TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 436.507 | Formula: C21H16N4O3S2
H donors: 2 H acceptors: 5 LogP: 3.79 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccncc1NS(=O)(=O)c1ccccc1)Nc1scc(n1)c1ccccc1
InChi: 1S/C21H16N4O3S2/c26-20(24-21-23-19(14-29-21)15-7-3-1-4-8-15)17-11-12-22-13-18(17)25-30(27,28)16-9-5-2-6-10-16/h1-14,25H,(H,23,24,26)
InChiKey: HNLRUKYPTOASMA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0053	0.0057	0.0425
Echinococcus multilocularis	cathepsin L	0.0053	0.0057	0.0446
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.1314	0.383	0.3811
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0145	0.0331	0.4926
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0053	0.0057	0.0026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0248	0.0641	0.1018
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0057	0.0079
Trypanosoma cruzi	cysteine peptidase, putative	0.0248	0.0641	0.6676
Schistosoma mansoni	cathepsin B (C01 family)	0.0053	0.0057	0.0031
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.3376	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0248	0.0641	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0134	0.1421
Plasmodium vivax	unspecified product	0.0132	0.0294	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0404	0.428
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0053	0.0057	0.0446
Echinococcus multilocularis	cysteine protease	0.0248	0.0641	0.6732
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Entamoeba histolytica	cysteine proteinase, putative	0.0132	0.0294	0.4307
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0031	0.0167
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0132	0.0294	0.0268
Echinococcus granulosus	cathepsin L cysteine protease	0.0132	0.0294	0.2994
Echinococcus multilocularis	cathepsin L cysteine protease	0.0248	0.0641	0.6732
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Trypanosoma cruzi	cysteine peptidase, putative	0.0132	0.0294	0.2875
Giardia lamblia	Cathepsin L-like protease	0.0053	0.0057	0.0026
Onchocerca volvulus		0.0248	0.0641	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0248	0.0641	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0053	0.0057	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0404	0.428
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Giardia lamblia	Cathepsin L precursor	0.0053	0.0057	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0404	0.428
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0132	0.0294	0.2875
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0248	0.0641	1
Echinococcus granulosus	cysteine protease	0.0132	0.0294	0.2994
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0057	0.0425
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0169	0.0404	0.0637
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0057	0.0079
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0248	0.0641	0.1018
Giardia lamblia	Encystation-specific protease	0.1314	0.383	0.3811
Brugia malayi	Cathepsin L-like precursor	0.0248	0.0641	0.6732
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0057	0.0079
Onchocerca volvulus		0.0248	0.0641	1
Onchocerca volvulus		0.0248	0.0641	1
Giardia lamblia	Cathepsin B precursor	0.0053	0.0057	0.0026
Trypanosoma cruzi	cysteine peptidase, putative	0.0248	0.0641	0.6676
Loa Loa (eye worm)	fibroinase	0.0248	0.0641	0.6786
Leishmania major	cathepsin L-like protease	0.0248	0.0641	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Brugia malayi	cathepsin B-like cysteine proteinase	0.035	0.0944	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0169	0.0404	0.4085
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0248	0.0641	0.0587
Brugia malayi	cathepsin L-like precursor	0.0169	0.0404	0.4184
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0057	0.0031
Trypanosoma cruzi	cysteine peptidase, putative	0.0248	0.0641	0.6676
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0248	0.0641	0.0587
Trypanosoma cruzi	cysteine proteinase, putative	0.0132	0.0294	0.2875
Giardia lamblia	Hypothetical protein	0.0053	0.0057	0.0026
Plasmodium vivax	unspecified product	0.0079	0.0134	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0057	0.0079
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0057	0.0031
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0053	0.0057	0.0425
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0248	0.0641	0.6786
Entamoeba histolytica	cysteine proteinase 1, putative	0.0132	0.0294	0.4307
Plasmodium vivax	vivapain-1	0.0132	0.0294	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0134	0.1421
Giardia lamblia	Cathepsin B precursor	0.0053	0.0057	0.0026
Giardia lamblia	Cysteine protease	0.0053	0.0057	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0031	0.033
Plasmodium vivax	vivapain-2	0.0248	0.0641	0.0587
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0031	0.0037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0248	0.0641	0.1018
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0057	0.0031
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0057	0.0425
Leishmania major	cathepsin L-like protease	0.0248	0.0641	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	0.0331	0.0306
Brugia malayi	Papain family cysteine protease containing protein	0.0132	0.0294	0.2994
Leishmania major	cathepsin L-like protease	0.0248	0.0641	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0248	0.0641	1
Plasmodium vivax	vivapain-3	0.0132	0.0294	0.0238
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.035	0.0944	1
Giardia lamblia	Cathepsin B precursor	0.0053	0.0057	0.0026
Brugia malayi	cathepsin F-like cysteine proteinase	0.0053	0.0057	0.0446
Schistosoma mansoni	cathepsin C	0.0053	0.0057	0.0031
Giardia lamblia	Cathepsin B precursor	0.0053	0.0057	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0132	0.0294	0.046
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0057	0.0079
Leishmania major	cathepsin L-like protease	0.0248	0.0641	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0053	0.0057	0.0079
