TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 307.322 | Formula: C14H13NO5S
H donors: 0 H acceptors: 4 LogP: 3.59 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCCSC(=O)c1cc2cc(ccc2oc1=O)[N+](=O)[O-]
InChi: 1S/C14H13NO5S/c1-2-3-6-21-14(17)11-8-9-7-10(15(18)19)4-5-12(9)20-13(11)16/h4-5,7-8H,2-3,6H2,1H3
InChiKey: JBJXXOYEBHNRCL-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	porcupine, putative	0.0096	0.086	1
Loa Loa (eye worm)	hhat protein	0.0096	0.086	0.0854
Schistosoma mansoni	cercarial elastase (S01 family)	0.0111	0.1014	0.0971
Echinococcus granulosus	neuropeptide receptor A26	0.0121	0.1123	0.1117
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0249	0.0243
Schistosoma mansoni	hypothetical protein	0.0088	0.0779	0.0735
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0249	0.0243
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0096	0.086	0.0853
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0096	0.086	0.0853
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0121	0.1123	0.1081
Echinococcus multilocularis	transmembrane protease serine 3	0.0111	0.1014	0.1008
Brugia malayi	PAN domain containing protein	0.0037	0.0249	0.1114
Echinococcus granulosus	transmembrane protease serine 3	0.0111	0.1014	0.1008
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0121	0.1123	0.1081
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0121	0.1123	0.1118
Echinococcus multilocularis	neuropeptide s receptor	0.0121	0.1123	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Brugia malayi	Trypsin family protein	0.0111	0.1014	0.4627
Brugia malayi	G-protein coupled receptor	0.0121	0.1123	0.5128
Echinococcus granulosus	dro:myosuppressin receptor	0.0121	0.1123	0.1117
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0121	0.1123	0.1118
Brugia malayi	hypothetical protein	0.0111	0.1014	0.4627
Brugia malayi	MBOAT family protein	0.0096	0.086	0.3918
Onchocerca volvulus		0.0037	0.0249	0.1114
Echinococcus granulosus	neuropeptide s receptor	0.0121	0.1123	0.1117
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0096	0.086	0.0816
Echinococcus multilocularis	fmrfamide receptor	0.0121	0.1123	0.1117
Onchocerca volvulus		0.0111	0.1014	0.4627
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0048	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0096	0.086	0.0854
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0096	0.086	0.0853
Onchocerca volvulus		0.0121	0.1123	0.5128
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Schistosoma mansoni	hypothetical protein	0.0121	0.1123	0.1081
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0121	0.1123	0.1117
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0096	0.086	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0047	0.0352	0.0346
Schistosoma mansoni	cercarial elastase (S01 family)	0.0111	0.1014	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Echinococcus granulosus	neuropeptides capa receptor	0.0121	0.1123	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Echinococcus granulosus	7TM GPCR rhodopsin	0.0121	0.1123	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0249	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0249	0.0243
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0121	0.1123	0.1117
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0121	0.1123	0.1117
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0096	0.086	0.0853
Brugia malayi	Dopamine receptor protein 1	0.0121	0.1123	0.5128
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0047	0.0352	0.0306
Toxoplasma gondii	PAN domain-containing protein	0.0392	0.3918	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0014	0.0012	0.0061
Echinococcus granulosus	g protein coupled receptor	0.0121	0.1123	0.1117
Schistosoma mansoni	neuropeptide receptor	0.0121	0.1123	0.1081
Echinococcus granulosus	enteropeptidase	0.0127	0.1183	0.1177
Loa Loa (eye worm)	acetyltransferase	0.0047	0.0352	0.0346
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0121	0.1123	0.1081
Echinococcus multilocularis	neuropeptide Y receptor	0.0121	0.1123	0.1117
Onchocerca volvulus		0.0121	0.1123	0.5128
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0121	0.1123	0.1117
