Detailed information for compound 1900960

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.443 | Formula: C21H26N2O2
  • H donors: 0 H acceptors: 2 LogP: 3.38 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1ccc2c(c1)c1CCCCCc1c(=O)n2C)C1CC1
  • InChi: 1S/C21H26N2O2/c1-3-23(15-10-11-15)20(24)14-9-12-19-18(13-14)16-7-5-4-6-8-17(16)21(25)22(19)2/h9,12-13,15H,3-8,10-11H2,1-2H3
  • InChiKey: DDMIDNCNRHDNEK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei glucose transporter, putative 0.0038 0.0579 0.6396
Trypanosoma brucei glucose transporter, putative 0.0038 0.0579 0.6396
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.0674 0.0779
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0117 0.0109
Schistosoma mansoni glucose transport protein 0.0121 0.2231 0.3395
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0555 0.079
Schistosoma mansoni sugar transporter 0.0017 0.0173 0.0196
Echinococcus granulosus lamin 0.0029 0.0419 0.0578
Trypanosoma brucei sugar transporter, putative 0.0017 0.0173 0.1913
Schistosoma mansoni glucose transport protein 0.0121 0.2231 0.3395
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0316 0.0418
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0173 0.0268
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.057 0.0404
Loa Loa (eye worm) hypothetical protein 0.0039 0.0616 0.0884
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0579 0.1973
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0875 0.1287
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0121 0.2231 0.3395
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0579 0.5544
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.057 0.0813
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0579 0.1973
Onchocerca volvulus 0.0017 0.0173 0.159
Echinococcus multilocularis snurportin 1 0.0337 0.648 1
Schistosoma mansoni transient receptor potential channel 0.007 0.1222 0.1827
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0579 0.5544
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0165 0.0183
Echinococcus granulosus solute carrier family 22 0.0017 0.0173 0.0196
Schistosoma mansoni lamin 0.0029 0.0419 0.0578
Schistosoma mansoni sugar transporter 0.0017 0.0173 0.0196
Echinococcus multilocularis lamin dm0 0.0029 0.0419 0.0578
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0173 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.057 0.1927
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.057 0.0813
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0524 0.0742
Loa Loa (eye worm) hypothetical protein 0.0067 0.1152 0.1718
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.057 0.0813
Loa Loa (eye worm) hypothetical protein 0.0014 0.0107 0.0093
Toxoplasma gondii facilitative glucose transporter GT1 0.0121 0.2231 0.3201
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0165 0.0183
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0173 0.5
Schistosoma mansoni glucose transport protein 0.0121 0.2231 0.3395
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0173 0.1913
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0555 0.1077
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0875 0.1756
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0579 0.1973
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.057 0.0404
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0371 0.0961
Trichomonas vaginalis ran, putative 0.0023 0.0295 0.059
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.0674 0.051
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2231 0.3395
Loa Loa (eye worm) hypothetical protein 0.0036 0.0555 0.079
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0555 0.1077
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0295 0.0189
Schistosoma mansoni sugar transporter 0.0017 0.0173 0.0196
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.057 0.0813
Brugia malayi major facilitator superfamily protein 0.0017 0.0173 0.0268
Echinococcus granulosus TRP transient receptor potential channel 0.0039 0.0616 0.0884
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0546 0.1059
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0305 0.0641
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0117 0.0109
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0841 0.1684
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0674 0.6838
Plasmodium falciparum mitogen-activated protein kinase 2 0.0196 0.3706 0.3595
Plasmodium falciparum protein kinase 7 0.0343 0.6602 0.6542
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.4761 0.7328
Echinococcus multilocularis short transient receptor potential channel 6 0.007 0.1222 0.1827
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0906 0.0745
Echinococcus granulosus short transient receptor potential channel 6 0.007 0.1222 0.1827
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0371 0.3046
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0371 0.5182
Schistosoma mansoni hypothetical protein 0.0051 0.0841 0.1234
Echinococcus granulosus transient receptor potential ion channel A 0.0103 0.1862 0.2821
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0165 0.0183
Loa Loa (eye worm) hypothetical protein 0.025 0.4761 0.7328