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0057	0.0284
Entamoeba histolytica	cysteine proteinase, putative	0.0132	0.0294	0.4307
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.0057	0.0604
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0248	0.0641	1
Brugia malayi	Papain family cysteine protease containing protein	0.0132	0.0294	0.2994
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0248	0.0641	0.1018
Schistosoma mansoni	cathepsin F (C01 family)	0.0248	0.0641	0.0616
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0294	0.4307
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0057	0.0079
Trypanosoma cruzi	cysteine protease, putative	0.0132	0.0294	0.2875
Plasmodium vivax	vivapain-2	0.0248	0.0641	0.0587
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0053	0.0057	0.0031
Toxoplasma gondii	cathepsin CPL	0.0248	0.0641	0.032
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0031	0.0167
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0132	0.0294	0.4307
Trypanosoma cruzi	cruzipain precursor, putative	0.0248	0.0641	0.6676
Schistosoma mansoni	cathepsin F (C01 family)	0.0248	0.0641	0.0616
Giardia lamblia	Cathepsin B precursor	0.0145	0.0331	0.0301
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.1314	0.383	0.3794
Brugia malayi	Cathepsin L-like precursor	0.0169	0.0404	0.4184
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.3376	1	1
Brugia malayi	fibroinase precursor	0.0053	0.0057	0.0446
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.3376	1	1
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0057	0.0425
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0053	0.0057	0.0031
Trypanosoma cruzi	cysteine proteinase, putative	0.0132	0.0294	0.2875
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0132	0.0294	0.0268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.035	0.0944	0.092
Loa Loa (eye worm)	ctsf protein	0.0248	0.0641	0.6786
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0248	0.0641	0.1018
Giardia lamblia	Cysteine protease	0.0053	0.0057	0.0026
Echinococcus granulosus	cathepsin b	0.035	0.0944	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0145	0.0331	0.3289
Echinococcus granulosus	cathepsin L	0.0132	0.0294	0.2994
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0057	0.0425
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0057	0.0284
Onchocerca volvulus		0.0248	0.0641	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0248	0.0641	0.6732
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0031	0.0167
Loa Loa (eye worm)	hypothetical protein	0.035	0.0944	1
Leishmania major	cathepsin L-like protease	0.0248	0.0641	1
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.0031	0.0167
Brugia malayi	Cathepsin L-like precursor	0.0248	0.0641	0.6732
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0248	0.0641	0.6732
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0057	0.0079
Giardia lamblia	Cathepsin B precursor	0.0053	0.0057	0.0026
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.3376	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0057	0.0446
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0248	0.0641	0.1018
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.0031	0.0005
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0248	0.0641	0.1018
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0031	0.0167
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0057	0.0079
Brugia malayi	Cathepsin L-like precursor	0.0248	0.0641	0.6732
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0053	0.0057	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0057	0.0604
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0248	0.0641	1
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0031	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0057	0.0604
Echinococcus multilocularis	cysteine protease	0.0248	0.0641	0.6732
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0053	0.0057	0.0079
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0248	0.0641	0.6732
Onchocerca volvulus		0.0248	0.0641	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0248	0.0641	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0248	0.0641	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0132	0.0294	0.046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0169	0.0404	0.0637
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0248	0.0641	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0057	0.0604
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.1314	0.383	0.3794
Brugia malayi	Papain family cysteine protease containing protein	0.0248	0.0641	0.6732
Toxoplasma gondii	cathepsin CPC1	0.3376	1	1
Giardia lamblia	Cysteine protease	0.0053	0.0057	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0248	0.0641	1
Giardia lamblia	Cathepsin L precursor	0.0053	0.0057	0.0026
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.1314	0.383	0.3811
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.0057	0.0604
Entamoeba histolytica	cysteine proteinase, putative	0.0132	0.0294	0.4307
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.0031	0.0005
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0039	0.0016	0.0165
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0053	0.0057	0.0079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0057	0.0079
Leishmania major	cathepsin L-like protease	0.0248	0.0641	1
Brugia malayi	Cathepsin L-like precursor	0.0079	0.0134	0.1277
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0057	0.0079
Leishmania major	cathepsin L-like protease	0.0248	0.0641	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.3376	1	1
Entamoeba histolytica	cysteine protease, putative	0.0248	0.0641	1
Entamoeba histolytica	cysteine proteinase, putative	0.0169	0.0404	0.6118
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0145	0.0331	0.052
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0248	0.0641	0.6786
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Entamoeba histolytica	cysteine proteinase 2	0.0132	0.0294	0.4307
