Detailed information for compound 20243

Basic information

Technical information
  • TDR Targets ID: 20243
  • Name: 5-hydroxy-5-methyl-4-(4-methylsulfonylphenyl) -3-naphthalen-2-ylfuran-2-one
  • MW: 394.44 | Formula: C22H18O5S
  • H donors: 1 H acceptors: 4 LogP: 3.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OC(C(=C1c1ccc2c(c1)cccc2)c1ccc(cc1)S(=O)(=O)C)(C)O
  • InChi: 1S/C22H18O5S/c1-22(24)20(15-9-11-18(12-10-15)28(2,25)26)19(21(23)27-22)17-8-7-14-5-3-4-6-16(14)13-17/h3-13,24H,1-2H3
  • InChiKey: CHUNHRFIWQZFCI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-hydroxy-5-methyl-4-(4-methylsulfonylphenyl)-3-(2-naphthyl)furan-2-one
  • 5-hydroxy-5-methyl-4-(4-methylsulfonylphenyl)-3-(2-naphthalenyl)-2-furanone
  • 5-hydroxy-5-methyl-4-(4-methylsulfonylphenyl)-3-naphthalen-2-yl-furan-2-one
  • 5-hydroxy-4-(4-mesylphenyl)-5-methyl-3-(2-naphthyl)furan-2-one
  • 5-hydroxy-5-methyl-4-(4-methylsulfonylphenyl)-3-(2-naphthyl)-2-furanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0387 0.2721 0.2721
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.1385 1 1
Plasmodium falciparum geranylgeranyltransferase, putative 0.0387 0.2721 0.2682
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0571 0.4062 0.4031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0052 0.0052
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0387 0.2721 0.2682
Toxoplasma gondii aspartyl protease ASP1 0.0047 0.0239 0.0188
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0571 0.4062 0.4062
Loa Loa (eye worm) hypothetical protein 0.0047 0.0239 0.0239
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0052 0.0052
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.1385 1 1
Onchocerca volvulus 0.0022 0.0052 0.0129
Onchocerca volvulus 0.0022 0.0052 0.0129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0052 0.0052
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0387 0.2721 0.2721
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0571 0.4062 0.4062
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.1117 0.8041 0.8041
Schistosoma mansoni protein farnesyltransferase subunit beta 0.1385 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0394 0.2768 0.2768
Trichomonas vaginalis ras-dva small GTPase, putative 0.0394 0.2768 0.2768
Trichomonas vaginalis ral, putative 0.0394 0.2768 0.2768
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0052 0.0052
Plasmodium vivax plasmepsin IV, putative 0.0047 0.0239 0.0188
Brugia malayi Cathepsin L-like precursor 0.0022 0.0052 0.0052
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0998 0.7174 0.7159
Brugia malayi Ras protein let-60 0.0394 0.2768 0.2768
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0387 0.2721 0.2721
Loa Loa (eye worm) Ras protein let-60 0.0394 0.2768 0.2768
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0387 0.2721 0.2721
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.1385 1 1
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.1281 0.9242 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0571 0.4062 0.4062
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0047 0.0239 0.0188
Onchocerca volvulus Peroxidase homolog 0.0032 0.0126 0.031
Onchocerca volvulus Peroxidase homolog 0.0032 0.0126 0.031
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0387 0.2721 0.2682
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0047 0.0239 0.0188
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0571 0.4062 0.4031
Brugia malayi Cathepsin L-like precursor 0.0022 0.0052 0.0052
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0387 0.2721 0.2721
Echinococcus granulosus cathepsin l1 0.0022 0.0052 0.0052
Entamoeba histolytica cysteine protease, putative 0.0022 0.0052 0.0052
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0387 0.2721 0.2721
Brugia malayi Blistered cuticle protein 3 0.0032 0.0126 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0052 0.0052
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0047 0.0239 0.0239
Giardia lamblia Prenyltransferase 0.1385 1 1
Onchocerca volvulus 0.0022 0.0052 0.0129
Onchocerca volvulus 0.0022 0.0052 0.0129
Brugia malayi Peroxidasin 0.0032 0.0126 0.0126
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0047 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Trypanosoma brucei hypothetical protein, conserved 0.0571 0.4062 0.4031
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0571 0.4062 0.4031
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.1385 1 1
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0387 0.2721 0.2682
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0571 0.4062 0.4031
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0571 0.4062 0.4062
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.1117 0.8041 0.8041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0052 0.0052
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.1117 0.8041 0.8041
