Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminyl-peptide cyclotransferase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Onchocerca volvulus | Glutaminyl cyclase homolog | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Brugia malayi | Peptidase family M28 containing protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma japonicum | ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | glutaminyl-peptide cyclotransferase | 361 aa | 292 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0031 | 0.1368 | 0.1327 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.1368 | 0.1327 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.2041 | 0.1894 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0022 | 0.0594 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0594 | 0.0594 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.1368 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0047 | 0.0047 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0022 | 0.0594 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0308 | 0.0128 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0022 | 0.0594 | 0.0295 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0022 | 0.0594 | 0.055 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0022 | 0.0594 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.3535 | 0.3415 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.1368 | 0.1327 |
Leishmania major | glutaminyl cyclase, putative | 0.0022 | 0.0594 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.1368 | 0.1368 |
Schistosoma mansoni | lamin | 0.0031 | 0.1368 | 0.1094 |
Schistosoma mansoni | lamin | 0.0031 | 0.1368 | 0.1094 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.3535 | 0.3535 |
Onchocerca volvulus | 0.0031 | 0.1368 | 0.0823 | |
Leishmania major | hypothetical protein, conserved | 0.0022 | 0.0594 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0182 | 0.0182 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0136 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0308 | 0.0262 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.3535 | 0.3535 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0022 | 0.0594 | 0.0295 |
Toxoplasma gondii | hypothetical protein | 0.0022 | 0.0594 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0022 | 0.0594 | 0.055 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1321 | 0.1321 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0594 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0308 | 0.0308 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0022 | 0.0594 | 0.055 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0308 | 0.0262 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0.0594 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0022 | 0.0594 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0136 | 1 | 1 |
Brugia malayi | leucyl aminopeptidase | 0.0022 | 0.0594 | 0.042 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0022 | 0.0594 | 0.0295 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0022 | 0.0594 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0594 | 0.0594 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0022 | 0.0594 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0022 | 0.0594 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2041 | 0.1788 |
Echinococcus multilocularis | lamin | 0.0031 | 0.1368 | 0.1327 |
Onchocerca volvulus | 0.0031 | 0.1368 | 0.0823 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0308 | 0.0128 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0022 | 0.0594 | 0.055 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0594 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0594 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0308 | 0.0262 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0022 | 0.0594 | 0.055 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0308 | 0.0262 |
Echinococcus multilocularis | musashi | 0.0031 | 0.1368 | 0.1327 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.3535 | 0.3415 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.1368 | 0.1327 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1368 | 0.1368 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0.0594 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.1368 | 0.1208 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0308 | 0.0262 |
Mycobacterium tuberculosis | Conserved protein | 0.0022 | 0.0594 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0022 | 0.0594 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0594 | 0.0594 |
Schistosoma mansoni | nicalin (M28 family) | 0.0022 | 0.0594 | 0.0295 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.1368 | 0.1368 |
Brugia malayi | nicalin | 0.0022 | 0.0594 | 0.042 |
Brugia malayi | FXNA | 0.0022 | 0.0594 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2041 | 0.2041 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0308 | 0.0262 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.1368 | 0.1208 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0308 | 0.0308 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2950 nM | BindingDB_Patents: Inhibition Assay. Fluorometric Assays: All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrically using H-Gln-beta NA. The samples consisted of 0.2 mM fluorogenic substrate, 0.25 U pyroglutamyl aminopeptidase (Unizyme, Horsholm, Denmark) in 0.2 M Tris/HCl, pH 8.0 containing 20 mM EDTA and an appropriately diluted aliquot of QC in a final volume of 250 ul. Excitation/emission wavelengths were 320/410 nm. The assay reactions were initiated by addition of glutaminyl cyclase. QC activity was determined from a standard curve of beta -naphthylamine under assay conditions. One unit is defined as the amount of QC catalyzing the formation of 1 umol pGlu-beta NA from H-Gln-beta NA per minute under the described conditions.In a second fluorometric assay, QC was activity determined using H-Gln-AMC as substrate. Reactions were carried out at 30 C. utilizing the NOVOStar reader for microplates (BMG labtechnology). | ChEMBL. | No reference |
Ki (binding) | = 348 nM | BindingDB_Patents: Inhibition Assay. Fluorometric Assays: All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrically using H-Gln-beta NA. The samples consisted of 0.2 mM fluorogenic substrate, 0.25 U pyroglutamyl aminopeptidase (Unizyme, Horsholm, Denmark) in 0.2 M Tris/HCl, pH 8.0 containing 20 mM EDTA and an appropriately diluted aliquot of QC in a final volume of 250 ul. Excitation/emission wavelengths were 320/410 nm. The assay reactions were initiated by addition of glutaminyl cyclase. QC activity was determined from a standard curve of beta -naphthylamine under assay conditions. One unit is defined as the amount of QC catalyzing the formation of 1 umol pGlu-beta NA from H-Gln-beta NA per minute under the described conditions.In a second fluorometric assay, QC was activity determined using H-Gln-AMC as substrate. Reactions were carried out at 30 C. utilizing the NOVOStar reader for microplates (BMG labtechnology). | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.