Detailed information for compound 1914795

Basic information

Technical information
  • TDR Targets ID: 1914795
  • Name: 2-(2-propan-2-yl-2,3-dihydro-1H-inden-5-yl)ac etic acid
  • MW: 218.292 | Formula: C14H18O2
  • H donors: 1 H acceptors: 2 LogP: 3.27 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cc1ccc2c(c1)CC(C2)C(C)C
  • InChi: 1S/C14H18O2/c1-9(2)12-7-11-4-3-10(6-14(15)16)5-13(11)8-12/h3-5,9,12H,6-8H2,1-2H3,(H,15,16)
  • InChiKey: MRASYQFTHLLRCS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-isopropylindan-5-yl)acetic acid
  • 2-(2-isopropyl-5-indanyl)acetic acid
  • 2-(2-propan-2-yl-2,3-dihydro-1H-inden-5-yl)ethanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0107
Brugia malayi transcriptional regulator, Sir2 family protein 0.0033 0.0105 0.0409
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0486 0.1238
Trichomonas vaginalis esterase, putative 0.0035 0.0137 0.0132
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0033 0.0105 0.0059
Toxoplasma gondii histone deacetylase SIR2-like 0.0033 0.0105 0.7644
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0129
Loa Loa (eye worm) pip kinase 2 0.0164 0.1813 0.504
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0137 0.0232
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0137 1
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0164 0.1813 0.1775
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0137 0.0129
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0959 0.3739
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0137 0.0536
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0382
Brugia malayi TAR-binding protein 0.0062 0.0486 0.1893
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0222 0.2566 0.6402
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0084 0.0097
Brugia malayi hypothetical protein 0.0071 0.0603 0.235
Echinococcus multilocularis chromatin regulatory protein sir2 0.0222 0.2566 0.2531
Entamoeba histolytica hypothetical protein 0.0071 0.0603 0.2024
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0486 0.1351
Echinococcus multilocularis tumor protein p63 0.0331 0.3982 0.3954
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0486 0.1238
Loa Loa (eye worm) hypothetical protein 0.0098 0.0959 0.2667
Leishmania major silent information regulator 2, putative 0.0222 0.2566 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0033 0.0105 0.015
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0222 0.2566 0.2531
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0486 0.1238
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1225 0.3406
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.3597 1
Trypanosoma brucei SIR2-like protein 4, putative 0.0033 0.0105 0.0409
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0105 0.0166
Leishmania major sir2-family protein-like protein 0.0033 0.0105 0.0409
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0084 0.0097
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0486 0.1893
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0033 0.0105 0.0409
Loa Loa (eye worm) hypothetical protein 0.0067 0.0554 0.1541
Brugia malayi RNA binding protein 0.0062 0.0486 0.1893
Echinococcus granulosus tar DNA binding protein 0.0062 0.0486 0.1117
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0222 0.2566 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0046 0.018
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0084 0.0038
Entamoeba histolytica hypothetical protein 0.0071 0.0603 0.2024
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0132
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0033 0.0105 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0137 0.0129
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0222 0.2566 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0382
Echinococcus multilocularis GPCR, family 2 0.0031 0.0084 0.0038
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0033 0.0105 0.0409
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0137 1
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0603 0.1568
Brugia malayi transcriptional regulator, Sir2 family protein 0.0222 0.2566 1
Schistosoma mansoni hypothetical protein 0.0171 0.1904 0.5231
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0105 0.0166
Giardia lamblia Hypothetical protein 0.0222 0.2566 1
Plasmodium falciparum importin beta, putative 0.0028 0.0046 0.4396
Loa Loa (eye worm) beta-lactamase 0.0035 0.0137 0.0382
Brugia malayi Pip kinase protein 2 0.0164 0.1813 0.7066
Echinococcus granulosus snurportin 1 0.0301 0.3597 0.9022
Brugia malayi RNA, U transporter 1 0.008 0.0723 0.2817
Loa Loa (eye worm) RNA binding protein 0.0062 0.0486 0.1351
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0137 0.0257
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0382
Loa Loa (eye worm) hypothetical protein 0.0164 0.1813 0.504
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0234
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0486 0.0442
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0959 0.3739
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0222 0.2566 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0164 0.1813 0.4976
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0382
Schistosoma mansoni hypothetical protein 0.0301 0.3597 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0486 0.1238
Echinococcus multilocularis snurportin 1 0.0301 0.3597 0.3567
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0046 0.018
Echinococcus granulosus tumor protein p63 0.0331 0.3982 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0222 0.2566 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0129
