Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % | |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0049 | 0.0333 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0049 | 0.0333 | 0.5 |
Brugia malayi | Choline O-acetyltransferase | 0.0049 | 0.0333 | 0.0333 |
Chlamydia trachomatis | SWIB complex protein | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0049 | 0.0333 | 0.5 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0269 | 0.5337 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0269 | 0.5337 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0049 | 0.0333 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0049 | 0.0333 | 0.5 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0049 | 0.0333 | 0.0333 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0049 | 0.0333 | 0.0625 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0049 | 0.0333 | 0.0625 |
Onchocerca volvulus | 0.0049 | 0.0333 | 1 | |
Brugia malayi | Choline O-acetyltransferase | 0.0049 | 0.0333 | 0.0333 |
Onchocerca volvulus | 0.0049 | 0.0333 | 1 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0269 | 0.5337 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0269 | 0.5337 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0269 | 0.5337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0049 | 0.0333 | 0.0333 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | choline O acetyltransferase | 0.0049 | 0.0333 | 0.0625 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0049 | 0.0333 | 0.5 |
Onchocerca volvulus | 0.0049 | 0.0333 | 1 | |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0035 | 0 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0049 | 0.0333 | 0.0333 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0049 | 0.0333 | 0.0625 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0049 | 0.0333 | 0.0333 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0049 | 0.0333 | 0.0333 |
Onchocerca volvulus | 0.0049 | 0.0333 | 1 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0049 | 0.0333 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0035 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0905 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 0.1699 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 24.1917 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.