TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 345.366 | Formula: C17H13F2N3OS
H donors: 2 H acceptors: 2 LogP: 4.43 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)F)c1sc(c(c1)C(=O)N)Nc1cccc(n1)C
InChi: 1S/C17H13F2N3OS/c1-9-3-2-4-15(21-9)22-17-12(16(20)23)8-14(24-17)11-6-5-10(18)7-13(11)19/h2-8H,1H3,(H2,20,23)(H,21,22)
InChiKey: AGPCFCFLRORQFL-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Janus kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	0.019	0.0314
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0008	0.019	0.0314
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0008	0.019	0.04
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1514	0.1479
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.019	0.0149
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0008	0.019	0.04
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0008	0.0212	0.0171
Brugia malayi	Cytochrome P450 family protein	0.0008	0.0228	0.0395
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0008	0.019	0.0314
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0212	0.0446
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0008	0.019	0.0149
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0008	0.019	0.0149
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.019	0.0149
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0025	0.1902	0.1868
Loa Loa (eye worm)	SH2 domain-containing protein	0.0006	0.0042	0.0088
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0008	0.019	0.0149
Schistosoma mansoni	thyroid hormone receptor	0.0008	0.019	0.0149
Onchocerca volvulus		0.0008	0.0212	0.0361
Onchocerca volvulus		0.0025	0.1902	0.3943
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	0.019	0.0314
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0008	0.0212	0.0171
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0025	0.1902	0.1868
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0008	0.019	0.0149
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0212	0.0446
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0008	0.019	0.0149
Brugia malayi	hypothetical protein	0.0008	0.0212	0.0361
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0006	0.0042	0.0088
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0025	0.1902	0.1868
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0025	0.1902	0.1868
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0212	0.0361
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0006	0.0042	0.0088
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0008	0.019	0.04
Brugia malayi	photoreceptor-specific nuclear receptor	0.0008	0.019	0.0314
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0212	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0008	0.019	0.0149
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0008	0.0212	0.0171
Echinococcus granulosus	tyrosine kinase	0.0008	0.0212	0.0171
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0008	0.0212	0.0171
Schistosoma mansoni	tyrosine kinase	0.0008	0.0212	0.0171
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0008	0.019	0.04
Loa Loa (eye worm)	hypothetical protein	0.0021	0.1514	0.3181
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0008	0.0212	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.019	0.04
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0008	0.019	0.0314
Echinococcus multilocularis	tyrosine protein kinase shark	0.0008	0.0212	0.0171
Brugia malayi	SH2 domain containing protein	0.0008	0.0212	0.0361
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0008	0.0212	0.0171
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0008	0.0212	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0008	0.019	0.04
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0008	0.019	0.0149
Schistosoma mansoni	RAR-like nuclear receptor	0.0008	0.019	0.0149
Brugia malayi	Cytochrome P450 family protein	0.0008	0.0228	0.0395
Echinococcus granulosus	p2X purinoceptor 4	0.0106	1	1
Onchocerca volvulus		0.0053	0.4761	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0008	0.019	0.04
Echinococcus multilocularis	p2X purinoceptor 4	0.0106	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0008	0.019	0.0149
Echinococcus granulosus	tyrosine protein kinase Srms	0.0008	0.0212	0.0171
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0006	0.0042	0.0088
Schistosoma mansoni	tyrosine kinase	0.0008	0.0212	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Schistosoma mansoni	P2X receptor subunit	0.0106	1	1
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0212	0.0361
Brugia malayi	protein-tyrosine kinase	0.0008	0.0212	0.0361
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0015	0.0917	1
Schistosoma mansoni	hypothetical protein	0.0053	0.4761	0.4739
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0025	0.1902	0.3943
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0008	0.0212	0.0171
Brugia malayi	Thrombospondin type 1 domain containing protein	0.0053	0.4761	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0008	0.0212	0.0171
