Detailed information for compound 188813

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 398.972 | Formula: C23H31ClN4
  • H donors: 0 H acceptors: 2 LogP: 6.27 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(c1cc(C)nc2c1n(C)nc2c1ccc(cc1Cl)C)CCCC
  • InChi: 1S/C23H31ClN4/c1-6-8-12-28(13-9-7-2)20-15-17(4)25-22-21(26-27(5)23(20)22)18-11-10-16(3)14-19(18)24/h10-11,14-15H,6-9,12-13H2,1-5H3
  • InChiKey: HFQZKJFJAWMKRL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 1 444 aa 445 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0175 0.6163 0.6138
Schistosoma mansoni DNA helicase recq5 0.0025 0.0474 0.0681
Trypanosoma brucei unspecified product 0.003 0.0643 0.2307
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.1154 0.1147
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0138 0.4765 0.8837
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0063 0.00000000040084
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0138 0.4765 0.8837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0306 0.1063
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0015 0.0063 0.025
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.1154 0.1313
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0084 0.2725 1
Echinococcus multilocularis fatty acid binding protein FABP2 0.0032 0.0717 0.0786
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0594 0.0588
Loa Loa (eye worm) flap endonuclease-1 0.0033 0.0777 0.0718
Brugia malayi Protein cec-1. 0.0015 0.0063 0.0056
Brugia malayi Muscleblind-like protein 0.0104 0.3464 0.3459
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0033 0.0777 0.2802
Brugia malayi TAR-binding protein 0.0038 0.0956 0.095
Schistosoma mansoni tar DNA-binding protein 0.0038 0.0956 0.1386
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0084 0.2725 1
Echinococcus granulosus GPCR family 2 0.0029 0.0594 0.0639
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0063 0.00000000056746
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0306 0.1063
Leishmania major trypanothione reductase 0.006 0.1812 0.6628
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1315 0.4789
Plasmodium falciparum glutathione reductase 0.0021 0.0306 0.1604
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0306 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0063 0.00000000056746
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0021 0.0306 0.1184
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0474 0.2613
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0015 0.0063 0.00000000047954
Echinococcus multilocularis PHD finger protein rhinoceros 0.0037 0.0929 0.1042
Loa Loa (eye worm) hypothetical protein 0.0029 0.0594 0.0534
Plasmodium falciparum thioredoxin reductase 0.0021 0.0306 0.1604
Echinococcus multilocularis transcription factor Dp 1 0.0049 0.137 0.1573
Loa Loa (eye worm) RNA binding protein 0.0038 0.0956 0.0899
Loa Loa (eye worm) glutathione reductase 0.006 0.1812 0.176
Schistosoma mansoni hypothetical protein 0.0037 0.0929 0.1345
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0077 0.245 0.34
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.0306 0.1604
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0063 0.00000000056746
Brugia malayi glutathione reductase 0.006 0.1812 0.1806
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.245 0.8983
Trichomonas vaginalis chromobox protein, putative 0.0054 0.1556 0.2126
Plasmodium falciparum flap endonuclease 1 0.0033 0.0777 0.4228
Echinococcus granulosus chromobox protein 1 0.0089 0.2903 0.3419
Schistosoma mansoni hypothetical protein 0.0015 0.0063 0.0082
Entamoeba histolytica hypothetical protein 0.0015 0.0063 0.0233
Brugia malayi Flap endonuclease-1 0.0033 0.0777 0.077
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0063 0.00000000056746
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.245 0.8983
Brugia malayi Pre-SET motif family protein 0.0025 0.0462 0.0455
Echinococcus granulosus transcription factor Dp 1 0.0049 0.137 0.1573
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.006 0.1812 0.2985
Loa Loa (eye worm) hypothetical protein 0.005 0.1411 0.1356
Brugia malayi polk-prov protein 0.0047 0.1315 0.1308
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0306 0.0292
Schistosoma mansoni tar DNA-binding protein 0.0038 0.0956 0.1386
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.1228 0.1782
Giardia lamblia Sgs1 DNA helicase, putative 0.0025 0.0474 0.3124
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0462 0.0664
Trypanosoma cruzi DNA polymerase kappa, putative 0.0077 0.245 0.8983
Trypanosoma brucei unspecified product 0.0069 0.2128 0.7795
Schistosoma mansoni DNA polymerase eta 0.0043 0.1154 0.1674
Loa Loa (eye worm) RecQ helicase 0.0025 0.0474 0.0413
Echinococcus granulosus fatty acid binding protein FABP2 0.0032 0.0717 0.0786