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0096	0.086	1
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0096	0.086	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0096	0.086	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0121	0.1123	0.5128
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0111	0.1014	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0096	0.086	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0096	0.086	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Schistosoma mansoni	neuropeptide F-like receptor	0.0121	0.1123	0.1081
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0121	0.1123	0.5128
Onchocerca volvulus		0.0121	0.1123	0.5128
Schistosoma mansoni	hypothetical protein	0.0121	0.1123	0.1081
Schistosoma mansoni	biogenic amine receptor	0.0121	0.1123	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Echinococcus granulosus	neuropeptide Y receptor	0.0121	0.1123	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Echinococcus granulosus	7tm_1 domain containing protein	0.0121	0.1123	0.1117
Trichomonas vaginalis	conserved hypothetical protein	0.0096	0.086	1
Echinococcus multilocularis	Mastin	0.0127	0.1183	0.1177
Brugia malayi	hypothetical protein	0.0121	0.1123	0.5128
Schistosoma mansoni	hypothetical protein	0.0111	0.1014	0.0971
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0121	0.1123	0.1117
Echinococcus multilocularis	allatostatin A receptor	0.0121	0.1123	0.1117
Echinococcus multilocularis	neuropeptide receptor	0.0121	0.1123	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0107	0.0101
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0121	0.1123	0.1117
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0121	0.1123	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Onchocerca volvulus		0.0037	0.0249	0.1114
Onchocerca volvulus		0.0121	0.1123	0.5128
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Schistosoma mansoni	amine GPCR	0.0121	0.1123	0.1081
Brugia malayi	PAN domain containing protein	0.0037	0.0249	0.1114
Brugia malayi	hypothetical protein	0.0121	0.1123	0.5128
Onchocerca volvulus		0.0111	0.1014	0.4627
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Brugia malayi	diacylglycerol acyltransferase	0.0096	0.086	0.3918
Schistosoma mansoni	cercarial elastase (S01 family)	0.0111	0.1014	0.0971
Treponema pallidum	alginate O-acetylation protein (algI)	0.0096	0.086	0.5
Echinococcus multilocularis	laminin	0.0017	0.0048	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0886	0.9011	0.901
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0096	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Loa Loa (eye worm)	neuropeptide F receptor	0.0121	0.1123	0.1118
Onchocerca volvulus		0.0121	0.1123	0.5128
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0121	0.1123	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0096	0.086	0.0854
Schistosoma mansoni	amine GPCR	0.0121	0.1123	0.1081
Onchocerca volvulus		0.0037	0.0249	0.1114
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0121	0.1123	0.1081
Schistosoma mansoni	neuropeptide receptor	0.0121	0.1123	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0121	0.1123	0.1117
Echinococcus multilocularis	neuropeptide Y receptor	0.0121	0.1123	0.1117
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0017	0.0048	0.0092
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0121	0.1123	0.1117
Brugia malayi	larval opioid receptor	0.0121	0.1123	0.5128
Schistosoma mansoni	hypothetical protein	0.0121	0.1123	0.1081
Echinococcus granulosus	tm gpcr rhodopsin	0.0121	0.1123	0.1117
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0096	0.086	0.0853
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0096	0.086	0.0853
Leishmania major	hypothetical protein, conserved	0.0096	0.086	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.1123	0.1081
Schistosoma mansoni	adenoreceptor	0.0121	0.1123	0.1081
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0121	0.1123	0.1117
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0121	0.1123	0.1117
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0111	0.1014	0.1008
Brugia malayi	Kringle domain containing protein	0.0088	0.0779	0.3547
Echinococcus granulosus	Mastin	0.0127	0.1183	0.1177