Echinococcus multilocularis	cathepsin b	0.035	0.0944	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0248	0.0641	0.6732
Trypanosoma cruzi	cysteine peptidase, putative	0.0248	0.0641	0.6676
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0079	0.0134	0.1421
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0057	0.0079
Loa Loa (eye worm)	cathepsin B	0.0145	0.0331	0.351
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.035	0.0944	0.092
Echinococcus granulosus	cathepsin l1	0.0248	0.0641	0.6732
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0057	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0248	0.0641	0.6786
Leishmania major	cathepsin L-like protease	0.0248	0.0641	1
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0057	0.0425
Leishmania major	cysteine peptidase A (CPA)	0.0248	0.0641	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0248	0.0641	0.1018
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0057	0.0604
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.0134	0.1128
Giardia lamblia	Cathepsin L precursor	0.0053	0.0057	0.0026
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.035	0.0944	0.092
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0132	0.0294	0.0268
Onchocerca volvulus		0.0248	0.0641	1
Giardia lamblia	Cathepsin L precursor	0.0053	0.0057	0.0026
Echinococcus granulosus	cathepsin L	0.0053	0.0057	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0057	0.0604
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0057	0.0425
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Giardia lamblia	Cysteine protease	0.0053	0.0057	0.0026
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Onchocerca volvulus		0.0248	0.0641	1
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.0031	0.0167
Schistosoma mansoni	cathepsin s	0.0079	0.0134	0.0108
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0057	0.0446
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0248	0.0641	0.1018
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0057	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0134	0.1421
Brugia malayi	Cathepsin L-like precursor	0.0169	0.0404	0.4184
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0132	0.0294	0.0238
Giardia lamblia	Cathepsin B precursor	0.0145	0.0331	0.0301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0248	0.0641	0.1018
Brugia malayi	Cathepsin L-like precursor	0.0248	0.0641	0.6732
Echinococcus multilocularis	cathepsin b	0.035	0.0944	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0248	0.0641	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.035	0.0944	0.092
Toxoplasma gondii	cathepsin CPC2	0.1314	0.383	0.3618
Onchocerca volvulus	Cathepsin L homolog	0.0248	0.0641	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0248	0.0641	0.6732
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0057	0.0604
Entamoeba histolytica	cysteine protease, putative	0.0132	0.0294	0.4307
Onchocerca volvulus	Cathepsin F homolog	0.0248	0.0641	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0053	0.0057	0.0031
Echinococcus granulosus	cathepsin l1	0.0169	0.0404	0.4184
Echinococcus granulosus	cathepsin b	0.035	0.0944	1
Brugia malayi	Cathepsin L-like precursor	0.0248	0.0641	0.6732
Giardia lamblia	Hypothetical protein	0.0053	0.0057	0.0026
Loa Loa (eye worm)	cysteine protease	0.0248	0.0641	0.6786
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0031	0.0037
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0057	0.0079
Giardia lamblia	Cathepsin L-like protease	0.0053	0.0057	0.0026
Giardia lamblia	Cathepsin L precursor	0.0053	0.0057	0.0026
Giardia lamblia	Cathepsin B precursor	0.0145	0.0331	0.0301
Echinococcus multilocularis	cathepsin L	0.0132	0.0294	0.2994
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0053	0.0057	0.0425
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0169	0.0404	0.4184
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0079	0.0134	0.1277
Trypanosoma cruzi	cruzipain precursor, putative	0.0079	0.0134	0.1128
Onchocerca volvulus		0.0169	0.0404	0.5946
Onchocerca volvulus	Cathepsin L homolog	0.0248	0.0641	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.3376	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0132	0.0294	0.4307
Brugia malayi	cathepsin L-like cysteine proteinase	0.0053	0.0057	0.0446
Entamoeba histolytica	cysteine proteinase, putative	0.0248	0.0641	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0053	0.0057	0.0446
Entamoeba histolytica	cysteine proteinase, putative	0.0248	0.0641	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0053	0.0057	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0057	0.0079
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0248	0.0641	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0053	0.0057	0.0446
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0248	0.0641	0.1018
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.2115	0.6227	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0145	0.0331	0.4926
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0248	0.0641	0.1018
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0057	0.0446
Schistosoma mansoni	cathepsin F (C01 family)	0.0169	0.0404	0.0379
Brugia malayi	Cathepsin L-like precursor	0.0248	0.0641	0.6732
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.0031	0.0167
Brugia malayi	cathepsin F-like cysteine proteinase	0.0079	0.0134	0.1277
Brugia malayi	cathepsin L precursor	0.0053	0.0057	0.0446
Giardia lamblia	Cathepsin L precursor	0.0053	0.0057	0.0026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0057	0.0079

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.8537 uM	PubChem BioAssay. qHTS for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter: K484 Substrate. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.8537 uM	PubChem BioAssay. Confirmation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter: K633. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3392688

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1923453