Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0019 | 0.0133 | 0.0212 |
Brugia malayi | RNase H family protein | 0.0039 | 0.0524 | 0.0914 |
Trypanosoma cruzi | GMP reductase | 0.0025 | 0.0247 | 0.0116 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0158 | 0.2809 | 0.6253 |
Schistosoma mansoni | ryanodine receptor related | 0.0158 | 0.2809 | 0.7835 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0698 | 0.1895 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0025 | 0.0247 | 0.0479 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0042 | 0.0587 | 0.0461 |
Echinococcus multilocularis | stromal cell derived factor 2 | 0.0025 | 0.0251 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2729 | 0.8705 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0039 | 0.0524 | 0.2411 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0027 | 0.0294 | 0.0472 |
Loa Loa (eye worm) | MIR domain-containing protein | 0.0025 | 0.0251 | 0.0398 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0698 | 0.1655 |
Leishmania major | hypothetical protein, conserved | 0.0091 | 0.1515 | 0.1401 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0039 | 0.0524 | 0.0396 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Trypanosoma brucei | DNA polymerase epsilon catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Leishmania major | DNA polymerase epsilon catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Echinococcus granulosus | acetylcholinesterase | 0.0048 | 0.0698 | 0.1895 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0042 | 0.0587 | 0.0461 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0023 | 0.0219 | 0.0425 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0023 | 0.0219 | 0.1137 |
Trichomonas vaginalis | DNA polymerase delta catalytic subunit, putative | 0.002 | 0.0158 | 0.0649 |
Echinococcus granulosus | carboxylesterase 5A | 0.0048 | 0.0698 | 0.1895 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0075 | 0.1214 | 0.1096 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0033 | 0.0407 | 0.0919 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0025 | 0.0247 | 0.0116 |
Echinococcus multilocularis | acetylcholinesterase | 0.0048 | 0.0698 | 0.1895 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0019 | 0.0133 | 0.5356 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0025 | 0.0247 | 0.0116 |
Brugia malayi | DNA polymerase family B containing protein | 0.002 | 0.0158 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1945 | 0.6075 |
Trypanosoma cruzi | GMP reductase | 0.0025 | 0.0247 | 0.0116 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0025 | 0.0247 | 0.0116 |
Plasmodium falciparum | DNA polymerase alpha catalytic subunit A | 0.002 | 0.0167 | 0.4016 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0048 | 0.0698 | 0.1895 |
Schistosoma mansoni | DNA polymerase zeta catalytic subunit | 0.002 | 0.0158 | 0.0074 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0281 | 0.5161 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2674 | 0.8518 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0252 | 0.4615 | 0.4542 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0042 | 0.0587 | 0.0461 |
Leishmania major | ribonuclease H1, putative | 0.0039 | 0.0524 | 0.0396 |
Trypanosoma cruzi | DNA polymerase epsilon catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Echinococcus multilocularis | ribonuclease H1 | 0.0039 | 0.0524 | 0.1311 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0043 | 0.0595 | 0.1354 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0072 | 0.1158 | 0.3437 |
Leishmania major | DNA polymerase delta catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.2244 | 0.7077 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0039 | 0.0524 | 1 |
Trypanosoma brucei | GMP reductase | 0.0025 | 0.0247 | 0.0116 |
Echinococcus multilocularis | dna polymerase epsilon catalytic subunit a | 0.002 | 0.0158 | 0.0085 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0025 | 0.0247 | 0.0385 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.0031 | 0.0379 | 0.631 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0099 | 0.1675 | 1 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0072 | 0.1158 | 0.3002 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0025 | 0.0247 | 0.0385 |
Giardia lamblia | Ribonuclease H | 0.0039 | 0.0524 | 0.4642 |
Entamoeba histolytica | DNA polymerase delta catalytic subunit, putative | 0.002 | 0.0158 | 0.2137 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0533 | 1 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0088 | 0.1459 | 0.4446 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0252 | 0.4615 | 0.4542 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.0587 | 0.0461 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0698 | 0.1895 |
Loa Loa (eye worm) | ryanodine receptor | 0.0043 | 0.0595 | 0.155 |
Brugia malayi | Variant SH3 domain containing protein | 0.0033 | 0.0407 | 0.0641 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0698 | 0.1321 |
Plasmodium vivax | DNA polymerase epsilon, catalytic subunit a, putative | 0.002 | 0.0158 | 0.0332 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0091 | 0.1528 | 0.1414 |
Echinococcus granulosus | acetylcholinesterase | 0.0048 | 0.0698 | 0.1895 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0058 | 0.0897 | 0.1786 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0072 | 0.1158 | 0.3437 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0058 | 0.0897 | 1 |
Toxoplasma gondii | DNA polymerase | 0.002 | 0.0158 | 0.0196 |
Echinococcus granulosus | dna polymerase epsilon catalytic subunit a | 0.002 | 0.0158 | 0.0085 |
Trypanosoma cruzi | DNA polymerase I alpha catalytic subunit, putative | 0.0031 | 0.0379 | 0.025 |
Echinococcus granulosus | DNA polymerase subunit gamma | 0.0174 | 0.3116 | 1 |
Plasmodium vivax | DNA polymerase delta catalytic subunit, putative | 0.002 | 0.0158 | 0.0332 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1675 | 0.5172 |