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.1385 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Echinococcus granulosus protein farnesyltransferase subunit beta 0.1385 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0571 0.4062 0.4062
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Echinococcus granulosus peroxidasin 0.0032 0.0126 0.0126
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0387 0.2721 0.2682
Plasmodium vivax prenyltransferase alpha subunit, putative 0.1117 0.8041 0.803
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0052 0.0052
Plasmodium falciparum plasmepsin I 0.0047 0.0239 0.0188
Brugia malayi Cathepsin L-like precursor 0.0022 0.0052 0.0052
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0387 0.2721 0.2721
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.1385 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0052 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0387 0.2721 0.2721
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0052 0.0052
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0052 0.0052
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0387 0.2721 0.2682
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0387 0.2721 0.2721
Giardia lamblia Rab geranylgeranyltransferase 0.1117 0.8041 0.7308
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0126 0.0126
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.0052 0.0052
Loa Loa (eye worm) ctsf protein 0.0022 0.0052 0.0052
Toxoplasma gondii hypothetical protein 0.0545 0.3873 0.3841
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0047 0.0239 0.0239
Plasmodium vivax geranylgeranyltransferase, putative 0.0387 0.2721 0.2682
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0387 0.2721 0.2721
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Onchocerca volvulus Chorion peroxidase homolog 0.0032 0.0126 0.031
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.0052 0.0052
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0387 0.2721 0.2721
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0571 0.4062 0.4062
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0052 0.0052
Trichomonas vaginalis rap1 and, putative 0.0394 0.2768 0.2768
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0571 0.4062 0.4062
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0571 0.4062 0.4062
Loa Loa (eye worm) hypothetical protein 0.1117 0.8041 0.8041
Trypanosoma cruzi protein farnesyltransferase, putative 0.1385 1 1
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.1117 0.8041 0.8041
Onchocerca volvulus 0.0032 0.0126 0.031
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0387 0.2721 0.2682
Plasmodium falciparum plasmepsin II 0.0047 0.0239 0.0188
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.1117 0.8041 0.803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0126 0.0126
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0126 0.0126
Plasmodium falciparum plasmepsin VI 0.0047 0.0239 0.0188
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0571 0.4062 0.4031
Onchocerca volvulus 0.0032 0.0126 0.031
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.1385 1 1
Onchocerca volvulus 0.0022 0.0052 0.0129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0052 0.0052
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Onchocerca volvulus 0.0032 0.0126 0.031
Entamoeba histolytica ras-1, putative 0.0394 0.2768 0.2768
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Echinococcus multilocularis peroxidasin 0.0032 0.0126 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Plasmodium falciparum protein farnesyltransferase subunit beta 0.1385 1 1
Giardia lamblia Rab geranylgeranyltransferase 0.0571 0.4062 0.1842
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.1385 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Leishmania major farnesyltransferase beta subunit 0.1385 1 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0571 0.4062 0.4062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0387 0.2721 0.2682
Trypanosoma brucei protein farnesyltransferase beta subunit 0.1385 1 1
Schistosoma mansoni peroxidasin 0.0032 0.0126 0.0126
Toxoplasma gondii hypothetical protein 0.0571 0.4062 0.4031
Brugia malayi Cathepsin L-like precursor 0.0022 0.0052 0.0052
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0571 0.4062 0.4062
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.1117 0.8041 0.803
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.0387 0.2721 0.2721
Loa Loa (eye worm) cysteine protease 0.0022 0.0052 0.0052
Trypanosoma cruzi protein farnesyltransferase, putative 0.1385 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0571 0.4062 0.4062
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0126 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0126 0.0126
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0052 0.0052
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0387 0.2721 0.2721