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2231 0.3395
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0173 0.2954
Onchocerca volvulus 0.0017 0.0173 0.159
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0371 1
Schistosoma mansoni transient receptor potential channel 0.0106 0.1931 0.2929
Onchocerca volvulus 0.0017 0.0173 0.159
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.057 0.0404
Loa Loa (eye worm) hypothetical protein 0.0106 0.1931 0.2929
Schistosoma mansoni ran 0.0023 0.0295 0.0385
Onchocerca volvulus 0.0017 0.0173 0.159
Onchocerca volvulus 0.0017 0.0173 0.159
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0131 0.0131
Echinococcus multilocularis lamin 0.0029 0.0419 0.0578
Schistosoma mansoni survival motor neuron protein 0.0051 0.0841 0.1234
Schistosoma mansoni protein kinase 0.0037 0.057 0.0813
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0196 0.3706 0.5495
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0173 0.0196
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0173 0.0268
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0242 0.0946
Loa Loa (eye worm) hypothetical protein 0.0032 0.0459 0.064
Leishmania major glucose transporter/membrane transporter D2, putative 0.0038 0.0579 0.5544
Trypanosoma brucei glucose transporter, putative 0.0038 0.0579 0.6396
Plasmodium vivax hexose transporter 0.0121 0.2231 0.2094
Loa Loa (eye worm) hypothetical protein 0.0029 0.0408 0.0561
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0555 0.079
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0295 0.0385
Schistosoma mansoni hypothetical protein 0.0036 0.0546 0.0776
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0371 0.0308
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0579 0.5544
Brugia malayi hypothetical protein 0.0017 0.0173 0.0268
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0579 0.1973
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0173 0.0196
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0295 0.1657
Loa Loa (eye worm) hypothetical protein 0.0027 0.0371 0.0504
Echinococcus multilocularis solute carrier family 22 0.0017 0.0173 0.0196
Schistosoma mansoni importin beta-1 0.0032 0.0459 0.064
Schistosoma mansoni transient receptor potential channel 0.007 0.1222 0.1827
Onchocerca volvulus 0.0017 0.0173 0.159
Onchocerca volvulus 0.0051 0.0841 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0165 0.0183
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.009 0.5
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0555 1
Echinococcus multilocularis GPCR, family 2 0.0017 0.0165 0.0183
Leishmania major glucose transporter, lmgt1 0.0038 0.0579 0.5544
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0295 0.3253
Leishmania major protein kinase, putative 0.0037 0.057 0.5415
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0165 0.025
Brugia malayi hypothetical protein 0.0017 0.0173 0.0268
Loa Loa (eye worm) hypothetical protein 0.0037 0.057 0.0813
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.057 0.0404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0107 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0579 0.1973
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0419 0.0788
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0579 0.1973
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.057 0.0813
Schistosoma mansoni protein kinase 0.0037 0.057 0.0813
Onchocerca volvulus 0.0029 0.0419 0.4679
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0906 1
Mycobacterium ulcerans sugar transporter 0.0017 0.0173 0.2954
Entamoeba histolytica protein kinase, putative 0.0037 0.057 1
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0906 0.1139
Echinococcus multilocularis short transient receptor potential channel 6 0.007 0.1222 0.1827
Plasmodium falciparum hexose transporter 0.0121 0.2231 0.2094
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0459 0.5067
Brugia malayi Importin beta-1 subunit 0.0032 0.0459 0.0874
Onchocerca volvulus 0.0017 0.0173 0.159
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0555 0.079
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.057 0.0617
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0295 0.0385
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0579 0.6396
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0341 0.0816
Echinococcus multilocularis solute carrier family 22 0.0017 0.0173 0.0196
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0906 1
Onchocerca volvulus 0.0017 0.0173 0.159
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0165 0.0183
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.057 0.0404
Loa Loa (eye worm) hypothetical protein 0.0029 0.0419 0.0578
Onchocerca volvulus 0.0017 0.0173 0.159
Onchocerca volvulus Putative transporter 0.0017 0.0173 0.159
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0341 0.0816
Brugia malayi Sugar transporter family protein 0.0017 0.0173 0.0268
Loa Loa (eye worm) hypothetical protein 0.0054 0.0906 0.1334
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0419 0.0578
Schistosoma mansoni sugar transporter 0.0017 0.0173 0.0196
Onchocerca volvulus 0.0017 0.0173 0.159
