TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 230.306 | Formula: C14H18N2O
H donors: 1 H acceptors: 0 LogP: 2.59 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC1=N[C@H](CO1)CCC1(CC1)c1ccccc1
InChi: 1S/C14H18N2O/c15-13-16-12(10-17-13)6-7-14(8-9-14)11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H2,15,16)/t12-/m0/s1
InChiKey: OSJWGWOEPQWSLS-LBPRGKRZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	trace amine-associated receptor 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	AT19640p	trace amine-associated receptor 1	332 aa	327 aa	20.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0191	0.1123
Toxoplasma gondii	ABC1 family protein	0.0041	0.0191	0.2432
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0011	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0191	0.0229
Mycobacterium ulcerans	putative regulatory protein	0.0027	0.0093	0.4877
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0011	0.0011
Brugia malayi	hypothetical protein	0.0063	0.0341	0.0407
Entamoeba histolytica	heat shock transcription factor, putative	0.0092	0.054	0.6856
Brugia malayi	beta-lactamase family protein	0.0041	0.0191	0.0229
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0011	0.0011
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0093	0.0545	0.0942
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0063	0.0341	0.0341
Entamoeba histolytica	hypothetical protein	0.0063	0.0341	0.433
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0145	0.0899	0.0899
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0191	0.1123
Brugia malayi	latrophilin 2 splice variant baaae	0.0032	0.0127	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0093	0.0111
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0011	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0191	0.0229
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0191	0.0229
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0027	0.0091	0.0137
Toxoplasma gondii	t-complex protein beta subunit	0.0027	0.0091	0.1161
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0037	0.0164	0.3383
Loa Loa (eye worm)	MH2 domain-containing protein	0.0111	0.0668	0.0798
Schistosoma mansoni	hypothetical protein	0.0032	0.0127	0.0219
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0084	0.0484	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0169	0.0292
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0191	0.1123
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0191	0.3951
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0057	0.0302	0.6226
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0039	0.0179	0.0213
Schistosoma mansoni	hypothetical protein	0.031	0.2019	0.3492
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0046	0.0227	0.0271
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0011	0.0013
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0.0064	0.1325
Mycobacterium ulcerans	lipase LipD	0.0041	0.0191	1
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.0297	0.0513
Entamoeba histolytica	hypothetical protein	0.0063	0.0341	0.433
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0129	0.0787	0.094
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0191	0.0287
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0191	0.3951
Entamoeba histolytica	hypothetical protein	0.0063	0.0341	0.433
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0011	0.0011
Echinococcus multilocularis	protein patched	0.0039	0.0179	0.0179
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.0297	0.0513
Brugia malayi	hypothetical protein	0.0282	0.1828	0.2183
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0191	0.3951
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0191	0.3951
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0749	0.0895
Entamoeba histolytica	hypothetical protein	0.0063	0.0341	0.433
Echinococcus granulosus	Niemann Pick C1 protein	0.0131	0.0803	0.1207
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0084	0.0484	1
Loa Loa (eye worm)	hypothetical protein	0.0282	0.1828	0.2183
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0145	0.0899	0.1556
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0084	0.0484	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0191	0.1123
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0037	0.0164	0.3383
Schistosoma mansoni	hypothetical protein	0.031	0.2019	0.3492
Echinococcus granulosus	Niemann Pick C1 protein	0.0092	0.0535	0.0804
Schistosoma mansoni	hypothetical protein	0.0015	0.0011	0.0018
Schistosoma mansoni	transcription factor LCR-F1	0.0063	0.0341	0.0589
Echinococcus granulosus	sterol regulatory element binding protein	0.0039	0.0179	0.0268
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0011	0.0222
Echinococcus multilocularis	sterol regulatory element binding protein	0.0039	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0127	0.0151
Brugia malayi	beta-lactamase	0.0041	0.0191	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0092	0.054	0.0644
Echinococcus granulosus	Protein patched homolog 1	0.0039	0.0179	0.0268
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0414	0.8544
Echinococcus granulosus	expressed conserved protein	0.0086	0.0497	0.0747
Brugia malayi	HSF-type DNA-binding domain containing protein	0.0092	0.054	0.0644
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0191	0.1123
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0084	0.0484	0.0838
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0011	0.0016
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0191	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0027	0.0093	0.0547
Brugia malayi	RNA binding protein	0.0057	0.0297	0.0354
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0191	1
Echinococcus granulosus	tar DNA binding protein	0.0057	0.0297	0.0446
Schistosoma mansoni	hypothetical protein	0.0015	0.0011	0.0018
Toxoplasma gondii	hypothetical protein	0.0027	0.0093	0.1186
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0011	0.0011
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0027	0.0093	0.4877
Brugia malayi	Niemann-Pick C1 protein precursor	0.0092	0.0535	0.0639
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0191	0.0229
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0191	0.0331
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0145	0.0899	0.1351
Schistosoma mansoni	hypothetical protein	0.0038	0.0169	0.0292