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.1117 0.8041 0.8041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Trypanosoma cruzi lanosterol synthase, putative 0.1281 0.9242 0.9242
Schistosoma mansoni cathepsin D (A01 family) 0.0139 0.0911 0.0911
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0047 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Entamoeba histolytica Ras family GTPase 0.0394 0.2768 0.2768
Brugia malayi Ras-related protein R-Ras2 0.0394 0.2768 0.2768
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.1117 0.8041 0.8041
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.1117 0.8041 0.8041
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0571 0.4062 0.4031
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Echinococcus granulosus ras gtpase 0.0394 0.2768 0.2768
Trichomonas vaginalis GTP-binding protein rit, putative 0.0394 0.2768 0.2768
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0052 0.0052
Brugia malayi Cathepsin L-like precursor 0.0022 0.0052 0.0052
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0126 0.031
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0052 0.0052
Trypanosoma cruzi lanosterol synthase, putative 0.1281 0.9242 0.9242
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0545 0.3873 0.3873
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0387 0.2721 0.2721
Schistosoma mansoni peroxidasin 0.0032 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0052
Trichomonas vaginalis dexras1, putative 0.0394 0.2768 0.2768
Onchocerca volvulus Cathepsin F homolog 0.0022 0.0052 0.0129
Trichomonas vaginalis rheb, putative 0.0394 0.2768 0.2768
Loa Loa (eye worm) fibroinase 0.0022 0.0052 0.0052
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.1385 1 1
Brugia malayi hypothetical protein 0.0032 0.0126 0.0126
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0052 0.0129
Brugia malayi Cathepsin L-like precursor 0.0022 0.0052 0.0052
Plasmodium falciparum plasmepsin IV 0.0047 0.0239 0.0188
Onchocerca volvulus 0.0022 0.0052 0.0129
Onchocerca volvulus 0.0571 0.4062 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.0052 0.0052
Onchocerca volvulus Dual oxidase homolog 0.0032 0.0126 0.031
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0052 0.0052
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0052 0.0052
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0052 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0052 0.0052
Echinococcus multilocularis ras gtpase 0.0394 0.2768 0.273
Plasmodium vivax aspartyl proteinase, putative 0.0047 0.0239 0.0188
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0052 0.0052
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0387 0.2721 0.2721
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0126
Trypanosoma brucei lanosterol synthase 0.1281 0.9242 0.9238
Schistosoma mansoni cathepsin D (A01 family) 0.0139 0.0911 0.0911
Leishmania major lanosterol synthase, putative 0.0894 0.6415 0.6397
Plasmodium vivax farnesyltransferase beta subunit, putative 0.1385 1 1
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.1385 1 1
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0571 0.4062 0.4031
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0387 0.2721 0.2721
Leishmania major geranylgeranyltransferase, putative 0.0387 0.2721 0.2682
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0126 0.0126
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0571 0.4062 0.4031
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.1117 0.8041 0.8041
Loa Loa (eye worm) blistered cuticle protein 3 0.0032 0.0126 0.0126
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0571 0.4062 0.4062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0052 0.0052
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0387 0.2721 0.2721
Onchocerca volvulus 0.0022 0.0052 0.0129
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.0052 0.0052
Entamoeba histolytica Ras family GTPase 0.0394 0.2768 0.2768

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 10 mg kg-1 Inhibition of carageenan induced rat paw oedema. ChEMBL. 12643942
IC50 (binding) = 0.45 uM Inhibitory of human Prostaglandin G/H synthase 2 expressed in CHO cells. ChEMBL. 12643942
IC50 (binding) = 0.45 uM Inhibitory of human Prostaglandin G/H synthase 2 expressed in CHO cells. ChEMBL. 12643942
IC50 (binding) = 3.2 uM Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 2 in human whole blood ChEMBL. 12643942
IC50 (binding) = 3.2 uM Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 2 in human whole blood ChEMBL. 12643942
IC50 (binding) = 30 uM Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 1 in the sensitive U937 microsome assay ChEMBL. 12643942
IC50 (binding) = 30 uM Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 1 in the sensitive U937 microsome assay ChEMBL. 12643942

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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