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0063 0.00000000047954
Trichomonas vaginalis DNA polymerase eta, putative 0.0077 0.245 0.34
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0594 0.0639
Echinococcus multilocularis lysine specific demethylase 5A 0.0045 0.1228 0.1402
Loa Loa (eye worm) hypothetical protein 0.0043 0.1154 0.1097
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0021 0.0306 0.5
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0306 0.169
Loa Loa (eye worm) PHD-finger family protein 0.0037 0.0929 0.0871
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0964 0.3495
Loa Loa (eye worm) hypothetical protein 0.0275 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0964 0.3495
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0306 0.1063
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0063 0.0082
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0122 0.4161 0.4934
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0306 0.1063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0462 0.0664
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0306 0.1063
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0474 0.0584
Trypanosoma brucei DNA polymerase IV, putative 0.0077 0.245 0.8983
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0084 0.2725 0.272
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0019 0.0102
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0122 0.4161 0.4934
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0063 0.00000000056746
Schistosoma mansoni tar DNA-binding protein 0.0038 0.0956 0.1386
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0033 0.0777 0.2802
Trypanosoma cruzi DNA polymerase kappa, putative 0.0077 0.245 0.8983
Leishmania major DNA polymerase eta, putative 0.0043 0.1154 0.4194
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0474 0.0467
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0474 0.0584
Trypanosoma brucei trypanothione reductase 0.006 0.1812 0.6628
Schistosoma mansoni tar DNA-binding protein 0.0038 0.0956 0.1386
Schistosoma mansoni hypothetical protein 0.0029 0.0594 0.0857
Schistosoma mansoni fatty acid binding protein 0.0032 0.0717 0.1036
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0084 0.2725 0.3204
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0306 0.1063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0063 0.00000000056746
Schistosoma mansoni eyes absent homolog 0.0058 0.171 0.2486
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0025 0.0474 0.0413
Loa Loa (eye worm) hypothetical protein 0.0058 0.171 0.1658
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.1018 0.1476
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.00000000040084
Trichomonas vaginalis conserved hypothetical protein 0.005 0.1411 0.192
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0084 0.2725 0.3968
Giardia lamblia PHD finger protein 15 0.0037 0.0929 0.6247
Echinococcus multilocularis muscleblind protein 0.0104 0.3464 0.4094
Schistosoma mansoni flap endonuclease-1 0.003 0.0655 0.0946
Onchocerca volvulus 0.0015 0.0063 0.000000056966
Giardia lamblia DINP protein human, muc B family 0.0052 0.1475 1
Mycobacterium ulcerans DNA polymerase IV 0.0077 0.245 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0077 0.245 0.8983
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0063 0.035
Brugia malayi Bromodomain containing protein 0.0037 0.0929 0.0922
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0025 0.0474 0.0494
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.1154 0.1313
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.1475 0.5382
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0474 0.1738
Trypanosoma brucei DNA polymerase IV, putative 0.0069 0.2128 0.7795
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0025 0.0462 0.048
Brugia malayi hypothetical protein 0.0015 0.0063 0.0056
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0094 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0964 0.3495
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0306 0.1063
Plasmodium falciparum phd finger protein, putative 0.0037 0.0929 0.5074
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0474 0.1681
Mycobacterium ulcerans DNA polymerase IV 0.0077 0.245 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0015 0.0063 0.0082
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.0306 0.1975
Echinococcus multilocularis flap endonuclease 1 0.0033 0.0777 0.0859
Schistosoma mansoni hypothetical protein 0.0029 0.0594 0.0857
Loa Loa (eye worm) hypothetical protein 0.0037 0.0929 0.0871
Plasmodium vivax flap endonuclease 1, putative 0.0033 0.0777 0.4287
Leishmania major DNA polymerase kappa, putative 0.0052 0.1475 0.5382
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0019 0.0017
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0063 0.0233