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Loa Loa (eye worm)	melatonin receptor type 1A	0.0121	0.1123	0.1118
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0121	0.1123	0.1117
Brugia malayi	Calcium binding EGF domain containing protein	0.0017	0.0048	0.0191
Schistosoma mansoni	zinc finger protein	0.0096	0.086	0.0816
Onchocerca volvulus	Arrow homolog	0.0017	0.0048	0.0191
Trypanosoma cruzi	GUP1, putative	0.0096	0.086	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0249	0.0243
Schistosoma mansoni	cercarial elastase (S01 family)	0.0111	0.1014	0.0971
Schistosoma mansoni	hypothetical protein	0.0111	0.1014	0.0971
Echinococcus granulosus	laminin	0.0017	0.0048	0.0041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Echinococcus multilocularis	enteropeptidase	0.0127	0.1183	0.1177
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0121	0.1123	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Loa Loa (eye worm)	G-protein coupled receptor	0.0121	0.1123	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Brugia malayi	neuropeptide F receptor	0.0121	0.1123	0.5128
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Entamoeba histolytica	vacuolar protein sorting 26	0.0096	0.086	1
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0096	0.086	0.0853
Echinococcus granulosus	glycoprotein Antigen 5	0.0127	0.1183	0.1177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.1123	0.1081
Onchocerca volvulus		0.0121	0.1123	0.5128
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0249	0.0243
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0096	0.086	0.0853
Echinococcus multilocularis	dro:myosuppressin receptor	0.0121	0.1123	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0249	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0779	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Onchocerca volvulus		0.0037	0.0249	0.1114
Entamoeba histolytica	hypothetical protein, conserved	0.0096	0.086	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0121	0.1123	0.5128
Echinococcus multilocularis	sex peptide receptor	0.0121	0.1123	0.1117
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0121	0.1123	0.1117
Toxoplasma gondii	subtilisin SUB12	0.0037	0.0249	0.0606
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0096	0.086	0.0853
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0121	0.1123	0.1117
Toxoplasma gondii	PAN domain-containing protein	0.0037	0.0249	0.0606
Echinococcus multilocularis	Tolloid protein 1	0.0019	0.0065	0.0058
Onchocerca volvulus		0.0111	0.1014	0.4627
Echinococcus multilocularis	glycoprotein Antigen 5	0.0127	0.1183	0.1177
Brugia malayi	Trypsin family protein	0.0224	0.2185	1
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0096	0.086	1
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0096	0.086	0.0854
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0121	0.1123	0.1081
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0096	0.086	0.217
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1014	0.1009
Loa Loa (eye worm)	MBOAT family protein	0.0096	0.086	0.0854
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0037	0.0249	0.0606
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0019	0.0065	0.0059
Onchocerca volvulus		0.0224	0.2185	1
Brugia malayi	hypothetical protein	0.0121	0.1123	0.5128
Loa Loa (eye worm)	trypsin family protein	0.0111	0.1014	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1014	0.1009
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0088	0.0779	0.9048
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Entamoeba histolytica	hypothetical protein	0.0096	0.086	1
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0096	0.086	0.0816
Schistosoma mansoni	opsin-like receptor	0.0121	0.1123	0.1081
Brugia malayi	Trypsin family protein	0.0111	0.1014	0.4627
Onchocerca volvulus		0.0121	0.1123	0.5128
Brugia malayi	PAN domain containing protein	0.0037	0.0249	0.1114
Onchocerca volvulus		0.0121	0.1123	0.5128
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0121	0.1123	0.5128
Echinococcus multilocularis	tissue type plasminogen activator	0.0088	0.0779	0.0773
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0121	0.1123	0.1081
