Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.5268 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0105 | 0.0069 | 0.0271 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0153 | 0.0162 | 0.0632 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.5268 | 1 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1397 | 0.2556 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0072 | 0.0007 | 0.0028 |
Brugia malayi | hypothetical protein | 0.0153 | 0.0162 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0162 | 0.0171 |
Schistosoma mansoni | beta-galactosidase | 0.077 | 0.1348 | 0.1122 |
Onchocerca volvulus | 0.0153 | 0.0162 | 0.3454 | |
Onchocerca volvulus | 0.0153 | 0.0162 | 0.3454 | |
Loa Loa (eye worm) | trehalase | 0.0153 | 0.0162 | 0.0171 |
Trypanosoma cruzi | glycosyl hydrolase, putative | 0.0074 | 0.001 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1397 | 0.2556 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0105 | 0.0069 | 0.0271 |
Onchocerca volvulus | 0.0153 | 0.0162 | 0.3454 | |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.3185 | 0.5994 | 1 |
Echinococcus granulosus | beta galactosidase | 0.077 | 0.1348 | 0.0636 |
Loa Loa (eye worm) | trehalase | 0.0153 | 0.0162 | 0.0171 |
Echinococcus multilocularis | beta galactosidase | 0.077 | 0.1348 | 0.0636 |
Brugia malayi | Trehalase family protein | 0.0153 | 0.0162 | 0.0156 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0105 | 0.0069 | 0.0271 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.001 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0464 | 0.0761 | 0.1167 |
Brugia malayi | Trehalase family protein | 0.0153 | 0.0162 | 0.0156 |
Onchocerca volvulus | 0.0312 | 0.0468 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0162 | 0.0171 |
Plasmodium vivax | hypothetical protein, conserved | 0.0235 | 0.032 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0072 | 0.0007 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0162 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0162 | 0.0171 |
Brugia malayi | Trehalase family protein | 0.0153 | 0.0162 | 0.0156 |
Trypanosoma brucei | glycosyl hydrolase, putative | 0.0074 | 0.001 | 0.5 |
Brugia malayi | Trehalase family protein | 0.0153 | 0.0162 | 0.0156 |
Loa Loa (eye worm) | TRE-1 protein | 0.0153 | 0.0162 | 0.0171 |
Leishmania major | glycosyl hydrolase, putative | 0.0074 | 0.001 | 0.5 |
Onchocerca volvulus | Trehalase homolog | 0.0153 | 0.0162 | 0.3454 |
Mycobacterium leprae | Possible hydrolase | 0.0074 | 0.001 | 0.5 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.3185 | 0.5994 | 1 |
Onchocerca volvulus | 0.0153 | 0.0162 | 0.3454 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0464 | 0.0761 | 0.1181 |
Onchocerca volvulus | 0.0153 | 0.0162 | 0.3454 | |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.1348 | 0.2171 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.1348 | 0.2171 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0105 | 0.0069 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0162 | 0.0171 |
Loa Loa (eye worm) | TRE-2 protein | 0.0153 | 0.0162 | 0.0171 |
Loa Loa (eye worm) | trehalase | 0.0153 | 0.0162 | 0.0171 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0105 | 0.0069 | 0.0016 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0105 | 0.0069 | 0.0271 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0105 | 0.0069 | 0.0271 |
Trichomonas vaginalis | trehalase, putative | 0.0153 | 0.0162 | 0.0632 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0235 | 0.032 | 0.5 |
Schistosoma mansoni | alpha-l-fucosidase | 0.3185 | 0.5994 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.