Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D5 | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D4 receptor | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | 5-hydroxytryptamine receptor 1, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134111 | All targets in OG5_134111 |
Brugia malayi | Dopamine receptor protein 1 | Get druggable targets OG5_134111 | All targets in OG5_134111 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0525 | 0.0038 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0117 | 0.1465 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0117 | 0.1465 | 0.067 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0117 | 0.1465 | 0.1279 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0117 | 0.1465 | 0.5 |
Toxoplasma gondii | peptidase family M13 protein | 0.0097 | 0.1032 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0117 | 0.1465 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.6612 | 0.6438 |
Onchocerca volvulus | 0.0398 | 0.7497 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.4981 | 0.4723 |
Echinococcus granulosus | aminopeptidase N | 0.0398 | 0.7497 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0117 | 0.1465 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1032 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 1 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0117 | 0.1465 | 0.1279 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0117 | 0.1465 | 0.067 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0117 | 0.1465 | 0.5 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0097 | 0.1032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.058 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1032 | 0.0572 |
Brugia malayi | Peptidase family M1 containing protein | 0.0398 | 0.7497 | 0.7209 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0117 | 0.1465 | 1 |
Brugia malayi | hypothetical protein | 0.0117 | 0.1465 | 0.0483 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0097 | 0.1032 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0398 | 0.7497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.058 | 0.0097 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0076 | 0.058 | 0.3962 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0097 | 0.1032 | 0.0653 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0117 | 0.1465 | 0.1279 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0117 | 0.1465 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0117 | 0.1465 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0525 | 0.0038 |
Entamoeba histolytica | aminopeptidase, putative | 0.0117 | 0.1465 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0117 | 0.1465 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0097 | 0.1032 | 0.7045 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0117 | 0.1465 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1032 | 0.0572 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0117 | 0.1465 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0525 | 0.0038 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0117 | 0.1465 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0117 | 0.1465 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0117 | 0.1465 | 0.067 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0525 | 0.0038 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0117 | 0.1465 | 0.067 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0117 | 0.1465 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0322 | 0.5866 | 0.5653 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0117 | 0.1465 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0525 | 0.0038 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0117 | 0.1465 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0525 | 0.0038 |
Loa Loa (eye worm) | aminopeptidase N | 0.0117 | 0.1465 | 0.1027 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0117 | 0.1465 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 185 nM | Displacement of [3H]N-methylspiperone from rat dopamine D4 receptor by PDSP assay | ChEMBL. | 24800940 |
Ki (binding) | = 274 nM | Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay | ChEMBL. | 24800940 |
Ki (binding) | = 1462 nM | Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by PDSP assay | ChEMBL. | 24800940 |
Ki (binding) | = 1522 nM | Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay | ChEMBL. | 24800940 |
Ki (binding) | = 2507 nM | Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by PDSP assay | ChEMBL. | 24800940 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.