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0096	0.086	0.0816
Brugia malayi	hypothetical protein	0.0121	0.1123	0.5128
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0111	0.1014	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0048	0.0042
Schistosoma mansoni	hypothetical protein	0.0096	0.086	0.0816
Toxoplasma gondii	PAN domain-containing protein	0.0037	0.0249	0.0606
Trypanosoma cruzi	glycerol uptake protein, putative	0.0096	0.086	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0088	0.0779	0.9054
Schistosoma mansoni	cercarial elastase (S01 family)	0.0111	0.1014	0.0971
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0121	0.1123	0.1081
Onchocerca volvulus		0.0037	0.0249	0.1114
Trypanosoma cruzi	GUP1, putative	0.0096	0.086	1
Brugia malayi	ORL1-like opioid receptor	0.0121	0.1123	0.5128
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0065	0.0059
Onchocerca volvulus		0.0121	0.1123	0.5128
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0096	0.086	0.0853
Schistosoma mansoni	cercarial elastase (S01 family)	0.0111	0.1014	0.0971
Brugia malayi	Hhat protein	0.0096	0.086	0.3918
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0017	0.0048	0.0042
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0111	0.1014	0.0971
Echinococcus multilocularis	fmrfamide receptor	0.0121	0.1123	0.1117
Onchocerca volvulus		0.0037	0.0249	0.1114
Brugia malayi	PAN domain containing protein	0.0037	0.0249	0.1114
Echinococcus multilocularis	g-protein coupled receptor	0.0121	0.1123	0.1117
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0096	0.086	0.217
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0096	0.086	0.0816
Onchocerca volvulus		0.0037	0.0249	0.1114
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0224	0.2185	0.2147
Schistosoma mansoni	cercarial elastase (S01 family)	0.0111	0.1014	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0121	0.1123	0.1117
Echinococcus granulosus	hypothetical protein	0.0121	0.1123	0.1117
Loa Loa (eye worm)	TK/ROR protein kinase	0.0088	0.0779	0.0773
Echinococcus granulosus	neuropeptide Y receptor	0.0121	0.1123	0.1117
Toxoplasma gondii	microneme protein MIC4	0.0037	0.0249	0.0606
Mycobacterium ulcerans	hypothetical protein	0.0111	0.1014	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0048	0.0042
Echinococcus multilocularis	sterol O acyltransferase 1	0.0982	1	1
Schistosoma mansoni	opsin-like receptor	0.0121	0.1123	0.1081
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0121	0.1123	0.5128
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.1123	0.1081
Brugia malayi	Dopamine receptor	0.0121	0.1123	0.5128
Brugia malayi	AKH receptor	0.0121	0.1123	0.5128
Loa Loa (eye worm)	G-protein coupled receptor	0.0121	0.1123	0.1118
Brugia malayi	Serotonin receptor	0.0121	0.1123	0.5128
Leishmania major	glycerol uptake protein, putative	0.0096	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0982	1	1
Brugia malayi	acetyltransferase, GNAT family protein	0.0047	0.0352	0.1589
Brugia malayi	PAN domain containing protein	0.0037	0.0249	0.1114
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0121	0.1123	0.1117
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0014	0.0012	0.0005
Onchocerca volvulus		0.0037	0.0249	0.1114
Loa Loa (eye worm)	MBOAT family protein	0.0096	0.086	0.0854
Schistosoma mansoni	biogenic amine receptor	0.0121	0.1123	0.1081
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0121	0.1123	0.1117
Echinococcus multilocularis	fibrillin 1	0.0017	0.0048	0.0041
Toxoplasma gondii	microneme protein MIC17B	0.0037	0.0249	0.0606
Echinococcus multilocularis	g protein coupled receptor	0.0121	0.1123	0.1117
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0121	0.1123	0.1117
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0226	0.2202	0.2165
Echinococcus granulosus	g protein coupled receptor	0.0121	0.1123	0.1117
Onchocerca volvulus		0.0111	0.1014	0.4627
Schistosoma mansoni	neuropeptide receptor	0.0121	0.1123	0.1081
Brugia malayi	G protein-coupled receptor	0.0121	0.1123	0.5128
Schistosoma mansoni	neuropeptide f receptor 76f	0.0121	0.1123	0.1081
Brugia malayi	sulfakinin receptor protein	0.0121	0.1123	0.5128
Toxoplasma gondii	microneme protein, putative	0.0037	0.0249	0.0606
