Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate lyase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Pyridoxal-dependent decarboxylase conserved domain containing protein | sphingosine-1-phosphate lyase 1 | 568 aa | 524 aa | 39.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0166 | 0.0108 | 0.0364 |
Plasmodium vivax | aspartyl protease, putative | 0.0166 | 0.0108 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0433 | 0.0777 | 0.0777 |
Plasmodium falciparum | plasmepsin III | 0.0166 | 0.0108 | 0.5 |
Plasmodium falciparum | plasmepsin X | 0.0166 | 0.0108 | 0.5 |
Plasmodium falciparum | plasmepsin V | 0.0166 | 0.0108 | 0.5 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0433 | 0.0777 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0166 | 0.0108 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0166 | 0.0108 | 0.0108 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0166 | 0.0108 | 0.0364 |
Onchocerca volvulus | 0.0166 | 0.0108 | 0.5 | |
Echinococcus granulosus | cathepsin b | 0.1313 | 0.2975 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0166 | 0.0108 | 0.0108 |
Onchocerca volvulus | 0.0166 | 0.0108 | 0.5 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0166 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0166 | 0.0108 | 0.0364 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0166 | 0.0108 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0433 | 0.0777 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.1313 | 0.2975 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1313 | 0.2975 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0166 | 0.0108 | 0.0108 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1313 | 0.2975 | 0.2975 |
Plasmodium vivax | aspartyl protease, putative | 0.0166 | 0.0108 | 0.5 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.1313 | 0.2975 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1313 | 0.2975 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1313 | 0.2975 | 0.2975 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1313 | 0.2975 | 0.2975 |
Giardia lamblia | Cathepsin B precursor | 0.0433 | 0.0777 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1313 | 0.2975 | 0.2975 |
Plasmodium vivax | aspartyl protease, putative | 0.0166 | 0.0108 | 0.5 |
Plasmodium falciparum | plasmepsin IX | 0.0166 | 0.0108 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0166 | 0.0108 | 0.0108 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0166 | 0.0108 | 0.0108 |
Brugia malayi | Pepsin A precursor | 0.0166 | 0.0108 | 0.0364 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0433 | 0.0777 | 1 |
Plasmodium falciparum | plasmepsin VII | 0.0166 | 0.0108 | 0.5 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0166 | 0.0108 | 0.0364 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0166 | 0.0108 | 0.0108 |
Echinococcus multilocularis | cathepsin b | 0.1313 | 0.2975 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0166 | 0.0108 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0166 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | cathepsin B | 0.0433 | 0.0777 | 0.2612 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0108 | 0.0364 |
Echinococcus multilocularis | cathepsin b | 0.1313 | 0.2975 | 1 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0166 | 0.0108 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0166 | 0.0108 | 0.0364 |
Toxoplasma gondii | cathepsin B | 0.0433 | 0.0777 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0166 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0108 | 0.0364 |
Entamoeba histolytica | s phingosine-1-phosphate lyase 1, putative | 0.0122 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin I | 0.0166 | 0.0108 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0166 | 0.0108 | 0.0108 |
Plasmodium vivax | plasmepsin V, putative | 0.0166 | 0.0108 | 0.5 |
Brugia malayi | hypothetical protein | 0.0166 | 0.0108 | 0.0364 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0166 | 0.0108 | 0.0364 |
Plasmodium falciparum | plasmepsin IV | 0.0166 | 0.0108 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0108 | 0.0364 |
Giardia lamblia | Cathepsin B precursor | 0.0433 | 0.0777 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0433 | 0.0777 | 0.2612 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0166 | 0.0108 | 0.0364 |
Plasmodium falciparum | plasmepsin VI | 0.0166 | 0.0108 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0166 | 0.0108 | 0.5 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0166 | 0.0108 | 0.0364 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0166 | 0.0108 | 0.0108 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0433 | 0.0777 | 1 |
Brugia malayi | hypothetical protein | 0.0166 | 0.0108 | 0.0364 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.7 uM | Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr | ChEMBL. | 24809814 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.