Detailed information for compound 1986350

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 550.585 | Formula: C27H31FN8O4
  • H donors: 1 H acceptors: 5 LogP: 2.72 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN1C(=O)Cn2c1nc1nc(n(c1c2=O)Cc1cc(F)ccc1C#N)N1CCC[C@H](C1)NC(=O)OC(C)(C)C
  • InChi: 1S/C27H31FN8O4/c1-5-34-20(37)15-36-23(38)21-22(32-25(34)36)31-24(35(21)13-17-11-18(28)9-8-16(17)12-29)33-10-6-7-19(14-33)30-26(39)40-27(2,3)4/h8-9,11,19H,5-7,10,13-15H2,1-4H3,(H,30,39)/t19-/m1/s1
  • InChiKey: BKMVBDOZLBKNIT-LJQANCHMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0017 0.0446 0.1744
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0017 0.0446 0.1373
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0057 0.216 0.2438
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0446 0.0425
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0017 0.0484 0.047
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0446 0.0365
Echinococcus multilocularis lysyl tRNA synthetase 0.0013 0.0283 0.0234
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0446 0.9405
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Loa Loa (eye worm) sugar transporter 0.0008 0.0084 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.216 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0017 0.0484 0.0617
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0017 0.0484 0.047
Plasmodium vivax lysine--tRNA ligase, putative 0.0013 0.0283 0.0201
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0017 0.0446 0.8111
Onchocerca volvulus Prolyl endopeptidase homolog 0.0017 0.0446 0.0425
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0017 0.0484 0.047
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0017 0.0446 0.1373
Loa Loa (eye worm) hypothetical protein 0.0017 0.0469 0.0499
Echinococcus granulosus calcium dependent protein kinase 0.0016 0.0438 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0446 0.1744
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0017 0.0484 0.0517
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Echinococcus multilocularis calcium dependent protein kinase 0.0016 0.0438 0.0416
Loa Loa (eye worm) hypothetical protein 0.0017 0.0484 0.0517
Brugia malayi lysyl-tRNA synthetase 0.0013 0.0283 0.0234
Trypanosoma brucei prolyl oligopeptidase, putative 0.0017 0.0446 0.1373
Trypanosoma brucei glucose transporter, putative 0.0018 0.0493 0.1553
Leishmania major protein kinase, putative 0.0017 0.0484 0.1517
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0017 0.0446 0.1373
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0011 0.0217 0.0641
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Schistosoma mansoni lysyl-tRNA synthetase 0.0013 0.0283 0.0234
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0017 0.0446 0.0558
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0446 0.9405
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0017 0.0484 0.047
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0017 0.0446 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0017 0.0469 0.1855
Trypanosoma brucei THT1 - hexose transporter, putative 0.0018 0.0493 0.1553
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.2722 0.3097
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0017 0.0484 0.047
Echinococcus granulosus lysyl tRNA synthetase 0.0013 0.0283 0.0234
Entamoeba histolytica prolyl oligopeptidase family protein 0.0017 0.0446 0.8111
Echinococcus granulosus General substrate transporter 0.0049 0.1821 0.2039
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0017 0.0484 0.0404
Trypanosoma cruzi oligopeptidase b 0.0017 0.0446 0.1373
Trypanosoma brucei glucose transporter, putative 0.0018 0.0493 0.1553
Toxoplasma gondii prolyl endopeptidase 0.0017 0.0446 0.0558
Mycobacterium tuberculosis Probable peptidase 0.0017 0.0446 1
Plasmodium vivax proline--tRNA ligase, putative 0.002 0.0589 0.051
Giardia lamblia Prolyl-tRNA synthetase 0.0017 0.0469 1
Plasmodium falciparum proline--tRNA ligase 0.002 0.0589 0.051
Mycobacterium ulcerans sugar transporter 0.0008 0.0084 0.1877
Trypanosoma cruzi prolyl endopeptidase 0.0017 0.0446 0.1373
Chlamydia trachomatis lysine--tRNA ligase 0.0013 0.0283 1
Leishmania major glucose transporter, lmgt3 0.0018 0.0493 0.1553
Schistosoma mansoni lysyl-tRNA synthetase 0.0013 0.0283 0.0234
Loa Loa (eye worm) hypothetical protein 0.0013 0.0283 0.0282
Trypanosoma brucei oligopeptidase b 0.0017 0.0446 0.1373
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0446 0.0425
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0017 0.0446 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0017 0.0469 0.0452
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0092 0.3649 0.3595
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0057 0.216 0.2438
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Brugia malayi hypothetical protein 0.0054 0.202 0.2273
Loa Loa (eye worm) major facilitator superfamily transporter 0.0008 0.0084 0.0049
Entamoeba histolytica prolyl oligopeptidase family protein 0.0017 0.0446 0.8111
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0011 0.0202 0.3265
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0493 0.1973
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0013 0.0283 0.0757
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0057 0.216 0.2438
Trypanosoma brucei glucose transporter, putative 0.0018 0.0493 0.1553
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0493 0.1973
