TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 356.442 | Formula: C18H20N4O2S
H donors: 1 H acceptors: 3 LogP: 2.5 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCn1c(SC/C(=C(\C(=N)C)/C#N)/O)nc2c(c1=O)cccc2
InChi: 1S/C18H20N4O2S/c1-3-4-9-22-17(24)13-7-5-6-8-15(13)21-18(22)25-11-16(23)14(10-19)12(2)20/h5-8,20,23H,3-4,9,11H2,1-2H3/b16-14+,20-12?
InChiKey: BRJACYJNKWQTLV-JCZQYWQXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0822	0.0822
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0822	0.0822
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0822	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0822	0.0822
Onchocerca volvulus		0.0012	0.0822	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.9547	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.6965	0.6965
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0822	0.0822
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0822	0.5
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0822	0.0822
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0822	0.0822
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.9547	0.9547
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0822	0.0822
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0822	0.0822
Brugia malayi	nuclear hormone receptor	0.0012	0.0822	0.0822
Brugia malayi	steroid hormone receptor	0.0012	0.0822	0.0822
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0822	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0822	0.0822
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0822	0.0822
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0822	0.0822
Brugia malayi	ecdysteroid receptor	0.0012	0.0822	0.0822
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0822	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0822	0.0822
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0822	0.0822
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0822	0.0822
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0822	0.0822
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.9547	0.9547
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0822	0.0822
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0822	0.0822
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0822	0.0822
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0822	0.0822
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0822	0.0822
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0822	0.0822
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.9547	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0822	0.0822
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0822	0.0822
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.6965	0.6965
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.9547	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0822	0.0822
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0822	0.0822
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.9547	0.9547
Schistosoma mansoni	coup transcription factor	0.0012	0.0822	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0822	0.0822
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.9547	0.9547
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0822	0.0822
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0822	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0822	0.0822
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0822	0.0822
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0822	0.0822
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0822	0.0822
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0822	0.0822
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.6965	0.6965
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.6965	0.6965
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.9547	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0076	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0822	0.0822
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0822	0.0822
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0822	0.0822
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0822	0.0822
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0822	0.0822
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0822	0.0822
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0822	0.0822
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0822	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.6965	0.6965
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0822	0.0822
Brugia malayi	TAR-binding protein	0.0076	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0822	0.0822
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.9547	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.6965	0.6965
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0822	0.0822
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0822	0.0822
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0822	0.0822
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.6965	0.6965
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.6965	0.6965
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0822	0.0822
Echinococcus multilocularis	tar DNA binding protein	0.0076	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0822	0.0822
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.9547	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0822	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0822	0.0822
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0822	0.0822
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0822	0.0822
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0822	0.0822
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0822	0.0822
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0822	0.0822
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0822	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0822	0.0822
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0822	0.0822
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.6965	0.6965
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0822	0.0822
Brugia malayi	RNA recognition motif domain containing protein	0.0076	1	1
Echinococcus granulosus	tar DNA binding protein	0.0076	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0822	0.0822
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0822	0.0822
Loa Loa (eye worm)	RNA binding protein	0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0822	0.0822

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.0119 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	5.8584 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3197900

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1877473