Echinococcus multilocularis	neuropeptides capa receptor	0.0121	0.1123	0.1117
Brugia malayi	GCC2 and GCC3 family protein	0.0016	0.003	0.0112
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0096	0.086	0.0853
Echinococcus multilocularis	somatostatin receptor	0.0121	0.1123	0.1117
Brugia malayi	hypothetical protein	0.0121	0.1123	0.5128
Toxoplasma gondii	kringle domain-containing protein	0.0088	0.0779	0.1964
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0017	0.0048	0.0191
Brugia malayi	neuropeptide F receptor	0.0121	0.1123	0.5128
Echinococcus multilocularis	g protein coupled receptor	0.0121	0.1123	0.1117
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0121	0.1123	0.1081
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0121	0.1123	0.5128
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0111	0.1014	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Schistosoma mansoni	histamine h1 receptor	0.0121	0.1123	0.1081
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Schistosoma mansoni	opsin-like receptor	0.0121	0.1123	0.1081
Brugia malayi	follicle stimulating hormone receptor	0.0121	0.1123	0.5128
Onchocerca volvulus		0.0037	0.0249	0.1114
Brugia malayi	MBOAT family protein	0.0096	0.086	0.3918
Toxoplasma gondii	PAN domain-containing protein	0.0392	0.3918	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0121	0.1123	0.1117
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0121	0.1123	0.1117
Echinococcus granulosus	neuropeptides capa receptor	0.0121	0.1123	0.1117
Echinococcus granulosus	neuropeptide FF receptor 2	0.0121	0.1123	0.1117
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0121	0.1123	0.1118
Brugia malayi	PAN domain containing protein	0.0037	0.0249	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Echinococcus granulosus	tm gpcr rhodopsin	0.0121	0.1123	0.1117
Echinococcus multilocularis	serotonin receptor	0.0121	0.1123	0.1117
Leishmania major	glycerol uptake protein, putative	0.0096	0.086	1
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0019	0.0065	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0249	0.0243
Onchocerca volvulus		0.0113	0.1041	0.4749
Echinococcus granulosus	fmrfamide receptor	0.0121	0.1123	0.1117
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0121	0.1123	0.1117
Loa Loa (eye worm)	hhat protein	0.0096	0.086	0.0854
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0096	0.086	0.0816
Loa Loa (eye worm)	TYRA-2 protein	0.0121	0.1123	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1014	0.1009
Onchocerca volvulus		0.0121	0.1123	0.5128
Schistosoma mansoni	hypothetical protein	0.0121	0.1123	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0249	0.0243
Brugia malayi	Trypsin family protein	0.0111	0.1014	0.4627
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.1123	0.1081
Brugia malayi	putative neuropeptide receptor	0.0121	0.1123	0.5128
Echinococcus granulosus	neuropeptide receptor	0.0121	0.1123	0.1117
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0121	0.1123	0.1117
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Brugia malayi	RE15519p	0.0121	0.1123	0.5128
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Brugia malayi	G-protein coupled receptor	0.0121	0.1123	0.5128
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0121	0.1123	0.1081
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.1123	0.1081
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0121	0.1123	0.1081
Loa Loa (eye worm)	neuropeptide F receptor	0.0121	0.1123	0.1118
Brugia malayi	Serotonin receptor	0.0121	0.1123	0.5128
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0045	0.0339	0.0332
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.1123	0.1081
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0113	0.1031	0.0989
Schistosoma mansoni	amine GPCR	0.0121	0.1123	0.1081
Echinococcus granulosus	g-protein coupled receptor	0.0121	0.1123	0.1117
Brugia malayi	G protein-coupled receptor F59B2.13	0.0121	0.1123	0.5128
Brugia malayi	Melatonin receptor type 1A	0.0121	0.1123	0.5128
Trypanosoma brucei	glycerol uptake protein, putative	0.0096	0.086	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0121	0.1123	0.1081
