Detailed information for compound 2071812

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.393 | Formula: C18H22N4O2
  • H donors: 1 H acceptors: 3 LogP: 1.35 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ncc2c(n1)CN(CC2)Cc1cccc(c1)OCC(=O)N
  • InChi: 1S/C18H22N4O2/c1-2-18-20-9-14-6-7-22(11-16(14)21-18)10-13-4-3-5-15(8-13)24-12-17(19)23/h3-5,8-9H,2,6-7,10-12H2,1H3,(H2,19,23)
  • InChiKey: FHOXWYSPDNRIFY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Peptidase family M1 containing protein 0.0046 0.0873 0.0941
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0061 0.0491
Loa Loa (eye worm) hypothetical protein 0.0046 0.0873 0.0873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.1198 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0181 0.2022
Brugia malayi Cathepsin L-like precursor 0.0016 0.0181 0.019
Onchocerca volvulus 0.0016 0.0181 0.1108
Echinococcus granulosus cathepsin l1 0.0016 0.0181 0.0181
Brugia malayi TATA binding protein associated factor 0.0046 0.0873 0.0941
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0046 0.0873 0.0873
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0046 0.0873 0.0873
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0005 0.0005
Echinococcus granulosus cathepsin L cysteine protease 0.0008 0.0005 0.0005
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0181 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Echinococcus granulosus cathepsin L 0.0008 0.0005 0.0005
Brugia malayi Cathepsin L-like precursor 0.0016 0.0181 0.019
Onchocerca volvulus 0.0022 0.0322 0.2418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Schistosoma mansoni aminopeptidase A (M01 family) 0.0046 0.0873 0.0873
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0181 0.1581
Trypanosoma cruzi aminopeptidase, putative 0.0046 0.0873 0.7277
Loa Loa (eye worm) hypothetical protein 0.0046 0.0873 0.0873
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.002 0.0286 0.0286
Loa Loa (eye worm) peptidase family M1 containing protein 0.0046 0.0873 0.0873
Trypanosoma brucei hypothetical protein, conserved 0.0058 0.1142 0.9528
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0181 0.0181
Echinococcus multilocularis cysteine protease 0.0016 0.0181 0.0181
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0181 0.1108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.1198 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0046 0.0873 0.0873
Brugia malayi Angiotensin-converting enzyme family protein 0.041 0.9232 1
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0181 0.1108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Schistosoma mansoni hypothetical protein 0.0022 0.0322 0.0322
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0181 0.0181
Echinococcus multilocularis cathepsin L 0.0008 0.0005 0.0005
Onchocerca volvulus 0.0016 0.0181 0.1108
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0046 0.0873 0.0873
Toxoplasma gondii aminopeptidase N protein 0.0046 0.0873 1
Leishmania major cathepsin L-like protease 0.006 0.1198 1
Onchocerca volvulus 0.0016 0.0181 0.1108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0181 0.1581
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0005 0.0044
Loa Loa (eye worm) POT family protein 0.0055 0.1072 0.1072
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0046 0.0868 0.0868
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0046 0.0873 0.7277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0061 0.0533
Brugia malayi Matrixin family protein 0.0013 0.0107 0.0111
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0181 0.1581
Loa Loa (eye worm) hypothetical protein 0.0016 0.0181 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.1198 1
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0181 0.1472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.1198 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0028 0.0459 0.3679
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0046 0.0873 0.0873
Trypanosoma cruzi protein phosphatase 2A regulatory subunit, putative 0.0058 0.1142 0.9528
Schistosoma mansoni protein phosphatase pp2a regulatory subunit B 0.0058 0.1142 0.1142
Brugia malayi POT family protein 0.0055 0.1072 0.1156
Trypanosoma cruzi cruzipain precursor, putative 0.006 0.1198 1
Leishmania major protein phosphatase 2A regulatory subunit, putative 0.0058 0.1142 0.9446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Trypanosoma brucei aminopeptidase, putative 0.0046 0.0873 0.7277
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.1198 1
Onchocerca volvulus 0.0022 0.0322 0.2418
Loa Loa (eye worm) hypothetical protein 0.0022 0.0322 0.0322
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0046 0.0873 0.6807
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0046 0.0873 0.6807
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0046 0.0868 0.0868
Echinococcus granulosus aminopeptidase N 0.0046 0.0873 0.0873
Schistosoma mansoni memapsin-2 (A01 family) 0.0081 0.1676 0.1676
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.1198 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0155 0.0155
Plasmodium vivax vivapain-2 0.0016 0.0181 0.2022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0181 0.1581
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0005 0.0005
Schistosoma mansoni furin-1 (S08 family) 0.0015 0.0153 0.0153
Onchocerca volvulus 0.0016 0.0181 0.1108
Brugia malayi Matrixin family protein 0.0013 0.0107 0.0111
Trichomonas vaginalis protein phosphatase pp2a regulatory subunit B, putative 0.0058 0.1142 1
