Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0475 | 0.0795 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0169 | 0.1807 |
Brugia malayi | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0169 | 0.0252 |
Giardia lamblia | Sentrin | 0.0033 | 0.0883 | 1 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.001 | 0.0102 | 0.0156 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0195 | 0.6247 | 1 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0169 | 0.0252 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Brugia malayi | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.0475 | 0.5326 |
Loa Loa (eye worm) | SMO-1 protein | 0.0033 | 0.0883 | 0.1397 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.001 | 0.0102 | 0.0175 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.5326 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0475 | 0.0795 |
Trypanosoma brucei | small ubiquitin-related modifier | 0.0033 | 0.0883 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0475 | 0.0744 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0308 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.0475 | 0.5326 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.5851 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0012 | 0.0169 | 0.1807 |
Toxoplasma gondii | small ubiquitin family modifier, putative | 0.0033 | 0.0883 | 1 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0033 | 0.0883 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0021 | 0.0475 | 0.5326 |
Trichomonas vaginalis | ubiquitin, putative | 0.0012 | 0.0169 | 0.1807 |
Schistosoma mansoni | z-protein (S1r protein) | 0.001 | 0.0102 | 0.0175 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0475 | 0.3449 |
Schistosoma mansoni | regulator of G protein signaling | 0.001 | 0.0102 | 0.0175 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.5326 |
Onchocerca volvulus | 0.001 | 0.0102 | 0.0146 | |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.0475 | 0.5326 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0475 | 0.0744 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0475 | 0.0744 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.001 | 0.0102 | 0.0146 |
Schistosoma mansoni | ras GTP exchange factor | 0.0007 | 0.0011 | 0.0019 |
Echinococcus multilocularis | geminin | 0.0183 | 0.5851 | 1 |
Schistosoma mansoni | dep domain containing protein | 0.001 | 0.0102 | 0.0175 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.001 | 0.0102 | 0.0156 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0475 | 0.0795 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.001 | 0.0102 | 0.0146 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0033 | 0.0883 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.001 | 0.0102 | 0.0146 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0475 | 0.0795 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.001 | 0.0102 | 0.0156 |
Onchocerca volvulus | 0.0012 | 0.0169 | 0.0252 | |
Entamoeba histolytica | ubiquitin like protein | 0.0033 | 0.0883 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.0475 | 0.0812 |
Brugia malayi | Ubiquitin-like protein SMT3 | 0.0033 | 0.0883 | 0.1397 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.5851 | 1 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0007 | 0.0011 | 0.0019 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.0475 | 0.3449 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.001 | 0.0102 | 0.0146 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0308 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0475 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.6247 | 1 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0308 | 1 | 1 |
Echinococcus multilocularis | ubiquitin | 0.0012 | 0.0169 | 0.027 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0475 | 0.3449 |
Schistosoma mansoni | ubiquitin-like protein sumo/smt3-related | 0.0033 | 0.0883 | 0.1509 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.001 | 0.0102 | 0.0156 |
Treponema pallidum | hypothetical protein | 0.0308 | 1 | 0.5 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.001 | 0.0102 | 0.0156 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.5326 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.0475 | 0.0812 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.001 | 0.0102 | 0.0156 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.001 | 0.0102 | 0.0156 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0475 | 0.0795 |
Echinococcus granulosus | ubiquitin | 0.0012 | 0.0169 | 0.027 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0007 | 0.0011 | 0.0019 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.5326 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0475 | 0.3449 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0308 | 1 | 1 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.001 | 0.0102 | 0.0156 |
Schistosoma mansoni | dishevelled | 0.001 | 0.0102 | 0.0175 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.001 | 0.0102 | 0.0156 |
Echinococcus granulosus | Small ubiquitin modifier 2 | 0.0033 | 0.0883 | 0.1492 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.001 | 0.0102 | 0.0146 |
Echinococcus granulosus | geminin | 0.0183 | 0.5851 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0475 | 0.0795 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.001 | 0.0102 | 0.0156 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0883 | 1 |
Brugia malayi | DIX domain containing protein | 0.001 | 0.0102 | 0.0146 |
Schistosoma mansoni | dishevelled | 0.001 | 0.0102 | 0.0175 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.0475 | 0.0812 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0475 | 0.0744 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.001 | 0.0102 | 0.0146 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0007 | 0.0011 | 0.0019 |
Echinococcus multilocularis | Small ubiquitin modifier 2 | 0.0033 | 0.0883 | 0.1492 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0475 | 0.3449 |
Brugia malayi | N-terminal motif family protein | 0.0195 | 0.6247 | 1 |
Leishmania major | small ubiquitin protein, putative | 0.0033 | 0.0883 | 1 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0007 | 0.0011 | 0.0019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.