Detailed information for compound 1890885

Basic information

Technical information
  • TDR Targets ID: 1890885
  • Name: 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(4-dimeth ylaminophenyl)methylideneamino]-5-[(4-fluorop henoxy)methyl]triazole-4-carboxamide
  • MW: 465.44 | Formula: C21H20FN9O3
  • H donors: 2 H acceptors: 5 LogP: 2.13 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)OCc1c(nnn1c1nonc1N)C(=O)N/N=C/c1ccc(cc1)N(C)C
  • InChi: 1S/C21H20FN9O3/c1-30(2)15-7-3-13(4-8-15)11-24-26-21(32)18-17(12-33-16-9-5-14(22)6-10-16)31(29-25-18)20-19(23)27-34-28-20/h3-11H,12H2,1-2H3,(H2,23,27)(H,26,32)/b24-11+
  • InChiKey: YCKPIDQSDIYOPV-BHGWPJFGSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(4-dimethylaminophenyl)methyleneamino]-5-[(4-fluorophenoxy)methyl]triazole-4-carboxamide
  • 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(4-dimethylaminophenyl)methyleneamino]-5-[(4-fluorophenoxy)methyl]-4-triazolecarboxamide
  • 1-(4-aminofurazan-3-yl)-N-[(4-dimethylaminobenzylidene)amino]-5-[(4-fluorophenoxy)methyl]triazole-4-carboxamide
  • 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(4-dimethylaminophenyl)methylideneamino]-5-[(4-fluorophenoxy)methyl]-1,2,3-triazole-4-carboxamide
  • MLS000769709
  • SMR000434514
  • STOCK3S-98887
  • 1-(4-Amino-furazan-3-yl)-5-(4-fluoro-phenoxymethyl)-1H-[1,2,3]triazole-4-carboxylic acid [1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-hydrazide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens acid phosphatase 1, soluble Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans C terminus of potential Low molecular weight phosphoTyrosine Phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans 3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene Get druggable targets OG5_127571 All targets in OG5_127571
Loa Loa (eye worm) phosphotyrosine protein phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) Get druggable targets OG5_127571 All targets in OG5_127571
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein Get druggable targets OG5_127571 All targets in OG5_127571
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_127571 All targets in OG5_127571
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) acid phosphatase 1, soluble 112 aa 107 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus importin subunit beta 1 0.0035 0.0304 0.0449
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0201 0.0359
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0226 0.3318 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0106 0.142 1
Schistosoma mansoni aldehyde dehydrogenase 0.0106 0.142 0.2455
Loa Loa (eye worm) hypothetical protein 0.0024 0.0133 0.0191
Echinococcus granulosus inositol monophosphatase 1 0.0064 0.0768 0.1282
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0057 0.0662 0.5
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0226 0.3318 0.8071
Brugia malayi glutaminase DH11.1 0.0276 0.4111 0.5883
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.0308 0.0441
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.0853 0.1969
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0034 0.029 0.0416
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.0853 0.1969
Echinococcus multilocularis survival motor neuron protein 1 0.0166 0.2379 0.2337
Mycobacterium ulcerans aldehyde dehydrogenase 0.0106 0.142 0.3455
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0235 0.7231
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0064 0.0768 0.2186
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.3318 0.8045
Schistosoma mansoni hypothetical protein 0.0034 0.029 0.0423
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0064 0.0768 0.1759
Schistosoma mansoni inositol monophosphatase 0.0064 0.0768 0.1282
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.3318 0.8045
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.3318 0.8045
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0106 0.142 0.1373
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0064 0.0768 0.1869
Schistosoma mansoni inositol monophosphatase 0.0064 0.0768 0.1282
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0226 0.3318 0.4748
Schistosoma mansoni hypothetical protein 0.0025 0.0154 0.0179
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.0308 0.0441
Echinococcus granulosus survival motor neuron protein 1 0.0166 0.2379 0.4178
Schistosoma mansoni aldehyde dehydrogenase 0.0106 0.142 0.2455
Brugia malayi Importin beta-1 subunit 0.0035 0.0304 0.0436
Mycobacterium ulcerans aldehyde dehydrogenase 0.0106 0.142 0.3455
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.5618 0.8041
Entamoeba histolytica hypothetical protein 0.0028 0.0201 0.0446
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.3318 0.8045
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0201 0.0359
Leishmania major importin beta-1 subunit, putative 0.0028 0.0201 0.1412
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.3318 0.8045
Loa Loa (eye worm) inositol-1 0.0064 0.0768 0.1099
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.3318 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0235 0.7231
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0064 0.0768 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0055 0.0133
Entamoeba histolytica hypothetical protein 0.0025 0.0154 0.0305
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0064 0.0768 0.5223
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0055 0.0078
Onchocerca volvulus 0.0226 0.3318 0.4521