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0084 0.0328
Loa Loa (eye worm) transcriptional regulator 0.0222 0.2566 0.7133
Mycobacterium leprae Probable lipase LipE 0.0035 0.0137 0.5
Brugia malayi transcriptional regulator, Sir2 family protein 0.0033 0.0105 0.0409
Loa Loa (eye worm) transcriptional regulator 0.0033 0.0105 0.0292
Schistosoma mansoni chromatin regulatory protein sir2 0.0222 0.2566 0.7096
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0046 0.336
Brugia malayi beta-lactamase family protein 0.0035 0.0137 0.0536
Onchocerca volvulus 0.0164 0.1813 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0137 0.0129
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0033 0.0105 0.0059
Echinococcus multilocularis geminin 0.0171 0.1904 0.1866
Schistosoma mansoni chromatin regulatory protein sir2 0.0222 0.2566 0.7096
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0132
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0222 0.2566 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0137 0.0129
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0137 0.0132
Mycobacterium ulcerans hypothetical protein 0.0035 0.0137 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0486 0.1238
Loa Loa (eye worm) sirtuin 4 0.0033 0.0105 0.0292
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0137 0.0257
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0129
Schistosoma mansoni hypothetical protein 0.0067 0.0554 0.1431
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0107
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0137 0.0129
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0084 0.0234
Brugia malayi NAD-dependent deacetylase SIRT1 0.0033 0.0105 0.0409
Leishmania major hypothetical protein, conserved 0.0035 0.0137 0.0536
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0033 0.0105 0.0409
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0222 0.2566 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0033 0.0105 0.015
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0137 0.0536
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1225 0.3406
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0033 0.0105 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0084 0.0328
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0137 0.0382
Echinococcus granulosus geminin 0.0171 0.1904 0.472
Brugia malayi Importin beta-1 subunit 0.0028 0.0046 0.018
Toxoplasma gondii histone deacetylase SIR2 0.0033 0.0105 0.7644
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0132
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0603 0.0559
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0137 0.0129
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0137 0.5
Schistosoma mansoni chromatin regulatory protein sir2 0.0222 0.2566 0.7096
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0033 0.0105 0.0059
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0959 0.2667
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0382
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0128
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2607 1
Brugia malayi beta-lactamase family protein 0.0035 0.0137 0.0536
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0137 0.0536
Echinococcus granulosus chromatin regulatory protein sir2 0.0222 0.2566 0.6402
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0105 0.7644
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0603 0.1415
Toxoplasma gondii ABC1 family protein 0.0035 0.0137 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0105 0.0166
Mycobacterium ulcerans beta-lactamase 0.0035 0.0137 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0164 0.1813 0.4976
Echinococcus granulosus GPCR family 2 0.0031 0.0084 0.0097
Schistosoma mansoni hypothetical protein 0.0071 0.0603 0.1568
Onchocerca volvulus 0.0048 0.0309 0.1024
Entamoeba histolytica hypothetical protein 0.0071 0.0603 0.2024
Brugia malayi MH2 domain containing protein 0.0119 0.1225 0.4776
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.0859
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0033 0.0105 0.015
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0107
Plasmodium vivax importin-beta 2, putative 0.0028 0.0046 0.336
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0382
Brugia malayi beta-lactamase 0.0035 0.0137 0.0536
Mycobacterium ulcerans lipase LipD 0.0035 0.0137 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0137 0.0092
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0164 0.1813 0.4489
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0084 0.0038
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0033 0.0105 0.0409
Loa Loa (eye worm) transcriptional regulator 0.0033 0.0105 0.0292
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0486 0.1351
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0137 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0105 0.0166
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0137 0.0132
Plasmodium vivax NAD-dependent deacetylase, putative 0.0033 0.0105 0.7644
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0554 0.216
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0309 0.074
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0222 0.2566 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0292
Entamoeba histolytica hypothetical protein 0.0071 0.0603 0.2024
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0137 0.0129
Schistosoma mansoni hypothetical protein 0.0171 0.1904 0.5231
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0137 0.0536

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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