Loa Loa (eye worm) TATA binding protein associated factor 0.0046 0.0873 0.0873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Brugia malayi Cathepsin L-like precursor 0.0011 0.0061 0.0061
Mycobacterium leprae PROBABLE HYDROLASE 0.0015 0.017 0.5
Onchocerca volvulus 0.0046 0.0873 0.7515
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0394 0.8871 0.8871
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.1198 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0061
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0443 1 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0046 0.0873 0.0873
Loa Loa (eye worm) serine/threonine protein phosphatase 2A 0.0058 0.1142 0.1142
Trichomonas vaginalis protein phosphatase PP2A regulatory subunit B, putative 0.0058 0.1142 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Loa Loa (eye worm) hypothetical protein 0.0022 0.0322 0.0322
Brugia malayi Cathepsin L-like precursor 0.0016 0.0181 0.019
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0046 0.0873 1
Loa Loa (eye worm) matrixin family protein 0.0028 0.0459 0.0459
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0061 0.0061
Loa Loa (eye worm) ctsf protein 0.0016 0.0181 0.0181
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0046 0.0873 1
Loa Loa (eye worm) endoprotease bli-4 0.0033 0.0587 0.0587
Brugia malayi Muscle positioning protein 4 0.0022 0.0322 0.0344
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0046 0.0873 0.0873
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0046 0.0873 0.7648
Leishmania major cathepsin L-like protease 0.006 0.1198 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0181 0.019
Toxoplasma gondii aminopeptidase n, putative 0.0046 0.0873 1
Onchocerca volvulus 0.0046 0.0873 0.7515
Onchocerca volvulus 0.0016 0.0181 0.1108
Echinococcus granulosus cysteine protease 0.0008 0.0005 0.0005
Onchocerca volvulus 0.0022 0.0322 0.2418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Onchocerca volvulus 0.0013 0.0107 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0061 0.0533
Plasmodium vivax vivapain-2 0.0016 0.0181 0.2022
Brugia malayi cathepsin L-like precursor 0.0011 0.0061 0.0061
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0181 0.0181
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.002 0.0286 0.0286
Leishmania major hypothetical protein, conserved 0.0058 0.1142 0.9446
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0181 0.1581
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0046 0.0873 0.0873
Entamoeba histolytica protein phosphatase regulatory subunit, putative 0.0058 0.1142 1
Brugia malayi proprotein convertase 2 0.0021 0.0302 0.0321
Brugia malayi sulfakinin receptor protein 0.006 0.1194 0.1289
Onchocerca volvulus 0.0022 0.0322 0.2418
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0046 0.0873 0.7277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0181 0.1581
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0046 0.0873 0.7277
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0046 0.0873 1
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0046 0.0873 0.6807
Brugia malayi Cathepsin L-like precursor 0.0016 0.0181 0.019
Loa Loa (eye worm) hypothetical protein 0.0013 0.012 0.012
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0181 0.2022
Loa Loa (eye worm) matrixin family protein 0.003 0.0516 0.0516
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0181 0.0181
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.1198 1
Leishmania major cathepsin L-like protease 0.006 0.1198 1
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.1142 0.9528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0181 0.1581
Onchocerca volvulus 0.0018 0.0228 0.1543
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0015 0.017 0.0179
Echinococcus granulosus protein phosphatase pp2a regulatory subunit b 0.0058 0.1142 0.1142
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0046 0.0873 0.0873
Brugia malayi Cathepsin L-like precursor 0.0011 0.0061 0.0061
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.041 0.9232 0.9232
Trypanosoma brucei Aminopeptidase M1, putative 0.0046 0.0873 0.7277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0181 0.1581
Echinococcus multilocularis 0.0027 0.0438 0.0438
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0181 0.1545
Echinococcus multilocularis protein phosphatase pp2a regulatory subunit b 0.0058 0.1142 0.1142
Loa Loa (eye worm) cysteine protease 0.0016 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.006 0.1194 0.1194
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0046 0.0873 0.7277
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0048 0.0932 0.0932
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0181 0.1581
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.1142 0.9528
Echinococcus granulosus cathepsin l1 0.0011 0.0061 0.0061
Trypanosoma cruzi Aminopeptidase M1, putative 0.0046 0.0873 0.7277
Trypanosoma cruzi major cysteine proteinase, putative 0.0047 0.0903 0.7525
Brugia malayi hypothetical protein 0.0397 0.8945 0.9689
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0443 1 1
Onchocerca volvulus 0.0016 0.0181 0.1108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0587 0.0587
Brugia malayi neuroendocrine convertase 1 precursor 0.0021 0.0302 0.0321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.1198 1
Trypanosoma cruzi protein phosphatase 2A regulatory subunit, putative 0.0058 0.1142 0.9528
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.002 0.0286 0.2502
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0055 0.1078 0.8997
Brugia malayi SEA domain containing protein 0.0022 0.0322 0.0344
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0181 0.0181