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0084	0.0484	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0011	0.0011
Leishmania major	T-complex protein 1, beta subunit, putative	0.0027	0.0091	0.1887
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0037	0.0164	0.0196
Schistosoma mansoni	patched 1	0.0039	0.0179	0.0309
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0011	0.0011
Loa Loa (eye worm)	pax transcription factor protein 2	0.0224	0.1438	0.1717
Brugia malayi	MH2 domain containing protein	0.0111	0.0668	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0227	0.0271
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0191	0.1123
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0037	0.0164	0.0246
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0093	0.1927
Echinococcus granulosus	geminin	0.031	0.2019	0.3032
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0257	0.1661	0.1983
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0027	0.0091	0.0158
Schistosoma mansoni	hypothetical protein	0.0015	0.0011	0.0018
Loa Loa (eye worm)	transcription factor SMAD2	0.0111	0.0668	0.0798
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0084	0.0484	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0145	0.0899	0.1351
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0.0011	0.0063
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0191	0.3951
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.1243	0.8374	1
Plasmodium vivax	hypothetical protein, conserved	0.0027	0.0093	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0011	0.0013
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0145	0.0899	0.0899
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0046	0.0227	0.0271
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0057	0.0302	0.6226
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0191	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0191	0.0331
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Plasmodium falciparum	GAF domain-related protein, putative	0.0027	0.0093	0.1186
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0084	0.0484	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0084	0.0484	1
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0027	0.0091	0.1887
Leishmania major	hypothetical protein, conserved	0.0023	0.0064	0.1325
Loa Loa (eye worm)	TAR-binding protein	0.0057	0.0297	0.0354
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0191	0.0229
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0037	0.0164	0.0283
Toxoplasma gondii	hypothetical protein	0.0027	0.0093	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0239	0.0285
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0013	0	0.5
Brugia malayi	TAR-binding protein	0.0057	0.0297	0.0354
Brugia malayi	RNA recognition motif domain containing protein	0.0057	0.0297	0.0354
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0027	0.0091	0.0158
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.0297	0.0513
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Echinococcus granulosus	muscleblind protein	0.0123	0.0749	0.1125
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0037	0.0164	0.0196
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0084	0.0484	0.0484
Brugia malayi	Kinesin motor domain containing protein	0.0129	0.0787	0.094
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0084	0.0484	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0057	0.0297	0.0354
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0011	0.0016
Trichomonas vaginalis	esterase, putative	0.0041	0.0191	0.3951
Brugia malayi	CHE-14 protein	0.0039	0.0179	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0191	0.0229
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0011	0.0013
Echinococcus multilocularis	protein dispatched 1	0.0045	0.0216	0.0216
Onchocerca volvulus		0.0282	0.1828	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0169	0.0292
Brugia malayi	follicle stimulating hormone receptor	0.0257	0.1661	0.1983
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0037	0.0164	0.3383
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0027	0.0093	0.0547
Schistosoma mansoni	microtubule-associated protein tau	0.0569	0.3785	0.6547
Trichomonas vaginalis	chaperonin, putative	0.0027	0.0091	0.1887
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0191	0.1123
Entamoeba histolytica	heat shock transcription factor, putative	0.0092	0.054	0.6856
Plasmodium vivax	T-complex protein 1 subunit beta, putative	0.0027	0.0091	0.1161
Plasmodium vivax	ataxin-2 like protein, putative	0.0023	0.0064	0.0816
Plasmodium vivax	kinesin-5	0.0129	0.0787	1
Brugia malayi	hypothetical protein	0.0015	0.001	0.0012
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0191	0.0191
Schistosoma mansoni	hypothetical protein	0.0063	0.0341	0.0589
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0092	0.0535	0.68
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0084	0.0484	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0023	0.0064	0.0816
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0011	0.0013
Giardia lamblia	Kinesin-5	0.0129	0.0787	1
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0414	0.8544
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0084	0.0484	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0191	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0164	0.0196
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0063	0.0341	0.0512
Loa Loa (eye worm)	RNA binding protein	0.0057	0.0297	0.0354
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0191	0.3951
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0191	0.3951
Onchocerca volvulus	Heat shock factor protein 2 homolog	0.0092	0.054	0.2128
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0027	0.0091	0.1887
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0145	0.0899	0.1556
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0484	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0084	0.0484	1
Loa Loa (eye worm)	T-complex protein 1	0.0027	0.0091	0.0109
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0084	0.0484	1
Plasmodium falciparum	T-complex protein 1 subunit beta	0.0027	0.0091	0.1161
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0057	0.0302	0.6226
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0011	0.0011
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0084	0.0484	1
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0191	1