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0092 0.3649 0.5495
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0011 0.0202 0.3265
Plasmodium falciparum hexose transporter 0.0057 0.216 0.2094
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0008 0.0084 0.1877
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0484 0.047
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0017 0.0469 0.0452
Plasmodium vivax CDK-related protein kinase 6, putative 0.0242 1 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0446 0.0425
Loa Loa (eye worm) hypothetical protein 0.0014 0.0333 0.034
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0017 0.0484 0.0404
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.2722 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0017 0.0484 0.1517
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0017 0.0484 0.0617
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0017 0.0484 0.047
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Leishmania major lysyl-tRNA synthetase, putative 0.0013 0.0283 0.0757
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.002 0.0589 0.1915
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0017 0.0469 0.0452
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.0446 0.8111
Leishmania major glucose transporter/membrane transporter D2, putative 0.0018 0.0493 0.1553
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0493 0.1973
Echinococcus granulosus acylamino acid releasing enzyme 0.0017 0.0446 0.0425
Echinococcus multilocularis General substrate transporter 0.0049 0.1821 0.2039
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0017 0.0484 0.047
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0493 0.1973
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0057 0.216 0.2438
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.8602 1
Treponema pallidum prolyl-tRNA synthetase 0.0006 0 0.5
Schistosoma mansoni protein kinase 0.0017 0.0484 0.047
Leishmania major glucose transporter, lmgt2 0.0018 0.0493 0.1553
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0017 0.0446 0.1373
Trypanosoma brucei glucose transporter 2A 0.0018 0.0493 0.1553
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Plasmodium falciparum calcium-dependent protein kinase 4 0.0017 0.0484 0.0404
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0017 0.0469 0.0452
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0017 0.0469 0.0452
Trypanosoma cruzi hexose transporter, putative 0.001 0.0154 0.0265
Plasmodium falciparum peptidase, putative 0.0017 0.0446 0.0365
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0493 0.1553
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0017 0.0446 0.0425
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0017 0.0446 0.1373
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.8602 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.2722 0.3097
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.002 0.0589 0.0779
Entamoeba histolytica protein kinase, putative 0.0017 0.0484 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0446 0.0472
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0057 0.216 0.2438
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.002 0.0589 0.1915
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.002 0.0589 0.1915
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0446 0.0425
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0017 0.0446 0.8111
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.2722 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.8602 1
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.2722 1
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0493 0.1553
Plasmodium falciparum lysine--tRNA ligase 0.0013 0.0283 0.0201
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0017 0.0484 0.0617
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0484 0.1927
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0446 0.0425
Entamoeba histolytica prolyl oligopeptidase family protein 0.0017 0.0446 0.8111
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0017 0.0446 0.1373
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0057 0.216 0.2438
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0013 0.0283 0.0757
Loa Loa (eye worm) hypothetical protein 0.0017 0.0446 0.0472
Loa Loa (eye worm) major facilitator superfamily transporter 0.0008 0.0084 0.0049
Toxoplasma gondii facilitative glucose transporter GT1 0.0057 0.216 0.3201
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0017 0.0484 0.0517
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0017 0.0469 0.0452
Toxoplasma gondii hypothetical protein 0.0017 0.0446 0.0558
Leishmania major glucose transporter, lmgt1 0.0018 0.0493 0.1553
Plasmodium vivax calcium-dependent protein kinase, putative 0.0017 0.0484 0.0404
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Schistosoma mansoni hypothetical protein 0.0057 0.216 0.2438
Echinococcus granulosus prolyl endopeptidase 0.0017 0.0446 0.0425
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0017 0.0446 0.9141
Schistosoma mansoni glucose transport protein 0.0057 0.216 0.2438
Schistosoma mansoni glucose transport protein 0.0057 0.216 0.2438
Plasmodium falciparum calcium-dependent protein kinase 2 0.0017 0.0484 0.0404
Trypanosoma brucei THT1 - hexose transporter, putative 0.0018 0.0493 0.1553
Loa Loa (eye worm) hypothetical protein 0.0017 0.0469 0.0499