Schistosoma mansoni | phosphoglucomutase | 0.0039 | 0.0524 | 0.1145 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0075 | 0.1214 | 0.1096 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0129 | 0.2244 | 0.618 |
Brugia malayi | DNA polymerase family B, exonuclease domain containing protein | 0.002 | 0.0158 | 0.0059 |
Schistosoma mansoni | DNA polymerase gamma | 0.0174 | 0.3116 | 0.8733 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0025 | 0.0247 | 0.2938 |
Mycobacterium ulcerans | DNA polymerase I | 0.0019 | 0.0133 | 0.0257 |
Trypanosoma brucei | RNA helicase, putative | 0.0146 | 0.2579 | 0.248 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.0058 | 0.0897 | 0.5913 |
Echinococcus granulosus | DNA polymerase delta catalytic subunit | 0.002 | 0.0158 | 0.0085 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0698 | 0.1321 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0025 | 0.0247 | 0.0116 |
Entamoeba histolytica | DNA polymerase alpha catalytic subunit, putative | 0.002 | 0.0167 | 0.294 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0197 | 0.3548 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0088 | 0.1459 | 0.4446 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0061 | 0.0946 | 1 |
Brugia malayi | DNA polymerase I family protein | 0.0174 | 0.3116 | 0.697 |
Chlamydia trachomatis | DNA polymerase I | 0.0019 | 0.0133 | 0.5 |
Onchocerca volvulus | 0.0025 | 0.0251 | 0.0615 | |
Mycobacterium ulcerans | hypothetical protein | 0.0281 | 0.5161 | 1 |
Brugia malayi | RNase H family protein | 0.0039 | 0.0524 | 0.0914 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0025 | 0.0247 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0048 | 0.0698 | 0.1895 |
Trypanosoma brucei | unspecified product | 0.0042 | 0.0587 | 0.0461 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0025 | 0.0247 | 0.0116 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0025 | 0.0247 | 0.0436 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.2579 | 0.7164 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0023 | 0.0219 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0075 | 0.1214 | 0.1096 |
Leishmania major | guanosine monophosphate reductase | 0.0025 | 0.0247 | 0.0116 |
Brugia malayi | RNase H family protein | 0.0039 | 0.0524 | 0.0914 |
Brugia malayi | MIR domain containing protein | 0.0025 | 0.0251 | 0.0277 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0031 | 0.0379 | 0.631 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0698 | 0.1895 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0533 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0039 | 0.0524 | 1 |
Plasmodium falciparum | DNA polymerase delta catalytic subunit | 0.002 | 0.0158 | 0.2918 |
Brugia malayi | DNA polymerase delta catalytic subunit | 0.002 | 0.0158 | 0.0059 |
Schistosoma mansoni | phosphoglucomutase | 0.0039 | 0.0524 | 0.1145 |
Leishmania major | DNA polymerase I alpha catalytic subunit, putative | 0.0031 | 0.0379 | 0.025 |
Trypanosoma cruzi | DNA polymerase epsilon catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Schistosoma mansoni | stromal cell-derived factor 2 precursor-like protein | 0.0025 | 0.0251 | 0.0348 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0048 | 0.0698 | 0.1895 |
Toxoplasma gondii | DNA polymerase family B protein | 0.002 | 0.0158 | 0.0196 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0013 | 0.0024 | 0.0954 |
Trypanosoma brucei | ribonuclease H1 | 0.0039 | 0.0524 | 0.0396 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.3116 | 1 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0133 | 0.2334 | 0.2231 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0113 | 0.1945 | 0.6075 |
Echinococcus multilocularis | DNA polymerase zeta catalytic subunit | 0.002 | 0.0158 | 0.0085 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0025 | 0.0247 | 0.0269 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0133 | 0.2334 | 0.2231 |
Schistosoma mansoni | DNA polymerase epsilon catalytic subunit | 0.002 | 0.0158 | 0.0074 |
Echinococcus granulosus | DNA polymerase zeta catalytic subunit | 0.002 | 0.0158 | 0.0085 |
Schistosoma mansoni | phosphoglucomutase | 0.0039 | 0.0524 | 0.1145 |
Trichomonas vaginalis | mannosyltransferase 1, putative | 0.0025 | 0.0251 | 0.3035 |
Toxoplasma gondii | hypothetical protein | 0.0086 | 0.1425 | 1 |
Entamoeba histolytica | MIR domain protein | 0.0025 | 0.0251 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0113 | 0.1945 | 0.6075 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0025 | 0.0247 | 0.0336 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.002 | 0.0158 | 0.0649 |
Trypanosoma brucei | DNA polymerase zeta catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0039 | 0.0524 | 0.0396 |
Echinococcus granulosus | stromal cell derived factor 2 | 0.0025 | 0.0251 | 0.0398 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0252 | 0.4615 | 0.4542 |
Loa Loa (eye worm) | DNA-directed DNA polymerase III | 0.002 | 0.0158 | 0.0085 |
Trichomonas vaginalis | DNA polymerase zeta catalytic subunit, putative | 0.002 | 0.0158 | 0.0649 |
Echinococcus multilocularis | DNA polymerase delta catalytic subunit | 0.002 | 0.0158 | 0.0085 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0025 | 0.0247 | 0.0385 |
Brugia malayi | cation channel family protein | 0.0242 | 0.4412 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0174 | 0.3116 | 1 |
Trypanosoma brucei | DNA polymerase delta catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0533 | 1 | 1 |
Schistosoma mansoni | DNA polymerase delta catalytic subunit | 0.002 | 0.0158 | 0.0074 |
Toxoplasma gondii | ribonuclease HI protein | 0.0039 | 0.0524 | 0.3026 |
Trypanosoma brucei | DNA polymerase alpha catalytic subunit | 0.0031 | 0.0379 | 0.025 |
Echinococcus granulosus | ribonuclease H1 | 0.0039 | 0.0524 | 0.1311 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0039 | 0.0524 | 1 |
Plasmodium vivax | DNA polymerase zeta catalytic subunit, putative | 0.002 | 0.0158 | 0.0332 |
Toxoplasma gondii | IMP dehydrogenas | 0.0025 | 0.0247 | 0.0889 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0075 | 0.1214 | 0.1096 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.