Brugia malayi	T-complex protein 1, beta subunit	0.0027	0.0091	0.0109
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0011	0.0137
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0.0064	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0179	0.0213
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0084	0.0484	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0191	0.0229
Toxoplasma gondii	kinesin motor domain-containing protein	0.0129	0.0787	1
Echinococcus multilocularis	muscleblind protein 1	0.0123	0.0749	0.0749
Schistosoma mansoni	hypothetical protein	0.0862	0.5781	1
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0084	0.0484	0.0728
Toxoplasma gondii	GAF domain-containing protein	0.0027	0.0093	0.1186
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0191	0.3951
Echinococcus multilocularis	Niemann Pick C1 protein	0.0131	0.0803	0.0803
Echinococcus granulosus	kinesin family 1	0.0991	0.6658	1
Entamoeba histolytica	kinesin, putative	0.0129	0.0787	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0145	0.0899	0.1074
Brugia malayi	Muscleblind-like protein	0.0123	0.0749	0.0895
Echinococcus granulosus	microtubule associated protein 2	0.0569	0.3785	0.5685
Echinococcus granulosus	GPCR family 2	0.0015	0.0011	0.0016
Brugia malayi	Angiotensin-converting enzyme family protein	0.1243	0.8374	1
Echinococcus multilocularis	kinesin family 1	0.0991	0.6658	0.6658
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0011	0.0013
Echinococcus multilocularis	expressed conserved protein	0.0086	0.0497	0.0497
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0027	0.0091	0.1887
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0011	0.0016
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0046	0.0227	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0064	0.0077
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0011	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0414	0.8544
Echinococcus multilocularis	geminin	0.031	0.2019	0.2019
Leishmania major	hypothetical protein, conserved	0.0041	0.0191	0.3951
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0263	0.1705	1
Brugia malayi	hypothetical protein	0.0023	0.0064	0.0077
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0011	0.0019
Schistosoma mansoni	hypothetical protein	0.0038	0.0169	0.0292
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0037	0.0164	0.0164
Giardia lamblia	TCP-1 chaperonin subunit beta	0.0027	0.0091	0.1161
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0011	0.0013
Schistosoma mansoni	hypothetical protein	0.0015	0.0011	0.0018
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0191	1
Echinococcus multilocularis	tar DNA binding protein	0.0057	0.0297	0.0297
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.0297	0.0513
Mycobacterium ulcerans	putative regulatory protein	0.0027	0.0093	0.4877
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0191	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0011	0.0222
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0011	0.0137
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0145	0.0899	0.1074
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0191	0.1123
Trypanosoma brucei	PAB1-binding protein , putative	0.0023	0.0064	0.1325
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0084	0.0484	1
Brugia malayi	beta-lactamase family protein	0.0041	0.0191	0.0229
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0011	0.0222
Echinococcus multilocularis	muscleblind protein	0.0123	0.0749	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0191	0.0229
Brugia malayi	T-complex protein 1, beta subunit	0.0027	0.0091	0.0109
Onchocerca volvulus		0.0224	0.1438	0.7614
Echinococcus multilocularis	Niemann Pick C1 protein	0.0092	0.0535	0.0535
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0011	0.0137
Plasmodium falciparum	kinesin-5	0.0129	0.0787	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Brugia malayi	Pax transcription factor protein 2	0.0224	0.1438	0.1717
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0191	0.1123
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0749	0.0895
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0027	0.0091	0.0091
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0.0064	0.0816
Echinococcus multilocularis	microtubule associated protein 2	0.0569	0.3785	0.3785
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0.0064	0.1325
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0191	0.1123
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.0297	0.0513
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0084	0.0484	1
Entamoeba histolytica	heat shock transcription factor, putative	0.0092	0.054	0.6856
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0535	0.0639
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0027	0.0091	0.1161
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0015	0.0011	0.0222
Toxoplasma gondii	hypothetical protein	0.0074	0.0414	0.5258
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0013	0	0.5
Schistosoma mansoni	kinesin eg-5	0.0129	0.0787	0.1361
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0015	0.0011	0.0137
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0027	0.0091	0.0158
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0191	0.2432
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0145	0.0899	0.1556
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0084	0.0484	1
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0179	0.3687

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.5 nM	BindingDB_Patents: Binding assay. Binding assay was performed at 4 C. in a final volume of 1 ml, and with an incubation time of 30 min. The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calculated Kd value of 60 nM to give a bound at around 0.1% of the total added radioligand concentration, and a specific binding which represented approximately 70-80% of the total binding. Non-specific binding was defined as the amount of [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline bound in the presence of the appropriate unlabelled ligand (10 µM). Competing ligands were tested in a wide range of concentrations (10 µM-30 µM). The final dimethylsulphoxide concentration in the assay was 2%, and it did not affect radioligand binding.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3652709

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1995589