Detailed information for compound 187895

Basic information

Technical information
  • TDR Targets ID: 187895
  • Name: N-(5-cyclopropyl-1H-pyrazol-3-yl)-3-(trifluor omethyl)benzamide
  • MW: 295.26 | Formula: C14H12F3N3O
  • H donors: 2 H acceptors: 2 LogP: 2.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)C(F)(F)F)Nc1n[nH]c(c1)C1CC1
  • InChi: 1S/C14H12F3N3O/c15-14(16,17)10-3-1-2-9(6-10)13(21)18-12-7-11(19-20-12)8-4-5-8/h1-3,6-8H,4-5H2,(H2,18,19,20,21)
  • InChiKey: WPMMQMUUPOYKSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-Benzamidoaminopyrazole deriv. 13

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens cyclin A2 References
Homo sapiens cyclin A1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.3844 0.2782
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.3828 0.2764
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.3828 0.2764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.3828 0.2764
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.3828 0.2764
Trypanosoma cruzi cyclin, putative 0.009 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.3828 0.2764
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.3828 0.2764
Trichomonas vaginalis cyclin B, putative 0.009 1 1
Brugia malayi nuclear receptor NHR-88 0.0052 0.3828 0.2764
Loa Loa (eye worm) hypothetical protein 0.0052 0.3828 0.2764
Plasmodium vivax protein kinase Crk2 0.0052 0.3844 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.3753 0.2676
Echinococcus granulosus cyclin dependent kinase 0.0052 0.3844 0.2782
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.3828 0.2764
Loa Loa (eye worm) hypothetical protein 0.0052 0.3828 0.2764
Entamoeba histolytica cyclin, putative 0.009 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.3828 0.2764
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.3828 0.2764
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.3828 0.2764
Echinococcus multilocularis cyclin B 0.009 1 1
Schistosoma mansoni nuclear hormone receptor 0.0052 0.3828 0.2764
Brugia malayi ecdysteroid receptor 0.0052 0.3828 0.2764
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.3828 0.2764
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.3844 0.2782
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.3828 0.2764
Trichomonas vaginalis cyclin B, putative 0.009 1 1
Plasmodium falciparum protein kinase 5 0.0052 0.3844 1
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.3844 0.2782
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.3828 0.2764
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.3828 0.2764
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.3844 0.2782
Trichomonas vaginalis cyclin A, putative 0.009 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.3903 0.2852
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.3844 0.2782
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.3828 0.2764
Schistosoma mansoni coup transcription factor 0.0052 0.3828 0.2764
Brugia malayi cell division control protein 2 homolog 0.0052 0.3844 0.2782
Loa Loa (eye worm) hypothetical protein 0.0052 0.3828 0.2764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.3828 0.2764
Trichomonas vaginalis cyclins, putative 0.009 1 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.3844 0.2782
Schistosoma mansoni thyroid hormone receptor 0.0052 0.3828 0.2764
Schistosoma mansoni thyroid hormone receptor 0.0052 0.3828 0.2764
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.3828 0.2764
Trichomonas vaginalis cyclin B, putative 0.009 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.3828 0.2764
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.3828 0.2764
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 1 1
Loa Loa (eye worm) hypothetical protein 0.009 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.3828 0.2764
Trypanosoma cruzi cyclin, putative 0.009 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.3844 0.2782
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.3828 0.2764
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.3828 0.2764
Trichomonas vaginalis cyclins, putative 0.009 1 1
Giardia lamblia Kinase, CMGC CDK 0.0052 0.3844 0.2782
Loa Loa (eye worm) hypothetical protein 0.0052 0.3828 0.2764
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.3844 0.2782
Schistosoma mansoni cyclin B 0.009 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.3828 0.2764
Giardia lamblia G2/mitotic-specific cyclin B 0.009 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.3828 0.2764
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.3844 0.2782
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.3828 0.2764
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.3828 0.2764
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.3828 0.2764
Echinococcus granulosus FTZ F1 alpha 0.0052 0.3828 0.2764
Brugia malayi steroid hormone receptor 0.0052 0.3828 0.2764
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.3844 0.2782
Loa Loa (eye worm) hypothetical protein 0.009 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.3828 0.2764
Loa Loa (eye worm) hypothetical protein 0.0052 0.3828 0.2764
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.3828 0.2764
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.3844 0.2782
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.3828 0.2764
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.3844 0.2782
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.3828 0.2764
Brugia malayi nuclear hormone receptor 0.0052 0.3828 0.2764
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.3828 0.2764
Giardia lamblia Kinase, CMGC CDK 0.0052 0.3844 0.2782
Trichomonas vaginalis cyclin B, putative 0.009 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.3828 0.2764
Trypanosoma brucei mitotic cyclin 6 0.009 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.3844 0.2782
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.3844 1
Onchocerca volvulus 0.009 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.3844 0.2782
Echinococcus granulosus cyclin B 0.009 1 1
Trichomonas vaginalis cyclins, putative 0.0062 0.5375 0.4577
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.3828 0.2764
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.3828 0.2764
Loa Loa (eye worm) hypothetical protein 0.0052 0.3828 0.2764
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.3844 0.2782
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.3844 0.2782
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.3828 0.2764
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.3828 0.2764
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.3828 0.2764
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.3828 0.2764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.3828 0.2764
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.3828 0.2764
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.3828 0.2764
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.3828 0.2764
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.3828 0.2764
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.3844 0.2782
Trypanosoma cruzi cyclin 6, putative 0.009 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.3828 0.2764
Loa Loa (eye worm) hypothetical protein 0.0052 0.3828 0.2764
Trichomonas vaginalis cyclins, putative 0.009 1 1
Trichomonas vaginalis cyclins, putative 0.009 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.3828 0.2764
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.3828 0.2764
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.3828 0.2764
Loa Loa (eye worm) hypothetical protein 0.0052 0.3828 0.2764
Leishmania major cyclin 0.009 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.3828 0.2764
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.3828 0.2764
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.3844 0.2782

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.301 Inhibition of CDK2/Cyclin A ChEMBL. 18037537
IC50 (binding) = 500 nM In vitro inhibitory concentration against cyclin-dependent kinase 2-cyclin A complex using ATP/P33gamma-ATP mix as radioligand ChEMBL. 15189033
IC50 (binding) = 500 nM In vitro inhibitory concentration against cyclin-dependent kinase 2-cyclin A complex using ATP/P33gamma-ATP mix as radioligand ChEMBL. 15189033
IC50 (binding) = 500 nM Inhibition of CDK2/Cyclin A ChEMBL. 18037537

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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