Echinococcus granulosus	neuropeptide receptor	0.0121	0.1123	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Echinococcus granulosus	allatostatin A receptor	0.0121	0.1123	0.1117
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0127	0.1183	0.114
Trichomonas vaginalis	conserved hypothetical protein	0.0096	0.086	1
Toxoplasma gondii	hypothetical protein	0.0037	0.0249	0.0606
Brugia malayi	PAN domain containing protein	0.0037	0.0249	0.1114
Onchocerca volvulus		0.0088	0.0779	0.3547
Echinococcus granulosus	orexin receptor type 2	0.0121	0.1123	0.1117
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0111	0.1014	0.1008
Leishmania major	glycerol uptake protein, putative	0.0096	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0249	0.0243
Echinococcus multilocularis	neuropeptides capa receptor	0.0121	0.1123	0.1117
Brugia malayi	PAN domain containing protein	0.0037	0.0249	0.1114
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0111	0.1014	0.0971
Onchocerca volvulus		0.0121	0.1123	0.5128
Schistosoma mansoni	sterol O-acyltransferase 1	0.0982	1	1
Schistosoma mansoni	myosin xvIII	0.0121	0.1123	0.1081
Echinococcus granulosus	tissue type plasminogen activator	0.0088	0.0779	0.0773
Schistosoma mansoni	neuropeptide F-like receptor	0.0121	0.1123	0.1081
Plasmodium falciparum	cysteine repeat modular protein 1	0.0088	0.0779	0.9061
Leishmania major	glycerol uptake protein, putative	0.0096	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0224	0.2185	0.218
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.1123	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Onchocerca volvulus		0.0121	0.1123	0.5128
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0014	0.0012	0.0061
Brugia malayi	putative neuropeptide receptor NPR1	0.0121	0.1123	0.5128
Schistosoma mansoni	cercarial elastase (S01 family)	0.0111	0.1014	0.0971
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0121	0.1123	0.1117
Toxoplasma gondii	microneme protein MIC17A	0.0037	0.0249	0.0606
Echinococcus granulosus	G protein coupled receptor 139	0.0121	0.1123	0.1117
Schistosoma mansoni	biogenic amine receptor	0.0121	0.1123	0.1081
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0121	0.1123	0.5128
Onchocerca volvulus		0.0121	0.1123	0.5128
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0017	0.0048	0.0092
Schistosoma mansoni	cercarial elastase (S01 family)	0.0111	0.1014	0.0971
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0096	0.086	1
Echinococcus granulosus	somatostatin receptor	0.0121	0.1123	0.1117
Echinococcus multilocularis	orexin receptor type 2	0.0121	0.1123	0.1117
Brugia malayi	MBOAT family protein	0.0096	0.086	0.3918
Echinococcus granulosus	Tolloid protein 1	0.0019	0.0065	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Echinococcus multilocularis	neuropeptide receptor A26	0.0121	0.1123	0.1117
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0121	0.1123	0.1117
Brugia malayi	hypothetical protein	0.0121	0.1123	0.5128
Echinococcus multilocularis	neuropeptide receptor	0.0121	0.1123	0.1117
Onchocerca volvulus		0.0121	0.1123	0.5128
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Loa Loa (eye worm)	MBOAT family protein	0.0096	0.086	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Brugia malayi	hypothetical protein	0.0121	0.1123	0.5128
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.1123	0.1117
Schistosoma mansoni	amine GPCR	0.0121	0.1123	0.1081
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0096	0.086	1
Onchocerca volvulus		0.0096	0.086	0.3918
Toxoplasma gondii	PAN domain-containing protein	0.0037	0.0249	0.0606
Brugia malayi	PAN domain containing protein	0.0037	0.0249	0.1114
Onchocerca volvulus		0.0121	0.1123	0.5128
Toxoplasma gondii	hypothetical protein	0.0037	0.0249	0.0606
Toxoplasma gondii	hypothetical protein	0.0096	0.086	0.217
Trypanosoma cruzi	glycerol uptake protein, putative	0.0096	0.086	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0121	0.1123	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0224	0.2185	0.218
Leishmania major	glycerol uptake protein, putative	0.0096	0.086	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0121	0.1123	0.1081
Schistosoma mansoni	cercarial elastase (S01 family)	0.0111	0.1014	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1014	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Brugia malayi	PAN domain containing protein	0.0037	0.0249	0.1114