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0017 0.0469 0.9253
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0493 0.1553
Entamoeba histolytica protein kinase, putative 0.0017 0.0484 1
Brugia malayi Cam kinase protein 1 0.0017 0.0484 0.047
Trypanosoma brucei THT1 - hexose transporter, putative 0.0018 0.0493 0.1553
Echinococcus multilocularis acylamino acid releasing enzyme 0.0017 0.0446 0.0425
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0057 0.216 0.2438
Plasmodium falciparum mitogen-activated protein kinase 2 0.0092 0.3649 0.3595
Trypanosoma brucei glucose transporter, putative 0.0018 0.0493 0.1553
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0013 0.0283 0.6352
Loa Loa (eye worm) hypothetical protein 0.0054 0.202 0.2311
Toxoplasma gondii protein kinase, putative 0.0161 0.6571 1
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.2722 1
Schistosoma mansoni glucose transport protein 0.0057 0.216 0.2438
Giardia lamblia Lysyl-tRNA synthetase 0.0013 0.0283 0.5182
Plasmodium falciparum calcium-dependent protein kinase 5 0.0017 0.0484 0.0404
Plasmodium falciparum calcium-dependent protein kinase 1 0.0017 0.0484 0.0404
Brugia malayi Sugar transporter family protein 0.0057 0.216 0.2438
Plasmodium falciparum protein kinase 7 0.0161 0.6571 0.6542
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.8602 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.002 0.0589 0.1915
Trypanosoma brucei glucose transporter, putative 0.0018 0.0493 0.1553
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0013 0.0283 0.0961
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.002 0.0589 0.1915
Loa Loa (eye worm) sugar transporter 0.0057 0.216 0.2475
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.8602 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0493 0.1973
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0008 0.0084 0.1877
Loa Loa (eye worm) hypothetical protein 0.0017 0.0446 0.0472
Trypanosoma brucei glucose transporter 1E 0.0018 0.0493 0.1553
Mycobacterium ulcerans integral membrane transport protein 0.0008 0.0084 0.1877
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.2722 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.0446 0.1744
Trypanosoma brucei prolyl endopeptidase 0.0017 0.0446 0.1373
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.2722 0.3097
Trypanosoma cruzi oligopeptidase b 0.0017 0.0446 0.1373
Plasmodium vivax hexose transporter 0.0057 0.216 0.2094
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0008 0.0084 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0446 0.1373
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0017 0.0484 0.047
Schistosoma mansoni protein kinase 0.0017 0.0484 0.047
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0013 0.0283 0.6352
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0493 0.1973
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0017 0.0469 1
Toxoplasma gondii lysine-tRNA ligase 0.0013 0.0283 0.0308
Trypanosoma brucei glucose transporter, putative 0.0018 0.0493 0.1553
Brugia malayi prolyl oligopeptidase family protein 0.007 0.2722 0.3097
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0017 0.0484 0.0404
Leishmania major oligopeptidase b 0.0017 0.0446 0.1373
Schistosoma mansoni protein kinase 0.0017 0.0484 0.047
Trypanosoma brucei glucose transporter, putative 0.0018 0.0493 0.1553
Echinococcus multilocularis prolyl endopeptidase 0.0017 0.0446 0.0425
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.8602 1
Trypanosoma brucei glucose transporter, putative 0.0018 0.0493 0.1553
Trypanosoma cruzi hexose transporter 0.0018 0.0493 0.1553
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.2722 0.4067
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0017 0.0484 0.047
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0446 0.0425
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0446 0.1373
Loa Loa (eye worm) prolyl oligopeptidase 0.0017 0.0446 0.0472
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0013 0.0283 0.3046
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0493 0.1973
Plasmodium falciparum calcium-dependent protein kinase 3 0.0017 0.0484 0.0404
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0049
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0057 0.216 0.2438

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 13.5 nM BindingDB_Patents: Enzyme Inhibition Assay. DPP4 activity was measured using a continuous fluorometric assay. The substrate, Gly-Pro-AMC, was cleaved by DPP4 to release the fluorescent AMC group. The reaction was monitored at the excitation wavelength of 360 nm and emission wavelength of 460 nm in a black 384-well plate using a PHERAstar Plus plate reader (BMG Labtech., Inc.) set at 37 C. The 30 ul assay solution contained 20 pM recombinant human DPP4 and 50 uM Gly-Pro-AMC substrate in assay buffer (100 mM HEPES, 100 mM NaCl, 0.1 mg/ml BSA, pH 7.5). The reaction was linear for at least 30 min (initial velocity) after addition of the substrate (no inhibitor control). All materials and reagents were pre-incubated at 37 C. prior to start of the experiment. Test compounds were serially diluted (3-fold) in 100% DMSO to avoid solubility issues; working solutions in 3% DMSO were prepared using assay buffer. 10 ul each of enzyme and compound solutions were mixed and pre-incubated at 37 C. for 30 minutes. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.