Entamoeba histolytica aminopeptidase, putative 0.0046 0.0873 0.7637
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0061 0.0061
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0005 0.0005
Brugia malayi Matrixin family protein 0.0013 0.0107 0.0111
Onchocerca volvulus 0.0022 0.0322 0.2418
Giardia lamblia Protein phosphatase PP2A regulatory subunit B 0.0058 0.1142 1
Echinococcus granulosus furin 0.0033 0.0587 0.0587
Brugia malayi hypothetical protein 0.006 0.1194 0.1289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.1198 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0443 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0013 0.0107 0.0107
Brugia malayi Matrixin family protein 0.003 0.0516 0.0554
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0046 0.0873 0.0873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0005 0.0044
Brugia malayi endoprotease bli-4 precursor 0.0033 0.0587 0.0631
Brugia malayi hypothetical protein 0.0046 0.0873 0.0941
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0046 0.0873 0.7648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.1198 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0046 0.0873 0.7648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Echinococcus multilocularis aminopeptidase N 0.0046 0.0873 0.0873
Echinococcus multilocularis cysteine protease 0.0016 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0013 0.0107 0.0107
Loa Loa (eye worm) fibroinase 0.0016 0.0181 0.0181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0181 0.1581
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0181 0.0181
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0015 0.017 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0181 0.1581
Schistosoma mansoni hypothetical protein 0.0018 0.0228 0.0228
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0181 0.0181
Loa Loa (eye worm) DOMON domain-containing protein 0.0022 0.0322 0.0322
Mycobacterium ulcerans aminopeptidase N PepN 0.0046 0.0873 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.003 0.0504 0.0504
Echinococcus granulosus neuroendocrine convertase 2 0.0021 0.0302 0.0302
Onchocerca volvulus 0.0046 0.0873 0.7515
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0181 0.1545
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0012 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.1198 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.1198 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0181 0.0181
Loa Loa (eye worm) aminopeptidase N 0.0046 0.0873 0.0873
Brugia malayi Peptidase family M1 containing protein 0.0046 0.0873 0.0941
Trypanosoma brucei Aminopeptidase M1, putative 0.0046 0.0873 0.7277
Loa Loa (eye worm) hypothetical protein 0.0046 0.0873 0.0873
Trypanosoma cruzi aminopeptidase, putative 0.0046 0.0873 0.7277
Loa Loa (eye worm) matrix metalloproteinase 0.0013 0.0107 0.0107
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0013 0.0107 0.0107
Onchocerca volvulus 0.0016 0.0181 0.1108
Brugia malayi Matrixin family protein 0.0013 0.0107 0.0111
Brugia malayi serine/threonine protein phosphatase 2A 0.0058 0.1142 0.1232
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0181 0.019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0015 0.0155 0.0162
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0012 0.0098 0.0098
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0046 0.0873 0.6807
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0046 0.0873 0.0873
Entamoeba histolytica cysteine protease, putative 0.0016 0.0181 0.1545
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0046 0.0873 0.7277
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0046 0.0873 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0046 0.0873 0.0873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Mycobacterium ulcerans aminopeptidase N PepN 0.0046 0.0873 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0046 0.0873 0.7277
Brugia malayi hypothetical protein 0.0046 0.0873 0.0941
Onchocerca volvulus Matrilysin homolog 0.0013 0.0107 0.0427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.1198 1
Trypanosoma brucei protein phosphatase 2A regulatory subunit, putative 0.0058 0.1142 0.9528
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0181 0.1108
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0046 0.0873 0.0873
Brugia malayi celfurPC protein 0.0027 0.0438 0.047
Brugia malayi Hemopexin family protein 0.0018 0.0228 0.0241
Toxoplasma gondii aminopeptidase N, putative 0.0046 0.0873 1
Trichomonas vaginalis serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, putative 0.0058 0.1142 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0072 0.1464 0.1464
Loa Loa (eye worm) hypothetical protein 0.0013 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0015 0.017 0.017
Brugia malayi Cathepsin L-like precursor 0.0016 0.0181 0.019
Onchocerca volvulus Matrilysin homolog 0.0028 0.0459 0.3679
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.002 0.0286 0.2502
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0046 0.0873 0.0873
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0181 0.2022
Echinococcus multilocularis neuroendocrine convertase 2 0.0021 0.0302 0.0302
Brugia malayi Peptidase family M1 containing protein 0.0046 0.0873 0.0941
Onchocerca volvulus Protein phosphatase PP2A 55 kDa regulatory subunit homolog 0.0058 0.1142 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0181 0.1581
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0033 0.0587 0.0587

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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