TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 431.449 | Formula: C25H17N7O
H donors: 2 H acceptors: 5 LogP: 4.06 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccncc1)Nc1ccc(cc1)c1nnc2n1c1cccnc1[nH]c1c2cccc1
InChi: 1S/C25H17N7O/c33-25(17-11-14-26-15-12-17)28-18-9-7-16(8-10-18)23-30-31-24-19-4-1-2-5-20(19)29-22-21(32(23)24)6-3-13-27-22/h1-15H,(H,27,29)(H,28,33)
InChiKey: YAEJPLJOPMZJHJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	v-akt murine thymoma viral oncogene homolog 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0951	0.0702
Echinococcus granulosus	serine threonine protein kinase nrc	0.0025	0.1664	0.259
Onchocerca volvulus	Cathepsin L homolog	0.0024	0.1618	1
Toxoplasma gondii	AGC kinase	0.0038	0.2705	0.3653
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0061	0.4595	0.4447
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0061	0.4595	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.291	0.5739
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0024	0.1618	0.2473
Onchocerca volvulus		0.0024	0.1618	1
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.4304	0.9326
Schistosoma mansoni	cathepsin F (C01 family)	0.0024	0.1618	0.3121
Echinococcus granulosus	cathepsin l1	0.0016	0.0951	0.0787
Onchocerca volvulus		0.0024	0.1618	1
Entamoeba histolytica	protein kinase, putative	0.004	0.291	0.6332
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0013	0.0665	0.0063
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.1618	0.2473
Echinococcus granulosus	NDR protein kinase	0.0013	0.0665	0.0063
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0024	0.1618	0.2473
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0041	0.2997	0.6306
Brugia malayi	Cathepsin L-like precursor	0.0024	0.1618	0.1388
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0061	0.4595	0.5
Brugia malayi	protein kinase C II.	0.0013	0.0665	0.0408
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.1618	0.3121
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Plasmodium vivax	vivapain-1	0.0013	0.064	0.086
Entamoeba histolytica	protein kinase, putative	0.0013	0.0665	0.1446
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0041	0.2997	0.6306
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0013	0.0665	0.0408
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0025	0.1664	0.3228
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0013	0.0665	0.0063
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0013	0.0665	0.0408
Echinococcus granulosus	serine:threonine protein kinase N2	0.0013	0.0665	0.0063
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0013	0.064	0.086
Echinococcus granulosus	proteasome prosome macropain	0.0061	0.4595	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.1618	0.2473
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0869	0.0579
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0024	0.1618	0.1388
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0013	0.064	0.086
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0951	0.0702
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0025	0.1664	0.3228
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0013	0.0665	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0951	0.0702
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0013	0.0642	0.0005
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0013	0.0665	0.0063
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.0665	0.0063
Brugia malayi	Cathepsin L-like precursor	0.0024	0.1618	0.1388
Brugia malayi	cathepsin L-like precursor	0.0016	0.0951	0.0702
Echinococcus multilocularis	rac serine:threonine kinase	0.0028	0.1869	0.3107
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0024	0.1618	0.2473
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.4304	0.9326
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.1618	0.2473
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.1869	0.4067
Echinococcus granulosus	Protein kinase C brain isozyme	0.0013	0.0665	0.0063
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.0665	0.0063
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0013	0.0665	0.0063
Echinococcus multilocularis	nervana 2	0.0025	0.1641	0.2532
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0665	0.0917
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.4304	0.9326
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0025	0.1664	0.259
Brugia malayi	RNA recognition motif domain containing protein	0.0057	0.4304	0.4147
Plasmodium vivax	vivapain-2	0.0024	0.1618	0.3121
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0041	0.2997	0.5958
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0665	0.0917
Echinococcus multilocularis	nervana 2	0.0025	0.1641	0.2532
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.4304	0.9326
Echinococcus multilocularis	cathepsin L cysteine protease	0.0024	0.1618	0.2473
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0951	0.0787
Brugia malayi	Cathepsin L-like precursor	0.0024	0.1618	0.1388
Echinococcus multilocularis	serine threonine protein kinase	0.0013	0.0665	0.0063
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Entamoeba histolytica	cysteine proteinase 2	0.0013	0.064	0.1392
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0013	0.0665	0.0063
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0013	0.0665	0.0408
Onchocerca volvulus		0.0024	0.1618	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0024	0.1618	0.1388
Loa Loa (eye worm)	TAR-binding protein	0.0057	0.4304	0.4147
