TDR Targets

Basic information

Technical information

TDR Targets ID: 1864251
Name: N'-[N'-(4-chlorophenyl)carbamimidoyl]-1-hexox ymethanimidamide
MW: 296.796 | Formula: C14H21ClN4O
H donors: 2 H acceptors: 0 LogP: 4.25 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCOC(=N)NC(=N)Nc1ccc(cc1)Cl
InChi: 1S/C14H21ClN4O/c1-2-3-4-5-10-20-14(17)19-13(16)18-12-8-6-11(15)7-9-12/h6-9H,2-5,10H2,1H3,(H4,16,17,18,19)
InChiKey: WPQZAJDHHUODKE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N'-[N'-(4-chlorophenyl)carbamimidoyl]-1-hexoxy-formamidine
N'-[amino-(4-chlorophenyl)iminomethyl]-1-hexoxyformamidine
N'-[N'-(4-chlorophenyl)carbamimidoyl]-1-hexoxy-methanimidamide
69232-15-1
NSC333325

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.017	0.2813	0.2902
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.017	0.2813	0.8244
Brugia malayi	beta-lactamase family protein	0.0031	0.0147	0.0367
Trypanosoma cruzi	small ubiquitin protein, putative	0.0028	0.0095	0.1329
Plasmodium vivax	metacaspase 1, putative	0.0024	0.0023	0.0279
Schistosoma mansoni	hypothetical protein	0.0029	0.0116	0.0405
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0053	0.0584	0.2445
Echinococcus granulosus	survival motor neuron protein 1	0.0201	0.3407	0.3392
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.017	0.2813	0.2902
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0527	0.9637	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0067	0.0833	1
Brugia malayi	hypothetical protein	0.0201	0.3407	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.1093	0.3163
Schistosoma mansoni	hypothetical protein	0.0144	0.2317	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0147	0.0367
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0124	0.1925	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0147	0.0367
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0053	0.0584	0.2445
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0031	0.0147	0.0367
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0052	0.0564	0.0563
Onchocerca volvulus		0.0031	0.0147	0.0445
Echinococcus multilocularis	survival motor neuron protein 1	0.0201	0.3407	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.1093	0.3163
Brugia malayi	Probable ClpP-like protease	0.0067	0.0833	0.2395
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.017	0.2813	0.8244
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.1925	0.5622
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.017	0.2813	0.2848
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0024	0.0023	0.0279
Schistosoma mansoni	hypothetical protein	0.0041	0.0346	0.1408
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0067	0.0833	1
Plasmodium vivax	hypothetical protein, conserved	0.0024	0.0023	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0147	0.0367
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.017	0.2813	1
Loa Loa (eye worm)	SMO-1 protein	0.0028	0.0095	0.0212
Toxoplasma gondii	small ubiquitin family modifier, putative	0.0028	0.0095	0.1141
Trichomonas vaginalis	esterase, putative	0.0031	0.0147	0.0129
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0124	0.1925	0.5622
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0067	0.0833	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0053	0.0584	0.1658
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0053	0.0584	0.1658
Leishmania major	hypothetical protein, conserved	0.0052	0.0564	1
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0052	0.0564	1
Leishmania major	small ubiquitin protein, putative	0.0028	0.0095	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0201	0.3407	1
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0024	0.0023	0.0279
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0095	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0833	0.2395
Echinococcus granulosus	geminin	0.0144	0.2317	0.2299
Schistosoma mansoni	hypothetical protein	0.0144	0.2317	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0067	0.0833	0.3532
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0052	0.0564	0.0563
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.0527	0.9637	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0053	0.0584	0.1658
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0067	0.0833	0.2395
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.017	0.2813	0.2902
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0833	0.5
Echinococcus multilocularis	geminin	0.0144	0.2317	0.6779
Trypanosoma cruzi	hypothetical protein, conserved	0.0052	0.0564	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0052	0.0564	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0042	0.0372	0.1032
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0147	0.1768
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0833	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0147	0.0367
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0124	0.1925	0.1907
