Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase eta, putative | 0.0022 | 0.0475 | 0.3449 |
Brugia malayi | Ubiquitin-like protein SMT3 | 0.0035 | 0.0883 | 0.1397 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.5851 | 1 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0007 | 0.0011 | 0.0019 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0022 | 0.0475 | 0.0812 |
Entamoeba histolytica | ubiquitin like protein | 0.0035 | 0.0883 | 1 |
Echinococcus multilocularis | ubiquitin | 0.0012 | 0.0169 | 0.027 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.6247 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.0475 | 0.3449 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0326 | 1 | 1 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.001 | 0.0102 | 0.0146 |
Echinococcus multilocularis | dna polymerase kappa | 0.0022 | 0.0475 | 0.0795 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.001 | 0.0102 | 0.0156 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.001 | 0.0102 | 0.0156 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0022 | 0.0475 | 0.0812 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.5326 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.001 | 0.0102 | 0.0156 |
Treponema pallidum | hypothetical protein | 0.0326 | 1 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0022 | 0.0475 | 0.3449 |
Schistosoma mansoni | ubiquitin-like protein sumo/smt3-related | 0.0035 | 0.0883 | 0.1509 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.001 | 0.0102 | 0.0156 |
Schistosoma mansoni | dishevelled | 0.001 | 0.0102 | 0.0175 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0326 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.5326 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.001 | 0.0102 | 0.0156 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.0475 | 0.3449 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0007 | 0.0011 | 0.0019 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.3449 |
Echinococcus granulosus | ubiquitin | 0.0012 | 0.0169 | 0.027 |
Echinococcus granulosus | dna polymerase eta | 0.0022 | 0.0475 | 0.0795 |
Echinococcus granulosus | geminin | 0.0193 | 0.5851 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.001 | 0.0102 | 0.0146 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.001 | 0.0102 | 0.0156 |
Echinococcus granulosus | Small ubiquitin modifier 2 | 0.0035 | 0.0883 | 0.1492 |
Schistosoma mansoni | DNA polymerase eta | 0.0022 | 0.0475 | 0.0812 |
Schistosoma mansoni | dishevelled | 0.001 | 0.0102 | 0.0175 |
Brugia malayi | DIX domain containing protein | 0.001 | 0.0102 | 0.0146 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0883 | 1 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.001 | 0.0102 | 0.0156 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0475 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.3449 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0007 | 0.0011 | 0.0019 |
Leishmania major | small ubiquitin protein, putative | 0.0035 | 0.0883 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0206 | 0.6247 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.3449 |
Echinococcus multilocularis | Small ubiquitin modifier 2 | 0.0035 | 0.0883 | 0.1492 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0007 | 0.0011 | 0.0019 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.3449 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.001 | 0.0102 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0169 | 0.0252 |
Giardia lamblia | Sentrin | 0.0035 | 0.0883 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.3449 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.3449 |
Brugia malayi | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0169 | 0.1807 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.0475 | 0.0795 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.001 | 0.0102 | 0.0156 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0206 | 0.6247 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0022 | 0.0475 | 0.5326 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0326 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.0475 | 0.0744 |
Echinococcus granulosus | dna polymerase kappa | 0.0022 | 0.0475 | 0.0795 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.001 | 0.0102 | 0.0175 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.5326 |
Trypanosoma brucei | small ubiquitin-related modifier | 0.0035 | 0.0883 | 1 |
Loa Loa (eye worm) | SMO-1 protein | 0.0035 | 0.0883 | 0.1397 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0022 | 0.0475 | 0.5326 |
Brugia malayi | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0169 | 0.0252 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.3449 |
Trichomonas vaginalis | ubiquitin, putative | 0.0012 | 0.0169 | 0.1807 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0022 | 0.0475 | 0.5326 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0035 | 0.0883 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0012 | 0.0169 | 0.1807 |
Toxoplasma gondii | small ubiquitin family modifier, putative | 0.0035 | 0.0883 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.5851 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.3449 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.0475 | 0.5326 |
Onchocerca volvulus | 0.001 | 0.0102 | 0.0146 | |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.0475 | 0.3449 |
Schistosoma mansoni | regulator of G protein signaling | 0.001 | 0.0102 | 0.0175 |
Schistosoma mansoni | z-protein (S1r protein) | 0.001 | 0.0102 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0102 | 0.0146 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0022 | 0.0475 | 0.5326 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.001 | 0.0102 | 0.0156 |
Schistosoma mansoni | dep domain containing protein | 0.001 | 0.0102 | 0.0175 |
Echinococcus multilocularis | geminin | 0.0193 | 0.5851 | 1 |
Schistosoma mansoni | ras GTP exchange factor | 0.0007 | 0.0011 | 0.0019 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.001 | 0.0102 | 0.0146 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0022 | 0.0475 | 0.0744 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.0475 | 0.0744 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.0475 | 0.0795 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.001 | 0.0102 | 0.0156 |
Onchocerca volvulus | 0.0012 | 0.0169 | 0.0252 | |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.001 | 0.0102 | 0.0146 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0035 | 0.0883 | 1 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.001 | 0.0102 | 0.0146 |
Echinococcus multilocularis | dna polymerase eta | 0.0022 | 0.0475 | 0.0795 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.