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0025	0.1664	0.259
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0061	0.4595	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.1618	0.3521
Trypanosoma cruzi	Protein kinase B	0.0028	0.1869	0.37
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0665	0.0917
Echinococcus granulosus	cathepsin l1	0.0024	0.1618	0.2473
Echinococcus multilocularis	tar DNA binding protein	0.0057	0.4304	0.9263
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0041	0.2997	0.5958
Onchocerca volvulus		0.0024	0.1618	1
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.064	0.1392
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0013	0.064	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.1618	0.2473
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0041	0.2997	0.6306
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0061	0.4595	1
Echinococcus granulosus	protein kinase c iota type	0.0013	0.0665	0.0063
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0061	0.4595	1
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Leishmania major	proteasome beta 5 subunit, putative	0.0061	0.4595	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.291	0.5739
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.1618	0.2473
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0024	0.1618	0.2473
Brugia malayi	Hr1 repeat family protein	0.0013	0.0665	0.0408
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0024	0.1618	0.2473
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0013	0.0665	0.0063
Brugia malayi	Proteasome A-type and B-type family protein	0.0061	0.4595	0.4447
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.1618	0.3121
Entamoeba histolytica	protein kinase 2, putative	0.0025	0.1664	0.3622
Brugia malayi	sulfakinin receptor protein	0.0126	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0013	0.064	0.1392
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.1618	0.2473
Trypanosoma brucei	rac serine-threonine kinase, putative	0.004	0.291	0.5739
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0665	0.0408
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.1618	0.2473
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0665	0.0917
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Plasmodium vivax	vivapain-2	0.0024	0.1618	0.3121
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.1618	0.2473
Trypanosoma cruzi	cruzipain precursor, putative	0.0024	0.1618	0.3121
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0038	0.2705	0.2505
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0013	0.064	0.086
Brugia malayi	TAR-binding protein	0.0057	0.4304	0.4147
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.1618	0.3121
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0665	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1618	0.1388
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0041	0.2997	0.2804
Onchocerca volvulus		0.0024	0.1618	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0028	0.1869	0.37
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.1869	0.4067
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Entamoeba histolytica	protein kinase, putative	0.004	0.291	0.6332
Brugia malayi	p70 ribosomal S6 kinase beta	0.0038	0.2705	0.2505
Schistosoma mansoni	cathepsin F (C01 family)	0.0024	0.1618	0.3121
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0061	0.4595	1
Loa Loa (eye worm)	RNA binding protein	0.0057	0.4304	0.4147
Loa Loa (eye worm)	fibroinase	0.0024	0.1618	0.1388
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.1618	0.2473
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.1618	0.2473
Entamoeba histolytica	cysteine protease, putative	0.0024	0.1618	0.3521
Echinococcus multilocularis	cysteine protease	0.0024	0.1618	0.2473
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0016	0.0951	0.0702
Brugia malayi	RNA binding protein	0.0057	0.4304	0.4147
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0951	0.0787
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0951	0.0702
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.1618	0.2473
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.1869	0.37
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0024	0.1618	0.2473
Echinococcus multilocularis	cysteine protease	0.0024	0.1618	0.2473
Onchocerca volvulus		0.0024	0.1618	1
Trypanosoma cruzi	cysteine protease, putative	0.0013	0.064	0.086
Onchocerca volvulus		0.0024	0.1618	1
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0665	0.0408
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0016	0.0951	0.1579
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0024	0.1618	0.2473
Brugia malayi	Papain family cysteine protease containing protein	0.0013	0.064	0.0383
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0061	0.4595	1
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.064	0.1392
Echinococcus multilocularis	Glutaredoxin protein 5	0.0025	0.1641	0.2532
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Echinococcus multilocularis	protein kinase c epsilon type	0.0013	0.0665	0.0063
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.1618	0.2473
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.1618	0.2473
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Echinococcus granulosus	protein kinase C gamma type	0.0013	0.0665	0.0063
Echinococcus granulosus	tar DNA binding protein	0.0057	0.4304	0.9263
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Plasmodium falciparum	proteasome subunit beta type-5	0.0061	0.4595	1
