Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 2 | Starlite/ChEMBL | No references |
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % | |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 2 | 658 aa | 629 aa | 30.7 % |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0392 | 0.0392 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.0392 | 0.0772 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.0392 | 0.0772 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0175 | 0.2114 | 0.2114 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0223 | 0.3278 | 0.3004 |
Schistosoma mansoni | hypothetical protein | 0.0223 | 0.3278 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0392 | 0.0392 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0175 | 0.2114 | 0.1792 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0298 | 0.5079 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0298 | 0.5079 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.0392 | 0.0772 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0298 | 0.5079 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0223 | 0.3278 | 0.3278 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0392 | 0.0392 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.0392 | 0.0772 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.0392 | 0.0772 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.0392 | 0.0772 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0298 | 0.5079 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 1 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0175 | 0.2114 | 0.4162 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.0392 | 0.0772 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.0392 | 0.0772 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.0392 | 0.0772 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0175 | 0.2114 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0175 | 0.2114 | 0.4162 |
Onchocerca volvulus | 0.0223 | 0.3278 | 1 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.0392 | 0.0772 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0298 | 0.5079 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.0392 | 0.0772 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0714 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 0.1108 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 8.0621 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.