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0153 0.5351 1
Echinococcus granulosus fatty acid binding protein FABP2 0.0032 0.0717 0.0786
Echinococcus granulosus peregrin 0.0037 0.0929 0.1042
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0015 0.0063 0.0056
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0094 0.0087
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.0306 0.1604
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.2442 0.2393
Loa Loa (eye worm) pigment dispersing factor receptor c 0.009 0.2942 0.2897
Trichomonas vaginalis conserved hypothetical protein 0.005 0.1411 0.192
Echinococcus granulosus Chromobox protein 3 0.0015 0.0063 0.000000048139
Brugia malayi hypothetical protein 0.0058 0.171 0.1704
Loa Loa (eye worm) hypothetical protein 0.0104 0.3464 0.3422
Echinococcus multilocularis Chromo domain 0.0015 0.0063 0.00000000047954
Echinococcus multilocularis thioredoxin glutathione reductase 0.006 0.1812 0.2106
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0153 0.5351 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0037 0.0929 0.1345
Echinococcus multilocularis Chromobox protein 3 0.0015 0.0063 0.000000048139
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.1154 0.1674
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0153 0.5351 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0033 0.0777 0.4287
Trichomonas vaginalis chromobox protein, putative 0.0089 0.2903 0.4046
Echinococcus multilocularis peregrin 0.0037 0.0929 0.1042
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0015 0.0063 0.035
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0306 0.5
Onchocerca volvulus Heterochromatin protein 1 homolog 0.005 0.1411 0.192
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0063 0.00000000056746
Schistosoma mansoni chromobox protein 0.0089 0.2903 0.4228
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0052 0.1475 0.2317
Brugia malayi jmjC domain containing protein 0.0045 0.1228 0.1221
Brugia malayi SET domain containing protein 0.0016 0.0099 0.0091
Loa Loa (eye worm) hypothetical protein 0.0039 0.1 0.0942
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0929 0.5124
Trichomonas vaginalis flap endonuclease-1, putative 0.0033 0.0777 0.1016
Brugia malayi chromobox protein homolog 3 0.005 0.1411 0.1405
Schistosoma mansoni tar DNA-binding protein 0.0038 0.0956 0.1386
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0462 0.0664
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0306 0.1063
Echinococcus granulosus dna polymerase eta 0.0043 0.1154 0.1313
Brugia malayi Pre-SET motif family protein 0.0175 0.6163 0.616
Echinococcus multilocularis muscleblind protein 1 0.0104 0.3464 0.4094
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0021 0.0306 0.1184
Entamoeba histolytica hypothetical protein 0.0015 0.0063 0.0233
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0025 0.0474 0.0494
Toxoplasma gondii PHD-finger domain-containing protein 0.0037 0.0929 0.5124
Loa Loa (eye worm) TAR-binding protein 0.0038 0.0956 0.0899
Brugia malayi Thioredoxin reductase 0.006 0.1812 0.1806
Loa Loa (eye worm) hypothetical protein 0.0062 0.1855 0.1803
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0306 0.1063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0306 0.1063
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.0306 0.169
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0306 0.0292
Schistosoma mansoni chromobox protein 0.0015 0.0063 0.0082
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0474 0.1681
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0015 0.0063 0.0082
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0306 0.0437
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.1228 0.1402
Onchocerca volvulus Alhambra homolog 0.0037 0.0929 0.1233
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1315 0.4789
Brugia malayi Valyl-tRNA synthetase 0.0015 0.0063 0.0056
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0474 0.0494
Echinococcus multilocularis fatty acid binding protein FABP2 0.0032 0.0717 0.0786
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0306 0.1063
Giardia lamblia Flap structure-specific endonuclease 0.0033 0.0777 0.5206
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0025 0.0474 0.0494
Trichomonas vaginalis set domain proteins, putative 0.0199 0.7082 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0054 0.1556 0.2126
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0025 0.0474 0.0494
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0063 0.00000000056746
Schistosoma mansoni DNA helicase recq1 0.0025 0.0474 0.0681
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.1154 0.4234
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0063 0.00000000056746
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0306 0.169
Toxoplasma gondii PHD-finger domain-containing protein 0.0037 0.0929 0.5124