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.4304	0.9326
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0061	0.4595	1
Echinococcus granulosus	serine/threonine protein kinase	0.0028	0.1869	0.3107
Brugia malayi	Cathepsin L-like precursor	0.0024	0.1618	0.1388
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0041	0.2997	0.5958
Trichomonas vaginalis	AGC family protein kinase	0.004	0.291	0.5739
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0013	0.0665	0.0408
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.064	0.1392
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Brugia malayi	Cathepsin L-like precursor	0.0024	0.1618	0.1388
Toxoplasma gondii	proteasome subunit beta type, putative	0.0061	0.4595	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.004	0.291	0.2715
Brugia malayi	Papain family cysteine protease containing protein	0.0013	0.064	0.0383
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.1618	0.2473
Schistosoma mansoni	serine/threonine kinase	0.0013	0.0665	0.0917
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0665	0.0917
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0061	0.4595	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0013	0.064	0.086
Loa Loa (eye worm)	ctsf protein	0.0024	0.1618	0.1388
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.1618	0.1388
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.1618	0.2473
Trypanosoma cruzi	cysteine proteinase, putative	0.0013	0.064	0.086
Brugia malayi	Protein kinase domain containing protein	0.004	0.291	0.2715
Entamoeba histolytica	protein kinase, putative	0.0038	0.2705	0.5888
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0013	0.0665	0.0063
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.1869	0.37
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0025	0.1641	0.2532
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0951	0.0702
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.1618	0.2473
Plasmodium vivax	unspecified product	0.0013	0.064	0.086
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.0665	0.0063
Trypanosoma cruzi	cysteine peptidase, putative	0.0013	0.064	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.1618	0.2473
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.1618	0.2473
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.1618	0.3121
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Loa Loa (eye worm)	cysteine protease	0.0024	0.1618	0.1388
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0024	0.1618	0.2473
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.064	0.1392
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0013	0.0665	0.0408
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0024	0.1618	0.2473
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0665	0.0408
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Echinococcus granulosus	nervana 2	0.0025	0.1641	0.2532
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0041	0.2997	0.5958
Echinococcus granulosus	nervana 2	0.0025	0.1641	0.2532
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0057	0.4304	0.4147
Echinococcus multilocularis	cathepsin L cysteine protease	0.0024	0.1618	0.2473
Onchocerca volvulus	Cathepsin F homolog	0.0024	0.1618	1
Loa Loa (eye worm)	hypothetical protein	0.0126	1	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.291	0.5739
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.1618	0.2473
Schistosoma mansoni	atypical protein kinase C	0.0013	0.0665	0.0917
Trichomonas vaginalis	AGC family protein kinase	0.004	0.291	0.5739
Mycobacterium ulcerans	proteasome PrcB	0.0061	0.4595	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0041	0.2997	0.2804
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0025	0.1664	0.259
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0025	0.1641	0.2532
Echinococcus granulosus	Glutaredoxin protein 5	0.0025	0.1641	0.2532
Trichomonas vaginalis	AGC family protein kinase	0.004	0.291	0.5739
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0665	0.0917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0013	0.0665	0.0063
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0061	0.4595	1
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0951	0.207
Entamoeba histolytica	cysteine protease, putative	0.0013	0.064	0.1392
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.1618	0.3521
Brugia malayi	Cathepsin L-like precursor	0.0024	0.1618	0.1388
Echinococcus multilocularis	protein kinase c iota type	0.0013	0.0665	0.0063
Echinococcus granulosus	protein kinase c epsilon type	0.0013	0.0665	0.0063
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0951	0.1579
Plasmodium vivax	vivapain-3	0.0013	0.064	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Trichomonas vaginalis	AGC family protein kinase	0.004	0.291	0.5739
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0061	0.4595	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.1618	0.2473
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0013	0.0665	0.0063
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.1618	0.2473
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0013	0.0665	0.0063
Onchocerca volvulus	Cathepsin L homolog	0.0024	0.1618	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 350 nM	BindingDB_Patents: Biochemical Assay. Biochemical assay using Akt AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay) technology.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3684368

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1977082