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.029 1
Echinococcus granulosus transient receptor potential gamma protein 0.0106 0.1931 0.2929
Echinococcus multilocularis solute carrier family 22 0.0017 0.0173 0.0196
Schistosoma mansoni protein kinase 0.0037 0.057 0.0813
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0173 0.0196
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0173 0.0196
Brugia malayi Cam kinase protein 1 0.0037 0.057 0.1109
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0875 0.1756
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0371 0.0504
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0674 0.6838
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.057 0.0813
Echinococcus granulosus solute carrier family 22 0.0017 0.0173 0.0196
Onchocerca volvulus 0.0017 0.0173 0.159
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0109
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0173 0.0196
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.057 0.0813
Brugia malayi RNA, U transporter 1 0.009 0.1606 0.3307
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0371 0.0504
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0371 0.0687
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0459 0.064
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0341 0.2293
Echinococcus granulosus importin subunit beta 1 0.0032 0.0459 0.064
Schistosoma mansoni hypothetical protein 0.0017 0.0165 0.0183
Echinococcus multilocularis transient receptor potential gamma protein 0.0106 0.1931 0.2929
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0579 0.6396
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.057 0.0404
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.057 0.0813
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.057 0.0404
Echinococcus granulosus General substrate transporter 0.0104 0.1894 0.2872
Schistosoma mansoni transient receptor potential channel 4 0.0106 0.1931 0.2929
Loa Loa (eye worm) hypothetical protein 0.0053 0.0875 0.1287
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0555 0.1855
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.2231 0.3395
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0295 0.1657
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0039 0.0616 0.0884
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Onchocerca volvulus 0.0017 0.0173 0.159
Plasmodium falciparum proline--tRNA ligase 0.0042 0.0674 0.051
Loa Loa (eye worm) hypothetical protein 0.003 0.042 0.058
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.057 0.1109
Onchocerca volvulus 0.0017 0.0173 0.159
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0906 0.0745
Echinococcus multilocularis transient receptor potential ion channel A 0.0103 0.1862 0.2821
Trypanosoma brucei glucose transporter 2A 0.0038 0.0579 0.6396
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0341 0.0816
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0337 0.648 1
Loa Loa (eye worm) sugar transporter 0.0017 0.0173 0.0196
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0674 0.7443
Onchocerca volvulus 0.0017 0.0173 0.159
Echinococcus multilocularis musashi 0.0029 0.0419 0.0578
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0165 0.0183
Loa Loa (eye worm) hypothetical protein 0.0036 0.0546 0.0776
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0371 0.0504
Echinococcus multilocularis General substrate transporter 0.0104 0.1894 0.2872
Toxoplasma gondii protein kinase, putative 0.0343 0.6602 1
Trypanosoma brucei glucose transporter, putative 0.0038 0.0579 0.6396
Echinococcus granulosus intermediate filament protein 0.0029 0.0419 0.0578
Schistosoma mansoni hypothetical protein 0.0017 0.0165 0.0183
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Echinococcus granulosus snurportin 1 0.0337 0.648 1
Loa Loa (eye worm) sugar transporter 0.0121 0.2231 0.3395
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0674 0.6838
Trypanosoma cruzi hexose transporter 0.0038 0.0579 0.5544
Onchocerca volvulus 0.0029 0.0419 0.4679
Echinococcus granulosus survival motor neuron protein 1 0.025 0.4761 0.7328
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0555 0.9461
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0148 0.0157
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0459 0.5067
Schistosoma mansoni hypothetical protein 0.0121 0.2231 0.3395
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0173 0.2954
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0371 0.0504
Entamoeba histolytica protein kinase, putative 0.0037 0.057 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.057 0.6292
Loa Loa (eye worm) hypothetical protein 0.0036 0.0546 0.0775
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0295 0.0123
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0555 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0371 0.4097
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2231 0.3395
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Leishmania major glucose transporter, lmgt3 0.0038 0.0579 0.5544
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.057 0.0404
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.057 0.0404
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0674 0.6838