Leishmania major hypothetical protein, conserved 0.003 0.0235 0.1656
Schistosoma mansoni transcription factor LCR-F1 0.0025 0.0154 0.0179
Loa Loa (eye worm) hypothetical protein 0.0125 0.1723 0.2467
Loa Loa (eye worm) hypothetical protein 0.0459 0.6987 1
Schistosoma mansoni hypothetical protein 0.0372 0.5618 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0083 0.1064 0.1015
Schistosoma mansoni hypothetical protein 0.0024 0.0133 0.0141
Trichomonas vaginalis glutaminase, putative 0.0276 0.4111 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0055 0.0642
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0055 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0055 0.0642
Echinococcus multilocularis Protein lozenge 0.0058 0.0662 0.0611
Brugia malayi hypothetical protein 0.0459 0.6987 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0083 0.1064 0.1814
Loa Loa (eye worm) hypothetical protein 0.0166 0.2379 0.3405
Brugia malayi Inositol-1 0.0064 0.0768 0.1099
Brugia malayi hypothetical protein 0.002 0.0065 0.0093
Loa Loa (eye worm) hypothetical protein 0.003 0.0235 0.0337
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0235 0.2757
Brugia malayi hypothetical protein 0.003 0.0235 0.0337
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0064 0.0768 0.5408
Trichomonas vaginalis inositol monophosphatase, putative 0.0064 0.0768 0.1759
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0064 0.0768 0.1759
Toxoplasma gondii aldehyde dehydrogenase 0.0106 0.142 1
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0156 0.222 1
Schistosoma mansoni glutaminase 0.0276 0.4111 0.729
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0201 0.0359
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0035 0.0308 0.0441
Plasmodium falciparum importin beta, putative 0.0035 0.0304 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.013 0.0187
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0125 0.1723 0.2467
Loa Loa (eye worm) hypothetical protein 0.0459 0.6987 1
Mycobacterium ulcerans glutaminase 0.0276 0.4111 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0064 0.0768 0.9
Schistosoma mansoni lipoxygenase 0.0083 0.1064 0.1814
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0106 0.142 0.2455
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0025 0.0154 0.01
Loa Loa (eye worm) hypothetical protein 0.0035 0.0308 0.0441
Echinococcus multilocularis snurportin 1 0.0372 0.5618 0.5594
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0304 0.3567
Schistosoma mansoni survival motor neuron protein 0.0034 0.029 0.0423
Brugia malayi hypothetical protein 0.0166 0.2379 0.3405
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0064 0.0768 0.9
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0304 0.3567
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0235 0.7231
Brugia malayi latrophilin 2 splice variant baaae 0.0024 0.0133 0.0191
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0055 0.0386
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0055 0.0642
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0235 0.2757
Brugia malayi hypothetical protein 0.0025 0.0154 0.0221
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0226 0.3318 0.4748
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0235 0.2757
Brugia malayi RNA, U transporter 1 0.0099 0.1317 0.1885
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0201 0.235
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.3318 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0025 0.0154 0.0179
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0064 0.0768 0.9
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0853 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0853 1
Entamoeba histolytica hypothetical protein 0.0025 0.0154 0.0305
Loa Loa (eye worm) glutaminase 0.0276 0.4111 0.5883
Schistosoma mansoni importin beta-1 0.0035 0.0304 0.0449
Plasmodium vivax importin-beta 2, putative 0.0035 0.0304 1
Echinococcus granulosus snurportin 1 0.0372 0.5618 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0304 0.0251
Mycobacterium ulcerans aldehyde dehydrogenase 0.0106 0.142 0.3455
Entamoeba histolytica hypothetical protein 0.0025 0.0154 0.0305
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0304 0.1827
Entamoeba histolytica hypothetical protein 0.0025 0.0154 0.0305
Loa Loa (eye worm) runx1 0.0058 0.0662 0.0948
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0106 0.142 0.6308
Schistosoma mansoni lozenge 0.0058 0.0662 0.1092
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0235 0.1321
Loa Loa (eye worm) hypothetical protein 0.0035 0.0304 0.0436
Onchocerca volvulus 0.0459 0.6987 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0055 0.0078
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.3318 0.8045
Leishmania major hypothetical protein, conserved 0.007 0.0853 0.6008
Loa Loa (eye worm) glutaminase 2 0.0276 0.4111 0.5883
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.167 0.3981
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.007 0.0853 1
Brugia malayi Cytochrome P450 family protein 0.0024 0.013 0.0187
Schistosoma mansoni lipoxygenase 0.0058 0.067 0.1106
Echinococcus multilocularis inositol monophosphatase 1 0.0064 0.0768 0.0717
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0057 0.0662 0.2804

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 12 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 80 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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