Onchocerca volvulus		0.0121	0.1123	0.5128
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0121	0.1123	0.5128
Brugia malayi	GnHR receptor homolog	0.0121	0.1123	0.5128
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Schistosoma mansoni	amine GPCR	0.0121	0.1123	0.1081
Brugia malayi	Dopamine receptor protein 2	0.0121	0.1123	0.5128
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.1123	0.1081
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0111	0.1014	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0249	0.0243
Giardia lamblia	Histone acetyltransferase GCN5	0.0013	0	0.5
Brugia malayi	hypothetical protein	0.0121	0.1123	0.5128
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Onchocerca volvulus		0.0121	0.1123	0.5128
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0111	0.1014	0.4627
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0121	0.1123	0.1081
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0096	0.086	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1014	0.1009
Schistosoma mansoni	neuropeptide receptor	0.0121	0.1123	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0121	0.1123	0.1118
Echinococcus granulosus	sex peptide receptor	0.0121	0.1123	0.1117
Brugia malayi	MBOAT family protein	0.0096	0.086	0.3918
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0096	0.086	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Echinococcus granulosus	tm gpcr rhodopsin	0.0121	0.1123	0.1117
Onchocerca volvulus		0.0037	0.0249	0.1114
Echinococcus granulosus	g protein coupled receptor	0.0121	0.1123	0.1117
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.1123	0.1081
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0121	0.1123	0.1117
Brugia malayi	hypothetical protein	0.0121	0.1123	0.5128
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0096	0.086	0.0853
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0037	0.0249	0.0606
Echinococcus granulosus	serotonin receptor	0.0121	0.1123	0.1117
Onchocerca volvulus		0.0111	0.1014	0.4627
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0017	0.0048	0.0042
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0121	0.1123	0.1081
Brugia malayi	Trypsin-like protease protein 5	0.0111	0.1014	0.4627
Toxoplasma gondii	microneme protein MIC17C	0.0037	0.0249	0.0606
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0096	0.086	0.0853
Brugia malayi	Fibulin-1 precursor	0.0017	0.0048	0.0191
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0249	0.0243
Echinococcus multilocularis	G protein coupled receptor 139	0.0121	0.1123	0.1117
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0121	0.1123	0.1117
Brugia malayi	hypothetical protein	0.0121	0.1123	0.5128
Schistosoma mansoni	cercarial elastase (S01 family)	0.0111	0.1014	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.0024
Echinococcus multilocularis	g protein coupled receptor	0.0121	0.1123	0.1117
Echinococcus multilocularis	serotonin receptor	0.0121	0.1123	0.1117
Trypanosoma brucei	glycerol uptake protein, putative	0.0096	0.086	1
Trypanosoma cruzi	glycerol uptake protein, putative	0.0096	0.086	1
Toxoplasma gondii	PAN domain-containing protein	0.0037	0.0249	0.0606
Echinococcus granulosus	biogenic amine 5HT receptor	0.0121	0.1123	0.1117
Trichomonas vaginalis	conserved hypothetical protein	0.0096	0.086	1
Onchocerca volvulus		0.0037	0.0249	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1123	0.1118
Brugia malayi	Protein kinase domain containing protein	0.0088	0.0779	0.3547
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0121	0.1123	0.1081
Brugia malayi	MBOAT family protein	0.0096	0.086	0.3918

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)		Inhibition of human recombinant MAO-B assessed as H2O2 production using p-tyramine substrate at 60 uM by fluorimetric method	ChEMBL.	24856304
Inhibition (binding)		Inhibition of human recombinant MAO-A assessed as H2O2 production using p-tyramine substrate at 60 uM by fluorimetric method	ChEMBL.	24856304

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3297872

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1899265