Leishmania major GTP-binding protein, putative 0.0023 0.0295 0.1657
Schistosoma mansoni intermediate filament proteins 0.0029 0.0419 0.0578
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0371 1
Plasmodium falciparum importin beta, putative 0.0032 0.0459 0.0291
Echinococcus granulosus short transient receptor potential channel 6 0.007 0.1222 0.1827
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Brugia malayi hypothetical protein 0.0054 0.0906 0.1821
Loa Loa (eye worm) hypothetical protein 0.0036 0.0555 0.079
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0906 0.0745
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0371 0.0201
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0371 0.0201
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0148 0.0215
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0371 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.057 0.0813
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0295 0.3178
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.057 0.0617
Echinococcus granulosus lamin dm0 0.0029 0.0419 0.0578
Trypanosoma brucei glucose transporter 1E 0.0038 0.0579 0.6396
Plasmodium vivax importin-beta 2, putative 0.0032 0.0459 0.0291
Echinococcus granulosus solute carrier family 22 0.0017 0.0173 0.0196
Onchocerca volvulus 0.0017 0.0173 0.159
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2231 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0316 0.0418
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0173 0.0196
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0371 0.2701
Trypanosoma brucei glucose transporter, putative 0.0038 0.0579 0.6396
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.2231 0.3395
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.057 0.0617
Trypanosoma brucei glucose transporter, putative 0.0038 0.0579 0.6396
Schistosoma mansoni hypothetical protein 0.0024 0.0316 0.0418
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.057 0.0813
Trypanosoma brucei glucose transporter, putative 0.0038 0.0579 0.6396
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0579 0.6396
Schistosoma mansoni lamin 0.0029 0.0419 0.0578
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0459 0.0444
Brugia malayi Transient-receptor-potential like protein 0.0039 0.0616 0.1206
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0173 0.0268
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0173 0.2954
Brugia malayi major facilitator superfamily protein 0.0017 0.0173 0.0268
Trypanosoma brucei glucose transporter, putative 0.0038 0.0579 0.6396
Leishmania major glucose transporter, lmgt2 0.0038 0.0579 0.5544
Leishmania major hypothetical protein, conserved 0.0054 0.0906 1
Echinococcus multilocularis solute carrier family 22 0.0017 0.0173 0.0196
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0419 0.0578
Brugia malayi Sugar transporter family protein 0.0017 0.0173 0.0268
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.2231 0.3395
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0165 0.025
Schistosoma mansoni hypothetical protein 0.0017 0.0165 0.0183
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0295 0.0123
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0295 0.0385
Loa Loa (eye worm) hypothetical protein 0.0017 0.0173 0.0196
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0524 0.0742
Brugia malayi hypothetical protein 0.0035 0.0527 0.1017
Entamoeba histolytica hypothetical protein 0.0027 0.0371 0.2779
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.029 1
Schistosoma mansoni hypothetical protein 0.0337 0.648 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0555 0.079
Brugia malayi hypothetical protein 0.025 0.4761 1
Echinococcus granulosus GPCR family 2 0.0017 0.0165 0.0183
Onchocerca volvulus 0.0017 0.0173 0.159
Echinococcus granulosus solute carrier family 22 0.0017 0.0173 0.0196
Schistosoma mansoni glucose transporter 0.0017 0.0173 0.0196
Leishmania major importin beta-1 subunit, putative 0.0026 0.0341 0.2293
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0579 0.1973
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.057 0.0813
Brugia malayi hypothetical protein 0.0017 0.0173 0.0268
Schistosoma mansoni ran 0.0023 0.0295 0.0385
Schistosoma mansoni hypothetical protein 0.0017 0.0165 0.0183
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0196 0.3706 0.3595
Brugia malayi Sugar transporter family protein 0.0121 0.2231 0.4633
Entamoeba histolytica hypothetical protein 0.0026 0.0341 0.1693
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0295 0.0525
Brugia malayi intermediate filament protein 0.0029 0.0419 0.0788
Plasmodium vivax CDK-related protein kinase 6, putative 0.0515 1 1
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0371 0.2701
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2231 0.3395
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0906 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 0 % Binding affinity to human GFP-tagged NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to plasma membrane at 30 uM after 24 hrs by fluorescence microscopic analysis ChEMBL. 24906511

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.