Schistosoma mansoni	P2X receptor subunit	0.0106	1	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0008	0.0212	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.019	0.0149
Loa Loa (eye worm)	SH2 domain-containing protein	0.0006	0.0042	0.0088
Schistosoma mansoni	retinoic acid receptor RXR	0.0008	0.019	0.0149
Echinococcus granulosus	c src tyrosine kinase	0.0008	0.0212	0.0171
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.0015	0.0917	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0008	0.019	0.0149
Echinococcus multilocularis	tyrosine kinase	0.0008	0.0212	0.0171
Leishmania major	endonuclease G, putative	0.0015	0.0917	1
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0025	0.1902	0.1868
Onchocerca volvulus		0.0008	0.0212	0.0361
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0212	0.0361
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0008	0.019	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1902	0.3996
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	0.019	0.0314
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0025	0.1902	0.1868
Schistosoma mansoni	tyrosine kinase	0.0008	0.0212	0.0171
Echinococcus granulosus	ectonucleotide	0.0021	0.1514	0.1479
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0212	0.0446
Brugia malayi	Tyrosine-protein kinase abl-1	0.0008	0.0212	0.0361
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0008	0.019	0.0314
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0025	0.1902	0.1868
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0008	0.0212	0.0171
Loa Loa (eye worm)	cytochrome P450 family protein	0.0008	0.0228	0.0479
Brugia malayi	nuclear hormone receptor	0.0008	0.019	0.0314
Echinococcus granulosus	FTZ F1 alpha	0.0008	0.019	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0008	0.019	0.0149
Brugia malayi	Steroid receptor seven-up type 2	0.0008	0.019	0.0314
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0008	0.0212	0.0171
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0008	0.0212	0.0171
Onchocerca volvulus	Protein ultraspiracle homolog	0.0008	0.019	0.0314
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0008	0.0212	0.0171
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0212	0.0446
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0008	0.019	0.0149
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0008	0.0212	0.0171
Loa Loa (eye worm)	TK protein kinase	0.0008	0.0212	0.0446
Echinococcus granulosus	tyrosine protein kinase shark	0.0008	0.0212	0.0171
Schistosoma mansoni	P2X receptor subunit	0.0106	1	1
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.0015	0.0917	0.5
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1514	0.1479
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0008	0.0212	0.0171
Brugia malayi	ecdysteroid receptor	0.0008	0.019	0.0314
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0008	0.0212	0.0171
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0008	0.0212	0.0171
Loa Loa (eye worm)	CYP4Cod1	0.0008	0.0228	0.0479
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0212	0.0446
Onchocerca volvulus		0.0008	0.019	0.0314
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0008	0.0228	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0008	0.0212	0.0171
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0008	0.019	0.04
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0025	0.1902	0.1868
Onchocerca volvulus		0.0008	0.0212	0.0361
Onchocerca volvulus		0.0008	0.0212	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1902	0.3996
Echinococcus granulosus	Endonuclease G	0.0015	0.0917	0.0879
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0006	0.0042	0.0088
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0008	0.0212	0.0171
Trypanosoma cruzi	endonuclease G, putative	0.0015	0.0917	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Echinococcus multilocularis	ecdysone induced protein 78C	0.0008	0.019	0.0149
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0008	0.019	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0008	0.019	0.04
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0025	0.1902	0.1868
Brugia malayi	SH2 domain containing protein	0.0008	0.0212	0.0361
Loa Loa (eye worm)	SH2 domain-containing protein	0.0006	0.0042	0.0088
Schistosoma mansoni	tyrosine kinase	0.0008	0.0212	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0212	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0008	0.019	0.04
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0212	0.0446
Echinococcus granulosus	ecdysone induced protein 78C	0.0008	0.019	0.0149
Schistosoma mansoni	P2X receptor subunit	0.0106	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	0.019	0.0314
Schistosoma mansoni	thyroid hormone receptor	0.0008	0.019	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Echinococcus multilocularis	p2X purinoceptor 4	0.0106	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1902	0.3996
Brugia malayi	SRC-1	0.0008	0.0212	0.0361
