Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0181 | 0.2832 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0131 | 0.1947 | 1 |
Onchocerca volvulus | 0.0181 | 0.2832 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0425 | 0.1501 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.2347 | 1 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.003 | 0.0121 | 0.0251 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0041 | 0.0325 | 0.0674 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0056 | 0.0589 | 0.122 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0325 | 0.0674 |
Giardia lamblia | Sentrin | 0.003 | 0.0121 | 0.0428 |
Leishmania major | ubiquitin-activating enzyme-like protein | 0.0031 | 0.0139 | 0.0288 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0181 | 0.2832 | 0.2938 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0131 | 0.1947 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0181 | 0.2832 | 0.2938 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0325 | 0.0674 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0031 | 0.0139 | 0.0288 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0181 | 0.2832 | 0.2938 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0181 | 0.2832 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0041 | 0.0325 | 0.0674 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0131 | 0.1947 | 0.1947 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0181 | 0.2832 | 0.2938 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0291 | 0.4825 | 1 |
Echinococcus granulosus | sumo-activating enzyme subunit 2 | 0.0031 | 0.0139 | 0.0139 |
Entamoeba histolytica | dual specificity protein phosphatase, putative | 0.056 | 0.9638 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0181 | 0.2832 | 0.2938 |
Echinococcus multilocularis | SUMO activating enzyme subunit 2 | 0.0031 | 0.0139 | 0.0715 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0121 | 0.0126 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0056 | 0.0589 | 0.0611 |
Leishmania major | small ubiquitin protein, putative | 0.003 | 0.0121 | 0.0251 |
Schistosoma mansoni | ubiquitin-activating enzyme E1b | 0.0031 | 0.0139 | 0.0715 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0047 | 0.0425 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0131 | 0.1947 | 0.6874 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0056 | 0.0589 | 0.122 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0291 | 0.4825 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0291 | 0.4825 | 1 |
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0047 | 0.0425 | 1 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0056 | 0.0589 | 0.122 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0486 | 0.1008 |
Schistosoma mansoni | ubiquitin-like protein sumo/smt3-related | 0.003 | 0.0121 | 0.0622 |
Loa Loa (eye worm) | SMO-1 protein | 0.003 | 0.0121 | 0.0428 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0425 | 0.972 |
Plasmodium falciparum | SUMO-activating enzyme subunit 2 | 0.0031 | 0.0139 | 0.0594 |
Trypanosoma cruzi | ubiquitin-activating enzyme, putative | 0.0026 | 0.0062 | 0.0129 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0131 | 0.1947 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0181 | 0.2832 | 0.2938 |
Leishmania major | hypothetical protein, conserved | 0.0056 | 0.0589 | 0.122 |
Trypanosoma cruzi | ubiquitin-activating enzyme, putative | 0.0031 | 0.0139 | 0.0288 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0056 | 0.0589 | 0.0611 |
Trypanosoma brucei | small ubiquitin-related modifier | 0.003 | 0.0121 | 0.0251 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0131 | 0.1947 | 0.6874 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0181 | 0.2832 | 0.2938 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0181 | 0.2832 | 1 |
Brugia malayi | Ubiquitin-like protein SMT3 | 0.003 | 0.0121 | 0.0428 |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0047 | 0.0425 | 0.0425 |
Toxoplasma gondii | ThiF family protein | 0.0031 | 0.0139 | 0.0577 |
Plasmodium vivax | SUMO-activating enzyme subunit 2, putative | 0.0031 | 0.0139 | 0.0594 |
Echinococcus multilocularis | Small ubiquitin modifier 2 | 0.003 | 0.0121 | 0.0622 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0291 | 0.4825 | 1 |
Trichomonas vaginalis | pps1 dual specificty phosphatase, putative | 0.056 | 0.9638 | 1 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0047 | 0.0425 | 0.2183 |
Brugia malayi | ThiF family protein | 0.0031 | 0.0139 | 0.0491 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.2067 | 0.4284 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0131 | 0.1947 | 0.1947 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.2067 | 0.4284 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0047 | 0.0425 | 0.2183 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.003 | 0.0121 | 0.0251 |
Loa Loa (eye worm) | ThiF family protein | 0.0031 | 0.0139 | 0.0491 |
Brugia malayi | ThiF family protein | 0.0047 | 0.0425 | 0.1501 |
Echinococcus granulosus | Small ubiquitin modifier 2 | 0.003 | 0.0121 | 0.0121 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0181 | 0.2832 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0434 | 1 |
Entamoeba histolytica | ubiquitin like protein | 0.003 | 0.0121 | 0.0126 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0138 | 0.2067 | 0.4284 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0042 | 0.0348 | 0.1788 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0181 | 0.2832 | 0.2938 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.