Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0019 | 0.0133 | 0.5356 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0533 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0698 | 0.1321 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.002 | 0.0158 | 0.0649 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0072 | 0.1158 | 0.3002 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0133 | 0.2334 | 0.2231 |
Trypanosoma brucei | RNA helicase, putative | 0.0146 | 0.2579 | 0.248 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0075 | 0.1214 | 0.1096 |
Giardia lamblia | Ribonuclease H | 0.0039 | 0.0524 | 0.4642 |
Trypanosoma brucei | unspecified product | 0.0042 | 0.0587 | 0.0461 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0058 | 0.0897 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2674 | 0.8518 |
Brugia malayi | DNA polymerase family B, exonuclease domain containing protein | 0.002 | 0.0158 | 0.0059 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0039 | 0.0524 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0698 | 0.1895 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0133 | 0.2334 | 0.2231 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0042 | 0.0587 | 0.0461 |
Echinococcus multilocularis | DNA polymerase zeta catalytic subunit | 0.002 | 0.0158 | 0.0085 |
Echinococcus granulosus | acetylcholinesterase | 0.0048 | 0.0698 | 0.1895 |
Loa Loa (eye worm) | ryanodine receptor | 0.0043 | 0.0595 | 0.155 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0042 | 0.0587 | 0.0461 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0252 | 0.4615 | 0.4542 |
Leishmania major | DNA polymerase delta catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Plasmodium falciparum | DNA polymerase delta catalytic subunit | 0.002 | 0.0158 | 0.2918 |
Trichomonas vaginalis | DNA polymerase delta catalytic subunit, putative | 0.002 | 0.0158 | 0.0649 |
Echinococcus granulosus | DNA polymerase zeta catalytic subunit | 0.002 | 0.0158 | 0.0085 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0023 | 0.0219 | 0.1137 |
Trypanosoma brucei | GMP reductase | 0.0025 | 0.0247 | 0.0116 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0088 | 0.1459 | 0.4446 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0023 | 0.0219 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0019 | 0.0133 | 0.0212 |
Brugia malayi | RNase H family protein | 0.0039 | 0.0524 | 0.0914 |
Schistosoma mansoni | phosphoglucomutase | 0.0039 | 0.0524 | 0.1145 |
Trypanosoma cruzi | DNA polymerase epsilon catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0061 | 0.0946 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0039 | 0.0524 | 1 |
Loa Loa (eye worm) | MIR domain-containing protein | 0.0025 | 0.0251 | 0.0398 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0025 | 0.0247 | 0.0436 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0039 | 0.0524 | 0.2411 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0025 | 0.0247 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1675 | 0.5172 |
Leishmania major | hypothetical protein, conserved | 0.0091 | 0.1515 | 0.1401 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0033 | 0.0407 | 0.0919 |
Chlamydia trachomatis | DNA polymerase I | 0.0019 | 0.0133 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0048 | 0.0698 | 0.1895 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0058 | 0.0897 | 0.1786 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0533 | 1 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0129 | 0.2244 | 0.618 |
Leishmania major | DNA polymerase I alpha catalytic subunit, putative | 0.0031 | 0.0379 | 0.025 |
Toxoplasma gondii | hypothetical protein | 0.0086 | 0.1425 | 1 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0031 | 0.0379 | 0.631 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0281 | 0.5161 | 1 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.0058 | 0.0897 | 0.5913 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0075 | 0.1214 | 0.1096 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0025 | 0.0247 | 0.0385 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0042 | 0.0587 | 0.0461 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0025 | 0.0247 | 0.0336 |
Brugia malayi | cation channel family protein | 0.0242 | 0.4412 | 1 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0025 | 0.0247 | 0.0116 |
Trypanosoma brucei | DNA polymerase zeta catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0158 | 0.2809 | 0.6253 |
Mycobacterium ulcerans | hypothetical protein | 0.0281 | 0.5161 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.0587 | 0.0461 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0252 | 0.4615 | 0.4542 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0533 | 1 | 1 |
Toxoplasma gondii | DNA polymerase family B protein | 0.002 | 0.0158 | 0.0196 |
Echinococcus granulosus | stromal cell derived factor 2 | 0.0025 | 0.0251 | 0.0398 |
Brugia malayi | MIR domain containing protein | 0.0025 | 0.0251 | 0.0277 |
Trypanosoma brucei | DNA polymerase epsilon catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.2244 | 0.7077 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0698 | 0.1895 |
Onchocerca volvulus | 0.0025 | 0.0251 | 0.0615 | |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1945 | 0.6075 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0197 | 0.3548 | 1 |
Trypanosoma brucei | DNA polymerase delta catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2729 | 0.8705 |
Mycobacterium ulcerans | DNA polymerase I | 0.0019 | 0.0133 | 0.0257 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.0031 | 0.0379 | 0.631 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.2579 | 0.7164 |
Echinococcus granulosus | carboxylesterase 5A | 0.0048 | 0.0698 | 0.1895 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0039 | 0.0524 | 1 |
Leishmania major | DNA polymerase epsilon catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Trypanosoma cruzi | DNA polymerase epsilon catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0075 | 0.1214 | 0.1096 |
