Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0025 | 0.0457 | 0.0603 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0025 | 0.0457 | 0.0603 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0025 | 0.0457 | 0.0603 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0025 | 0.0457 | 0.5 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0066 | 0.3754 | 1 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0066 | 0.3754 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.1769 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0025 | 0.0457 | 1 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0025 | 0.0457 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0457 | 0.0217 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0066 | 0.3754 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0866 | 0.1769 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0066 | 0.3754 | 1 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0066 | 0.3754 | 1 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0066 | 0.3754 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0866 | 0.1769 |
Brugia malayi | protein ZK524.3 | 0.0025 | 0.0457 | 0.0457 |
Brugia malayi | hypothetical protein | 0.003 | 0.0866 | 0.0866 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0025 | 0.0457 | 0.0603 |
Onchocerca volvulus | 0.0041 | 0.1719 | 0.5 | |
Giardia lamblia | Leucyl-tRNA synthetase | 0.0025 | 0.0457 | 0.0603 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0066 | 0.3754 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0457 | 0.0217 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.1769 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0025 | 0.0457 | 1 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0025 | 0.0457 | 0.5 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0041 | 0.1719 | 0.151 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0025 | 0.0457 | 0.0603 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.1769 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0866 | 0.0636 |
Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.0457 | 0.0457 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.1769 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Mycobacterium ulcerans | leucyl-tRNA synthetase | 0.0025 | 0.0457 | 0.0603 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0025 | 0.0457 | 0.0603 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.1769 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0066 | 0.3754 | 0.3597 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0.0457 | 0.0603 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0025 | 0.0457 | 0.0603 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0066 | 0.3754 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0457 | 0.0217 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0066 | 0.3754 | 1 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0025 | 0.0457 | 0.0603 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0066 | 0.3754 | 1 |
Plasmodium falciparum | methionine--tRNA ligase, putative | 0.0025 | 0.0457 | 0.0603 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.1769 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0025 | 0.0457 | 0.0603 |
Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3754 | 0.3754 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3754 | 1 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0066 | 0.3754 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0246 | 0.0246 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0066 | 0.3754 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0066 | 0.3754 | 1 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0066 | 0.3754 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.