Brugia malayi	latrophilin 2 splice variant baaae	0.0029	0.0116	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0116	0.0274
Schistosoma mansoni	eyes absent homolog	0.008	0.1093	0.4665
Schistosoma mansoni	ubiquitin-like protein sumo/smt3-related	0.0028	0.0095	0.0313
Leishmania major	hypothetical protein, conserved	0.0031	0.0147	0.2295
Echinococcus granulosus	Small ubiquitin modifier 2	0.0028	0.0095	0.0072
Brugia malayi	Ubiquitin-like protein SMT3	0.0028	0.0095	0.0212
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0044	0.0395	0.11
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0042	0.0372	0.1032
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.1925	0.5622
Trichomonas vaginalis	penicillin-binding protein, putative	0.0031	0.0147	0.0129
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0833	0.2574
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0147	0.2295
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.017	0.2813	0.2902
Plasmodium falciparum	metacaspase 1	0.0024	0.0023	0.0279
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0044	0.0395	0.0786
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0053	0.0584	0.0562
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0042	0.0372	0.1032
Trichomonas vaginalis	D-aminoacylase, putative	0.0031	0.0147	0.0129
Plasmodium falciparum	metacaspase-like protein	0.0024	0.0023	0.0279
Plasmodium falciparum	small ubiquitin-related modifier	0.0028	0.0095	0.1141
Echinococcus granulosus	peptidase Clp S14 family	0.0044	0.0395	0.0373
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0067	0.0833	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0147	0.0367
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0031	0.0147	0.0367
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0041	0.0346	0.0954
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0147	0.2295
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0067	0.0833	0.0812
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0044	0.0395	0.4744
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0044	0.0395	0.0786
Brugia malayi	jmjC domain containing protein	0.0053	0.0584	0.1658
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0833	1
Trypanosoma brucei	hypothetical protein, conserved	0.0031	0.0147	0.2295
Brugia malayi	hypothetical protein	0.008	0.1093	0.3163
Onchocerca volvulus		0.0031	0.0147	0.0445
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0833	0.2574
Brugia malayi	beta-lactamase family protein	0.0031	0.0147	0.0367
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0196	0.3302	1
Onchocerca volvulus		0.017	0.2813	1
Mycobacterium leprae	conserved hypothetical protein	0.0031	0.0147	0.1768
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0031	0.0147	0.0541
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0833	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.017	0.2813	0.2848
Echinococcus multilocularis	Small ubiquitin modifier 2	0.0028	0.0095	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0147	0.0367
Mycobacterium leprae	Probable lipase LipE	0.0031	0.0147	0.1768
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0124	0.1925	0.8292
Onchocerca volvulus		0.0041	0.0346	0.1158
Schistosoma mansoni	jumonji domain containing protein	0.0053	0.0584	0.2445
Onchocerca volvulus		0.0031	0.0147	0.0445
Plasmodium vivax	small ubiquitin-related modifier, putative	0.0028	0.0095	0.1141
Trichomonas vaginalis	D-aminoacylase, putative	0.0031	0.0147	0.0129
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0833	0.5
Trypanosoma cruzi	small ubiquitin protein, putative	0.0028	0.0095	0.1329
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.017	0.2813	0.2902
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0024	0.0023	0.0279
Echinococcus granulosus	beta LACTamase domain containing family member	0.0031	0.0147	0.0124
Toxoplasma gondii	ABC1 family protein	0.0031	0.0147	0.1768
Echinococcus granulosus	lysine specific demethylase 5A	0.0053	0.0584	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0372	0.1032
Trichomonas vaginalis	D-aminoacylase, putative	0.0031	0.0147	0.0129
Brugia malayi	jmjC domain containing protein	0.0053	0.0584	0.1658
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0031	0.0147	0.0367
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.017	0.2813	0.2902
Loa Loa (eye worm)	beta-lactamase	0.0031	0.0147	0.0367
Schistosoma mansoni	survival motor neuron protein	0.0041	0.0346	0.1408
Brugia malayi	beta-lactamase	0.0031	0.0147	0.0367
Trypanosoma brucei	small ubiquitin-related modifier	0.0028	0.0095	0.1329
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.017	0.2813	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0031	0.0147	0.0541
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0124	0.1925	0.5622
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0118	0.1811	0.5273
Trichomonas vaginalis	penicillin-binding protein, putative	0.0031	0.0147	0.0129

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3229010

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1864251