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.0053	0.4761	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0008	0.019	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Schistosoma mansoni	endonuclease related	0.0015	0.0917	0.0879
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0008	0.019	0.0314
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	0.019	0.0314
Echinococcus granulosus	tyrosine protein kinase Blk	0.0008	0.0212	0.0171
Schistosoma mansoni	tyrosine kinase	0.0008	0.0212	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0008	0.019	0.04
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Trypanosoma cruzi	endonuclease G, putative	0.0015	0.0917	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0212	0.0446
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0015	0.0917	1
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0025	0.1902	0.1868
Echinococcus granulosus	p2X purinoceptor 4	0.0106	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0008	0.0212	0.0171
Onchocerca volvulus		0.0025	0.1902	0.3943
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0008	0.0212	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0008	0.019	0.04
Loa Loa (eye worm)	cytochrome P450 family protein	0.0008	0.0228	0.0479
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0008	0.0212	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0008	0.019	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0008	0.019	0.04
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0008	0.0212	0.0171
Echinococcus multilocularis	p2X purinoceptor 4	0.0106	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.019	0.0149
Brugia malayi	nuclear receptor NHR-88	0.0008	0.019	0.0314
Trypanosoma brucei	endonuclease G, putative	0.0015	0.0917	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0008	0.019	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Loa Loa (eye worm)	TK/ABL protein kinase	0.0008	0.0212	0.0446
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0025	0.1902	0.1868
Onchocerca volvulus		0.0008	0.0212	0.0361
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0212	0.0361
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0008	0.0212	0.0171
Echinococcus multilocularis	Endonuclease G	0.0015	0.0917	0.0879
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0212	0.0446
Echinococcus multilocularis	FTZ F1 alpha	0.0008	0.019	0.0149
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0008	0.0212	0.0171
Loa Loa (eye worm)	steroid hormone receptor	0.0008	0.019	0.04
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0008	0.019	0.0314
Loa Loa (eye worm)	STAT protein	0.0006	0.0042	0.0088
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0025	0.1902	0.1868
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0025	0.1902	0.1868
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0212	0.0446
Schistosoma mansoni	tyrosine kinase	0.0008	0.0212	0.0171
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0008	0.0212	0.0171
Onchocerca volvulus	Bile acid receptor homolog	0.0008	0.019	0.0314
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	0.019	0.0314
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0025	0.1902	0.1868
Brugia malayi	steroid hormone receptor	0.0008	0.019	0.0314
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0008	0.019	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0006	0.0042	0.0088
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0008	0.0212	0.0171
Trypanosoma brucei	endonuclease G, putative	0.0015	0.0917	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0008	0.0212	0.0171
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0008	0.0212	0.0171
Echinococcus multilocularis	ectonucleotide	0.0021	0.1514	0.1479
Trypanosoma brucei	endonuclease G, putative	0.0015	0.0917	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	0.019	0.0314
Echinococcus multilocularis	c src tyrosine kinase	0.0008	0.0212	0.0171
Brugia malayi	endonuclease G, mitochondrial precursor	0.0015	0.0917	0.1855
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0008	0.019	0.0149
Onchocerca volvulus		0.0008	0.0212	0.0361
Loa Loa (eye worm)	SRC-1	0.0008	0.0212	0.0446
Schistosoma mansoni	coup transcription factor	0.0008	0.019	0.0149
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0008	0.019	0.04
Schistosoma mansoni	nuclear hormone receptor	0.0008	0.019	0.0149
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0025	0.1902	0.1868
Echinococcus granulosus	tyrosine kinase	0.0008	0.0212	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0042	0.0088
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0212	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0008	0.019	0.04
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0042	0.0088
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0008	0.019	0.0149

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 178 nM	Inhibition of JAK2 (unknown origin)	ChEMBL.	24666646
T1/2 (ADMET)	= 24 min	Half life in human liver microsomes	ChEMBL.	24666646

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3234880

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1884482