Echinococcus granulosus | DNA polymerase delta catalytic subunit | 0.002 | 0.0158 | 0.0085 |
Trypanosoma cruzi | GMP reductase | 0.0025 | 0.0247 | 0.0116 |
Brugia malayi | DNA polymerase delta catalytic subunit | 0.002 | 0.0158 | 0.0059 |
Plasmodium vivax | DNA polymerase delta catalytic subunit, putative | 0.002 | 0.0158 | 0.0332 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0113 | 0.1945 | 0.6075 |
Brugia malayi | RNase H family protein | 0.0039 | 0.0524 | 0.0914 |
Brugia malayi | Variant SH3 domain containing protein | 0.0033 | 0.0407 | 0.0641 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0048 | 0.0698 | 0.1895 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0025 | 0.0247 | 1 |
Toxoplasma gondii | DNA polymerase | 0.002 | 0.0158 | 0.0196 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0023 | 0.0219 | 0.0425 |
Echinococcus multilocularis | DNA polymerase delta catalytic subunit | 0.002 | 0.0158 | 0.0085 |
Echinococcus multilocularis | hypothetical protein | 0.0174 | 0.3116 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0025 | 0.0247 | 0.0116 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.002 | 0.0158 | 0.0026 |
Echinococcus granulosus | DNA polymerase subunit gamma | 0.0174 | 0.3116 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.0025 | 0.0247 | 0.0116 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0072 | 0.1158 | 0.3437 |
Echinococcus granulosus | ribonuclease H1 | 0.0039 | 0.0524 | 0.1311 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0025 | 0.0247 | 0.2938 |
Trypanosoma brucei | DNA polymerase alpha catalytic subunit | 0.0031 | 0.0379 | 0.025 |
Brugia malayi | DNA polymerase I family protein | 0.0174 | 0.3116 | 0.697 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0025 | 0.0247 | 0.0385 |
Toxoplasma gondii | ribonuclease HI protein | 0.0039 | 0.0524 | 0.3026 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0043 | 0.0595 | 0.1354 |
Trypanosoma cruzi | GMP reductase | 0.0025 | 0.0247 | 0.0116 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0091 | 0.1528 | 0.1414 |
Echinococcus multilocularis | dna polymerase epsilon catalytic subunit a | 0.002 | 0.0158 | 0.0085 |
Entamoeba histolytica | MIR domain protein | 0.0025 | 0.0251 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.3116 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0025 | 0.0247 | 0.0479 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0113 | 0.1945 | 0.6075 |
Schistosoma mansoni | phosphoglucomutase | 0.0039 | 0.0524 | 0.1145 |
Echinococcus multilocularis | acetylcholinesterase | 0.0048 | 0.0698 | 0.1895 |
Plasmodium vivax | DNA polymerase epsilon, catalytic subunit a, putative | 0.002 | 0.0158 | 0.0332 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0025 | 0.0247 | 0.0269 |
Entamoeba histolytica | DNA polymerase delta catalytic subunit, putative | 0.002 | 0.0158 | 0.2137 |
Schistosoma mansoni | DNA polymerase zeta catalytic subunit | 0.002 | 0.0158 | 0.0074 |
Plasmodium falciparum | DNA polymerase alpha catalytic subunit A | 0.002 | 0.0167 | 0.4016 |
Trypanosoma brucei | ribonuclease H1 | 0.0039 | 0.0524 | 0.0396 |
Brugia malayi | RNase H family protein | 0.0039 | 0.0524 | 0.0914 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0025 | 0.0247 | 0.0116 |
Schistosoma mansoni | DNA polymerase delta catalytic subunit | 0.002 | 0.0158 | 0.0074 |
Trypanosoma cruzi | DNA polymerase I alpha catalytic subunit, putative | 0.0031 | 0.0379 | 0.025 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0075 | 0.1214 | 0.1096 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0013 | 0.0024 | 0.0954 |
Schistosoma mansoni | stromal cell-derived factor 2 precursor-like protein | 0.0025 | 0.0251 | 0.0348 |
Echinococcus multilocularis | acetylcholinesterase | 0.0048 | 0.0698 | 0.1895 |
Loa Loa (eye worm) | DNA-directed DNA polymerase III | 0.002 | 0.0158 | 0.0085 |
Schistosoma mansoni | DNA polymerase gamma | 0.0174 | 0.3116 | 0.8733 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0099 | 0.1675 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0025 | 0.0247 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0698 | 0.1895 |
Plasmodium vivax | DNA polymerase zeta catalytic subunit, putative | 0.002 | 0.0158 | 0.0332 |
Schistosoma mansoni | phosphoglucomutase | 0.0039 | 0.0524 | 0.1145 |
Trichomonas vaginalis | DNA polymerase zeta catalytic subunit, putative | 0.002 | 0.0158 | 0.0649 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0025 | 0.0247 | 0.0116 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0088 | 0.1459 | 0.4446 |
Brugia malayi | DNA polymerase family B containing protein | 0.002 | 0.0158 | 0.0059 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0039 | 0.0524 | 0.0396 |
Echinococcus multilocularis | ribonuclease H1 | 0.0039 | 0.0524 | 0.1311 |
Echinococcus granulosus | acetylcholinesterase | 0.0048 | 0.0698 | 0.1895 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0698 | 0.1321 |
Trichomonas vaginalis | mannosyltransferase 1, putative | 0.0025 | 0.0251 | 0.3035 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0252 | 0.4615 | 0.4542 |
Schistosoma mansoni | ryanodine receptor related | 0.0158 | 0.2809 | 0.7835 |
Echinococcus multilocularis | stromal cell derived factor 2 | 0.0025 | 0.0251 | 0.0398 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0698 | 0.1655 |
Entamoeba histolytica | DNA polymerase alpha catalytic subunit, putative | 0.002 | 0.0167 | 0.294 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0027 | 0.0294 | 0.0472 |
Echinococcus granulosus | dna polymerase epsilon catalytic subunit a | 0.002 | 0.0158 | 0.0085 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0025 | 0.0247 | 0.0116 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0039 | 0.0524 | 0.0396 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0072 | 0.1158 | 0.3437 |
Leishmania major | ribonuclease H1, putative | 0.0039 | 0.0524 | 0.0396 |
Schistosoma mansoni | DNA polymerase epsilon catalytic subunit | 0.002 | 0.0158 | 0.0074 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.