951
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Brugia malayi Protein kinase domain containing protein 0.0065 0.011 0.0072
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.0215 0.0177
Trypanosoma brucei cdc2-related kinase 3 0.0065 0.011 0.0072
Plasmodium falciparum protein kinase 5 0.0065 0.011 0.0072
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0444 0.1982 0.1893
Trichomonas vaginalis CMGC family protein kinase 0.0256 0.105 0.0951
Trichomonas vaginalis casein kinase II beta chain, putative 0.013 0.0428 0.0322
Brugia malayi Homeodomain interacting protein kinase protein 1 0.077 0.3589 0.3564
Trichomonas vaginalis CMGC family protein kinase 0.0256 0.105 0.0951
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0444 0.1982 0.1893
Entamoeba histolytica hypothetical protein 0.0225 0.0896 0.0795
Loa Loa (eye worm) casein kinase II 0.013 0.0428 0.0428
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.013 0.0428 0.0322
Giardia lamblia Casein kinase II beta chain 0.013 0.0428 0.0322
Loa Loa (eye worm) hypothetical protein 0.0202 0.0786 0.0786
Echinococcus granulosus dual specificity 0.0256 0.105 0.1015
Plasmodium falciparum casein kinase II beta chain 0.0444 0.1982 0.1951
Entamoeba histolytica protein kinase, putative 0.0225 0.0896 0.0795
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0256 0.105 0.1015
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0225 0.0896 0.0861
Trichomonas vaginalis CMGC family protein kinase 0.007 0.0134 0.0025
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Loa Loa (eye worm) hypothetical protein 0.0051 0.0039 0.0039
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Trichomonas vaginalis casein kinase II beta chain, putative 0.0444 0.1982 0.1893
Echinococcus granulosus dual specificity 0.0225 0.0896 0.0861

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.21 uM In vitro inhibitory activity against human histone deacetylase (HDAC) using HeLa nuclear extract ChEMBL. 15149697
IC50 (binding) = 0.21 uM Inhibitory concentration against human histone deacetylase ChEMBL. 15715470
IC50 (binding) = 0.21 uM In vitro inhibitory activity against human histone deacetylase (HDAC) using HeLa nuclear extract ChEMBL. 15149697
IC50 (binding) = 0.21 uM Inhibitory concentration against human histone deacetylase ChEMBL. 15715470

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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