Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.0475 | 0.5326 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Schistosoma mansoni | z-protein (S1r protein) | 0.001 | 0.0102 | 0.0175 |
Schistosoma mansoni | regulator of G protein signaling | 0.001 | 0.0102 | 0.0175 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0475 | 0.3449 |
Onchocerca volvulus | 0.001 | 0.0102 | 0.0146 | |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.5326 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0475 | 0.0795 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0033 | 0.0883 | 1 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.001 | 0.0102 | 0.0146 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.001 | 0.0102 | 0.0146 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0475 | 0.0795 |
Onchocerca volvulus | 0.0012 | 0.0169 | 0.0252 | |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.001 | 0.0102 | 0.0156 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0475 | 0.0744 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0475 | 0.0744 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.001 | 0.0102 | 0.0146 |
Schistosoma mansoni | ras GTP exchange factor | 0.0007 | 0.0011 | 0.0019 |
Schistosoma mansoni | dep domain containing protein | 0.001 | 0.0102 | 0.0175 |
Echinococcus multilocularis | geminin | 0.0184 | 0.5851 | 1 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.001 | 0.0102 | 0.0156 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.001 | 0.0102 | 0.0156 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0196 | 0.6247 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0169 | 0.1807 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0475 | 0.0795 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Brugia malayi | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0169 | 0.0252 |
Giardia lamblia | Sentrin | 0.0033 | 0.0883 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0012 | 0.0169 | 0.1807 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.5851 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Toxoplasma gondii | small ubiquitin family modifier, putative | 0.0033 | 0.0883 | 1 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0033 | 0.0883 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0021 | 0.0475 | 0.5326 |
Trichomonas vaginalis | ubiquitin, putative | 0.0012 | 0.0169 | 0.1807 |
Brugia malayi | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0169 | 0.0252 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.0475 | 0.5326 |
Loa Loa (eye worm) | SMO-1 protein | 0.0033 | 0.0883 | 0.1397 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.5326 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0475 | 0.0795 |
Trypanosoma brucei | small ubiquitin-related modifier | 0.0033 | 0.0883 | 1 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.001 | 0.0102 | 0.0175 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0475 | 0.0744 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.031 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.0475 | 0.5326 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.001 | 0.0102 | 0.0156 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0883 | 1 |
Schistosoma mansoni | dishevelled | 0.001 | 0.0102 | 0.0175 |
Brugia malayi | DIX domain containing protein | 0.001 | 0.0102 | 0.0146 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.0475 | 0.0812 |
Echinococcus granulosus | Small ubiquitin modifier 2 | 0.0033 | 0.0883 | 0.1492 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.001 | 0.0102 | 0.0156 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.001 | 0.0102 | 0.0146 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0475 | 0.0795 |
Echinococcus granulosus | geminin | 0.0184 | 0.5851 | 1 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.001 | 0.0102 | 0.0146 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0007 | 0.0011 | 0.0019 |
Echinococcus multilocularis | Small ubiquitin modifier 2 | 0.0033 | 0.0883 | 0.1492 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Brugia malayi | N-terminal motif family protein | 0.0196 | 0.6247 | 1 |
Leishmania major | small ubiquitin protein, putative | 0.0033 | 0.0883 | 1 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0007 | 0.0011 | 0.0019 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0475 | 0.0744 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.001 | 0.0102 | 0.0146 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.031 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0475 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.6247 | 1 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.031 | 1 | 1 |
Echinococcus multilocularis | ubiquitin | 0.0012 | 0.0169 | 0.027 |
Entamoeba histolytica | ubiquitin like protein | 0.0033 | 0.0883 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.0475 | 0.0812 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0007 | 0.0011 | 0.0019 |
Brugia malayi | Ubiquitin-like protein SMT3 | 0.0033 | 0.0883 | 0.1397 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.5851 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.0475 | 0.3449 |
Echinococcus granulosus | ubiquitin | 0.0012 | 0.0169 | 0.027 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0007 | 0.0011 | 0.0019 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.031 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0475 | 0.3449 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.001 | 0.0102 | 0.0156 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.5326 |
Schistosoma mansoni | dishevelled | 0.001 | 0.0102 | 0.0175 |
Schistosoma mansoni | ubiquitin-like protein sumo/smt3-related | 0.0033 | 0.0883 | 0.1509 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0475 | 0.3449 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.001 | 0.0102 | 0.0156 |
Treponema pallidum | hypothetical protein | 0.031 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.5326 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.001 | 0.0102 | 0.0156 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.001 | 0.0102 | 0.0156 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.0475 | 0.0812 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.001 | 0.0102 | 0.0156 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0475 | 0.0795 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 93 % | Activity of human erythrocyte purine nucleoside phosphorylase assessed as ribose relase at 5 umol after 30 mins by orcinol reaction relative to guanosine | ChEMBL. | 31484 |
Km (binding) | = 1.9 10'-4M | Activity of human erythrocyte purine nucleoside phosphorylase assessed as ribose relase after 30 mins by Lineweaver-Burk plot analysis | ChEMBL. | 31484 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.