Mycobacterium tuberculosis Probable dehydrogenase 0.0138 0.4765 0.8837
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0306 0.1063
Echinococcus multilocularis expressed protein 0.0233 0.8369 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.245 0.8983
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.0255 0.9238 0.9233
Onchocerca volvulus 0.0199 0.7082 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0024 0.0427 0.0438
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0306 0.1063
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0063 0.00000000056746
Schistosoma mansoni hypothetical protein 0.0029 0.0594 0.0857
Schistosoma mansoni jumonji domain containing protein 0.0097 0.3205 0.4668
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0038 0.0956 0.0899
Brugia malayi M-phase phosphoprotein, mpp8 0.0015 0.0063 0.0056
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0084 0.2725 0.2679
Echinococcus multilocularis chromobox protein 1 0.0089 0.2903 0.3419
Brugia malayi jmjC domain containing protein 0.0122 0.4161 0.4157
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.0255 0.9238 0.9237
Plasmodium vivax thioredoxin reductase, putative 0.006 0.1812 1
Trichomonas vaginalis chromobox protein, putative 0.0089 0.2903 0.4046
Echinococcus granulosus expressed protein 0.0233 0.8369 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0084 0.2725 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0063 0.00000000056746
Plasmodium vivax SET domain protein, putative 0.0025 0.0462 0.2551
Echinococcus granulosus flap endonuclease 1 0.0033 0.0777 0.0859
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0063 0.035
Loa Loa (eye worm) hypothetical protein 0.0058 0.171 0.1658
Loa Loa (eye worm) hypothetical protein 0.0025 0.0462 0.0401
Entamoeba histolytica hypothetical protein 0.0015 0.0063 0.0233
Brugia malayi PHD-finger family protein 0.0037 0.0929 0.0922
Loa Loa (eye worm) hypothetical protein 0.0104 0.3464 0.3422
Treponema pallidum NADH oxidase 0.0021 0.0306 0.5
Trichomonas vaginalis chromobox protein, putative 0.0054 0.1556 0.2126
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0021 0.0306 0.1184
Echinococcus granulosus chromobox protein 1 0.0089 0.2903 0.3419
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0474 0.2613
Echinococcus granulosus bloom syndrome protein 0.0025 0.0474 0.0494
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.1228 0.1782
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.245 0.8983
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.245 0.8983
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.245 0.8983
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0214 0.7652 0.9137
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0025 0.0474 0.2537
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0306 0.0346
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0015 0.0063 0.035
Echinococcus multilocularis dna polymerase eta 0.0043 0.1154 0.1313
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0025 0.0462 0.048
Echinococcus granulosus dna polymerase kappa 0.0077 0.245 0.2873
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0306 0.1063
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0138 0.4765 0.8837
Echinococcus multilocularis chromobox protein 1 0.0089 0.2903 0.3419
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0594 0.0534
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.1154 0.4194
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.245 0.8983
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0015 0.0063 0.00000000047954
Loa Loa (eye worm) heterochromatin protein 1 0.0089 0.2903 0.2858
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.245 0.8983
Loa Loa (eye worm) hypothetical protein 0.0025 0.0474 0.0413
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0138 0.4765 0.8837
Echinococcus multilocularis tar DNA binding protein 0.0038 0.0956 0.1075
Echinococcus granulosus PHD finger protein rhinoceros 0.0037 0.0929 0.1042
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0306 0.1063
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0084 0.2725 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0063 0.0082
Echinococcus granulosus tar DNA binding protein 0.0038 0.0956 0.1075
Echinococcus granulosus thioredoxin glutathione reductase 0.006 0.1812 0.2106
Schistosoma mansoni hypothetical protein 0.0062 0.1855 0.2698
Echinococcus granulosus Chromo domain 0.0015 0.0063 0.00000000047954
Echinococcus multilocularis jumonji domain containing protein 0.0052 0.1485 0.1712
Brugia malayi Heterochromatin protein 1 0.0089 0.2903 0.2898
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0063 0.00000000047954
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0306 0.1063
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.0306 0.169
Echinococcus granulosus jumonji domain containing protein 0.0052 0.1485 0.1712
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0306 0.1063
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.1154 0.1097
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0025 0.0462 0.2551
Brugia malayi Calcitonin receptor-like protein seb-1 0.009 0.2942 0.2937
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0474 0.2537
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0063 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.245 0.8983
Trypanosoma brucei DNA polymerase IV, putative 0.0077 0.245 0.8983
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0214 0.7652 0.9137
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0594 0.0588
Trypanosoma brucei unspecified product 0.003 0.0643 0.2307
Mycobacterium tuberculosis Probable reductase 0.0138 0.4765 0.8837
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0474 0.0584
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0084 0.2725 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0855 0.1128
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0474 0.0467
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.1154 0.1147
Mycobacterium tuberculosis Probable oxidoreductase 0.0153 0.5351 1
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0306 0.0346
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0033 0.0777 0.2802
Onchocerca volvulus 0.0039 0.1 0.1334
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0063 0.00000000056746
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.1154 0.1674
Trypanosoma cruzi DNA polymerase kappa, putative 0.0077 0.245 0.8983
Entamoeba histolytica Flap nuclease, putative 0.0033 0.0777 0.2851
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.1154 0.4194
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0022 0.034 0.1877
Plasmodium falciparum glutathione reductase 0.006 0.1812 1
Schistosoma mansoni chromobox protein 0.0089 0.2903 0.4228
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0015 0.0063 0.035
Echinococcus multilocularis dna polymerase kappa 0.0077 0.245 0.2873
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0015 0.0063 0.025
Brugia malayi RNA binding protein 0.0038 0.0956 0.095
Schistosoma mansoni hypothetical protein 0.0029 0.0594 0.0857
Onchocerca volvulus 0.004 0.1018 0.136
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0063 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0855 0.1128
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0306 0.0299
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0474 0.1681
Plasmodium falciparum thioredoxin reductase 0.006 0.1812 1
Toxoplasma gondii thioredoxin reductase 0.006 0.1812 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0025 0.0462 0.048
Brugia malayi latrophilin 2 splice variant baaae 0.0062 0.1855 0.185
Plasmodium falciparum heterochromatin protein 1 0.0015 0.0063 0.025
Brugia malayi CHD4 protein 0.0015 0.0063 0.0056
Schistosoma mansoni chromobox protein 0.0015 0.0063 0.0082
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0594 0.0639
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.1228 0.1172
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0474 0.0467
Trypanosoma cruzi trypanothione reductase, putative 0.006 0.1812 0.6628
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0063 0.00000000056746
Plasmodium vivax glutathione reductase, putative 0.006 0.1812 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.1154 0.168
Brugia malayi RNA recognition motif domain containing protein 0.0038 0.0956 0.095
Loa Loa (eye worm) hypothetical protein 0.0064 0.1944 0.1892
Echinococcus granulosus muscleblind protein 0.0104 0.3464 0.4094
Loa Loa (eye worm) thioredoxin reductase 0.006 0.1812 0.176
Echinococcus multilocularis GPCR, family 2 0.0029 0.0594 0.0639
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0084 0.2725 0.3204
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0019 0.0102
Schistosoma mansoni fatty acid binding protein 0.0032 0.0717 0.1036
Loa Loa (eye worm) hypothetical protein 0.0047 0.1315 0.1259
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0019 0.0102
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0052 0.1475 0.5382
Brugia malayi Associated with TFs and helicases family protein 0.0015 0.0063 0.0056
Plasmodium vivax heterochromatin protein 1, putative 0.0015 0.0063 0.035

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2.8 nM Binding affinity towards Corticotropin releasing factor receptor 1 was measured through displacement of [125I]-sauvagine expressed in HEK293 cells ChEMBL. 12951128
Ki (binding) = 2.8 nM Binding affinity towards Corticotropin releasing factor receptor 1 was measured through displacement of [125I]-sauvagine expressed in HEK293 cells ChEMBL. 12951128

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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